Article
Polymer Science
Victor Delorme, Ghislain David, Stephane Dejean, Julia Mouton, Xavier Garric, Jean Coudane, Helene van den Berghe
Summary: Describes the synthesis of a fully biodegradable amphiphilic copolymer PCL-g-CHT, which has a hydrophobic PCL backbone and hydrophilic CHT grafts. The copolymer self-assembles into nanomicelles and can be used for novel drug delivery systems.
MACROMOLECULAR RAPID COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Penghao Sun, Siheng Wang, Zhen Huang, Lei Zhang, Fuhao Dong, Xu Xu, He Liu
Summary: The development of sustainable cellulose paper materials to replace petroleum-based plastics is challenging but highly desirable. Researchers have developed a new rosin-based modifier that improves the hydrophobicity and reduces capillarity of cellulose paper. The modified cellulose composite paper shows excellent water resistance and strength, and can be completely degraded and recycled, making it a promising eco-friendly alternative to plastics.
Article
Chemistry, Physical
Angel J. Satti
Summary: This study focuses on the synthesis of chitosan-caprolactone graft copolymers (Ch-g-CL) through Radio Induced Grafting (RIG) of heterogeneous blends of solid chitosan polymers and liquid epsilon-caprolactone monomer. It was found that copolymerization was successful on nanochitosan blends, with up to 29% caprolactone incorporation. The reaction most likely occurred through caprolactone grafting from/onto chitosan's amine groups. The RIG syntheses led to tunable Ch-g-CL structures with potential applications in biomedical fields.
RADIATION PHYSICS AND CHEMISTRY
(2023)
Article
Chemistry, Applied
Nasim Ghasemi, Mohammad Reza Vakili, Afsaneh Lavasanifar
Summary: This study developed methods for reproducible production of partially cross-linked copolymers and assessed the effect of cross-linker type and molar ratio on the formation of viscoelastic thermogels. The results showed that only copolymers formed under specific conditions exhibited thermo-reversible viscoelastic hydrogels.
REACTIVE & FUNCTIONAL POLYMERS
(2022)
Review
Chemistry, Multidisciplinary
Jiansen Pan, Xiaoqing Ai, Chunfeng Ma, Guangzhao Zhang
Summary: This article reviews the recent progress in degradable vinyl polymers for marine anti-biofouling, focusing on the strategies for preparing these polymers, the synthesis and performance of various types of degradable polymers, and their potential applications. Polymers with degradable main chains and hydrolyzable side groups combine the advantages of SPC and degradable polymers, making them promising materials for high-efficiency, long-lasting, environmentally friendly, and broad-spectrum coatings to inhibit marine biofouling.
ACCOUNTS OF CHEMICAL RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Jean Coudane, Benjamin Nottelet, Julia Mouton, Xavier Garric, Helene van den Berghe
Summary: Synthetic biopolymers are attractive alternatives to biobased polymers due to their low immune response in living organisms. This review explores the potential of grafting polymer chains onto the backbone of poly E-caprolactone (PCL) to expand its applications, with a focus on the biomedical field.
Article
Polymer Science
Ankita Mandal, Andreas F. M. Kilbinger
Summary: Star polymers have attracted attention due to their distinctive properties. A one-pot synthesis of narrowly dispersed and degradable homoarm and miktoarm star polymers exploiting the catalytic living ring-opening metathesis polymerization mechanism was presented. Various complex polymeric architectures were synthesized using appropriate chain transfer agents.
Article
Agricultural Engineering
Juan Yu, Chaoqun Xu, Xiaoli Song, Chuanwei Lu, Chunpeng Wang, Jifu Wang, Fuxiang Chu
Summary: In this study, a series of rosin-based polymers were successfully prepared using a ATRP initiator derived from dehydroabietic acid, showing improved thermal stability, UV-blocking performance, hydrophobicity and mechanical properties. The DA-g-P(MMA-co-LMA) polymers exhibited good mechanical and elastic properties, comparable to other sustainable TPEs polymers. This work provides an alternative avenue for designing rosin-based polymers to enhance thermal, UV-blocking, and mechanical performance.
