Article
Infectious Diseases
Simon Graspeuntner, Katharina Koethke, Celeste Scholz, Lea Semmler, Mariia Lupatsii, Laura Kirchhoff, Jennifer Herrmann, Katharina Rox, Kathrin Wittstein, Nadja Kaeding, Lars C. Hanker, Marc Stadler, Mark Broenstrup, Rolf Mueller, Kensuke Shima, Jan Rupp
Summary: Current treatment methods for Chlamydia trachomatis have detrimental effects on the host's microbiota. This study analyzed the potential use of the myxobacterial natural product SorA as an alternative treatment, showing its effectiveness in vitro and in vivo. SorA demonstrated minimal inhibitory concentrations against C. trachomatis and successfully reduced chlamydial shedding in mice. It did not have significant side effects on the vaginal microbiota or human-derived lactobacilli but affected the gut microbial composition during intraperitoneal application.
Article
Multidisciplinary Sciences
Jasmine C. Labuda, Oanh H. Pham, Claire E. Depew, Kevin D. Fong, Bokyung Lee, Jordan A. Rixon, Stephen J. McSorley
Summary: Barrier tissues can be protected from infections such as Chlamydia via circulating immune memory, even in the absence of tissue-resident immune cells. Blocking the rapid mobilization of circulating memory CD4 T cells to the female reproductive tract inhibits this protective response. This provides an unexpected opportunity for vaccine development against infections of the female reproductive tract.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biology
Mihai Zurzu, Mihnea Ioan Nicolescu, Laurentiu Mogoanta, Stelian Pantea, Mugurel Constantin Rusu
Summary: A distinctive population of CD34+ TCs was found coating the myenteric ganglia in the colon, distinguishable from perivascular cells and vascular ECs. Immunohistochemical study using different markers can help accurately identify TCs.
Review
Medicine, Research & Experimental
Fan Ding, Qili Hu, Yixing Wang, Min Jiang, Zhengyu Cui, Run Guo, Liping Liu, Fang Chen, Hai Hu, Gang Zhao
Summary: The motility of the gallbladder involves the storage, concentration, and delivery of bile. Multiple factors control gallbladder motor functions, such as innervation, humoral factors, and neuropeptides. Gallbladder emptying is the result of coordinated contractions of the muscular layers of the gallbladder wall, mediated by rhythmic contractions of smooth muscle cells, GB neurons, telocytes, and interstitial cells of Cajal. This article introduces the STIN syncytium as a new motor unit in the gallbladder, providing pacemaker activity and propagation pathways for contractions.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2023)
Article
Immunology
Animamalar Mayavannan, Emily Shantz, Ian D. Haidl, Jun Wang, Jean S. Marshall
Summary: This study found that human mast cells react to Chlamydia spp. infection through multiple mechanisms, including TLR2-dependent pathways. Additionally, mast cells play an important role in shaping in vivo immune responses in Chlamydia reproductive tract infection by promoting effector cell recruitment and modifying the chemokine microenvironment.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Reproductive Biology
E. M. Donnellan, P. Lonergan, K. G. Meade, S. Fair
Summary: Despite passing quality control checks, bulls with apparently normal semen quality may have low field fertility rates. This study assessed the interaction between spermatozoa and the female reproductive tract in bulls with divergent field fertility. The results showed that there were no significant differences in most sperm motility and functional parameters between high and low fertility bulls. However, high fertility bulls had a higher straight-line velocity and a stronger binding ability to oviductal explants. There was also a positive correlation between straight-line velocity and sperm rheotactic response.
Article
Obstetrics & Gynecology
Kate Devine, Shelley Dolitsky, Inga Ludwin, Artur Ludwin
Summary: The high effectiveness of modern assisted reproductive technology (ART) and the increasing use of ART by noninfertile patients in the United States raise doubts about the relevance of a standard, one-size-fits-all infertility evaluation. This article explores the necessity of uterine cavity and tubal assessment for all patients seeking ART, as well as the most appropriate, efficient, and cost-effective tests in the current times.
FERTILITY AND STERILITY
(2022)
Article
Chemistry, Multidisciplinary
Na Ri Choi, Jeong Nam Kim, Byung Joo Kim
Summary: This study investigated the effects of trypsin on pacemaker potentials in murine small intestinal ICCs, finding that trypsin depolarized pacemaker potentials through NK1 and NK2 receptors, depending on G protein, phospholipase C, protein kinase C, inositol triphosphate pathways, and extracellular Ca2+ but independent of the TRPV4 pathway.
