Article
Immunology
German A. Contreras, Jose M. Munita, Shelby Simar, Courtney Luterbach, An Q. Dinh, Kirsten Rydell, Pranoti Sahasrabhojane, Rafael Rios, Lorena Diaz, Katherine Reyes, Marcus Zervos, Helina M. Misikir, Gabriela Sanchez-Petitto, Catherine Liu, Yohei Doi, Lilian M. Abbo, Luis Shimose, Harald Seifert, Carlota Gudiol, Fernanda Barberis, Claudia Pedroza, Samuel L. Aitken, Samuel A. Shelburne, Davidvan Duin, Truc T. Tran, Blake M. Hanson, Cesar A. Arias
Summary: This study aims to investigate the clinical and molecular epidemiology of VRE bloodstream infections and found that failure of early eradication of VRE is associated with poor outcomes. The results of the study indicate that microbiological failure is the strongest predictor of in-hospital mortality in patients with E faecium bacteremia.
OPEN FORUM INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Yu-Chung Chuang, Tai-Chung Tseng, Jann-Tay Wang, Chi-Ying Lin, Sung-Hsi Huang, Yee-Chun Chen, Shan-Chwen Chang
Summary: A prospective observational multicenter study found that higher daptomycin dose and susceptibility to fosfomycin were associated with lower mortality in patients with VRE bloodstream infection (BSI). The combination of daptomycin and fosfomycin was less effective for patients with fosfomycin-resistant isolates.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Infectious Diseases
Mu-Chun Yang, Yao-Kuang Wu, Chou-Chin Lan, Mei-Chen Yang, Sheg-Kang Chiu, Ming-Yieh Peng, Wen-Lin Su
Summary: Patients with septicemia caused by vancomycin-resistant Enterococcus (VRE) bacteremia have higher mortality rates than patients infected by VSE. Timely administration of appropriate antibiotics is crucial for critically ill patients with VRE infection, as delayed treatment increases the risk of 28-day mortality.
INFECTION AND DRUG RESISTANCE
(2022)
Review
Microbiology
Kelly A. Cairns, Andrew A. Udy, Trisha N. Peel, Iain J. Abbott, Michael J. Dooley, Anton Y. Peleg
Summary: Vancomycin-resistant enterococci (VRE) are a common cause of bloodstream infections (BSIs) with high morbidity and mortality rates. The management of VRE BSI presents significant challenges, including drug dosing, resistance emergence, and optimal treatment strategies. Therapeutic drug monitoring (TDM) shows promise in predicting drug toxicity for VRE-active agents, but there is limited evidence for predicting antimicrobial efficacy for VRE BSIs. This article provides an overview of treatment options, the role of TDM in clinical infection management, and future challenges and perspectives.
CLINICAL MICROBIOLOGY REVIEWS
(2023)
Article
Biophysics
Stephen Maurer, Kathleen A. Linder, Carol A. Kauffman, Philip McDonald, Jonathan T. Arcobello, Jon Karl D. Velasco, Pranatharthi Chandrasekar, Sanjay Revankar, Marisa H. Miceli
Summary: We conducted a retrospective review of the infectious complications and outcomes over a 2-year follow-up period of adult patients who received a second allogeneic hematopoietic cell transplant (2nd allo-HCT) during a five-year period at two cancer centers in Michigan. Sixty patients, of whom 44 (73%) had acute leukemia or myelodysplastic syndrome, were studied. The majority (n = 37,62%) received a 2nd allo-HCT because of relapsed leukemia. Infection episodes after the 2nd allo-HCT totaled 112. Bacteria were identified in 76 episodes, the majority of which occurred pre-engraftment. The most common infecting organisms were Enterococcus species and Clostridioides difficile. Viral infections, predominantly cytomegalovirus, accounted for 59 infection episodes and occurred mostly in pre-engraftment and early post-engraftment periods. There were 16 proven/probable fungal infections, of which 9 were invasive aspergillosis or candidiasis. Mortality was 45% (n = 27) at one year and 65% (n = 39) at 2 years after transplant, and 16 deaths (41%) were due to infection. Of those 16 infection deaths, 8 were bacterial, 4 fungal, 2 both bacterial and fungal, and 2 viral. Failure to engraft neutrophils or platelets was significantly associated with decreased survival, p < 0.0001 and p < 0.001, respectively. Infections are common after a 2nd allo-HCT and are associated with a high mortality rate.
BONE MARROW TRANSPLANTATION
(2022)
Article
Pharmacology & Pharmacy
Waqas Aslam, Naomi E. Mathew, Courtney Shaver, Veronica Brito, Shirley Jones, Alejandro C. Arroliga, Shekhar Ghamande
Summary: The study highlights the detrimental impact of inappropriate antibiotic therapy and other risk factors on morbidity and mortality associated with VRE bacteremia.
