Article
Biochemistry & Molecular Biology
Guoyao Wu, Xilong Li, Heewon Seo, Bryan A. McLendon, Avery C. Kramer, Fuller W. Bazer, Gregory A. Johnson
Summary: This study demonstrates a novel mechanism of OPN/SPP1 in increasing ion transport across the porcine chorioallantoic placenta by binding to integrins.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2022)
Article
Medicine, Research & Experimental
Wenchen Cai, Bonan Zhang, Tian Li, Fuyu Jin, Yaqian Li, Hong Xu, Fang Yang
Summary: The study investigated mRNA profiles of rats exposed to crystalline silica and found 1,338 differentially expressed mRNAs in the lungs of silicotic rats, including genes related to silicosis. Analysis using GO and KEGG databases revealed significant changes in biological processes, cellular components, and molecular functions of these mRNAs.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Oncology
Jung Woo Eun, Jung Hwan Yoon, Hye Ri Ahn, Seokhwi Kim, Young Bae Kim, Su Bin Lim, Won Park, Tae Wook Kang, Geum Ok Baek, Moon Gyeong Yoon, Ju A. Son, Ji Hyang Weon, Soon Sun Kim, Hyo Jung Cho, Jae Youn Cheong
Summary: This study discovered that cancer-associated fibroblasts (CAFs) play a crucial role in inducing resistance to tyrosine kinase inhibitors (TKIs) in hepatocellular carcinoma (HCC). The CAF-derived SPP1 was identified as a candidate molecule driving TKI resistance, and inhibitors of SPP1 can reverse this resistance. Additionally, the plasma level of SPP1 before TKI treatment can serve as a potential biomarker for predicting treatment response in advanced HCC patients.
CANCER COMMUNICATIONS
(2023)
Article
Oncology
Jianzhong Yi, Yungeng Liu, Lei Zhang, Chuanfa Fang
Summary: The study revealed that SPP-1 was significantly elevated in CRC tissues, associated with advanced clinical progress and low overall survival rate. SPP-1 could interact with beta-catenin and positively regulate its protein expression, enhancing its nuclear accumulation. Upregulation of SPP-1 promoted cell proliferation and in vivo tumor formation ability, while reducing apoptosis, all of which depended on beta-catenin.
Article
Endocrinology & Metabolism
Mandy E. Turner, Christine A. White, Sarah M. Taylor, Kathryn Neville, Karen Rees-Milton, Wilma M. Hopman, Michael A. Adams, Tassos Anastassiades, Rachel M. Holden
Summary: SPP-24 is a cytokine-binding bone matrix protein primarily synthesized by the liver, potentially functioning as an inhibitor of bone formation and ectopic vascular calcification. Circulating levels of SPP-24 are significantly altered by kidney function and are associated with biomarkers involved in mineral metabolism, such as phosphate, PTH, and the Wnt-signaling inhibitor Dickkopf-related protein 1. Further study is needed to determine the role of circulating SPP-24 in bone formation and ectopic mineralization.
CALCIFIED TISSUE INTERNATIONAL
(2021)
Article
Cardiac & Cardiovascular Systems
Mei Zhou, Yuexin Zhu, Zeyi Zhou, Feiran Qi, Shuai Zheng, Shijuan Gao, Yulin Li, Yan Liu, Jie Du
Summary: This study found that Fbn1 mutation causes Marfan syndrome with thoracic aortic aneurysm as the main complication. The expression of the Spp1 gene was found to be increased in the cases and it plays an important role in the communication between fibroblasts and smooth muscle cells, possibly affecting the development of TAA through the regulation of Acta2, Tagln, and collagen expression. In patients, elevated plasma levels of SPP1 were associated with an increased risk of TAA.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Jorge Lopez-Tello, Zoe Schofield, Raymond Kiu, Matthew J. Dalby, Douwe van Sinderen, Gwenaelle Le Gall, Amanda N. Sferruzzi-Perri, Lindsay J. Hall
Summary: This study demonstrates that the bacterium Bifidobacterium breve UCC2003, a key member of the maternal gut microbiota, modulates maternal body adaptations, placental structure, and nutrient transporter capacity, with implications for fetal metabolism and growth.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Pharmacology & Pharmacy
De-cui Cheng, Yao Su, Feifei Li, Xianming Xu
Summary: This study aimed to investigate the efficiency of insulin on reducing gestational lipid profiles and propose a real-world approach to assist clinicians. The results showed that the use of insulin in the management of gestational hypertriglyceridemia is safe and efficient, and it can improve the outcomes of newborns and mothers.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Thorsten Braun, Loreen Ehrlich, Wolfgang Henrich, Sebastian Koeppel, Ievgeniia Lomako, Philipp Schwabl, Bettina Liebmann
Summary: The study identified the presence of microplastics (> 50 μm) in placenta and meconium samples from caesarean deliveries, with polyethylene, polypropylene, polystyrene, and polyurethane being the main types detected. However, airborne polyurethane microplastics were also found in the operating room, indicating potential contamination sources. Further research into nano-sized plastics in human tissues is recommended.
