Article
Hematology
Alexis Leonard, Akshay Sharma, Naoya Uchida, David Stroncek, Sandhya R. Panch, Kamille West, Eoghan Molloy, Thomas E. Hughes, Sara Hauffe, Tiffani Taylor, Courtney Fitzhugh, Jane S. Hankins, Megan Wilson, Shengdar Q. Tsai, Mitchell J. Weiss, Matthew Hsieh, John F. Tisdale
Summary: Recent studies have shown that plerixafor mobilization and apheresis in patients with sickle cell disease can safely collect sufficient CD34(+) hematopoietic stem cells for clinical gene therapy applications. The quantity of CD34(+) cells mobilized by plerixafor varies among SCD patients for unknown reasons, and factors influencing this yield include age, baseline and pre-apheresis CD34(+) cell counts, and disease severity markers unique to SCD.
Article
Biophysics
Gaurav Kharya, Atish Bakane, Shirali Agarwal, Archana Rauthan
Summary: The T-cell-replete haploidentical transplant with PTIS, augmented John Hopkins conditioning and plerixafor-based mobilization is a safe and effective way of treating patients suffering from SCD, with minimal or no risk of graft failure and acceptable GvHD rates.
BONE MARROW TRANSPLANTATION
(2021)
Article
Biophysics
Carlo Lazzaro, Luca Castagna, Francesco Lanza, Daniele Laszlo, Giuseppe Milone, Luca Pierelli, Riccardo Saccardi
Summary: The study compared the cost-effectiveness of using G-CSF alone versus high-dose cyclophosphamide + G-CSF mobilization in Italian multiple myeloma patients eligible for autograft. The findings revealed that G-CSF alone was a more cost-effective option, demonstrating incremental savings and a higher probability of successful apheresis.
BONE MARROW TRANSPLANTATION
(2021)
Article
Biology
Astrid S. Jorgensen, Viktorija Daugvilaite, Katia De Filippo, Christian Berg, Masa Mavri, Tau Benned-Jensen, Goda Juzenaite, Gertrud Hjorto, Sara Rankin, Jon Vabeno, Mette M. Rosenkilde
Summary: Plerixafor exhibits biased action by reversing the CXCL12 gradient across the bone marrow endothelium and showing superior therapeutic effect in HSC mobilization. In contrast, AMD11070, despite having superior antagonism, does not perform as effectively in HSC mobilization in vivo.
COMMUNICATIONS BIOLOGY
(2021)
Article
Biophysics
Kristina Hoelig, Helmuth Schmidt, Gero Huetter, Michael Kramer, Raphael Teipel, Katharina Heidrich, Kristin Zimmer, Falk Heidenreich, Matthias Blechschmidt, Tigran Torosian, Rainer Ordemann, Frank Kroschinsky, Elke Ruecker-Braun, Laszlo Gopsca, Eva Maria Wagner-Drouet, Uta Oelschlaegel, Alexander H. Schmidt, Martin Bornhaeuser, Gerhard Ehninger, Johannes Schetelig
Summary: In allogeneic PBSC donors with poor mobilization response to G-CSF, the study found that the use of plerixafor (P) can effectively increase the yield of CD34+ cells, helping to achieve the target cell count without severe adverse events.
BONE MARROW TRANSPLANTATION
(2021)
Article
Hematology
Andrew Johnsrud, Abdullah Ladha, Lori Muffly, Parveen Shiraz, Gary Goldstein, Victoria Osgood, Judith A. Shizuru, Laura Johnston, Sally Arai, Wen-Kai Weng, Robert Lowsky, Andrew R. Rezvani, Everett H. Meyer, Matthew J. Frank, Robert S. Negrin, David B. Miklos, Surbhi Sidana
Summary: Comparing stem cell mobilization strategies in multiple myeloma patients, it was found that the success rates and mobilization failure rates were similar between chemomobilization and G-CSF with on-demand PXF, with higher complication rates and lower costs in the latter group.
TRANSPLANTATION AND CELLULAR THERAPY
(2021)
Article
Cell & Tissue Engineering
Naokazu Nakamura, Tomoyasu Jo, Yasuyuki Arai, Mayumi Matsumoto, Tomomi Sakai, Hiroko Tsunemine, Akifumi Takaori-Kondo, Nobuyoshi Arima
Summary: In a retrospective cohort study of 43 Japanese patients undergoing autologous stem cell transplantation, it was found that the use of plerixafor resulted in a shorter time to neutrophil and platelet engraftment compared to not using plerixafor. Additionally, the incidence of sepsis was significantly lower in the plerixafor group.
