期刊
BIOLOGY LETTERS
卷 7, 期 1, 页码 98-100出版社
ROYAL SOC
DOI: 10.1098/rsbl.2010.0547
关键词
mutation; adaptation; evolution
资金
- Foundation for Research Science and Technology (New Zealand)
- Massey University
- NSF [DEB-0844355]
- DARPA FunBio
- Marsden Fund Council from government funding administered by the Royal Society of New Zealand
Theoretical studies of adaptation emphasize the importance of understanding the distribution of fitness effects (DFE) of new mutations. We report the isolation of 100 adaptive mutants-without the biasing influence of natural selection-from an ancestral genotype whose fitness in the niche occupied by the derived type is extremely low. The fitness of each derived genotype was determined relative to a single reference type and the fitness effects found to conform to a normal distribution. When fitness was measured in a different environment, the rank order changed, but not the shape of the distribution. We argue that, even with detailed knowledge of the genetic architecture underpinning the adaptive types (as is the case here), the DFEs remain unpredictable, and we discuss the possibility that general explanations for the shape of the DFE might not be possible in the absence of organism-specific biological details.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据