Review
Biochemistry & Molecular Biology
Angela K. Odle, Melanie C. MacNicol, Gwen Childs, Angus M. MacNicol
Summary: Proper expression of GnRH receptors by pituitary gonadotropes is crucial for maintaining maximum reproductive capacity, as it must be tightly regulated to maintain normal expression patterns and interpret finely tuned GnRH pulses. Research has shown that Gnrhr expression is regulated both transcriptionally and post-transcriptionally, with RNA-binding proteins and microRNAs playing important roles in regulation. These post-transcriptional regulators may also be influenced by metabolic cues, particularly by the adipokine leptin. Further exploration of post-transcriptional regulation is necessary to fully understand the complexity of GnRHR regulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Toxicology
Tomas Smutny, Lucie Hyrsova, Albert Braeuning, Magnus Ingelman-Sundberg, Petr Pavek
Summary: The pregnane X receptor (PXR) is a key transcription factor known for regulating xenobiotic detoxification, but it is also involved in endogenous metabolism and various pathological states. Non-coding RNAs, especially microRNAs, have been shown to post-transcriptionally regulate PXR expression. In addition, PXR is controlled by multiple transcription factors and genetic polymorphisms, with long non-coding RNAs also playing a role in PXR expression regulation.
ARCHIVES OF TOXICOLOGY
(2021)
Review
Cell Biology
Monika Vilimova, Sebastien Pfeffer
Summary: A significant portion of miRNA genes in animal genomes tend to cluster together. These miRNA clusters are transcribed as polycistronic transcripts, benefiting from common transcriptional regulation. However, there are discrepancies in the accumulation of mature miRNAs produced from the same cluster, suggesting unforeseen post-transcriptional regulatory mechanisms.
WILEY INTERDISCIPLINARY REVIEWS-RNA
(2023)
Article
Biochemistry & Molecular Biology
Wing-Keung Chu, Li-Man Hung, Chun-Wei Hou, Jan-Kan Chen
Summary: This study found that MIR630 represses the expression of NANOG through transcriptional and post-transcriptional regulation, leading to the differentiation of NT2/D1 cells. MIR630 may have multiple binding sites in the 3'UTR of NANOG and may act together with other miRNAs to maximally suppress NANOG expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Eun B. Lee, V. Praveen Chakravarthi, Michael W. Wolfe, M. A. Karim Rumi
Summary: Gonadotropins play vital roles in ovarian development and oocyte maturation, signaling through protein kinases and regulated by estrogen receptors. Er beta is crucial in regulating follicle development and ovulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Endocrinology & Metabolism
Colin M. Clay, Brian D. Cherrington, Amy M. Navratil
Summary: Gonadotropes cells in the anterior pituitary gland play a critical role in reproductive health by generating the LH surge required for ovulation through increasing sensitivity to GnRH, elevating GnRHR expression, and altering cellular morphology.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Biochemical Research Methods
Mattia Furlan, Stefano de Pretis, Mattia Pelizzola
Summary: Despite RNA abundance being commonly assumed as a proxy for transcriptional activity, it is now possible to calculate how synthesis, processing, and degradation rates collectively determine the abundance of each gene's RNA. Different transcriptional outputs can correspond to different combinations of kinetic rates, indicating the existence of markedly different modes of gene expression regulation and their profound effects on gene self-expression regulation.
BRIEFINGS IN BIOINFORMATICS
(2021)
Review
Cell Biology
Qiuqin Ma, Shihui Long, Zhending Gan, Gianluca Tettamanti, Kang Li, Ling Tian
Summary: Autophagy, a widely conserved process in eukaryotes, is regulated by nutrient deprivation, energy stress, and other unfavorable conditions through multiple pathways. It is primarily governed at the RNA and protein levels in a synergistic manner.
