Article
Endocrinology & Metabolism
Melanie C. Faure, Rita Khoueiry, Jusal Quanico, Herve Acloque, Marie-Justine Guerquin, Michael J. Bertoldo, Claire Chevaleyre, Christelle Rame, Isabelle Fournier, Michel Salzet, Joelle Dupont, Pascal Froment
Summary: The study found that fetal exposure to metformin may lead to reduced fertility in male offspring, manifested by lower sperm head quality and higher DNA damage. This could be attributed to hypermethylation of sperm genomic DNA and lower expression of the TET1 protein.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
Jason Ioannidis, Gunes Taylor, Debiao Zhao, Long Liu, Alewo Idoko-Akoh, Daoqing Gong, Robin Lovell-Badge, Silvana Guioli, Mike J. McGrew, Michael Clinton
Summary: In birds, sex determination is thought to depend on a sex chromosome gene dosage mechanism, with the gene DMRT1 playing a key role. Experiments showed that ZZ chickens lacking DMRT1 developed ovaries instead of testes, while blocking estrogen synthesis in ZW embryos led to testis development, highlighting the interconnected roles of DMRT1 and estrogen in avian sex determination.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Baojian Chen, Lena Maas, Duarte Figueiredo, Yu Zhong, Ricardo Reis, Mengran Li, Anneke Horstman, Tjitske Riksen, Mieke Weemen, Hang Liu, Charlotte Siemons, Shaojiang Chen, Gerco C. Angenent, Kim Boutilier
Summary: The BBM transcription factor plays a major role in plant cell totipotency and seed development. This study reexamined the expression and function of BBM in Arabidopsis, and identified its crucial roles in the timing of embryo progression and the maintenance of zygotic embryo development. The study also demonstrated the engineering potential of BBM genes for asexual embryo development in dicot species.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Agriculture, Multidisciplinary
Chun-yang Lu, Shi-shuai Ge, Wei He, Hao-wen Zhang, Xian-ming Yang, Bo Chu, Kong-ming Wu
Summary: This study developed a model for accurately forecasting the reproductive dynamics of Spodoptera frugiperda populations by using female ovarian and male testes images. An WeChat applet was also developed to predict the reproductive state and oviposition of S. frugiperda. It can be a valuable tool for population monitoring and early warning system for plant protection.
JOURNAL OF INTEGRATIVE AGRICULTURE
(2023)
Review
Endocrinology & Metabolism
Ceren Canse, Ecem Yildirim, Aylin Yaba
Summary: Cell-cell junctions play crucial roles in maintaining cell integrity, polarity, cell fate specification, and morphogenesis during embryonic development. By orchestrating mechanotransduction, morphokinetics, and signaling networks, these junctions, along with cell adhesion molecules and cytoskeletal elements, regulate the development of early embryos. This review focuses on the structure, organization, function, and expression pattern of cell-cell junction complexes during early embryonic development. Understanding the importance of dynamic junction formation and maturation processes will provide insights into the molecular mechanisms underlying developmental abnormalities in early embryos.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cell Biology
Zhaojun Geng, Yongxun Jin, Fushi Quan, Siyi Huang, Shuming Shi, Bing Hu, Zhichao Chi, Ilkeun Kong, Mingjun Zhang, Xianfeng Yu
Summary: This study found that MXC has significant effects on the development of early porcine embryos, leading to decreased cleavage rate, blastocyst rate, hatching rate, and total cell count. Moreover, MXC increases the production of reactive oxygen species, decreases mitochondrial membrane potential, and reduces mitochondrial copy number during early embryo development. Furthermore, MXC treatment leads to increased blastocyst apoptosis and DNA damage, decreased cell proliferation, and altered expression of pluripotency-related and apoptosis-related genes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Cell Biology
Lei Luo, Yanna Dang, Yan Shi, Panpan Zhao, Yunhai Zhang, Kun Zhang
Summary: SIN3A is a central scaffold protein involved in the regulation of HDAC1 expression during early embryonic development in mammals. The maternal origin of SIN3A was confirmed in pigs, cattle, mice, and humans, with its depletion causing developmental arrest in pigs but not in bovines. Furthermore, SIN3A affects CCNB1 expression, which is crucial for embryonic development, and can be partially rescued by exogenous CCNB1 mRNA injection.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Environmental Sciences
Yifan Hong, Shengde Wu, Guanghui Wei
Summary: Microplastics and nanoplastics have raised concerns regarding their potential toxicity to the reproductive system and their impact on human health. These particles can enter the body through ingestion, inhalation, and skin contact, causing disturbances in the development of reproductive cells and other somatic cells. Furthermore, the synergistic reproductive toxicity of these plastic particles and the contaminants they carry has been observed.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
G. Delbes, M. Blazquez, J. Fernandino, P. Grigorova, B. F. Hales, C. Metcalfe, L. Navarro-Martin, L. Parent, B. Robaire, A. Rwigemera, G. Van der Kraak, M. Wade, V Marlatt
Summary: Endocrine disrupting chemicals (EDCs) have been found to impact reproductive health, with early exposures during critical developmental stages having immediate effects on gonadal and reproductive tract development, as well as potential long-term effects on reproductive health in both males and females. Understanding the mechanisms regulating sex determination, differentiation, and gonadal development in fish and rodents has improved our understanding of how EDCs affect reproduction.
