Article
Biochemistry & Molecular Biology
Mohammad Morsali, Adrian Moreno, Andriana Loukovitou, Ievgen Pylypchuk, Mika H. Sipponen
Summary: This study reports the synthesis of stable lignin nanoparticles and explores their potential applications. The nanoparticles have a high biobased content and exhibit structural stability in different environments. They can also be modified by various reactions to expand their applicability.
Article
Biochemistry & Molecular Biology
Mohammad Morsali, Adrian Moreno, Andriana Loukovitou, Ievgen Pylypchuk, Mika H. Sipponen
Summary: This study reports the synthesis of hydroxymethylated lignin nanoparticles and their stabilization through hydrothermal curing. These particles have high biobased content, tunable particle size distribution, and structural stability in both aqueous media and organic solvents. The stabilized lignin particles can be further modified and reused, showing potential for their use in circular biobased nanomaterials.
Article
Food Science & Technology
Mangang Wu, Zhikun Li, Ranran Wei, Yi Luan, Juan Hu, Qingling Wang, Rui Liu, Qingfeng Ge, Hai Yu
Summary: The study investigated the role of sulfhydryl groups and disulfide bonds in different protein-stabilized emulsions. Addition of the sulfhydryl-blocking agent NEM reduced disulfide bond formation, disrupted the internal protein structure, decreased emulsifying activity and stability, and increased emulsion droplet size. The effects were similar across different protein types, but subtle differences were observed in the degree of impact on emulsifiers.
Article
Biochemistry & Molecular Biology
Shixin Song, Yufei Li, Qiyuan Zhu, Xin Zhang, Yang Wang, Li Tao, Lei Yu
Summary: In this study, buckwheat protein colloidal particles (BPCPs) were prepared by heat treatment to stabilize the oil-water interface. The results showed that the prepared BPCPs could be used as a novel Pickering emulsifier with certain particle size, surface hydrophobicity, and wettability. The effects of BPCPs concentration, ionic strength, and heat treatment on the structure and properties of Pickering emulsions were investigated.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Food Science & Technology
Yameng Han, Ling Zhu, Emad Karrar, Xiguang Qi, Hui Zhang, Gangcheng Wu
Summary: This review summarizes protein particle-stabilized Pickering foams and their complexes with other biopolymers. It discusses the main mechanisms controlling foam stability to better understand the complex behavior of Pickering foams. The main applications and challenges of protein-stabilized Pickering foams are highlighted.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2023)
Article
Biology
Motonori Matsusaki, Rina Okada, Yuya Tanikawa, Shingo Kanemura, Dai Ito, Yuxi Lin, Mai Watabe, Hiroshi Yamaguchi, Tomohide Saio, Young-Ho Lee, Kenji Inaba, Masaki Okumura
Summary: The physiological functions of proteins are determined by their unique three-dimensional structures, with conserved disulfide-catalysts and chaperone networks playing a crucial role in correct protein folding and prevention of aggregation. Disruption of these networks is implicated in pathology. Complex formation among PDIs accelerates protein folding and prevents aggregation.
Article
Biochemistry & Molecular Biology
Fenggui Fan, Hao Zhang, Qian Wei, Yahui Wei
Summary: This study reveals the evolutionary conservation of PDI-S between land plants and algal organisms, and elucidates the induction mechanism of AtPDI11 under ER stress and the crucial importance of the D domain for its activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Biomedical
Geoffroy Goujon, Victor Baldim, Caroline Roques, Nicolas Bia, Johanne Seguin, Bruno Palmier, Alain Graillot, Cedric Loubat, Nathalie Mignet, Isabelle Margaill, Jean-Francois Berret, Virginie Beray-Berthat
Summary: This study investigates the relationship between oxidative stress and pathologies such as ischemic stroke, aiming to develop CNPs with antioxidant capacities for potential therapeutic use. The results show that coated CNPs are non-toxic to endothelial cells and can reduce the production of ROS, with one CNP significantly decreasing mitochondrial superoxide anion and DNA oxidation.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Chemistry, Applied
Sashikumar Ramamirtham, Catherine P. Whitby, Davoud Zare, Mike Weeks, Martin A. K. Williams
Summary: Structural manipulation of beta-lactoglobulin through processes like heat treatment and complexation has shown success in industrial formulations. The formation of disulfide linkages between monomers at the interface triggers assembly into non-native dimers, while native dimers form extended networks, impacting the interfacial elastic strength. The relationship between the quaternary structure of beta-lg and its interfacial network suggests a potential role in its biological function.
