期刊
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
卷 14, 期 7, 页码 795-798出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.bbmt.2008.04.008
关键词
autologous stem cell transplantation; cyclophosphamide; lenalidomide; multiple myeloma; stem cell mobilization
资金
- NCI NIH HHS [K23 CA109260, K23 CA109260-01] Funding Source: Medline
- NCRR NIH HHS [UL1 RR024996] Funding Source: Medline
A total of 28 treatment-naive patients with stage II or II multiple myeloma (MM) were treated with the combination of clarithromycin, lenalidomide, and dexamethasone (BiRD). Stem cells were collected following granulocyte-colony stimulating factor (G-CSF) or cyclophosphamide (Cy) plus G-CSF mobilization at maximum response. Sufficient stem cells for 2 autologous stem cell transplants were collected from all patients mobilized with Cy plus G-CSF, versus 33% mobilized,with G-CSF alone (P < .0001). The duration of prior lenalidomide therapy did not correlate with success of stem cell harvests (P = .91). In conclusion, Cy can be added to G-CSF for stem cell mobilization to successfully overcome the suppressive effect of prior treatment with lenalidomide. (C) 2008 American Society for Blood and Marrow Transplantation.
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