Review
Oncology
Francisco J. Cueto, David Sancho
Summary: Current cancer immunotherapy efforts focus on enhancing T cell effector function, but stimulating dendritic cells (DCs) may improve treatment outcomes. Specifically, utilizing the Flt3/Flt3L axis to boost DC function shows promising potential for cancer immunotherapy.
Article
Immunology
Tracy X. Cui, Alexander E. Brady, Ying-Jian Zhang, Christina T. Fulton, Adam M. Goldsmith, Antonia P. Popova
Summary: Premature infants with bronchopulmonary dysplasia (BPD) develop chronic respiratory symptoms after viral infections. Hyperoxia exposure increases activated lung dendritic cells (DCs) and proinflammatory responses in neonatal mice. This study found that early-life hyperoxia stimulates Flt3L expression, leading to expansion and activation of lung CD103+ DCs, thus mediating inflammation. In preterm infants, FLT3L levels positively correlated with proinflammatory cytokines levels and may contribute to the development of BPD.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Dawn S. Lin, Luyi Tian, Sara Tomei, Daniela Amann-Zalcenstein, Tracey M. Baldwin, Tom S. Weber, Jaring Schreuder, Olivia J. Stonehouse, Jai Rautela, Nicholas D. Huntington, Samir Taoudi, Matthew E. Ritchie, Philip D. Hodgkin, Ashley P. Ng, Stephen L. Nutt, Shalin H. Naik
Summary: The study examines the mechanism of clonal tuning during Flt3L-mediated emergency hematopoiesis, revealing the selective expansion of specific HSPC clones to increase the production of type 1 conventional dendritic cells without affecting other lineages. This is achieved through maintaining proliferative 'early progenitor'-like state in Flt3L-responsive HSPCs, leading to the expansion of transitional cDC1-primed progenitor stages marked by Irf8 expression. The findings define the mechanistic action of Flt3L through clonal tuning, which has important implications for emergency hematopoiesis models.
NATURE CELL BIOLOGY
(2021)
Article
Rheumatology
Ann-Christin Pecher, Katharina Renate Ach, Wichard Vogel, Joerg Christoph Henes
Summary: This study evaluated the feasibility of reducing cyclophosphamide dosing in mobilization chemotherapy for SSc patients undergoing autologous stem cell transplantation. The results showed that reducing cyclophosphamide dosing did not affect stem cell collection, and higher doses of cyclophosphamide may be associated with more side effects. Risk factors for poor mobilization included low body weight, prior rituximab therapy, and cardiac involvement.
Review
Hematology
Jian Chen, Hillard M. Lazarus, Parastoo B. Dahi, Scott Avecilla, Sergio A. Giralt
Summary: Hematopoietic cell transplantation (HCT) is a primary treatment for many cancers, with mobilization being the first essential step. Poor mobilization is a major factor affecting successful transplantation. Novel agents are being investigated to enhance mobilization response, and further understanding of the molecular mechanism of mobilization may lead to new therapeutic strategies for successful mobilization.
Article
Cell & Tissue Engineering
Akira Ishii, Tomoyasu Jo, Yasuyuki Arai, Shinichiro Oshima, Junya Kanda, Toshio Kitawaki, Keiko Matsui, Norimi Niwa, Yoko Nakagawa, Akifumi Takaori-Kondo, Miki Nagao
Summary: This study developed a novel quantitative prediction model for CD34(+) cell collection yield, incorporating four clinical parameters available the day before leukapheresis. The results suggest a more proactive use of plerixafor in patients with poorly controlled disease or heavy pre-treatment history to optimize stem cell transplantation outcomes, with no impact on clinical outcomes of ASCT.
Article
Multidisciplinary Sciences
Xin Gao, Dachuan Zhang, Chunliang Xu, Huihui Li, Kathleen M. Caron, Paul S. Frenette
Summary: Nociceptive nerves play a role in enforcing HSC mobilization through CGRP secretion, collaborating with sympathetic nerves to maintain HSCs in the bone marrow. CGRP directly activates HSCs via the G alpha(s)/adenylyl cyclase/cAMP pathway, and consumption of capsaicin-containing food enhances HSC mobilization in mice.
Article
Oncology
Selina Buehler, Dilara Akhoundova, Barbara Jeker, Myriam Legros, Katja Seipel, Michael Daskalakis, Ulrike Bacher, Thomas Pabst
Summary: High-dose chemotherapy followed by autologous stem cell transplantation is the standard treatment for multiple myeloma (MM). This study evaluated the safety and efficacy of using ixazomib in combination with G-CSF for stem cell mobilization in MM patients. The combination showed promising mobilizing activity, although some patients required the addition of plerixafor for optimal stem cell collection.
