Article
Agriculture, Dairy & Animal Science
Mohammed I. A. Ibrahim, June Williams, Christo J. Botha
Summary: The study revealed that treatment with Di-n-butyl phthalate (DBP) during the pre-pubertal period induced dose-dependent histometric and morphological changes in the epithelium of the epididymal region of Japanese quail, with the proximal efferent ductule being especially sensitive.
ANIMAL REPRODUCTION SCIENCE
(2021)
Review
Cell Biology
Paul S. Cooke, William H. Walker
Summary: This review summarizes the physiological functions of classical and nonclassical androgen and estrogen signaling pathways in the testis and reproductive tract. The study highlights the essential role of nonclassical signaling in the overall response to hormones, and the abnormalities in spermatogenesis and the male reproductive tract associated with the absence of either nonclassical or classical receptor pathways.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2022)
Article
Environmental Sciences
Kai Luo, Xiaotu Liu, Min Nian, Yuqing Wang, Jin Qiu, Hao Yu, Xiangfeng Chen, Jun Zhang
Summary: This study found that PFAS mixture was significantly and inversely associated with estradiol and estradiol/total testosterone, with perfluoro-n-undecanoic acid (PFuDA) being the major contributor. Certain individual PFAS, such as perfluoro-n-tridecanoic acid (PFTrDA) and perfluoro-n-dodecanoic acid (PFDoA), were found to have negative effects on Leydig cells function. However, the associations with branched isomers or F-53B were sporadic and inconsistent.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Agriculture, Dairy & Animal Science
Kavita Ranjeeta Lall, Kegan Romelle Jones, Gary Wayne Garcia
Summary: This paper is a literature review on the reproductive technologies used in male Neo-tropical hystricomorphic rodents. It provides important insights into their reproductive anatomy and technologies, which are critical for the conservation and preservation of these species.
Article
Multidisciplinary Sciences
Erin L. McCullough, Emma Whittington, Akanksha Singh, Scott Pitnick, Mariana F. Wolfner, Steve Dorus
Summary: This study investigates the life history of Drosophila melanogaster sperm proteome and reveals substantial compositional changes after sperm are transferred to the female reproductive tract (FRT). Multiple seminal fluid proteins initially associate with sperm, but become undetectable after sperm storage. Female-derived proteins also associate with sperm immediately after mating, and contribute nearly 20% to the postmating sperm proteome after storage in the FRT. These female-derived proteins are enriched in processes associated with energy metabolism, suggesting their role in supporting sperm viability during the period between copulation and fertilization.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Cell Biology
Paul S. Cooke, Ana M. Mesa, Vijay K. Sirohi, Ellis R. Levin
Summary: Estrogen signaling through membrane estrogen receptor1 (mESR1) is essential for normal reproductive function in both males and females. Recent research has expanded our understanding of the role of mESR1 in estrogen responses, although its precise mechanism of action remains to be fully established.
Article
Developmental Biology
Brett Nixon, Amanda L. Anderson, Elizabeth G. Bromfield, Jacinta H. Martin, Tessa Lord, Shenae L. Cafe, Shaun D. Roman, David A. Skerrett-Byrne, Andrew L. Eamens, Geoffry N. De Iuliis, Stephen D. Johnston
Summary: This study investigated the morphology and histology of the male reproductive system of crocodiles, focusing on the role of the excurrent duct system in sperm production and modification. The findings suggest that the ducts are involved in seminal fluid production and/or modification, contributing to the nourishment, protection, and storage of crocodile sperm. The structural characteristics of the crocodile male excurrent duct system share closer similarities with birds than with other groups within the Reptilia class or Mammalia, reflecting their common Archosaurs ancestry.
REPRODUCTION FERTILITY AND DEVELOPMENT
(2021)
Article
Nutrition & Dietetics
Martin J. J. Ronis, Horacio Gomez-Acevedo, Kartik Shankar, Leah Hennings, Neha Sharma, Michael L. Blackburn, Isabelle Miousse, Harry Dawson, Celine Chen, Kelly E. Mercer, Thomas M. Badger
Summary: This study found that soy infant formula does not have estrogenic effects or significantly alter male reproductive development in newborn male piglets, compared to sow milk and milk formula.
Review
Biochemistry & Molecular Biology
Xiaoli Wang, Lisha Yin, Yujiao Wen, Shuiqiao Yuan
Summary: Mitochondria adjust their morphology to suit different cell types and environments, playing important roles in spermatogenesis. Deficiencies in mitochondria can cause male infertility and regulate piRNA biogenesis. This review describes the characteristics of mitochondria, focusing on key mitochondrial factors and the underlying molecular mechanisms in spermatogenesis.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Anatomy & Morphology
Takuya Omotehara, Hiroki Nakata, Masahiro Itoh
Summary: The study found that in male mouse embryos, efferent tubules are formed by the connection of mesonephric tubules and Wolffian duct, with branching and folding changes. After gonadal fate is determined, mesonephric tubules regress and remodel into twisting efferent tubules, connected to the rete testis.