AMERICAN JOURNAL OF THERAPEUTICS
(2021)
Article
Infectious Diseases
Mary Catherine McEllistrem, Hayley R. Nordstrom, Aaron Lucas, Brooke K. Decker, Daria Van Tyne
Summary: VRE bacteremia is associated with higher mortality rates and longer hospitalizations compared to VSE bacteremia. Differences in genetic characteristics and biofilm formation exist between VSE and VRE strains, with VRE strains potentially remaining protected in the heart valves and causing infection when disrupted during cardiac surgery. This study highlights the importance of understanding bacterial adherence and biofilm formation in endocarditis patients.
MICROBIAL DRUG RESISTANCE
(2022)
Article
Microbiology
Junzo Hisatsune, Koichi Tanimoto, Tadahiro Kohara, Yoshinari Myoken, Yoshiharu Tomita, Motoyuki Sugai
Summary: A vancomycin-resistant Enterococcus faecium carrying the vanD1 gene was isolated from a fecal sample of a hospitalized patient in Japan. The strain showed moderate resistance to vancomycin but remained susceptible to teicoplanin. The plasmid pEF-D carrying the vanD1 gene had a similar backbone gene organization to pMG1 or pHT beta.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Immunology
Margaret L. Lind, Amanda Phipps, Stephen Mooney, Catherine Liu, Alison Fohner, Kevin Patel, Masumi Ueda, Steven A. Pergam
Summary: In evaluating SIs in allogeneic HCT recipients, SIRS was the most sensitive but least specific criteria, qSOFA was the most specific but least sensitive, and NEWS showed moderate sensitivity and specificity.
CLINICAL INFECTIOUS DISEASES
(2021)
Review
Endocrinology & Metabolism
Carlos L. Correa-Martinez, Franziska Schuler, Stefanie Kampmeier
Summary: Current literature suggests a male preference (59%) in the distribution of VRE BSI cases. Further primary studies should address the question of male-specific factors favoring the enhanced frequency of VRE BSI.
BIOLOGY OF SEX DIFFERENCES
(2021)
Article
Infectious Diseases
Emily Fox, David Ha, Mark Bounthavong, Lina Meng, Emily Mui, Marisa Holubar, Stanley Deresinski, William Alegria
Summary: This study found that patients with severe neutropenia, 4 out of 4 positive index blood culture bottles, and lack of source control were more likely to develop persistent VRE bacteremia despite directed antibiotic treatment.
BMC INFECTIOUS DISEASES
(2022)
Article
Public, Environmental & Occupational Health
Craig H. Gilliam, Jessica Brazelton de Cardenas, Delia Carias, Gaby Maron Alfaro, Randall T. Hayden, Hana Hakim
Summary: This article describes a cluster of 6 pediatric hematopoietic cell transplant recipients who developed Lactobacillus bacteremia attributed to the use of probiotics. Whole-genome sequencing confirmed the relatedness between Lactobacillus isolates obtained from probiotics and patients' blood. Clinical studies are required to evaluate the safety of probiotic use in immunocompromised patients.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2023)
Article
Immunology
Tamar R. R. Lubell, Andrea T. T. Cruz, Melisa S. S. Tanverdi, Julie B. B. Ochs, Steven Lobritto, Sukhpreet Saini, Evangelia Mavrogiorgos, Peter S. S. Dayan
Summary: This study aimed to determine the frequency of bacteremia, septic shock, and bacterial meningitis in pediatric liver transplant recipients in the outpatient setting, and to identify clinical factors associated with bacteremia. The results showed that bacteremia was an important cause of infection within 2 years of pediatric liver transplantation, and clinical factors increased the risk of bacteremia.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2023)
Article
Multidisciplinary Sciences
Philip G. Ferstl, Natalie Filmann, Eva-Maria Heilgenthal, Andreas A. Schnitzbauer, Wolf O. Bechstein, Volkhard A. J. Kempf, David Villinger, Tilman G. Schultze, Michael Hogardt, Christoph Stephan, Haitham Mutlak, Nina Weiler, Marcus M. Muecke, Jonel Trebicka, Stefan Zeuzem, Oliver Waidmann, Martin-Walter Welker
Summary: The prevalence of multidrug-resistant organisms is a major health concern for liver cirrhosis patients. This study found that MDRO colonization in liver transplant candidates and recipients is associated with increased mortality on the waiting list, especially with CRGN colonization.