Article
Forestry
Qiao-Lu Zang, Yao Zhang, Su-Ying Han, Wan-Feng Li, Li-Wang Qi
Summary: The study investigated the expression and regulatory mechanisms of miR171 and its target gene LaSCL6 during somatic embryogenesis in Larix kaempferi. It identified five members of the miR171 family that cleave LaSCL6 mRNA at different sites and improved a method for measuring miRNA activity. The expression patterns of mature miR171s and their primary transcripts differed during somatic embryogenesis, indicating regulation of MIR171 gene transcription and cleavage of intermediate products.
TREES-STRUCTURE AND FUNCTION
(2021)
Review
Genetics & Heredity
Dharmendra Kumar Soni, Roopa Biswas
Summary: ncRNAs, especially miRNAs and lncRNAs, play crucial regulatory roles in lung diseases, and their dysregulation is associated with various pulmonary disorders. Research suggests that exploring the interactions between miRNAs and lncRNAs, as well as their functions in regulating mRNA expression, may help in early diagnosis and the development of novel therapeutic approaches for lung diseases.
FRONTIERS IN GENETICS
(2021)
Review
Biochemistry & Molecular Biology
Rocio Soledad Tognacca, Javier Francisco Botto
Summary: Seed dormancy is a crucial developmental stage regulated by temperature and light, with a delicate balance of hormone signaling. Chromatin remodeling and alternative splicing play important roles in seed germination. Understanding post-transcriptional processes in crop seeds may lead to genotypes with improved performance and productivity.
PLANT COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Ana Rodriguez-Galan, Sara G. Dosil, Manuel Jose Gomez, Irene Fernandez-Delgado, Lola Fernandez-Messina, Fatima Sanchez-Cabo, Francisco Sanchez-Madrid
Summary: T cell activation results in changes in the miRNA repertoire, with some individual miRNAs being specifically upregulated. Using next-generation sequencing, differential expression of multiple miRNAs not previously linked to T cell activation was identified. Upregulated miRNAs showed a higher frequency of 3' adenylation, which may serve a protective function in the adverse environment and could be utilized to improve miRNA stability for T cell-targeted therapy.
Article
Biochemistry & Molecular Biology
Xuan Zhang, Yinghui Wei, Xiaoxuan Li, Chengyu Li, Liangliang Zhang, Zhaojun Liu, Yan Cao, Weijian Li, Xiying Zhang, Jiaqing Zhang, Ming Shen, Honglin Liu
Summary: CORT inhibits Lhcgr expression in mouse ovarian granulosa cells (GCs), leading to impaired follicular development. The effect of CORT is mediated by its receptor Nr3c1 in GCs. Nr3c1 may regulate Lhcgr transcription by inhibiting the expression of Lhcgr transcription factors AP1 and Creb.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Pasi K. Korhonen, Tao Wang, Neil D. Young, Gangi R. Samarawickrama, Deepani D. Fernando, Guangxu Ma, Robin B. Gasser, Katja Fischer
Summary: This study revealed significant negative and positive correlations between miRNAs and gene transcription levels between different developmental stages of Sarcoptes scabiei, which may be associated with processes such as metabolism and genetic information processing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Vivek Kumar Raxwal, Somya Singh, Manu Agarwal, Karel Riha
Summary: The study revealed that new genes in rice have relatively low expression levels, possibly controlled by distal enhancers and chromatin conformation at their TSS; the chromatin in TSS regions may be remodeled in response to abiotic stress, indicating conditional expression of young genes. Furthermore, transcripts of young genes in Arabidopsis are prone to nonsense-mediated RNA decay, restricting their expression.