ENVIRONMENTAL RESEARCH
(2022)
Review
Developmental Biology
Peter J. Rugg-Gunn, Naomi Moris, Patrick P. L. Tam
Summary: Recent progress in human embryo research, including advancements in culturing embryos, analyzing embryogenesis and gastrulation, mapping lineage trajectories, and experimenting on stem cell-based embryo models, has provided valuable insights into the principles of development. This has the potential to enhance our understanding of human development in various contexts and improve infertility and developmental disorder treatments. However, there are still technical challenges that need to be overcome to further advance in this field.
Article
Veterinary Sciences
Pietro Cacialli
Summary: This study investigated the expression patterns of ngf and trka in the testis and ovary of adult zebrafish, revealing predominant expression in spermatogony B and spermatocytes in the testis, and at different stages of oocyte development in the ovary.
VETERINARY SCIENCES
(2022)
Article
Cell Biology
Dongjie Zhou, Ming-Hong Sun, Wen-Jie Jiang, Xiao-Han Li, Song-Hee Lee, Geun Heo, Jungseok Choi, Kwan-Suk Kim, Xiang-Shun Cui
Summary: In this study, the mRNA level of YME1L1 was knocked down in pig embryos and the expression patterns of YME1L1 and related proteins were examined. It was found that YME1L1 is localized in the punctate structures of mitochondria and highly expressed from the 4-cell stage. Knocking down YME1L1 led to decreased blastocyst rate and quality, mitochondrial fragmentation, excessive ROS production, lower mitochondrial membrane potential and ATP levels. Moreover, YME1L1 knockdown induced OPA1 cleavage and cytochrome c release. These findings demonstrate that YME1L1 is crucial for regulating mitochondrial fission, function, and apoptosis during porcine embryo preimplantation development.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Jindong Hao, Siyi Huang, Dongxu Wang, Yongxun Jin, Mingjun Zhang, Jiabao Zhang, Xianfeng Yu
Summary: WTAP plays an indispensable role in the early embryonic development of pigs, as its loss promotes embryonic cell apoptosis and reduces the rate and quality of development.
Article
Biochemistry & Molecular Biology
Yongfu La, Xiaoming Ma, Pengjia Bao, Min Chu, Ping Yan, Xian Guo, Chunnian Liang
Summary: This study summarized the changes in piRNA expression patterns during the early development of yak testis and provided new insights into the regulatory role of piRNA in yak testis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Agriculture, Dairy & Animal Science
Adomar Laurindo Neto, Felipe Lopes Ruas, Bruno Silva Espirito Santo, Ana Clara Degan Mattos, Junior Borges Silva, Marcos Flavio Diniz Jr, Danilo Fonseca Cardoso Pereira, Izabelle Pereira Lacerda, Jose Oliveira Carvalho, Guilherme Pugliesi
Summary: This study tested the impact of supplementing long-acting P4 at different times during the initial dioestrus on the pregnancy rates of dairy and beef recipients undergoing fixed-time embryo transfer. The results showed that using iP4 during FTET can enhance the pregnancy rates of beef recipients, although the effectiveness of iP4 supplementation on pregnancy maintenance may vary under different experimental conditions.
REPRODUCTION IN DOMESTIC ANIMALS
(2023)