Article
Immunology
Stephanie Shulder, Pranita D. Tamma, Suiyini Fiawoo, Kathryn Dzintars, Daniel Escobar, Daniel J. Livorsi, Anurag N. Malani, Danica Palacio, Emily S. Spivak, Matty Zimmerman, Jacqueline T. Bork
Summary: A 24-site observational cohort study showed that infectious diseases consultation (IDC) reduced the risk of 30-day mortality by 40% in hospitalized patients with Gram-negative bacteremia (GN-BSI).
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Sho Ogura, Muneyoshi Kimura, Shinsuke Takagi, Takashi Mitsuki, Mitsuhiro Yuasa, Kosei Kageyama, Daisuke Kaji, Aya Nishida, Yuki Taya, Kazuya Ishiwata, Hisashi Yamamoto, Yuki Asano-Mori, Go Yamamoto, Naoyuki Uchida, Atsushi Wake, Shuichi Taniguchi, Hideki Araoka
Summary: This study aimed to clarify the characteristics of gram-negative bacteremia among allo-HSCT recipients on LVFX prophylaxis, specifically focusing on ESBL-producing pathogens. The results showed that GNB was not a significant cause of death, and empiric CFPM administration in cases of LVFX breakthrough ESBL-EC bacteremia did not lead to significantly poor prognosis, suggesting it may be an acceptable strategy.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2021)
Article
Multidisciplinary Sciences
Yanfeng Liu, Ya Liu, Yi Liu, Xuefeng Chen, Yan Jia
Summary: This study analyzed the epidemiological characteristics and antibiotic sensitivity of gram-negative bacteria (GNB) infections in allo-HSCT recipients. It identified independent risk factors for carbapenem-resistant GNB (CRGNB) infections and death. The study found a high incidence and mortality of GNB infections in allo-HSCT recipients. Factors such as the use of carbapenem antibiotics, special immunosuppressants, and prolonged hematopoietic reconstruction were associated with CR-GNB infections, while longer intervals between diagnosis and transplantation, elevated bilirubin levels, and septic shock were independent risk factors for mortality.
Article
Hematology
Amanda M. Casto, Sachiko Seo, David M. Levine, Barry E. Storer, Xinyuan Dong, John A. Hansen, Michael Boeckh, Paul J. Martin
Summary: This study found that only the donor ABCB1 gene variant was associated with CMV reactivation after allogeneic hematopoietic cell transplantation. Other genetic variants previously linked to CMV phenotypes did not significantly alter the risk for CMV reactivation or disease post-transplant.
Article
Microbiology
Fabian Herrera, Diego Torres, Alberto Carena, Federico Nicola, Andres Rearte, Elena Temporiti, Laura Jorge, Ricardo Valentini, Florencia Bues, Silvia Relloso, Pablo Bonvehi
Summary: This is a prospective observational study on short-course antibiotic therapy for Gram-negative bacilli bacteremia in immunosuppressed patients. The findings suggest that 7 days of antibiotic therapy might be adequate under certain conditions.