APPLIED SCIENCES-BASEL
(2022)
Review
Reproductive Biology
Andrew T. Major, Martin A. Estermann, Zahida Y. Roly, Craig A. Smith
Summary: The female reproductive tract in vertebrates has evolved considerable diversification, with the development of Mullerian duct playing a key role. While the formation of the Mullerian duct is a conserved process, genetic regulatory divergence has led to diversity in duct structure. Developmental plasticity in Hox gene code and wnt signaling may underlie the morphological variation of the uterus in mammals and evolution of the vagina, contributing to the diversity of female reproductive tracts seen today in vertebrates.
BIOLOGY OF REPRODUCTION
(2022)
Article
Pharmacology & Pharmacy
Yoshihiro Otsuka, Xiaopeng Bai, Yoshimasa Tanaka, Eikichi Ihara, Takatoshi Chinen, Haruei Ogino, Yoshihiro Ogawa
Summary: The interstitial cells of Cajal (ICCs) play a central role in DMPP-induced relaxation through membrane hyperpolarization via the activation of anoctamin-1. ATP may serve as a neurotransmitter for inhibitory enteric neurons that stimulate ICCs. ICCs act as the interface for neurotransmission of nicotinic acetylcholine receptor to induce LES relaxation.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Reproductive Biology
Lyndal Hulse, Chiara Palmieri, Kenneth W. Beagley, Rebecca Larkin, Tamara Keeley, Jaime Gosalvez, Stephen D. Johnston
Summary: The study suggests that Chlamydia infection and inflammation may not be the predominant reason for disruption to spermatogenesis in wild koalas, with testicular degeneration and atrophy appearing to be the primary cause of decreased sperm concentration, regardless of Chlamydia infection.
Review
Physiology
Bernard T. Drumm, Keith D. Thornbury, Mark A. Hollywood, Gerard P. Sergeant
Summary: Urinary continence is maintained by the contracture of urethral sphincters, including the role of Ano1 channels expressed in urethral ICC in increasing smooth muscle excitability. However, the specific role of urethral Ano1 channels remains unclear due to differences in species and experimental approaches. Clarifying this situation is crucial for developing new treatments for urinary incontinence.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2021)
Article
Genetics & Heredity
Guo-Dong Zhu, Xun-Jie Cao, Ya-Ping Li, Jia-Xin Li, Zi-Jian Leng, Li-Min Xie, Xu-Guang Guo
Summary: By analyzing the RNA transcription profiles of different tissues infected with Chlamydia trachomatis, key genes in conjunctival and reproductive tract infections were identified. These genes may have potential applications in future clinical treatments and diagnosis.
Review
Gastroenterology & Hepatology
Yingyu Liu, Ying Fan, Shuodong Wu
Summary: This review paper summarizes the morphology, identification, classification, function, and distribution of interstitial Cajal-like cells (ICLCs) in the biliary tract and their relationship to biliary tract diseases. Based on the function and distribution of ICLCs in the biliary tract system, ICLCs will provide a more reliable theoretical basis for the mechanisms of pathogenesis of and treatments for biliary tract diseases.
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
(2021)
Article
Obstetrics & Gynecology
Mengyao Zeng, Liu Yang, Yanyan Mao, Yang He, Min Li, Jun Liu, Qianxi Zhu, Liang Chen, Weijin Zhou
Summary: Preconception reproductive tract infections may be associated with adverse pregnancy outcomes, including spontaneous abortion, preterm birth, and macrosomia.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Multidisciplinary Sciences
Rose E. Dixon, Oscar Vivas, Karen I. Hannigan, Eamonn J. Dickson
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2017)
Article
Biochemistry & Molecular Biology
Debapriya Ghosh, Madeline Nieves-Cintron, Sendoa Tajada, Ingrid Brust-Mascher, Mary C. Horne, Johannes W. Hell, Rose E. Dixon, Luis F. Santana, Manuel F. Navedo
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2018)
Article
Biochemical Research Methods
Daisuke Sato, Rose E. Dixon, Luis F. Santana, Manuel F. Navedo
PLOS COMPUTATIONAL BIOLOGY
(2018)
Article
Neurosciences
Rose E. Dixon
JOURNAL OF PHYSIOLOGY-LONDON
(2018)
Article
Cell & Tissue Engineering
Ana De La Mata, Sendoa Tajada, Samantha O'Dwyer, Collin Matsumoto, Rose E. Dixon, Nirmala Hariharan, Claudia M. Moreno, Luis Fernando Santana