Article
Oncology
Toshio Nishimura, Kazuto Nakamura, Soichi Yamashita, Sadatomo Ikeda, Keiko Kigure, Takashi Minegishi
Article
Endocrinology & Metabolism
Kohshiro Nakao, Hiroshi Kishi, Fumiharu Imai, Hiroto Suwa, Takashi Hirakawa, Takashi Minegishi
Article
Pathology
Yoshiyasu Takayama, Nozomi Matsumura, Sumihito Nobusawa, Hayato Ikota, Takashi Minegishi, Hideaki Yokoo
Article
Obstetrics & Gynecology
Shota Ogawa, Hiromitsu Shinozaki, Kunihiko Hayashi, Masahiro Itoh, Masayuki Soda, Takashi Kameda, Kiyoshi Ozawa, Hidemi Yokota, Kiyoshi Kamioka, Takashi Minegishi
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2018)
Article
Oncology
Kohshiro Nakao, Takashi Hirakawa, Hiroto Suwa, Kayoko Kogure, Sadatomo Ikeda, Soichi Yamashita, Takashi Minegishi, Hiroshi Kishi
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2018)
Article
Endocrinology & Metabolism
Fumiharu Imai, Hiroshi Kishi, Kohshiro Nakao, Toshio Nishimura, Takashi Minegishi
Article
Obstetrics & Gynecology
Takashi Minegishi, Norihiro Sugino, Osamu Ishihara, Jo Kitawaki, Tasuku Harada, Takashi Murakami
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2014)
Meeting Abstract
Developmental Biology
Hisanobu Saakata, Maki Inoue, Takashi Kameda, Takashi Minegishi, Yu Hayashi, Shinichi Shimizu
Article
Multidisciplinary Sciences
Masayuki Iwamune, Kazuto Nakamura, Yoshikazu Kitahara, Takashi Minegishi
Article
Oncology
Tatsuya Ohno, Shin-ei Noda, Kazutoshi Murata, Yuya Yoshimoto, Noriyuki Okonogi, Ken Ando, Tomoaki Tamaki, Shingo Kato, Takashi Hirakawa, Tatsuya Kanuma, Takashi Minegishi, Takashi Nakano
Editorial Material
Obstetrics & Gynecology
Ryuji Kawaguchi, Koji Matsumoto, Shigeo Akira, Ken Ishitani, Kazuhiro Iwasaku, Yutaka Ueda, Ryugo Okagaki, Hiroya Okano, Toshimichi Oki, Kaori Koga, Michiko Kido, Takumi Kurabayashi, Yasushi Kuribayashi, Yuichi Sato, Kaori Shiina, Yasushi Takai, Satoshi Tanimura, Osamu Chaki, Masakazu Terauchi, Yukiharu Todo, Yasuyuki Noguchi, Sayaka Nose-Ogura, Tsukasa Baba, Akira Hirasawa, Takuma Fujii, Tsuneo Fujii, Tetsuo Maruyama, Etsuko Miyagi, Kaoru Yanagida, Osamu Yoshino, Mitsutoshi Iwashita, Tsugio Maeda, Takashi Minegishi, Hiroshi Kobayashi
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2019)
Article
Obstetrics & Gynecology
Hiroshi Tamura, Hiroshi Kishi, Mari Kitade, Mikiko Asai-Sato, Atsushi Tanaka, Takashi Murakami, Takashi Minegishi, Norihiro Sugino
REPRODUCTIVE MEDICINE AND BIOLOGY
(2017)
Article
Obstetrics & Gynecology
Hiroshi Tamura, Hiroshi Kishi, Mari Kitade, Mikiko Asai-Sato, Atsushi Tanaka, Takashi Murakami, Takashi Minegishi, Norihiro Sugino
REPRODUCTIVE MEDICINE AND BIOLOGY
(2017)
Article
Medicine, General & Internal
Takahiro Oike, Tatsuya Ohno, Shin-Ei Noda, Tomomi Murata, Takashi Hirakawa, Junko Hirato, Mio Furuya, Hiro Sato, Yuka Hirota, Takashi Minegishi, Takashi Nakano
CLINICAL CASE REPORTS
(2016)
Article
Oncology
Kyoichi Kaira, Kazuto Nakamura, Takashi Hirakawa, Hisao Imai, Hideyuki Tominaga, Noboru Oriuchi, Shushi Nagamori, Yoshikatsu Kanai, Norifumi Tsukamoto, Tetsunari Oyama, Takayuki Asao, Takashi Minegishi
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2015)