Article
Immunology
Yan Jia, Yun Li, Yi Liu, Ziyue Yang, Xuefeng Chen, Yanfeng Liu
Summary: This study aimed to investigate the clinical characteristics and risk factors for mortality with CRGNB infection in HSCT recipients, in order to provide useful information for guiding the application of antibiotics and improving the prognosis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Immunology
Andrew Bock, Blake M. Hanson, Felicia Ruffin, Joshua B. Parsons, Lawrence P. Park, Batu Sharma-Kuinkel, Michael Mohnasky, Cesar A. Arias, Vance G. Fowler, Joshua T. Thaden
Summary: Recurrent gram-negative bacterial bloodstream infections (GNB-BSI) are mainly caused by relapse, and pulsed-field gel electrophoresis accurately differentiates relapse from reinfection. Having a cardiac device is a risk factor for relapse.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Immunology
Lilli Leimi, Jessica R. Koski, Outi Kilpivaara, Kim Vettenranta, A. Inkeri Lokki, Seppo Meri
Summary: This study investigated genetic complement system variants in patients with documented endotheliopathy and found that variants in complement genes may be related to endotheliopathy and poor prognosis in these patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Christopher J. Severyn, Benjamin A. Siranosian, Sandra Tian-Jiao Kong, Angel Moreno, Michelle M. Li, Nan Chen, Christine N. Duncan, Steven P. Margossian, Leslie E. Lehmann, Shan Sun, Tessa M. Andermann, Olga Birbrayer, Sophie Silverstein, Carol G. Reynolds, Soomin Kim, Niaz Banaei, Jerome Ritz, Anthony A. Fodor, Wendy B. London, Ami S. Bhatt, Jennifer S. Whangbo
Summary: This pilot study examined the impact of gut decontamination (GD) on gut microbiome composition and the incidence of acute graft-versus-host disease (aGVHD) in patients undergoing allogeneic hematopoietic cell transplantation (HCT). The study found that GD did not affect gut microbiome diversity or clinical outcomes, but it may protect against gut-derived bloodstream infections (BSI) by decreasing the prevalence or abundance of gut pathogens.
Article
Medicine, General & Internal
Theresa Hahn, Junke Wang, Leah M. Preus, Ezgi Karaesmen, Abbas Rizvi, Alyssa Clay-Gilmour, Qianqian Zhu, Yiwen Wang, Li Yan, Song Liu, Daniel O. Stram, Loreall Pooler, Xin Sheng, Christopher A. Haiman, David Van den Berg, Amy Webb, Guy Brock, Stephen R. Spellman, Kenan Onel, Philip L. McCarthy, Marcelo C. Pasquini, Lara E. Sucheston-Campbell
Summary: Through genome-wide analysis, novel non-HLA genetic loci were found to be associated with 1-year survival after unrelated donor BMT.
Article
Oncology
Seom Gim Kong, Seri Jeong, Sangjin Lee, Jee-Yeong Jeong, Da Jung Kim, Ho Sup Lee
Summary: The study revealed that the cumulative incidence rates of early TRM at 50 and 100 days were 2.9% and 8.3% respectively. Predictable factors for early TRM included age, time from diagnosis to transplantation, number of prior transplantations, graft source, and previous iron chelation therapy.
Review
Infectious Diseases
Jessica Waters, Andrew F. F. Shorr
Summary: Newer antibiotics have been developed and proven effective in treating various types of multidrug-resistant infections, but there is limited information on their efficacy specifically for bloodstream infections.
Article
Oncology
Justin C. Tossey, Zeinab El Boghdadly, Erica E. Reed, Jennifer Dela-Pena, Kelci Coe, Sherry N. Williams, Lynn C. Wardlow
Summary: This study compared the outcomes of cancer patients transitioning from IV to PO therapy with those continuing IV treatment. The PO therapy group had lower treatment failure rates, shorter hospital stays, and fewer complications.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Agriculture, Multidisciplinary
Hongyan Yang, Lan Wang, Libo Yuan, Heng Du, Boyuan Pan, Kui Lu
Summary: In this study, a series of hybrid peptides were designed by connecting an antimicrobial peptide Ce(1-8) with a lipopolysaccharide-targeting peptide Lf(28-34) via different linkers. The results showed that the linkers played a crucial role in the antimicrobial activity of the hybrid peptides against Gram-negative bacteria. Among these hybrid peptides, peptide CL5 with a dipeptide rigid linker exhibited excellent activity and selectivity against Gram-negative bacteria. It was found that the interaction of the peptides with LPS was crucial for their antimicrobial activity. Mechanistic studies revealed that peptide CL5 disrupted the integrity of bacterial membranes, leading to the death of Gram-negative bacterial cells. This study highlights the importance of linker selection in the design of hybrid peptides and provides a foundation for the development of antimicrobial peptides.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Infectious Diseases
Fan Zhang, Hao Wang, Liyu Liu, Teng Su, Bing Ji
Summary: A machine learning model was developed in this study to predict gram-positive and gram-negative bacteremia based on routine laboratory parameters.
BMC INFECTIOUS DISEASES
(2023)
