Article
Biochemistry & Molecular Biology
Tzu-Jung Yu, Yuan-Bin Cheng, Li-Ching Lin, Yi-Hong Tsai, Bo-Yi Yao, Jen-Yang Tang, Fang-Rong Chang, Chia-Hung Yen, Fu Ou-Yang, Hsueh-Wei Chang
Summary: PHA is a potential natural product for anti-breast-cancer, which modulates oxidative-stress response, cell-cycle disturbance, apoptosis, and gamma H2AX-detected DNA damage.
Article
Horticulture
Elis Marina de Freitas, Thayne Nargyle Botelho Vital, Gabriel Fernandes Costa Guimaraes, Fernando Augusto da Silveira, Carlos Nick Gomes, Fernando Franca da Cunha
Summary: This study aimed to determine the permanent wilting point (PWP) of Physalis peruviana L. in different soils. The results showed that P. peruviana wilted 1.7 days faster in sandy soil compared to sandy clay loam soil. The matric potential equivalent to PWP varied for different soil textures.
Article
Spectroscopy
Romeu da Silva Leite, Marilza Neves do Nascimento, Salvador Hernandez-Navarro, Norlan Miguel Ruiz Potosme, Sivakumaran Karthikeyan
Summary: This study evaluates the use of ATR-FTIR spectroscopy for analyzing water deficit tolerance in Physalis peruviana plants. The results suggest that chemical treatments attenuate water deficit effects on plants, influencing both phenotypic characterization and spectral analyses. Functional groups in leaves, stems, and roots are influenced by water deficit and priming treatments.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Fisheries
Haoran Zhang, Fuqing Zhao, Xiaoxue Gai, Jingzeng Cai, Xintong Zhang, Xiaoming Chen, Yue Zhu, Ziwei Zhang
Summary: Cadmium is a common environmental pollutant that has toxic effects on fish head kidney lymphocytes. This study utilized an in vitro Cd exposure model and antioxidant treatment to demonstrate that Cd induced lymphocyte apoptosis, which could be alleviated by antioxidants.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Shuangquan Wen, Li Wang, Hui Zou, Jianhong Gu, Ruilong Song, Jianchun Bian, Yan Yuan, Zongping Liu
Summary: This study evaluated the neuroprotective potential of Puerarin against cadmium-induced neuronal injury for the first time, showing that Puerarin ameliorated neuronal injury and oxidative stress induced by cadmium. Additionally, Puerarin stimulated cadmium excretion, thereby reducing apoptosis in cerebral cortical neurons.
Article
Environmental Sciences
Min Wang, Yueyue Wang, Size Wang, Lulu Hou, Zilin Cui, Qi Li, He Huang
Summary: Cadmium (Cd) is a common heavy metal pollutant with toxic effects on the testes. Selenium (Se) can antagonize the toxicity of Cd, but the underlying mechanisms are still unclear. In this study, chicken testis samples were collected after Cd exposure and Cd/Se treatment to investigate the effects on oxidative stress, endoplasmic reticulum stress (ERS), and programmed necrosis. The results showed that Se alleviated Cd-induced damage by improving histopathological changes and restoring antioxidant levels. Se also inhibited the expression of stress-related proteins and regulated programmed necrosis markers. Overall, Se can protect against Cd-induced toxicity in the chicken testis by mitigating oxidative stress, ERS, and programmed necrosis.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Plant Sciences
Francisco Romario Andrade Figueiredo, Jackson Silva Nobrega, Reynaldo Teodoro de Fatima, Jean Telvio Andrade Ferreira, Marcia Paloma da Silva Leal, Marlenildo Ferreira Melo, Thiago Jardelino Dias, Manoel Bandeira de Albuquerque
Summary: This study evaluated the application of a biostimulant to alleviate the negative effects of salinity on the growth and gas exchange of Physalis peruviana plants. Experimental results showed that the seaweed-based biostimulant improved photosynthetic capacity, reduced transpiration rate, and mitigated the deleterious effects of salinity on plant growth components. Further research on the biochemical and enzyme activities of the plant's antioxidant system is recommended to better understand the effectiveness of biostimulant application in mitigating salt stress.
PHYSIOLOGY AND MOLECULAR BIOLOGY OF PLANTS
(2021)
Article
Environmental Sciences
Cao Zhaohui, Tang Cifei, Huang Di, Zeng Weijia, Han Cairui, Li Zecong, Hu Xiaobo
Summary: In this study, it was found that cadmium exposure induced cell death in HepG2 cells via a ROS-mediated PERK-CHOP-related apoptotic signaling pathway, providing a novel insight into the mechanisms of cadmium-induced hepatotoxicity. Inhibitors targeting oxidative stress and ER stress might be potential strategies for preventing or treating this disorder.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Food Science & Technology
Lesley A. Cortes, Diana C. Moncayo, Diego A. Castellanos
Summary: An active antifungal packaging system combined with modified atmospheres (MAP) was proposed to preserve cape gooseberry. The antifungal effect of oregano essential oil, cinnamaldehyde, and 2-nonanone in the vapor phase was evaluated, and cinnamaldehyde was found to have the highest antifungal capacity. This compound was included inside an active packaging system to extend the shelf life of the fruit.
FOOD PACKAGING AND SHELF LIFE
(2023)
Article
Biochemistry & Molecular Biology
Daissy Monroy-Velandia, Ericsson Coy-Barrera
Summary: Colombia is the main producer of cape gooseberry (Physalis peruviana L.), which is known for its various consumption practices and medicinal properties. The plant is moderately tolerant to unfavorable conditions, such as nutrient-poor soils or high salt concentrations. This study aimed to investigate the metabolic and growth differences of P. peruviana plants under varying salt conditions at different growth substages. The results showed that salt stress negatively affected plant growth and caused specific metabolic changes.
