Article
Engineering, Environmental
Gu Cheng, Jinhong Dai, Jiawei Dai, Hang Wang, Shuo Chen, Yingheng Liu, Xiayi Liu, Xiaoran Li, Xue Zhou, Hongbing Deng, Zhi Li
Summary: The SF-chitin hybrid nanofiber/TGF-beta 1-functionalized scaffold developed in this study promotes chondrocyte adhesion and proliferation in vitro, as well as cartilage regeneration in vivo, offering a suitable strategy for the repair of cartilage defects.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Bruno Zwingenberger, Corina Vater, Roland L. Bell, Julia Bolte, Elisabeth Mehnert, Ronny Bruenler, Dilbar Aibibu, Stefan Zwingenberger
Summary: The study found that CHS scaffolds exhibited higher osteogenic properties in vitro, but resulted in lower bone-healing outcomes compared to CBA and MCM in vivo. Future improvements on CHS scaffolds are needed for better mechanical stability and osteoconductivity.
Article
Biochemistry & Molecular Biology
Elke Gossla, Anne Bernhardt, Robert Tonndorf, Dilbar Aibibu, Chokri Cherif, Michael Gelinsky
Summary: Replacement of damaged cartilage tissue with tissue engineering faces challenges due to the limited self-healing capacity of the non-vascularized tissue. A new approach using chitosan flock scaffolds combined with alginate hydrogel has been developed to support chondrogenic differentiation of human chondrocytes, showing promising results in gene expression and extracellular matrix production for cartilage regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biotechnology & Applied Microbiology
Shuai Chen, Carmen J. Gil, Liqun Ning, Linqi Jin, Lilanni Perez, Gabriella Kabboul, Martin L. Tomov, Vahid Serpooshan
Summary: This article discusses the significance of Adhesive Tissue Engineering Scaffolds (ATESs), reviewing their key characteristics and requirements, exploring mechanisms of action for securing the scaffold onto tissue, and presenting strategies for assessing adhesive properties. Current applications and future prospects of advanced ATES systems in regenerative medicine therapies are highlighted, along with key challenges in various fields of tissue engineering.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Polymer Science
Cristiana Luminita Gijiu, Raluca Isopescu, Daniel Dinculescu, Maria Memecica, Manuela-Rossemary Apetroaei, Mirela Anton, Verginica Schroder, Ileana Rau
Summary: This study experimentally investigated and optimized the extraction of chitin from crab shells to obtain chitosan with a predefined deacetylation degree and molecular mass. By varying four parameters, including NaOH concentration, temperature, HCl concentration, and number of acidic treatments, the optimum operating conditions were determined. The results showed that a high deacetylation degree of chitosan can be achieved with 5% NaOH concentration and low temperatures, while high molecular mass chitosan can be obtained with a single step acidic treatment.
Review
Polymer Science
Gamal Abdel Nasser Atia, Hany K. Shalaby, Mehrukh Zehravi, Mohamed Mohamady Ghobashy, Hager Abdel Nasser Attia, Zubair Ahmad, Farhat S. Khan, Abhijit Dey, Nobendu Mukerjee, Athanasios Alexiou, Md. Habibur Rahman, Joanna Klepacka, Agnieszka Najda
Summary: This article examined and summarized the current developments in chitosan-based materials, focusing on the modification of chitosan and its use in periodontal regeneration. The study critically reviewed various preparation and modification techniques to enhance chitosan performance and discussed the uses of chitosan-based products in depth.
Article
Engineering, Biomedical
You Chen, Yuanyuan Chen, Xiong Xiong, Rongwei Cui, Guowei Zhang, Chen Wang, Dongqin Xiao, Shuxin Qu, Jie Weng
Summary: In this study, a novel hydrogel was developed by hybridizing different materials and pre-crosslinking to enhance osteochondral repair. The research found that the new hydrogel had controllable properties, good cell compatibility, and significantly promoted bone and cartilage repair in experiments.
MATERIALS TODAY BIO
(2022)
Review
Chemistry, Applied
Amol D. Gholap, Satish Rojekar, Harshad S. Kapare, Nikhar Vishwakarma, Sarjana Raikwar, Atul Garkal, Tejal A. Mehta, Harsh Jadhav, Mahendra Kumar Prajapati, Uday Annapure
Summary: Chitosan, a natural polysaccharide derived from chitin, holds great potential as a biomaterial in various biomedical applications due to its biocompatibility, biodegradability, antibacterial activity, and ease of modification. This review provides an overview of the use of chitosan scaffolds in tissue engineering, regenerative medicine, and drug delivery systems. It highlights the structural and biological properties of chitosan and explores different fabrication methods, such as gelation, electrospinning, and 3D printing. The review emphasizes the role of chitosan scaffolds in promoting cell adhesion, proliferation, and differentiation for tissue regeneration, as well as their potential in wound healing and infection management. Additionally, it discusses the challenges and future objectives in scaffold design, mechanical properties, and understanding interactions with host tissues.
