Article
Chemistry, Multidisciplinary
Wei Zhou, Fei Wang, Aimin Li, Silei Bai, Xinxin Feng, Qing He
Summary: A superphane-based carcerand with 18 anion binding sites and a fully enclosed interior space was designed and synthesized. The carcerand was capable of imprisoning H2PO4- anion and highly toxic arsenate anion, resulting in non-toxic arsenate carceplex in HEK293T cell line.
CELL REPORTS PHYSICAL SCIENCE
(2023)
Article
Oncology
Yu Zheng, Yuan-Fei Mao, Hui-Jin Zhao, Li Chen, Li-Ning Wang, Yun-Xiang Zhang, Jiong Hu, Jun-Min Li, Xiao-Yang Li, Hong-Ming Zhu
Summary: This study investigated the arsenic metabolism in APL patients who completed ATO treatment and found a decreased arsenic methylation capacity after treatment. The increased proportion of iAs(III) in urine was associated with chronic liver toxicity, highlighting the importance of monitoring urine PMI and considering SNPs of the AS3MT gene in determining ATO dosage.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2021)
Article
Biology
Yanan Jiang, Jianing Li, Yujie Liu, Xiuyun Shen, Junyi Li, Fengnan Zhi, Juan Xu, Xia Li, Tingting Shao, Yingqi Xu
Summary: ATOdb is a comprehensive database that collects experimentally supported data related to ATO and provides integrated analysis tools. It includes detailed information about ATO, its targets, conditions, and combined drugs. ATOdb also offers data visualization and analysis results, accessible through an easy-to-use web interface.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Toxicology
Sixun Guo, Xinyu Wang, Chunlu Gao, Zhiqiang Wu, Hongzhu Chen, Liwang Lin, Meihua Guo, Yanhui Gao, Xin Hai
Summary: Arsenic trioxide has been successfully used in the treatment of acute promyelocytic leukemia, and this study established a method to determine arsenic species in red blood cells, finding that the concentration of DMA is highest in plasma while MMA is the most predominant methylated arsenic in RBCs. High affinity of MMA with human Hb contributes to the accumulation of arsenic in RBCs of APL patients.
TOXICOLOGY LETTERS
(2021)
Article
Pharmacology & Pharmacy
Hiroshi Yamauchi, Ayako Takata
Summary: The study investigated 61 patients with acute arsenic poisoning and found that adults had higher arsenic intake and more severe symptom progression, while children demonstrated better methylation capacity during acute arsenic poisoning, leading to relatively milder symptom progression.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Jiang Sun, Mengying Cheng, Tingxian Ye, Bin Li, Yinghui Wei, Hangsheng Zheng, Hongyue Zheng, Meiqi Zhou, Ji-Gang Piao, Fanzhu Li
Summary: Hepatocellular carcinoma is a major threat to human health and economic development. Arsenic trioxide has shown effectiveness in treating this cancer, but its optimal concentration and bioavailability in tumor tissue need to be addressed. Nanotechnology-based delivery systems have been developed to overcome these challenges and improve the efficacy of arsenic trioxide.
Article
Materials Science, Multidisciplinary
Xuepeng Li, Dachun Liu, Juan Wang, Jun Chang, Ziyang Wang
Summary: Arsenic-iron precipitate was treated using a carbon thermal magnetization reduction method to recover arsenic and iron. Arsenic was recovered as As2O3 and iron was recovered as Fe3O4 by roasting the precipitate mixed with coke powder at a low temperature. The recovery of arsenic and iron in the form of Fe3O4 and As2O3 with a purity of 99.91 wt.% was achieved under specific conditions. The reaction mechanism involved the decomposition and reduction of FeAsO4, resulting in the generation of Fe3O4 and volatilization of As2O3.
Article
Chemistry, Multidisciplinary
Qinglong Yan, Rui Sun, Zhifen Cui, Jichao Zhang, Yu Zhag, Qi Zhang, Shitai Zhu, Lihua Wang, Qian Li, Min Lu, Zhu, Chunhai Fan
Summary: Nanodiamonds (NDs) demonstrate a potent multiple organ-specific anti-metastatic mechanism in arsenic trioxide (ATO)-based therapy for liver cancer, effectively inhibiting ATO-associated metastasis in the liver, spleen, and intestines. This study reveals a potential strategy for inhibiting multiple-organ cancer metastasis through nanoparticle-mediated modulation of autophagy.