DEVELOPMENTAL DYNAMICS
(2022)
Article
Environmental Sciences
Brooke N. Anderson, Juliana Kaloczi, Courtney Holden, Amanda Einig, Linda Donaldson, Hunter Malone, Michelle S. Passerotti, Lisa J. Natanson, Heather D. Bowlby, James A. Sulikowski
Summary: This study used frozen stored porbeagle muscle tissues to analyze the relationship between testosterone and estradiol concentrations and maturity and reproductive stage. The results suggest that muscle hormone concentrations have the potential to serve as a non-lethal indicator of reproductive stage in oophagous sharks. The study also highlights the value of specimen sharing and continued use of stored vertebral muscle tissue for reproductive hormone analysis to maximize data obtained from biological samples. These methods would be particularly valuable for research on threatened species.
FRONTIERS IN MARINE SCIENCE
(2023)
Article
Immunology
Megan B. Vogt, Erin M. McDonald, Mark Delorey, Paul S. Mead, Sarah A. Hook, Alison F. Hinckley, Stephen R. Werre, Aaron C. Brault, Nisha K. Duggal
Summary: In a study of Zika virus-infected men, prolonged shedding of Zika virus RNA in semen was associated with inflammation in the male reproductive tract, indicated by higher leukocyte counts and inflammatory cytokine levels in semen.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Developmental Biology
Isabella Aprea, Tabea Noethe-Menchen, Gerard W. Dougherty, Johanna Raidt, Niki T. Loges, Thomas Kaiser, Julia Wallmeier, Heike Olbrich, Timo Struenker, Sabine Kliesch, Petra Pennekamp, Heymut Omran
Summary: Recent studies have shown that the motility of efferent duct cilia is crucial for male reproductive fitness in both mice and humans. Deficiency of the DNAH5 gene can lead to obstructive oligozoospermia, affecting male fertility but not sperm motility. Further research on environmental factors or genes causing efferent duct cilia dysmotility may provide insights into other causes of oligozoospermia.
MOLECULAR HUMAN REPRODUCTION
(2021)
Review
Cell Biology
Mohammed Hoque, Eunice N. Kim, Danny Chen, Feng-Qian Li, Ken-Ichi Takemaru
Summary: Cilia are hair-like organelles on the cell surface that play important roles in various biological processes and their dysfunction can lead to diseases. Multiciliated cells in the male reproductive tract are crucial for male fertility.
Article
Multidisciplinary Sciences
Martin Blomberg Jensen, Christine Hjorth Andreassen, Anne Jorgensen, John Erik Nielsen, Li Juel Mortensen, Ida Marie Boisen, Peter Schwarz, Jorma Toppari, Roland Baron, Beate Lanske, Anders Juul
Summary: There are limited treatment options for male infertility. The study demonstrates the important role of the receptor activator of NF-kappa B ligand (RANKL) signaling pathway in sperm production and maturation, showing potential as a target for male infertility treatment.
NATURE COMMUNICATIONS
(2021)
Article
Clinical Neurology
Melanie S. Askari, Laura Helena Andrade, Alexandre Chiavegatto Filho, Camila Magalhaes Silveira, Erica Siu, Yuan-Pang Wang, Maria Carmen Viana, Silvia S. Martins
JOURNAL OF AFFECTIVE DISORDERS
(2017)
Article
Endocrinology & Metabolism
Raquel S. Campello, Luciana A. Fatima, Joao Nilton Barreto-Andrade, Thais F. Lucas, Rosana C. Mori, Catarina S. Porto, Ubiratan F. Machado
JOURNAL OF MOLECULAR ENDOCRINOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Rafael de Souza Silva, Ana Paola G. Lombardi, Deborah Simao de Souza, Carolina M. Vicente, Catarina S. Porto
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2018)
Article
Cell Biology
Deborah S. Souza, Ana Paola G. Lombardi, Carolina M. Vicente, Thais Fabiana G. Lucas, Adolfo G. Erustes, Gustavo J. S. Pereira, Catarina S. Porto
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2019)
Article
Medicine, General & Internal
Carolina Hanna Chaim, Erica Rosanna Siu, Carlos Felipe Cavalcanti Carvalho, Fernanda Piotto Frallonardo, Flavia Ismael, Arthur Guerra de Andrade, Antonio Ventriglio, Julio Torales, Dinesh Bhugra, Joao Mauricio Castaldelli-Maia
SAO PAULO MEDICAL JOURNAL
(2019)
Article
Endocrinology & Metabolism
Ana Paola G. Lombardi, Carolina M. Vicente, Catarina S. Porto
FRONTIERS IN ENDOCRINOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Ana Paola G. Lombardi, Renan P. Cavalheiro, Catarina S. Porto, Carolina M. Vicente
Summary: This study demonstrates that ER activates rapid response molecules such as SRC and PI3K/AKT to enhance the tumorigenic potential of prostate cancer cells, increasing cell proliferation, migration, invasion, and tumor formation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Carolina Hanna Chaim, Geilson Lima Santana, Paula de Vries Albertin, Camila Magalhaes Silveira, Erica Rosanna Siu, Maria Carmen Viana, Wang Yuan Pang, Laura Helena Andrade
Summary: The study found high comorbidity between alcohol use disorders and personality disorders, particularly with Cluster B personality disorders. Cluster B personality disorders showed significant associations with alcohol consumption and disorders, especially more severe cases.