CARBOHYDRATE POLYMERS
(2024)
Article
Biotechnology & Applied Microbiology
Satyendra Jyoti, Satyendra Singh, Sumistha Das, Shaili Srivastava
Summary: A comparative study was conducted to remove hexavalent chromium from wastewater using synthesized nanoparticles such as chitin, chitosan, zinc oxide, and ZnO-chitosan composite. The results showed that the ZnO-chitosan nanobiocomposite had the highest uptake capacity for chromium (VI). The optimal conditions for adsorption were found to be a concentration of 20 ppm, a dosage of 0.5 g/l, pH 3, and a time of 60 min.
ENVIRONMENTAL TECHNOLOGY & INNOVATION
(2023)
Article
Chemistry, Physical
Jing-Jing Shi, Yu-Wei Ge, Zhang-Hao Fan, Yang Li, Wei-Tao Jia, Ya-Ping Guo
Summary: This study developed a nacre-mimetic layered scaffold for the treatment of breast cancer bone metastases. The scaffold had appropriate mechanical strengths, excellent anti-tumor and pro-osteogenesis activities, and could avoid damage and promote bone tissue regeneration.
Review
Pharmacology & Pharmacy
Yevgeniy Kim, Zharylkasyn Zharkinbekov, Kamila Raziyeva, Laura Tabyldiyeva, Kamila Berikova, Dias Zhumagul, Kamila Temirkhanova, Arman Saparov
Summary: Chitosan, a biopolymer derived from chitin, has great potential for tissue regeneration and controlled drug delivery. It possesses qualities such as biocompatibility, low toxicity, and antimicrobial activity, making it attractive for biomedical applications. Chitosan can be fabricated into different structures, including nanoparticles, scaffolds, hydrogels, and membranes, which can be customized for specific outcomes. It has been shown to stimulate tissue regeneration and repair in various tissues and organs, and is an efficient carrier for medications, genes, and bioactive compounds.
Review
Pharmacology & Pharmacy
Nimeet Desai, Dhwani Rana, Sagar Salave, Raghav Gupta, Pranav Patel, Bharathi Karunakaran, Amit Sharma, Jyotsnendu Giri, Derajram Benival, Nagavendra Kommineni
Summary: Chitosan, derived from chitin, is a promising material for drug delivery and biomedical applications. Different extraction techniques can produce chitosan with unique properties, which can be further modified to enhance bioactivities. Chitosan-based drug delivery systems have been developed for various administration routes, allowing for targeted and sustained release of drugs. It has also been used in biomedical applications such as tissue regeneration and gene delivery. Modified chitosan derivatives offer innovative materials with potential in biomedical applications. This article summarizes recent findings on chitosan and its applications in drug delivery and biomedical science.
Article
Biochemistry & Molecular Biology
Haofeng Qiu, Junjie Deng, Rufang Wei, Xiang Wu, Shengjia Chen, Yanyu Yang, Chenyang Gong, Lingling Cui, Zhangyong Si, Yabin Zhu, Rong Wang, Dangsheng Xiong
Summary: Dually cross-linked hydrogels made of oxidized hyaluronic acid and HTCC methacrylate showed appropriate rheological properties, self-healing capability, and exhibited superior lubrication and tissue adhesion properties. The hydrogels also demonstrated good antibacterial ability, cell proliferation promotion, and robust regenerating ability for articular cartilage both in vitro and in vivo. This lubricant-adhesive hydrogel holds promise for joint injury treatment and regeneration.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Materials Science, Multidisciplinary
Han Yin, Zineng Yan, Jiang Wu, Muzhe Li, Qian Ge, Tieyuan Zhang, Yang Ma, Xiang Sui, Shuyun Liu, Quanyi Guo
Summary: This study aimed to investigate the potential of M2 macrophages-derived exosomes (M2D-Exo) to enhance the repair of acellular cartilage extracellular matrix (ACECM) scaffolds. The results showed that M2D-Exo could promote the migration, proliferation, and chondrogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs). It was also found that M2D-Exo could reduce the expression of proinflammatory factors and promote M2 polarization, ultimately protecting chondrocytes and inhibiting chondrocyte apoptosis. In vivo experiments confirmed the efficacy of M2D-Exo in promoting the repair of ACECM scaffolds.
MATERIALS & DESIGN
(2023)
Article
Engineering, Biomedical
Panjian Lu, Gang Wang, Tianmei Qian, Xiaodong Cai, Ping Zhang, Meiyuan Li, Yinying Shen, Chengbin Xue, Hongkui Wang
Summary: Research suggests that an appropriate amount of PLGA scaffolds can promote successful nerve regeneration, contributing to aspects such as the structure of the regenerated nerve, reinnervation of the target muscle, and Schwann cell migration and maturation. Additionally, the correct ratio of PLGA and chitosan degradation products helps reduce inflammatory response and enhance the regeneration microenvironment.
MATERIALS TODAY BIO
(2021)