Article
Chemistry, Medicinal
Judith A. Carrall, Wilford Lie, Jacob M. Lambert, Hugh H. Harris, Barry Lai, Carolyn T. Dillon
Summary: This research aims to design and develop tumor-homing peptide complexes of arsenic to strategically target specific cancers, with the goal of achieving dose reduction and decreased side effects. Studies show that the most stable complex exhibits 1000 times greater toxicity towards leukemia cells than human blood cells, indicating potential for in vivo studies.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Medicine, Research & Experimental
Xiuyun Shen, Fengnan Zhi, Chunpeng Shi, Jincheng Xu, Yuqiu Chao, Juan Xu, Yunlong Bai, Yanan Jiang, Baofeng Yang
Summary: The lncRNA Kcnq1ot1/miR-34a-5p/Sirt1 pathway is involved in ATO-induced cardiotoxicity. Propranolol can attenuate ATO-induced cardiotoxicity at least partially through the lncRNA Kcnq1ot1/miR-34a-5p/Sirt1 pathway.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Mengzhen Yu, Yanwen Zhang, Meirong Fang, Shah Jehan, Wenhu Zhou
Summary: This article reviews the medical applications of arsenic trioxide (ATO) and discusses the potential of ATO nanotechnology in the treatment of solid tumors. Nanotechnology can enhance the bioavailability and targeting capabilities of ATO, thereby improving the effectiveness of cancer treatment.
Article
Environmental Sciences
Lixuan Tang, Juan Lan, Xuanxuan Jiang, Riming Huang, Qiling Pang, Shaofeng Wu, Fang Wan, Gaolong Zhong, Zhaoxin Tang, Lianmei Hu
Summary: This study found that curcumin can counteract the immunosuppressive effect of arsenic on ducks, demonstrating anti-inflammatory and autophagy-restoring properties.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Medicine, Research & Experimental
Jian Lv, Mengliang Wu, Chunrong Pang, Rui Duan, Hong Zhang, Shuo Tian, Haixia Yang, Xin Hai
Summary: Torsemide increased the plasma concentrations of arsenic metabolites in APL patients treated with ATO by inhibiting the transporter MRP4 in a dose-dependent manner. This effect was also observed in rats treated with both ATO and torsemide. Torsemide reduced the excretion of arsenic in urine and increased its concentration in the kidneys of rats.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Iman M. Ahmad, Alicia J. Dafferner, Ramia J. Salloom, Maher Y. Abdalla
Summary: This study explored new strategies that could lead to the development of less toxic and more effective therapies against PDAC by combining increased cellular stress and targeting autophagy.
Article
Engineering, Environmental
Jullieta E. Lum, Valerie A. Schoepfer, Heather E. Jamieson, Joyce M. McBeth, Anezka Borcinova Radkova, Mary P. Walls, Matthew B. J. Lindsay
Summary: Historical mining and mineral processing at Giant Mine in Yellowknife, Canada, has left a legacy of arsenic and antimony contamination. The stored arsenic trioxide roaster waste (ATRW) was found to primarily consist of arsenolite, but also showed minor associations with iron oxides. The presence of different forms of arsenic and antimony has implications for the environmental behavior and remediation of ATRW. Overall, this study provides important insights into the phase associations and environmental fate of ATRW solids.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Letter
Biophysics
A. M. Cornelison, R. M. Saliba, A. Afrough, Y. Dinh, Y. Nieto, Q. Bashir, N. Shah, S. Parmar, C. Hosing, U. Popat, E. Shpall, R. Champlin, M. H. Qazilbash
BONE MARROW TRANSPLANTATION
(2016)
Article
Oncology
Philip A. Thompson, Travis Perera, David Marin, Betul Oran, Uday Popat, Muzaffar Qazilbash, Nina Shah, Simrit Parmar, Katayoun Rezvani, Amanda Olson, Partow Kebriaei, Paolo Anderlini, Gabriela Rondon, Amin Alousi, Stefan Ciurea, Richard E. Champlin, Ashish Bajel, Jeffrey Szer, Elizabeth J. Shpall, David Ritchie, Chitra M. Hosing
LEUKEMIA & LYMPHOMA
(2016)
Article
Hematology
Sameh Gaballa, Rima M. Saliba, Samer Srour, Gary Lu, Jonathan E. Brammer, Nina Shah, Qaiser Bashir, Krina Patel, Fabian Bock, Simrit Parmar, Chitra Hosing, Uday Popat, Ruby Delgado, Gabriela Rondon, Jatin J. Shah, Elisabet E. Manasanch, Robert Z. Orlowski, Richard Champlin, Muzaffar H. Qazilbash