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Article
Chemistry, Multidisciplinary
Ting-Lun Chen, Yen-Po Lin, Chih-Hsuan Chien, Yi-Chen Chen, Yi-Ju Yang, Wei-Lung Wang, Lee-Feng Chien, Han-Yu Hsueh
Summary: Marine biofouling is a significant problem impacting ship maintenance, economy, and ecosystem safety. Inspired by frogskins, wrinkled slippery coatings with antifouling, anti-icing, and self-cleaning properties are created using degradable di-block copolymer self-assembly and hydrolysis-driven surface wrinkling. These coatings show flexible, stable, transparent, and easily tunable antibiofouling characteristics.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Polymer Science
Lawrence Hill, Hunter Sims, Ngoc Nguyen, Christopher Collins, Jeffery Palmer, Fiona Wasson
Summary: Mid-chain degradable polymers can be prepared using difunctional initiators that include triggers for the desired stimuli. However, there is limited research on preparing difunctional initiators that respond to oxidizing conditions. In this study, a difunctional initiator with an oxidizable trigger was synthesized, and its polymerization kinetics showed controlled behavior. The polymer synthesized using this initiator exhibited a significant decrease in molecular weight in the presence of hydrogen peroxide compared to a control polymer without a degradable linkage. The observed molecular weight decrease in both polymers was attributed to the cleavage of the difunctional initiator and hydrolysis of the ester pendent groups, resulting in an increase in polydispersity after oxidative degradation.
Article
Materials Science, Multidisciplinary
Evgenii A. Ksendzov, Pavel A. Nikishau, Irina M. Zurina, Viktoria S. Presniakova, Peter Timashev, Yuri A. Rochev, Svetlana Kotova, Sergei Kostjuk
Summary: A series of well-defined macromonomers and copolymers were synthesized via ROP and RAFT-mediated copolymerization, respectively. The cloud point temperature and transition temperature of the graft copolymers showed dependence on the copolymer composition. Films prepared from these copolymers displayed better cell adhesion compared to neat PNIPAM.
ACS APPLIED POLYMER MATERIALS
(2022)
Review
Polymer Science
Hao Sun, Yifei Liang, Matthew P. Thompson, Nathan C. Gianneschi
Summary: The development of degradable polymers via olefin metathesis polymerization has attracted significant attention in recent years. This versatile method allows for the incorporation of diverse degradable moieties into monomers and the synthesis of a wide range of degradable polymers. Emphasis is placed on exploring different olefin metathesis polymerization strategies and the control of polymerization reactions.
PROGRESS IN POLYMER SCIENCE
(2021)
Review
Chemistry, Multidisciplinary
Farzad Seidi, Yajie Zhong, Huining Xiao, Yongcan Jin, Daniel Crespy
Summary: Prodrugs, such as polyprodrugs, are developed to enhance therapeutic effects and reduce side effects. The degradation of polyprodrugs and release rate of drugs can be controlled by different types of covalent bonds in the polymer structure. Stimuli-responsive groups allow for selective degradation of the polymer backbone in targeted tumors. The combination of polyprodrugs with gene delivery segments and targeting moieties may lead to more efficient synergistic therapy.
CHEMICAL SOCIETY REVIEWS
(2022)
Article
Materials Science, Multidisciplinary
Dan Zhao, Xue Liang, Jiewen Wang, Jianzhong Du, Yunqing Zhu
Summary: This study presents a simple and effective approach to synthesize degradable polyurethanes with high bio-based carbon content and desirable mechanical properties by sourcing diols and isocyanates from biorenewable resources and introducing degradability via the Tishchenko reaction. The obtained polyurethanes can be completely degraded in a NaOH solution, expanding the end-of-life options.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Chemistry, Analytical
Wen-Bo Xie, Hao Li, Lei Zeng, Li-Juan Jiang, Wen Li, Lu Xia, Fu-Hou Lei
Summary: A column with a unique three-membered phenanthrene skeleton of rosin showed complementary selectivity to a C18 column for certain separations. By utilizing thiol-ene click chemistry reaction, two novel stationary phases, BRB@SiO2 and BRLA@SiO2, were successfully prepared with functional ligands. The characterization results confirmed the successful preparation of these stationary phases, which exhibited typical reversed-phase chromatography performance and good hydrophobicity, hydrophobic selectivity, and steric selectivity. The BRB@SiO2 and BRLA@SiO2 columns showed better separation effects for Panax notoginseng saponins compared to the C18 column, and the BRLA@SiO2 column could be used as a replacement for the detection of P. notoginseng saponins.