Article
Infectious Diseases
Sho Ogura, Muneyoshi Kimura, Shinsuke Takagi, Takashi Mitsuki, Mitsuhiro Yuasa, Kosei Kageyama, Daisuke Kaji, Aya Nishida, Yuki Taya, Kazuya Ishiwata, Hisashi Yamamoto, Yuki Asano-Mori, Go Yamamoto, Naoyuki Uchida, Atsushi Wake, Shuichi Taniguchi, Hideki Araoka
Summary: This study aimed to clarify the characteristics of gram-negative bacteremia among allo-HSCT recipients on LVFX prophylaxis, specifically focusing on ESBL-producing pathogens. The results showed that GNB was not a significant cause of death, and empiric CFPM administration in cases of LVFX breakthrough ESBL-EC bacteremia did not lead to significantly poor prognosis, suggesting it may be an acceptable strategy.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2021)
Meeting Abstract
Hematology
Roni Tamari, Christina Cho, Patrick Hilden, Molly Maloy, Taylor Borrill, Ioannis Politikos, Genovefa A. Papanicolaou, Ann A. Jakubowski, Boglarka Gyurkocza, Brian C. Shaffer, Esperanza B. Papadopoulos, Doris M. Ponce, James W. Young, Parastoo B. Dahi, Gunjan L. Shah, Craig S. Sauter, Hugo Castro-Malaspina, Sergio A. Giralt, Miguel-Angel Perales
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
(2018)
Meeting Abstract
Hematology
Rocco Richards, Leslie Cheteyan, Esperanza B. Papadopoulos, Ann A. Jakubowski, Hugo Castro-Malaspina, Genovefa A. Papanicolaou, Yeon Joo Lee
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
(2018)
Meeting Abstract
Hematology
Carmen Lau, Ioannis Politikos, Sean M. Devlin, Alexandra G. Jacob, Molly Maloy, Kristine Naputo, Aishat Afuye, Valkal Bhatt, Parastoo B. Dahi, Miguel-Angel Perales, Sergio A. Giralt, Richard J. O'Reilly, Doris M. Ponce, Susan E. Prockop, Gunjan L. Shah, Genovefa A. Papanicolaou, Andromachi Scaradavou, Juliet N. Barker
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
(2018)
Article
Infectious Diseases
David J. Epstein, Susan K. Seo, Janice M. Brown, Genovefa A. Papanicolaou
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2018)
Article
Infectious Diseases
David J. Epstein, Susan K. Seo, Yao-Ting Huang, Jay H. Park, Virginia M. Klimek, Ellin Berman, Martin S. Tallman, Mark G. Frattini, Genovefa A. Papanicolaou
JOURNAL OF INFECTION
(2018)
Article
Medicine, General & Internal
Drew J. Winston, Kathleen M. Mullane, Oliver A. Cornely, Michael J. Boeckh, Janice Wes Brown, Steven A. Pergam, Igoris Trociukas, Pavel Zak, Michael D. Craig, Genovefa A. Papanicolaou, Juan D. Velez, Jens Panse, Kimberly Hurtado, Doreen A. Fernsler, Jon E. Stek, Lei Pang, Shu-Chih Su, Yanli Zhao, Ivan S. F. Chan, Susan S. Kaplan, Janie Parrino, Ingi Lee, Zoran Popmihajlov, Paula W. Annunziato, Ann Arvin
Article
Immunology
Claudia Rosillo, Ana Maria Avila, Yao-Ting Huang, Sean Devlin, Christina Cho, Juan Montoro, Molly A. Maloy, Genovefa A. Papanicolaou, Pere Barba, Miguel-Angel Perales
TRANSPLANT INFECTIOUS DISEASE
(2018)
Article
Immunology
Seong Jin Kim, Yao-Ting Huang, Julia Foldi, Yeon Joo Lee, Molly Maloy, Sergio A. Giralt, Ann A. Jakubowski, Genovefa A. Papanicolaou
TRANSPLANT INFECTIOUS DISEASE
(2018)
Article
Immunology
Yeon Joo Lee, Melissa Bacchus, Elizabeth Schmidt, Mohit Chawla, Juliet N. Barker, Genovefa A. Papanicolaou
TRANSPLANT INFECTIOUS DISEASE
(2018)
Article
Immunology
Yeon Joo Lee, Dionysios Neofytos, Seong Jin Kim, Leslie Cheteyan, Yao-Ting Huang, Esperanza B. Papadopoulos, Ann A. Jakubowski, Genovefa A. Papanicolaou
TRANSPLANT INFECTIOUS DISEASE
(2018)
Editorial Material
Hematology
Genovefa Papanicolaou
LANCET HAEMATOLOGY
(2018)
Meeting Abstract
Surgery
D. Florescu, M. Grimley, G. Papanicolaou, V. Prasad, E. Vainorius, G. Chittick, T. Brundage, G. Nichols
AMERICAN JOURNAL OF TRANSPLANTATION
(2018)
Article
Immunology
Yeon Joo Lee, Yao-Ting Huang, Seong Jin Kim, Marina Kerpelev, Victoria Gonzalez, Anna Kaltsas, Genovefa Papanicolaou
CLINICAL INFECTIOUS DISEASES
(2018)
Article
Hematology
Yao-Ting Huang, Seong Jin Kim, Yeon Joo Lee, Daniel Burack, Paige Nichols, Molly Maloy, Miguel-Angel Perales, Sergio A. Giralt, Ann A. Jakubowski, Genovefa A. Papanicolaou
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
(2017)
Review
Biophysics
C. E. Dandoy, M. I. Ardura, G. A. Papanicolaou, J. J. Auletta
BONE MARROW TRANSPLANTATION
(2017)