期刊
BIOLOGY LETTERS
卷 8, 期 2, 页码 308-311出版社
ROYAL SOC
DOI: 10.1098/rsbl.2011.0760
关键词
Harmonia axyridis; insect immunity; harmonine; antimicrobial activity
资金
- German Federal State of Hessen as part of the LOEWE-Schwerpunkt Insektenbiotechnologie
- DFG
- MALSIG consortium of the EU
- GSLS of the University of Wurzburg
- Erwin-Stein-Foundation (Giessen, Germany)
The harlequin ladybird beetle Harmonia axyridis has been introduced in many countries as a biological control agent, but has become an invasive species threatening the biodiversity of native ladybirds. Its invasive success has been attributed to its vigorous resistance against diverse pathogens. This study demonstrates that harmonine ((17R, 9Z)-1,17-diaminooctadec-9-ene), which is present in H. axyridis haemolymph, displays broad-spectrum antimicrobial activity that includes human pathogens. Antibacterial activity is most pronounced against fast-growing mycobacteria and Mycobacterium tuberculosis, and the growth of both chloroquine-sensitive and -resistant Plasmodium falciparum strains is inhibited. Harmonine displays gametocytocidal activity, and inhibits the exflagellation of microgametocytes and zygote formation. In an Anopheles stephensi mosquito feeding model, harmonine displays transmission-blocking activity.
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