AMERICAN JOURNAL OF HEMATOLOGY
(2016)
Article
Hematology
Joumana Kmeid, Jakapat Vanichanan, Dimpy P. Shah, Firas El Chaer, Jacques Azzi, Ella J. Ariza-Heredia, Chitra Hosing, Victor Mulanovich, Roy F. Chemaly
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
(2016)
Article
Biophysics
J. E. Brammer, R. M. Saliba, J. L. Jorgensen, C. Ledesma, S. Gaballa, M. Poon, R. T. Maziarz, R. E. Champlin, C. Hosing, P. Kebriaei
BONE MARROW TRANSPLANTATION
(2017)
Article
Oncology
Elias Jabbour, Stefan Faderl, Koji Sasaki, Tapan Kadia, Naval Daver, Naveen Pemmaraju, Keyur Patel, Joseph D. Khoury, Carlos Bueso-Ramos, Zachary Bohannan, Farhad Ravandi, Gautam Borthakur, Srdan Verstovsek, Darla Miller, Rita Maduike, Chitra Hosing, Hagop M. Kantarjian, Guillermo Garcia-Manero
Article
Oncology
Yago Nieto, Benigno C. Valdez, Peter F. Thall, Roy B. Jones, Wei Wei, Alan Myers, Chitra Hosing, Sairah Ahmed, Uday Popat, Elizabeth J. Shpall, Muzaffar Qazilbash, Alison Gulbis, Paolo Anderlini, Nina Shah, Qaiser Bashir, Amin Alousi, Yasuhiro Oki, Michelle Fanale, Bouthaina Dabaja, Chelsea Pinnix, Richard Champlin, Borje S. Andersson
Article
Oncology
Sameh Gaballa, Isabell Ge, Riad El Fakih, Jonathan E. Brammer, Piyanuch Kongtim, Ciprian Tomuleasa, Sa A. Wang, Dean Lee, Demetrios Petropoulos, Kai Cao, Gabriela Rondon, Julianne Chen, Aimee Hammerstrom, Lindsey Lombardi, Gheath Alatrash, Martin Korbling, Betul Oran, Partow Kebriaei, Sairah Ahmed, Nina Shah, Katayoun Rezvani, David Marin, Qaiser Bashir, Amin Alousi, Yago Nieto, Muzaffar Qazilbash, Chitra Hosing, Uday Popat, Elizabeth J. Shpall, Issa Khouri, Richard E. Champlin, Stefan O. Ciurea
Article
Oncology
Ryan W. Jacobs, Rima M. Saliba, Koji Sasaki, Shatha Farhan, Aristides Armas, Nina D. Shah, Qaiser Bashir, Sofia Qureshi, Gabriela Rondon, Chitra Hosing, Uday Popat, Simrit Parmar, Jatin J. Shah, Michael Wang, Donna M. Weber, Sheeba K. Thomas, Robert Z. Orlowski, Richard E. Champlin, Muzaffar H. Qazilbashi
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
(2016)
Review
Oncology
Chelsea C. Pinnix, Jatin J. Shah, Hubert Chuang, Colleen M. Costelloe, L. Jeffrey Medeiros, Christine F. Wogan, Valerie Reed, Grace L. Smith, Sarah Milgrom, Krina Patel, Jinhai Huo, Francesco Turturro, Jorge Romaguera, Luis Fayad, Yasuhiro Oki, Michelle A. Fanale, Jason Westin, Loretta Nastoupil, Fredrick B. Hagemeister, Alma Rodriguez, Muzaffar Qazilbash, Nina Shah, Qaiser Bashir, Sairah Ahmed, Yago Nieto, Chitra Hosing, Eric Rohren, Bouthaina Dabaja
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
(2016)
Article
Hematology
Talha Badar, Amanda Megan Cornelison, Nina D. Shah, Qaiser Bashir, Simrit Parmar, Krina Patel, Chitra Hosing, Uday Popat, Donna M. Weber, Sheeba K. Thomas, Jatin J. Shah, Robert Z. Orlowski, Richard E. Champlin, Muzaffar H. Qazilbash
EUROPEAN JOURNAL OF HAEMATOLOGY
(2016)
Article
Medicine, Research & Experimental
Partow Kebriaei, Harjeet Singh, M. Helen Huls, Matthew J. Figliola, Roland Bassett, Simon Olivares, Bipulendu Jena, Margaret J. Dawson, Pappanaicken R. Kumaresan, Shihuang Su, Sourindra Maiti, Jianliang Dai, Branden Moriarity, Marie-Andree Forget, Vladimir Senyukov, Aaron Orozco, Tingting Liu, Jessica McCarty, Rinelca N. Jackson, Judy S. Moyes, Gabriela Rondon, Muzaffar Qazilbash, Stefan Ciurea, Amin Alousi, Yago Nieto, Katy Rezvani, David Marin, Uday Popat, Chitra Hosing, Elizabeth J. Shpall, Hagop Kantarjian, Michael Keating, William Wierda, Kim Anh Do, David A. Largaespada, Dean A. Lee, Perry B. Hackett, Richard E. Champlin, Laurence J. N. Cooper
JOURNAL OF CLINICAL INVESTIGATION
(2016)
Article
Oncology
Jonathan E. Brammer, Issa Khouri, David Marin, Celina Ledesma, Gabriela Rondon, Stefan O. Ciurea, Yago Nieto, Richard E. Champlin, Chitra Hosing, Partow Kebriaei
LEUKEMIA & LYMPHOMA
(2017)
Article
Oncology
Esmeralda C. Teo, Benigno C. Valdez, Jie Ji, Yang Li, Yan Liu, Jonathan E. Brammer, Chitra Hosing, Yago Nieto, Richard E. Champlin, Borje S. Andersson
LEUKEMIA & LYMPHOMA
(2016)
Article
Oncology
Benigno C. Valdez, Jonathan E. Brammer, Yang Li, David Murray, Esmeralda C. Teo, Yan Liu, Chitra Hosing, Yago Nieto, Richard E. Champlin, Borje S. Andersson