Article
Cell Biology
Carla Macheroni, Thais Fabiana Gameiro Lucas, Deborah Simao Souza, Carolina Meloni Vicente, Gustavo Jose da Silva Pereira, Itabajara da Silva Vaz Junior, Maria Aparecida Juliano, Catarina Segreti Porto
Summary: This study investigated the expression of estrogen receptors in human testicular embryonal carcinoma NT2/D1 cells and their effects on cell proliferation. The results showed that estrogen receptors were mainly located in the nuclei, while a splice variant was found in the perinuclear region and cytoplasm. Activation of estrogen receptors increased the expression of cell cycle proteins and promoted cell proliferation. Additionally, estrogen induced an increase in cell number and viability, and this effect was blocked by estrogen receptor antagonists.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2022)
Article
Neurosciences
Angelica Jardim Costa, Rafaela Brito Oliveira, Patricia Wachilewski, Michelle Sayuri Nishino, Taysa Bervian Bassani, Roberta Sessa Stilhano, Janete Maria Cerutti, Bruno Nozima, Catarina Segreti Porto, Gustavo Jose da Silva Pereira, Ana Lopez Ramirez, Soraya Soubhi Smaili, Rodrigo Portes Ureshino
Summary: Alzheimer's disease (AD) is a neurodegenerative disease associated with aging, which is more common in women than men. Hormone replacement therapy, particularly estrogen, has been shown to reduce memory loss in menopausal women by inducing autophagy to remove protein aggregates. This study found that 17β-estradiol induces autophagy by activating AMPK, independent of mTOR signals. Furthermore, it was discovered that 17β-estradiol increases LC3-II levels and clears tau protein through autophagy.
Article
Biochemistry & Molecular Biology
N. O. Maruyama, H. F. Estrela, E. B. Oliveira Sales, T. F. Lucas, C. S. Porto, C. T. Bergamaschi, R. R. Campos
Summary: In this study, the effects of 17β-estradiol on sympathetic vasomotor activity and blood pressure in a hypertensive rat model were investigated. The expression of estrogen receptors in the rostral ventrolateral medulla (RVLM) was also studied. The results showed that microinjection of 17β-estradiol into the RVLM led to a greater reduction in mean arterial pressure and renal sympathetic nerve activity in control rats compared to hypertensive rats. The expression levels of estrogen receptors GPER and ERα were significantly higher in the RVLM of hypertensive rats. Chronic treatment with losartan reduced the expression levels of estrogen receptors in hypertensive rats.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2022)
Review
Endocrinology & Metabolism
Deborah Simao Souza, Carla Macheroni, Gustavo Jose Silva Pereira, Carolina Meloni Vicente, Catarina Segreti Porto
Summary: Prostate cancer is the most common cancer among men worldwide, and hormone-related factors, such as androgens, estrogens, and their receptors, play a crucial role in its development and progression. Galectin-3, a family of proteins, is involved in various stages of tumor development and progression, but its expression regulation is still poorly understood. This review focuses on the interplay between Galectin-3 and estrogen receptor signaling pathways in prostate cancer cells and proposes a molecular mechanism involving ER, Galectin-3, and beta-catenin in the modulation of nuclear transcriptional events. Further understanding of the role of Galectin-3 and ER in prostate cancer could lead to the discovery of new drug targets to treat castration-resistant prostate cancer.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Carla Macheroni, Thais Fabiana Gameiro Lucas, Catarina Segreti Porto
Article
Substance Abuse
Daniela Cristina Belchior Mota, Camila Magalhaes Silveira, Erica Siu, Henrique Pinto Gomide, Laura Helena Andrade Guerra, Telmo Mota Ronzani, Brian Rush
JOURNAL OF STUDIES ON ALCOHOL AND DRUGS
(2019)
Meeting Abstract
Biochemistry & Molecular Biology
Nadia Oliveira Maruyama, Heder Frank Estrela, Thais F. Lucas, Catarina Segreti Porto, Cassia Toledo Bergamaschi, Ruy Ribeiro de Campos