期刊
BIOMACROMOLECULES
卷 11, 期 9, 页码 2213-2220出版社
AMER CHEMICAL SOC
DOI: 10.1021/bm100537b
关键词
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资金
- FCT - Portuguese Foundation for Science and Technology
- European project [NMP2-CT-2006-026741]
The unique properties of silk fibroin were combined with keratin to develop new wound-dressing materials. Silk fibroin/keratin (SF/K) films were prepared to reduce high levels of elastase found on chronic wounds. This improved biological function was achieved by the incorporation of a small peptide synthesized based on the reactive-site loop of the Bowman Birk Inhibitor (BBI) protein. In vitro degradation and release were evaluated using porcine pancreatic elastase (PPE) solution as a model of wound exudate. It was found that biological degradation and release rate are highly dependent on film composition. Furthermore, the level of PPE activity can be tuned by changing the film composition, thus showing an innovative way of controlling the elastase-antielastase imbalance found on chronic wounds.
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