Article
Psychology, Clinical
Geetanjali Basarkod, Herbert W. Marsh, Baljinder K. Sahdra, Philip D. Parker, Jiesi Guo, Theresa Dicke, Oliver Ludtke
Summary: This study demonstrates the importance of assessing psychological questionnaires in large-scale surveys by examining the dimensions of reading self-concept across different reading achievement levels.
Article
Psychology, Educational
Stephanie Lichtenfeld, Reinhard Pekrun, Herbert W. Marsh, Ulrike E. Nett, Kristina Reiss
Summary: This longitudinal study examined the development of achievement emotions in mathematics from grades second to fourth in German students and their relation to math achievement. The study found that enjoyment decreased over time, while boredom and anxiety remained stable. Enjoyment positively predicted subsequent achievement, while boredom and anxiety negatively predicted subsequent achievement. The findings highlight the importance of addressing students' achievement emotions in the early years of schooling to improve their performance.
JOURNAL OF EDUCATIONAL PSYCHOLOGY
(2023)
Review
Virology
Xiao Guo, Dongying Liu, Yukai Huang, Youcai Deng, Ying Wang, Jingrui Mao, Yuancheng Zhou, Yongai Xiong, Xinghong Gao
Summary: The mRNA vaccine technology has rapidly developed during the COVID-19 global pandemic. The COVID-19 mRNA vaccine plays a crucial role in preventing viral infection and also benefits the exploration and application of other viral mRNA vaccines. This review provides an overview of the optimization of mRNA vaccine development process, as well as the good immune efficacy and safety observed in clinical studies. Additionally, the important role of mRNA immunomodulators in treating viral diseases is briefly described.
Letter
Oncology
Kathryn T. T. Maples, Kevin H. H. Hall, Nisha S. S. Joseph, Craig C. C. Hofmeister, Vikas Gupta, Madhav V. V. Dhodapkar, Jonathan L. L. Kaufman, Ajay K. K. Nooka, Sagar Lonial
BLOOD CANCER JOURNAL
(2023)
Retraction
Chemistry, Multidisciplinary
Hai Wang, Pranay Agarwal, Gang Zhao, Guang Ji, Christopher M. Jewell, John P. Fisher, Xiongbin Lu, Xiaoming He
ACS CENTRAL SCIENCE
(2023)
Article
Education & Educational Research
Geetanjali Basarkod, Herbert W. Marsh, Jiesi Guo, Philip D. Parker, Theresa Dicke, Reinhard Pekrun
Summary: In this study, student-level achievement is found to positively predict academic enjoyment in math, science, and reading, while class-level achievement has a negative effect on enjoyment—the Happy-Fish-Little-Pond Effect. These results show relative universality across different academic domains and countries.
LEARNING AND INSTRUCTION
(2023)
Review
Psychology, Educational
Herbert W. Marsh, Jiesi Guo, Philip D. Parker, Reinhard Pekrun, Geetanjali Basarkod, Theresa Dicke, Roberto H. Parada, Johnmarshall Reeve, Rhonda Craven, Joseph Ciarrochi, Baljinder Sahdra, Emma K. Devine
Summary: School victimization issues remain largely unresolved due to over-reliance on unidimensional conceptions of victimization and data from a few developed OECD countries. Our study tested a three-component model of victimization across 77 countries and demonstrated its superior explanatory power compared to competing models. The findings suggest that different components of victimization, such as relational, verbal, and physical, have unique relationships with key outcomes including gender differences and well-being indicators. These findings contribute to the advancement of victimization theory and have implications for policy and intervention.
EDUCATIONAL PSYCHOLOGY REVIEW
(2023)
Editorial Material
Psychology, Educational
Hefer Bembenutty, Gregory Arief D. Liem, Kelly-Ann Allen, Ronnel B. B. King, Andrew J. J. Martin, Herbert W. W. Marsh, Rhonda G. G. Craven, Avi Kaplan, Dale H. H. Schunk, Maria K. K. DiBenedetto, Jesus Alfonso D. Datu
Summary: This tribute commemorates the life and work of Dennis Michael McInerney, a renowned scholar who passed away in Hong Kong on May 20th, 2022. It acknowledges his profound impact on both professional and personal spheres, while highlighting the breadth and significance of his scholarly contributions. McInerney was a thought leader who urged us to reevaluate how we approach scientific investigations in the context of teaching and learning, which is evident in his widely read books and research articles published in eminent journals. Throughout his illustrious career, he dedicated a substantial portion of his efforts to studying the challenges associated with understanding culture and its role in motivation research. His belief in the necessity of Indigenous educational research to assess the applicability of mainstream motivation theories across culturally diverse groups and in cross-cultural contexts underscores his enduring influence.