ANALYTICA CHIMICA ACTA
(2023)
Article
Chemistry, Multidisciplinary
Noah Hutchinson, Yuelin Wu, Yale Wang, Muskan Kanungo, Anna DeBruine, Emma Kroll, De'Jorra Gilmore, Zachary Eckrose, Stephanie Gaston, Phoebe Matel, Matey Kaltchev, Anne-Marie Nickel, Subha Kumpaty, Xiaolin Hua, Wujie Zhang
Summary: This research focuses on the green synthesis of gold nanoparticles using upland cress as a reducing and capping agent. The synthesized gold nanoparticles are spherical and well-dispersed with good stability and exhibit concentration-dependent antimicrobial properties. They also show catalytic activity and potential applications in biomedicine.
Article
Chemistry, Multidisciplinary
Jiangsheng Xu, Yunhua Liu, Sheng Liu, Wenquan Ou, Alisa White, Samantha Stewart, Katherine H. R. Tkaczuk, Lee M. Ellis, Jun Wan, Xiongbin Lu, Xiaoming He
Summary: Colon and rectal cancers are leading causes of cancer-related deaths in the United States. Genomic analyses reveal the frequent hemizygous deletion of TP53 gene, an important tumor suppressor, in both cancers. Targeting TP53 directly has been unsuccessful, but the co-deletion of POLR2A gene with TP53 in these cancers suggests RNA interference with POLR2A siRNA as a potential strategy. However, efficient delivery of siRNA into the cytosol is a major challenge. To overcome this barrier, pH-responsive MetC-nanoparticles with a bomb effect are developed for effective cytosolic delivery of POLR2A siRNA, enhancing therapeutic efficacy for TP53-deficient cancer.
Article
Chemistry, Multidisciplinary
Jiangsheng Xu, James G. Shamul, Elyahb Allie Kwizera, Xiaoming He
Summary: Mitochondria are critical organelles for producing energy in cells and can be targeted for cancer therapy. Mitochondria-targeting nanotechnologies have shown high efficacy for cancer treatment both in vitro and in vivo, and can be intelligently designed based on the characteristics of the tumor microenvironment.
Article
Chemistry, Multidisciplinary
Elyahb A. Kwizera, Wenquan Ou, Sojeong Lee, Samantha Stewart, James G. Shamul, Jiangsheng Xu, Nancy Tait, Katherine H. R. Tkaczuk, Xiaoming He
Summary: In this study, a robust electromicrofluidic chip was developed for efficient capture and release of heterogeneous circulating tumor cells (CTCs), which is important for cancer research and therapeutic development.
Correction
Chemistry, Multidisciplinary
Elyahb A. Kwizera, Wenquan Ou, Sojeong Lee, Samantha Stewart, James G. Shamul, Jiangsheng Xu, Nancy Tait, Katherine H. R. Tkaczuk, Xiaoming He
Article
Polymer Science
Leman Buzoglu Kurnaz, Yishayah Bension, Chuanbing Tang
Summary: Reprocessable and biobased thermosets were prepared using renewable feedstocks, lignin and polyamine, which were oxidized to produce polycarbonyl and further reacted to form a crosslinked network of imines. The mechanical strength and thermal properties of the thermosets can be adjusted by changing feedstock ratios, and the dynamic imine crosslinks can be reformed.
MACROMOLECULAR CHEMISTRY AND PHYSICS
(2023)
Article
Engineering, Biomedical
Bin Jiang, Alisa White, Wenquan Ou, Sarah Van Belleghem, Samantha Stewart, James G. Shamul, Shaik O. Rahaman, John P. Fisher, Xiaoming He
Summary: The conventional approach for fabricating PDMS microfluidic devices is inconvenient and requires specialized facilities. This study discovered that reducing the curing agent for crosslinking the PDMS prepolymer increases the noncovalent binding energy of the PDMS surfaces, allowing for the convenient fabrication of leak-free microfluidic devices without the need for plasma or other treatments. This method enables easy loading and retrieval of cells and is faster and more convenient than the conventional covalent bonding method.