Article
Oncology
Yafei Liu, Guanchao Ye, Bo Dong, Lan Huang, Chunyang Zhang, Yinliang Sheng, Bin Wu, Lu Han, Chunli Wu, Yu Qi
Summary: This study provides a comprehensive overview of the role of SPP1 in various cancer types, suggesting it is an important player and a potential prognostic marker in different types of cancer.
ANNALS OF TRANSLATIONAL MEDICINE
(2022)
Article
Chemistry, Physical
Constantin Kappas
Summary: This article discusses the management and evaluation of radiation doses for pregnant women and pregnant workers in clinical settings where ionizing radiation is used. The study found that the majority of conventional radiographic procedures and diagnostic procedures in nuclear medicine are at doses much lower than the exposure associated with fetal harm. However, certain therapies in nuclear medicine, Radiation Therapy, multiple CT scans, and invasive radiology have the potential to cause serious damage to the fetus.
RADIATION PHYSICS AND CHEMISTRY
(2022)
Article
Agriculture, Dairy & Animal Science
Maria Grazia Cappai, Petra Wolf, Annette Liesegang, Giovanni Paolo Biggio, Andrea Podda, Antonio Varcasia, Claudia Tamponi, Fiammetta Berlinguer, Ignazio Cossu, Walter Pinna, Raffaele Cherchi
Summary: Monitoring serum protein fraction (SPF) levels, including metabolic profiling, in pregnant jennies can provide insights into the overall health status of the mother. Adequate dietary nutrient supplementation during mid-gestation is crucial to prevent homeostasis perturbation of jennies.
Review
Biotechnology & Applied Microbiology
Yi Liao, Ran Wang, Fuqiang Wen
Summary: SPP1 is a potential diagnostic and prognostic biomarker for patients with IPF. It has high sensitivity and specificity in distinguishing between IPF and lung cancer patients.
Article
Agriculture, Dairy & Animal Science
Chiara Pagamici, Roger Stephan
Summary: This study assessed the prevalence of pregnant sheep and lambs being slaughtered in Switzerland and found that 7.6% of female animals were pregnant at slaughter, with 25.5% in the third trimester of pregnancy. As it is uncertain whether fetuses can feel pain, measures should be taken to minimize the slaughter of pregnant animals.
Article
Clinical Neurology
Erez Berman, Natalia Erenburg, Ron Beloosesky, Sara Eyal, Michal Kovo
Summary: The study found that CBD is sequestered in placental tissue, with lower concentrations in the fetal compartment. CBD did not significantly alter placental gene expression. While the placenta acts as a depot for CBD, there are still potential risks associated with its use during pregnancy.
Article
Biology
Stephen Meek, Tom Watson, Lel Eory, Gus McFarlane, Felicity J. Wynne, Stephen McCleary, Laura E. M. Dunn, Emily M. Charlton, Chloe Craig, Barbara Shih, Tim Regan, Ryan Taylor, Linda Sutherland, Anton Gossner, Cosmin Chintoan-Uta, Sarah Fletcher, Philippa M. Beard, Musa A. Hassan, Finn Grey, Jayne C. Hope, Mark P. Stevens, Monika Nowak-Imialek, Heiner Niemann, Pablo J. Ross, Christine Tait-Burkard, Sarah M. Brown, Lucas Lefevre, Gerard Thomson, Barry W. McColl, Alistair B. Lawrence, Alan L. Archibald, Falko Steinbach, Helen R. Crooke, Xuefei Gao, Pentao Liu, Tom Burdon
Summary: This study investigates the potential of porcine pluripotent stem cells to provide a limitless source of macrophages, demonstrating their molecular and functional characteristics, as well as their susceptibility to infection by pig pathogens. The study also shows the successful application of CRISPR/Cas9 gene editing in these cells, presenting new opportunities for researching host-pathogen interactions in pigs.