FOOD HYDROCOLLOIDS
(2021)
Article
Biochemistry & Molecular Biology
Jinxin Hu, Mei Yu, Yanan Chang, Huali Tang, Wanxin Wang, Lipu Du, Ke Wang, Yueming Yan, Xingguo Ye
Summary: In this study, wheat protein disulfide isomerase (PDI) was found to play a crucial role in wheat flour-processing quality. Mutants lacking TaPDI genes exhibited reduced grain size, increased accumulation of protein bodies, and altered rheological properties of dough.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Multidisciplinary
Rajarshi Roy Raju, Joachim Koetz
Summary: This study reports a modified approach for the batch scale preparation of completely engulfed core-shell emulsions or partially engulfed Janus emulsions with colorful optical properties. The in situ reduction of gold chloride at the olive oil interface leads to the formation of compartmentalized emulsion droplets in water, with time-dependent morphological transformations observed depending on the presence of chitosan or presynthesized AuNPs. The Pickering effect of AuNPs brings color effects to microdroplets and induces surprising self-assembly.
Article
Chemistry, Multidisciplinary
Yitong Wang, Jin Yuan, Shuli Dong, Jingcheng Hao
Summary: Water-in-water (W/W) emulsions are prepared using poly(ethylene glycol)/dextran and stabilized by DNA strands. The emulsions exhibit onion-ring-like structures, which are explained by a nanofluid film model. The behavior of the emulsions can be controlled by the type of DNA, DNA concentration, and volume fraction of dispersed phase.
Review
Food Science & Technology
Chenzhi Wang, Jianhui Wu, Chunhua Wang, Changdao Mu, To Ngai, Wei Lin
Summary: This article introduces the concept and fabrication methods of protein-based particles as promising emulsion stabilizers in the food industry, and discusses the shape, interfacial arrangement and interaction of these particles. The article also explores the novel applications and future perspectives of these materials.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Xian He, Wanshui Yang, Qihong Zhao, Xinsheng Qin
Summary: In this study, Pickering emulsions stabilized by quinoa protein isolate (QPI) and (-)-epigallocatechin-3-gallate (EGCG) hybrid particles were prepared using ultrasonic emulsification technique. The interaction forces between QPI and EGCG were characterized and the results showed that the hybrid particles were formed mainly via hydrophobic interactions, hydrogen bonds, and electrostatic interactions. The emulsion exhibited solid-like properties and the antioxidant interfacial structure provided by the QPI/EGCG hybrid particles limited lipid oxidation and digestion. This study provides a basis for the development of food and drug delivery systems utilizing the antioxidant properties of plant polyphenols.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Dogus Murat Altintas, Simona Gallo, Cristina Basilico, Marina Cerqua, Alessio Bocedi, Annapia Vitacolonna, Orsola Botti, Elena Casanova, Ilaria Rancati, Chiara Milanese, Sara Notari, Giorgia Gambardella, Giorgio Ricci, Pier Giorgio Mastroberardino, Carla Boccaccio, Tiziana Crepaldi, Paolo Maria Comoglio
Summary: The PSI domain of the MET receptor regulates its disulfide isomerase activity and is essential for the cleavage, maturation, and biological functions of the MET protein.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Aria Ahmed-Cox, Elvis Pandzic, Stuart T. Johnston, Celine Heu, John McGhee, Friederike M. Mansfeld, Edmund J. Crampin, Thomas P. Davis, Renee M. Whan, Maria Kavallaris
Summary: Nanoparticles show promise in cancer therapy, but face challenges in clinical trials. Developing advanced 3D cell models like tumor spheroids can help evaluate nanoparticle designs and understand how different cell characteristics influence uptake. A new analysis platform, DONUTS, allows for spatial and temporal quantification of nanoparticle uptake in 3D tumor spheroids, offering insight into penetration kinetics and cell type variations.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Biotechnology & Applied Microbiology
Holly Holliday, Jessica Yang, Eoin Dodson, Iva Nikolic, Alvin Kamili, Madeleine Wheatley, Niantao Deng, Sarah Alexandrou, Thomas P. Davis, Maria Kavallaris, C. Elizabeth Caldon, Joshua McCarroll, Katleen De Preter, Pieter Mestdagh, Glenn M. Marshall, Kaylene J. Simpson, Jamie Fletcher, Alexander Swarbrick
Summary: This study discovered that miR-99b-5p, miR-380-3p, and miR-485-3p enhance the chemotherapeutic effects of doxorubicin in high-risk neuroblastoma. These miRNAs are often lost in patients and their low expression predicts poor survival outcomes.
