The entrapment of two hydrophobic molecules, benzophenone and tamoxifen, into self-assembling cyclodextrin (CD)-based nanogels has been studied. These nanogels formed spontaneously upon the association of a hydrophobically modified dextran (MD) and a cyclodextrin polymer (p beta CD). The interactions of benzophenone and tamoxifen with MD and p beta CD were investigated using phase solubility studies, circular dichroism, and isothermal titration calorimetry. Both hydrophobic molecules were included into the CD cavities of the p beta CD and were also solubilized by MD into its hydrophobic microdomains. We took advantage of these interactions to form benzophenone- and tamoxifen-loaded nanogels. The highest benzophenone loadings were obtained by solubilizing it in both p beta CD and MD solutions before mixing them to form nanogels. These studies open new possibilities of applications of the nanogels, mainly in the cosmetic field, as sun screen carriers prepared by a simple green technology.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据