Article
Pharmacology & Pharmacy
Laura Saludas, Elisa Garbayo, Adrian Ruiz-Villalba, Silvia Hernandez, Pieter Vader, Felipe Prosper, Maria J. Blanco-Prieto
Summary: Extracellular vesicles (EVs), as the next-generation therapies, have attracted great interest. This study investigated the effects of different cell culture conditions and purification methods on EV isolation using cardiac progenitor cells (CPCs). The findings contribute to the establishment of the basis for the use of EVs as therapeutic platforms.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2022)
Article
Veterinary Sciences
Hamish A. Salvesen, Fiona A. Sargison, Alan L. Archibald, Tahar Ait-Ali
Summary: Research suggests that Lawsonia intracellularis disrupts host autophagy response in the ileum, potentially aiding in bacterial propagation and pathogenesis by disturbing the normal intestinal homeostasis.
VETERINARY RESEARCH COMMUNICATIONS
(2022)
Article
Genetics & Heredity
Mazdak Salavati, Shernae A. Woolley, Yennifer Cortes Araya, Michelle M. Halstead, Claire Stenhouse, Martin Johnsson, Cheryl J. Ashworth, Alan L. Archibald, Francesc X. Donadeu, Musa A. Hassan, Emily L. Clark
Summary: This research identified regulatory sequences in the pig genome through Omni-ATAC-Seq analysis of semitendinosus muscle from 24 male piglets. Over 50% of the open chromatin regions were found near known transcription start sites. Differential analysis revealed genomic regions with significantly different chromatin accessibility across developmental time points.
G3-GENES GENOMES GENETICS
(2022)
Article
Agriculture, Dairy & Animal Science
M. P. Sanchez, T. Tribout, S. Fritz, V Wolf, C. Laithier, M. Brochard, D. Boichard
Summary: As part of the From'MIR project, this study assessed the reliability of ssEBVs for CMP, estimated genetic trends, and simulated different breeding objectives for the Montbeliarde breed. Reliability of ssEBVs ranged from 61% to 64%, with the TD3 model being the most accurate. The inclusion of additional candidate SNPs improved the reliabilities of ssEBVs and led to positive genetic trends for all CMP traits. The TMI-Cheese scenario yielded the best responses for CMP traits.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Oncology
Valentin Costes, Aurelie Chaulot-Talmon, Eli Sellem, Jean-Philippe Perrier, Anne Aubert-Frambourg, Luc Jouneau, Charline Pontlevoy, Chris Hoze, Sebastien Fritz, Mekki Boussaha, Chrystelle Le Danvic, Marie-Pierre Sanchez, Didier Boichard, Laurent Schibler, Helene Jammes, Florence Jaffrezic, Helene Kiefer
Summary: This study demonstrates the potential of sperm DNA methylation in predicting bull fertility and identifies differentially methylated cytosines related to fertility. The results are important for improving fertility prediction models and understanding the interplay between DNA methylation and other molecular features in fertility regulation. The findings may have potential applications in human medicine as well.
CLINICAL EPIGENETICS
(2022)
Editorial Material
Genetics & Heredity
Ruidong Xiang, Lingzhao Fang, Marie-Pierre Sanchez, Hao Cheng, Zhe Zhang
FRONTIERS IN GENETICS
(2022)
Article
Agriculture, Dairy & Animal Science
Raphaelle Duclos, Elsa Delanoue, Anne-Charlotte Dockes, Laurent Journaux, Michel Sourdioux, Jean-Pierre Bidanel
Summary: This article examines the controversies surrounding the application of genetic tools to farm animals and argues that this subject has the potential to become a public debate. It reviews the uncertainties and legal framework debates related to this topic, explores possible approaches for discussing the subject, and provides an overview of the actors involved in the discussion. The article suggests that the topic remains confined to the scientific and professional environment, but a few positions have emerged with regards to animal welfare.