EDUCATIONAL PSYCHOLOGY REVIEW
(2023)
Review
Psychology, Educational
Herbert W. Marsh, Reinhard Pekrun, Jiesi Guo, John Hattie, Eyal Karin
Summary: This study suggests that parents' educational expectations and aspirations have a positive impact on academic outcomes and benefits of attending high-ability schools. However, there are negative effects of the gap between parents' aspirations and expectations, as well as the school-average achievement on expectations, aspirations, and subsequent outcomes.
EDUCATIONAL PSYCHOLOGY REVIEW
(2023)
Article
Chemistry, Multidisciplinary
Ya-fei Deng, Shu-ting Wu, Hong-yan Peng, Lei Tian, Ya-na Li, Yao Yang, Meng Meng, Lan-lan Huang, Pei-wen Xiong, Song-yang Li, Qing-lan Yang, Li-li Wang, Xiao-yao Li, Li-ping Li, Xiu-lan Lu, Xiao-hui Li, Yan-ling Wei, Zheng-hui Xiao, Jian-hua Yu, You-cai Deng
Summary: In this study, the researchers found that mTORC1 plays a critical role in the development and function of ILC3s, while mTORC2 is not essential. mTORC1 deficiency disrupts ILC3 heterogeneity and leads to differentiation into ILC1-like phenotypes. Furthermore, when mTORC1 activity is diminished, mTORC2 activity increases to protect ILC3s from severe loss and immune activity against intestinal infection.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Psychology, Educational
Michiko Sakaki, Kou Murayama, Anne C. Frenzel, Thomas Goetz, Herbert W. Marsh, Stephanie Lichtenfeld, Reinhard Pekrun
Summary: This study examined the development of adolescents' emotions in mathematics over time. The results showed a decrease in enjoyment and pride, and an increase in anger, boredom, and hopelessness. These emotional changes were associated with changes in perceived control, intrinsic value, achievement value, and achievement in mathematics.
Article
Psychology, Clinical
Herbert W. Marsh, Madeleine I. Fraser, Arman Rakhimov, Joseph Ciarrochi, Jiesi Guo
Summary: The self-compassion research is driven by Neff's six-factor Self-Compassion Scale (SCS). There is a debate on SCS's global structure, with different opinions on whether it has one or two global factors. The authors propose a new bifactor model with two global factors, which has important implications for theory, scoring, and clinical application.
PSYCHOLOGICAL ASSESSMENT
(2023)
Article
Psychology, Educational
Herbert W. Marsh, Reinhard Pekrun, Theresa Dicke, Jiesi Guo, Philip D. Parker, Geetanjali Basarkod
Summary: This study examines the compositional effects of school-average achievement and school-average socioeconomic status (SES) on students' academic self-concept (ASC), GPA, and long-term outcomes. The results show that school-average SES has a positive effect on ASC and educational attainment, while school-average achievement has a negative effect on ASC and educational and occupational expectations. The findings have implications for theory, methodology, school selection, and policy.
EDUCATIONAL PSYCHOLOGY REVIEW
(2023)
Letter
Oncology
Sara A. Scott, Ellen M. Marin, Kathryn T. Maples, Nisha S. Joseph, Craig C. Hofmeister, Vikas A. Gupta, Madhav V. Dhodapkar, Jonathan L. Kaufman, Sagar Lonial, Ajay K. Nooka
BLOOD CANCER JOURNAL
(2023)
Article
Psychology, Multidisciplinary
Herbert W. Marsh, Johnmarshall Reeve, Jiesi Guo, Reinhard Pekrun, Roberto H. Parada, Philip D. Parker, Geetanjali Basarkod, Rhonda Craven, Hye-Ryen Jang, Theresa Dicke, Joseph Ciarrochi, Baljinder K. Sahdra, Emma K. Devine, Sung Hyeon Cheon
Summary: Peer victimization at school is a worldwide problem with significant implications across various stakeholders. Despite 50 years of efforts to solve the problem, the results have been disappointing. However, a critical examination of current research has identified limitations and potential solutions, including the use of reliable measures, cross-national data analysis, and a social-ecological perspective. These solutions have been integrated into recent interventions, such as training teachers to create a supportive classroom climate and encouraging student-bystanders to adopt pro-defending and antibullying attitudes. It is important to focus on developing an interpersonally supportive classroom climate at the beginning of the school year to promote positive social norms and attitudes among students.
PERSPECTIVES ON PSYCHOLOGICAL SCIENCE
(2023)