BIOACTIVE MATERIALS
(2022)
Article
Engineering, Biomedical
Leman Buzoglu Kurnaz, Yuanyuan Luo, Xiaoming Yang, Amjed Alabresm, Ryan Leighton, Rani Kumar, JiHyeon Hwang, Alan W. Decho, Prakash Nagarkatti, Mitzi Nagarkatti, Chuanbing Tang
Summary: Facial amphiphilicity is a unique chemical structure feature of antimicrobial peptides and polymers, and it has been extensively studied. This research introduces the Facial Amphiphilicity Index (FAI) as a quantitative measure to characterize the chemical compositions and structural features that determine antimicrobial efficacy. The study finds that larger cross-sectional areas contribute to better antimicrobial efficacy, while intermediate FAIs are more suitable for specific antimicrobial systems.
BIOACTIVE MATERIALS
(2023)
Editorial Material
Biotechnology & Applied Microbiology
Wujie Zhang
BIOENGINEERING-BASEL
(2022)
Article
Genetics & Heredity
Pei-Chih Lee, Samantha Stewart, Olga Amelkina, Hannah Sylvester, Xiaoming He, Pierre Comizzoli
Summary: Intracellular trehalose delivery through CRNPs improves the dehydration tolerance of COCs, opening up new possibilities for oocyte storage and preservation of fertility at ambient temperatures.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2023)
Article
Polymer Science
Yishayah Bension, Leman Buzoglu Kurnaz, Ting Ge, Chuanbing Tang
Summary: In this study, lignin, which is rich in polyphenolic structure and globular architecture, was surface modified with functionalized silyl ether groups via thiol-ene chemistry to create reconstructable thermosets. These thermosets not only exhibited enhanced mechanical properties but also improved degradability. The structure-property relationship was explored by synthesizing different crosslinkers and altering the cross-linking density and the size of cross-linkers had a significant impact on the mechanical properties of the final thermosets. Furthermore, the chemical recycling of these thermosets was investigated for their conversion to initial motifs under basic environments.
Retraction
Chemistry, Multidisciplinary
Hai Wang, Pranay Agarwal, Gang Zhao, Guang Ji, Christopher M. Jewell, John P. Fisher, Xiongbin Lu, Xiaoming He
ACS CENTRAL SCIENCE
(2023)
Article
Engineering, Biomedical
Samantha Stewart, Wenquan Ou, Helim Aranda-Espinoza, Shaik O. Rahaman, Xiaoming He
Summary: Ovarian follicles develop in a regulated mechanical microenvironment, and disruptions to this microenvironment can cause infertility. The viscoelastic properties of ovarian tissue have not been extensively studied. This study characterizes the elastic and viscoelastic properties of ovarian tissue from both reproductive age groups of domestic cats and identifies possible connections between mechanical and compositional heterogeneities. These findings may have important implications for biomimetic follicle culture.
ACTA BIOMATERIALIA
(2023)
Article
Materials Science, Composites
Yi Shen, Xinyu Wang, Shijian Xu, Caoxing Huang, Juan Yu, Qiang Yong, Daihui Zhang, Jifu Wang, Chuanwei Lu, Fuxiang Chu
Summary: In this study, a sustainable, mechanically robust, and reproducible metal polymer composite elastomer was successfully fabricated. The composite was derived from cellulose, plant oil, natural rubber, and liquid metal, and exhibited excellent mechanical elasticity, reproducibility, and photothermal conversion performance.
COMPOSITES SCIENCE AND TECHNOLOGY
(2023)
Article
Polymer Science
Huina Lin, Luis Ramos, JiHyeon Hwang, Tianyu Zhu, Md Waliullah Hossain, Qi Wang, Sophya Garashchuk, Chuanbing Tang
Summary: Cationic metallopolymers with a complete hydrocarbon framework were synthesized and used as anion-exchange membranes in alkaline fuel cells. These polymers showed high chemical and thermal stability, low swelling, and favorable mechanical properties. They exhibited high hydroxide conductivity and retained 94% of the conductivity after exposure to high alkaline conditions for 45 days. The main-chain hydrocarbon-based polymers were found to have lower water uptake and swelling ratio compared to side-chain cobaltocenium polymer-based AEMs, while maintaining similar ion exchange capacity and hydroxide conductivity.