Article
Multidisciplinary Sciences
Francesco De Logu, Romina Nassini, Alan Hegron, Lorenzo Landini, Dane D. Jensen, Rocco Latorre, Julia Ding, Matilde Marini, Daniel Souza Monteiro de Araujo, Paulina Ramirez-Garcia, Michael Whittaker, Jeffri Retamal, Mustafa Titiz, Alessandro Innocenti, Thomas P. Davis, Nicholas Veldhuis, Brian L. Schmidt, Nigel W. Bunnett, Pierangelo Geppetti
Summary: This study reveals that the CGRP-mediated neuronal/Schwann cell pathway mediates allodynia associated with neurogenic inflammation, contributing to the algesic action of CGRP in mice.
NATURE COMMUNICATIONS
(2022)
Review
Materials Science, Multidisciplinary
Jia Li, Cyrille Boyer, Xuewen Zhang
Summary: This paper discusses the application progress of 3D printing in the preparation of photocatalysts, focusing on the advantages of photopolymerization-based 3D printing technology and prospects for its application in the production of photocatalyst products.
MACROMOLECULAR MATERIALS AND ENGINEERING
(2022)
Article
Chemistry, Multidisciplinary
Prabal Sapkota, Cyrille Boyer, Sean Lim, Kondo-Francois Aguey-Zinsou
Summary: In this study, a Pt/Cu catalyst was successfully synthesized by alloying Pt with low-cost transition metal, and it exhibited high catalytic activity in fuel cells. Compared to using Pt alone, using Pt/Cu catalyst not only improved the hydrogen oxidation and oxygen reduction activity by 2.4 times, but also achieved a 1.4-fold increase in power output with a 22% reduction in Pt usage.
RESEARCH ON CHEMICAL INTERMEDIATES
(2022)
Article
Chemistry, Multidisciplinary
He Zhang, Liang Zhang, Zhenbang Cao, Soshan Cheong, Cyrille Boyer, Zhigang Wang, Sung Lai Jimmy Yun, Rose Amal, Zi Gu
Summary: By constructing an ultra-thin nanosheet, the low drug loading capacity limitation of nanoparticle carriers in drug delivery has been addressed, leading to exceptional drug loading capacity and enhanced therapeutic performance in cancer treatment.
Article
Materials Science, Multidisciplinary
Shengxiang Cai, Francois-Marie Allioux, Jianbo Tang, Jialuo Han, Jin Zhang, Yilin He, Salina Merhebi, Michael J. Christoe, Mohannad Mayyas, Edgar H. H. Wong, Cyrille Boyer, Raymond Neff, Kourosh Kalantar-Zadeh
Summary: In this study, polyurethane-based sponges with gallium microdroplets embedded inside were developed, resulting in conductive sponges. These sponges exhibit excellent elastic recovery and conductivity durability, with a remarkable reversible change in resistivity range.