Article
Neurosciences
Danica W. Ito, Karen Hannigan, Debapriya Ghosh, Bing Xu, Silvia G. del Villar, Yang K. Xiang, Eamonn J. Dickson, Manuel F. Navedo, Rose E. Dixon
JOURNAL OF PHYSIOLOGY-LONDON
(2019)
Article
Cell Biology
Oscar Vivas, Scott A. Tiscione, Rose E. Dixon, Daniel S. Ory, Eamonn J. Dickson
Article
Physiology
Daisuke Sato, Gonzalo Hernandez-Hernandez, Collin Matsumoto, Sendoa Tajada, Claudia M. Moreno, Rose E. Dixon, Samantha O'Dwyer, Manuel F. Navedo, James S. Trimmer, Colleen E. Clancy, Marc D. Binder, L. Fernando Santana
JOURNAL OF GENERAL PHYSIOLOGY
(2019)
Article
Cell Biology
Scott A. Tiscione, Oscar Vivas, Kenneth S. Ginsburg, Donald M. Bers, Daniel S. Ory, Luis F. Santana, Rose E. Dixon, Eamonn J. Dickson
JOURNAL OF CELL BIOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Candice Kutchukian, Oscar Vivas, Maria Casas, Julia G. Jones, Scott A. Tiscione, Sergi Simo, Daniel S. Ory, Rose E. Dixon, Eamonn J. Dickson
Summary: In this study, it was found that dysfunction of the lysosomal Niemann-Pick C1 (NPC1) cholesterol transporter initiates a signaling cascade that alters the cholesterol/phosphatidylinositol 4-phosphate (PtdIns4P) countertransport cycle between the Golgi-endoplasmic reticulum and lysosome-endoplasmic reticulum membrane contact sites. These disruptions in signaling pathways lead to abnormal intracellular trafficking and growth signaling.
Article
Multidisciplinary Sciences
Scott A. Tiscione, Maria Casas, Jonathan D. Horvath, Vincent Lam, Keiko Hino, Daniel S. Ory, L. Fernando Santana, Sergi Simo, Rose E. Dixon, Eamonn J. Dickson
Summary: The study shows that loss-of-function, knockout, or neurodegenerative disease-causing mutations in NPC1 can lead to damaging alterations in the expression and distribution of IP3R1, causing cell death. This process is mediated by SREBP-dependent increases in PS1, with mutants of PS1 recapitulating the Ca2+ phenotypes.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Neurosciences
Eleonora Grandi, Manuel F. Navedo, Jeffrey J. Saucerman, Donald M. Bers, Nipavan Chiamvimonvat, Rose E. Dixon, Dobromir Dobrev, Ana M. Gomez, Osama F. Harraz, Bence Hegyi, David K. Jones, Trine Krogh-Madsen, Walter Lee Murfee, Matthew A. Nystoriak, Nikki G. Posnack, Crystal M. Ripplinger, Rengasayee Veeraraghavan, Seth Weinberg
Summary: This white paper summarises the outcomes of the seventh UC Davis Cardiovascular Research Symposium on Systems Approach to Understanding Cardiovascular Disease and Arrhythmia. The Symposium aimed to bring together experts in cardiovascular biomedicine to focus on the diversity and signaling involved in cardiovascular function. The paper presents an overview of major cell types, explores the complexity of cardiovascular development and disease at various levels, and discusses technological innovations for advancing understanding of integrated cardiovascular function and dysfunction.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Multidisciplinary Sciences
Taylor L. Voelker, Silvia G. del Villar, Maartje Westhoff, Alexandre D. Costa, Andrea M. Coleman, Johannes W. Hell, Mary C. Horne, Eamonn J. Dickson, Rose E. Dixon
Summary: CaV1.2 channels in the heart are affected by angiotensin II, a therapeutic target of heart failure drugs and regulator of blood pressure. Angiotensin II causes a decrease in PIP2, which leads to the suppression of CaV1.2 currents. This study found that PIP2 depletion destabilizes CaV1.2 channels and reduces their expression and function. The results suggest that PIP2 plays a crucial role in maintaining cardiac excitability and that angiotensin II-induced PIP2 depletion impairs excitation-contraction coupling.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Multidisciplinary Sciences
Maria Casas, Karl D. Murray, Keiko Hino, Nicholas C. Vierra, Sergi Simo, James S. Trimmer, Rose E. Dixon, Eamonn J. Dickson
Summary: The loss of NPC1 function alters the nanoscale distribution and function of ion channels, leading to abnormal calcium entry, mitochondrial dysfunction, and neurotoxicity. These findings provide insights into the molecular mechanisms connecting NPC1 loss to NPC-associated neuropathology.
NATURE COMMUNICATIONS
(2023)
Meeting Abstract
Biophysics
Danica W. Ito, Karen I. Hannigan, Luis F. Santana, Rose E. Dixon
BIOPHYSICAL JOURNAL
(2018)