INRA PRODUCTIONS ANIMALES
(2022)
Article
Biochemistry & Molecular Biology
Jun Li, Ruoshui Li, Izabela Tuleta, Silvia C. Hernandez, Claudio Humeres, Anis Hanna, Bijun Chen, Nikolaos G. Frangogiannis
Summary: The role of macrophage Smad7 in regulating inflammation and repair after myocardial infarction is limited. The anti-inflammatory effects of TGF-beta in macrophages are not restrained by endogenous Smad7 induction.
Article
Biochemistry & Molecular Biology
David Wragg, Sonia E. Eynard, Benjamin Basso, Kamila Canale-Tabet, Emmanuelle Labarthe, Olivier Bouchez, Kaspar Bienefeld, Malgorzata Bienkowska, Cecilia Costa, Ales Gregorc, Per Kryger, Melanie Parejo, M. Alice Pinto, Jean-Pierre Bidanel, Bertrand Servin, Yves Le Conte, Alain Vignal
Summary: Honey bee subspecies originate from specific geographical areas and have been imported to different regions. To better understand Western European honey bee populations, researchers conducted a genome sequence and SNP genotype analysis.
MOLECULAR ECOLOGY RESOURCES
(2022)
Article
Cardiac & Cardiovascular Systems
Bijun Chen, Ruoshui Li, Silvia C. Hernandez, Anis Hanna, Kai Su, Arti V. Shinde, Nikolaos G. Frangogiannis
Summary: TGF-beta signaling through Smad2/3 regulates macrophage responses in myocardial infarction. Smad3 plays a crucial role in mediating the anti-inflammatory and phagocytic effects of TGF-beta, while the activation of Smad2 does not affect these processes. Smad3, but not Smad2, is the main mediator of transcriptional effects of TGF-beta on macrophages.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Linda Alex, Izabela Tuleta, Silvia C. Hernandez, Anis Hanna, Harikrishnan Venugopal, Maider Astorkia, Claudio Humeres, Akihiko Kubota, Kai Su, Deyou Zheng, Nikolaos G. Frangogiannis
Summary: This study found that pericytes in the heart play a role in tissue repair, remodeling, and fibrosis. After myocardial infarction, a subpopulation of pericytes exhibits transient expression of fibroblast markers and contributes to the formation of fibrotic tissue. Pericyte-specific TGF-beta signaling is involved in the maturation of blood vessels in the infarcted area and protects against adverse remodeling.
Review
Agriculture, Dairy & Animal Science
G. Sahana, Z. Cai, M. P. Sanchez, A. C. Bouwman, D. Boichard
Summary: Genotype data from dairy cattle selection programs greatly facilitate GWAS to identify variants related to economic traits. Results can enhance the accuracy of genomic prediction, analyze more complex models, elucidate the genetic architecture of a trait, and decipher the underlying biology of traits.
JOURNAL OF DAIRY SCIENCE
(2023)
Article
Agriculture, Dairy & Animal Science
Marie-Pierre Sanchez, Thierry Tribout, Naveen K. Kadri, Praveen K. Chitneedi, Steffen Maak, Chris Hoze, Mekki Boussaha, Pascal Croiseau, Romain Philippe, Mirjam Spengeler, Christa Kuehn, Yining Wang, Changxi Li, Graham Plastow, Hubert Pausch, Didier Boichard
Summary: This study performs a meta-analysis of genome-wide association studies (GWAS) to identify variants associated with beef production traits in cattle. The fixed-effects method is more informative in identifying potentially causal variants, and the meta-analysis approach highlights a larger number of quantitative trait loci (QTL) in genomic regions known for their effects on growth and meat/carcass traits. Candidate variants identified in genes associated with growth and carcass traits provide insights into the genetic architecture of complex traits in beef cattle.
GENETICS SELECTION EVOLUTION
(2023)
Article
Agriculture, Dairy & Animal Science
Marie-Pierre Sanchez, Thierry Tribout, Sebastien Fritz, Raphael Guatteo, Christine Fourichon, Laurent Schibler, Arnaud Delafosse, Didier Boichard
Summary: This study investigates the genetic determinism of resistance to bovine paratuberculosis and shows that this trait can be predicted from SNP genotypes. The study finds that resistance to JD is moderately heritable and identifies 16 genomic regions associated with this resistance. The study also highlights the importance of genomic predictions in controlling paratuberculosis.
GENETICS SELECTION EVOLUTION
(2022)