ADVANCED MATERIALS TECHNOLOGIES
(2022)
Article
Nanoscience & Nanotechnology
Xuan Luo, Wenjin Xing, Iliana Delcheva, Fayed Abdullah Alrashaidi, Amir Heydari, Dennis Palms, Vi Khanh Truong, Krasimir Vasilev, Zhongfan Jia, Wei Zhang, Peng Su, Kasturi Vimalanathan, Aghil Igder, Gregory A. Weiss, Youhong Tang, Melanie MacGregor, Colin L. Raston
Summary: A shear-stress-mediated platform called portable vortex-fluidic device (P-VFD) has been developed to overcome the diffusion-limit and achieve fast reaction rates. The platform consists of a plasma oxazoline-coated polyvinyl chloride (POx-PVC) film with tough hydrogel covalently bound to its surface and a reactor tube for reactions. The hydrogel arrays on the film provide a strong matrix for entrapping biomolecules and tolerate shear stress, resulting in a >6-fold increase in reaction rate.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Shangxu Jiang, Yihui Xie, Yuan Xie, Li-Juan Yu, Xiaoqing Yan, Fu-Gang Zhao, Chanaka J. Mudugamuwa, Michelle L. Coote, Zhongfan Jia, Kai Zhang
Summary: This study investigates the (electro)chemical behavior of TEMPO in organic and aqueous Lewis acid electrolytes and unveils its reversible disproportionation process in aqueous media. Based on these findings, a radical polymer aqueous AIBs is designed and demonstrates promising stability and performance.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Jasmine M. M. Pople, Thomas P. P. Nicholls, Le Nhan Pham, Witold M. M. Bloch, Lynn S. S. Lisboa, Michael V. V. Perkins, Christopher T. T. Gibson, Michelle L. L. Coote, Zhongfan Jia, Justin M. M. Chalker
Summary: In this study, a new method for the synthesis of high sulfur content polymers was developed using electrochemically initiated ring-opening polymerization. This method offers improved safety and control of structure by eliminating the need for hazardous chemical initiators. The resulting polymer exhibits good solubility and processability. Thermal depolymerization of the polymer allows for its recycling back to the cyclic trisulfide monomer. The polymer also demonstrates effective gold sorption, suggesting potential applications in mining and electronic waste recycling.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Thomas P. Nicholls, Zhongfan Jia, Justin M. Chalker
Summary: An electrochemical synthesis method has been developed for the production of gold(I)-N-heterocyclic carbene (Au-NHC) complexes. This method allows for the production of complexes without any by-products, which can be directly used as catalysts without purification.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Materials Science, Biomaterials
Paulina D. Ramirez-Garcia, Nicholas A. Veldhuis, Nigel W. Bunnett, Thomas P. Davis
Summary: In this article, we propose a new opportunity to target intracellular compartments by delivering antagonists via nanoparticles to G-protein coupled receptors. We specifically discuss the application of this approach in antagonizing endosomal receptors involved in pain for developing long-lasting analgesics, and also highlight the potential broader applications. We also discuss the materials used and provide design requirements for future successful applications.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Chemistry, Multidisciplinary
Chanaka J. Mudugamuwa, Yuan Xie, Kai Zhang, Thomas P. Nicholls, Justin M. Chalker, Zhongfan Jia
Summary: New functionalized surfactants have been developed as efficient catalysts for the electrochemical oxidation of long-chain fatty alcohols, resulting in increased reaction rates and conversions.
Review
Chemistry, Multidisciplinary
Nicholas Andrikopoulos, Huayuan Tang, Yue Wang, Xiufang Liang, Yuhuan Li, Thomas P. Davis, Pu Chun Ke
Summary: Therapeutic peptides are important drugs that specifically target abnormal protein-protein interactions associated with amyloid diseases. The use of nanoparticles in combination with peptide drugs has emerged as a promising strategy for enhancing their efficacy against amyloid aggregation and cellular inflammation. However, there is still a lack of understanding of the chemistry and function of peptido-nanocomposites, and a systematic analysis of their application against a range of amyloid pathogeneses is missing.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Polymer Science
Zihnil A. I. Mazrad, May Lai, Thomas P. Davis, Joseph A. Nicolazzo, Kristofer J. Thurecht, Meike N. Leiske, Kristian Kempe
Summary: This study explores the application of a new initiator in polymer synthesis. The results show that this initiator can achieve a higher degree of control over the polymerization process under irradiation, resulting in well-defined polymers. In addition, tailored amine-based polymers can be prepared by using different terminating agents.