Article
Horticulture
Sara Agudelo-Sanchez, Yadiela Mosquera-Palacios, Dairon David-Usuga, Susana Cartagena-Montoya, Yudy Duarte-Correa
Summary: This study evaluated the effects of different postharvest treatments on the conservation of cape gooseberry fruit. It was found that immersion and coating processes resulted in the lowest weight loss and improved sensory characteristics and texture. The immersion treatment, in particular, showed promising results and can be considered as an alternative for postharvest treatment.
Article
Medicine, Research & Experimental
Hany H. Arab, Ahmed M. Ashour, Ahmed H. Eid, El-Shaimaa A. Arafa, Hana J. Al Khabbaz, Sarah A. Abd El-Aal
Summary: This study found that galangin can attenuate cadmium-induced nephrotoxicity through reducing oxidative stress and apoptosis, as well as promoting autophagy.
Article
Environmental Sciences
Jitender Kumar Bhardwaj, Harish Panchal
Summary: The study revealed that quercetin has a significant protective effect against testicular toxicity induced by cadmium, reducing oxidative stress and restoring antioxidant status. The experiment further elucidated the potential benefits of quercetin in preventing or managing male reproductive toxicity caused by increasing cadmium contamination in the environment.
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
(2021)
Article
Environmental Sciences
Lu-xi Lin, Qin-qin Cao, Chao-dong Zhang, Ting-ting Xu, Ke Yue, Qinghao Li, Fang Liu, Xuebing Wang, Hai-ju Dong, Shu-cheng Huang, Fu-chun Jian
Summary: This study investigated the effects of AFB1 on the testes of sheep and found that AFB1 can cause testicular damage and dysfunction. The mechanisms involved rumen dysbacteriosis, testicular oxidative stress, and apoptosis.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Biochemistry & Molecular Biology
Chuckles Ch. Marak, Guruswami Gurusubramanian, Vikas Kumar Roy
Summary: Cycas pectinata seeds have been traditionally used as a food source and for improving male sexual potency. A study examined the effect of Cycas pectinata seed extract (CPE) on testicular activity in mice. The results showed that CPE significantly increased sperm parameters, antioxidant status, and germ cell proliferation.
PROCESS BIOCHEMISTRY
(2023)
Article
Biochemical Research Methods
Rafa S. Almeer, Saad Alkahtani, Saud Alarifi, Ahmed E. Abdel Moneim, Saba Abdi, Gadah Albasher
Summary: This study demonstrated that supplementation with Ziziphus spina-christi leaf extract (ZSCLE) can protect against cortical deficits caused by mercuric chloride (HgCl2) exposure. ZSCLE prevents mercury deposition in the cortical slices, reduces oxidative stress, activates antioxidant enzymes, and suppresses cortical inflammation. It also reduces neuron loss and ameliorates histopathological changes associated with HgCl2 toxicity.
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
(2022)
Article
Oncology
Mohamed S. Othman, Amal H. Al-Bagawi, Sofian T. Obeidat, Mohamed A. Fareid, Ola A. Habotta, Ahmed E. Abdel Moneim
Summary: In this study, the effects of zinc nanoparticles biosynthesized with berberine (ZnNPs-BER) on colorectal cancer (CRC) cells were investigated. The results showed that ZnNPs-BER exhibited a higher antitumor potential compared to 5-fluorouracil (5-FU) and berberine alone. It induced oxidative stress, inflammation, and apoptotic changes in tumor cells and affected the cell cycle.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2022)
Article
Environmental Sciences
Mohamed S. Othman, Azza M. Khaled, Amal H. Al-Bagawi, Mohamed A. Fareid, Reda A. Hameed, Fatama A. Abu Zahra, Ahmed E. Abdel Moneim
Summary: The study aims to identify the active components in Echinops spinosus plant from the Hail area of Saudi Arabia and investigate its anti-diabetic properties. The results showed that both ESTE and ESHFF demonstrated anti-diabetic properties by lowering glucose levels and alleviating diabetic complications in the kidneys and liver.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Ahmed Ali Nada, Anita Eckstein Andicsova, Jaroslav Mosnacek
Summary: This article reviews the significance of electrically conductive materials fabricated from natural polymers in various applications. It discusses the preparation methods and properties of conductive polymers and hydrogels, with a focus on those that can be synthesized from renewable resources. The article also presents the self-healing systems and electrical conductivity values of conductive hydrogels based on natural polymers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Materials Science, Multidisciplinary
Marwa S. Salem, Ahmed Shaker, Mohamed S. Othman, Amal H. Al-Bagawia, Mostafa Fedawy, Ghada Mohamed Aleid
Summary: The study identifies antimony sulfide (Sb2S3) as a suitable absorber material for thin film solar cells, but current issues lead to poor photovoltaic performance. To enhance the power conversion efficiency, design guidelines are proposed using device simulation, resulting in an optimized PCE of around 22%.
Article
Integrative & Complementary Medicine
Mohamed S. Othman, Sofian T. Obeidat, Amal H. Al-Bagawi, Mohamed A. Fareid, Alaa Fehaid, Ahmed E. Abdel Moneim
Summary: This study evaluated the potential of green-synthesized selenium nanoparticles (SeNPs) containing berberine (SeNPs-Ber) as an anticancer agent. The results showed that SeNPs-Ber significantly improved survival rate, reduced tumor size, and activated apoptotic cascade in tumor cells. Moreover, SeNPs-Ber reduced oxidative stress and improved histopathological alterations in tumor tissue. These findings suggest that green-synthesized SeNPs-Ber has promising anticancer properties and can be used as supplementary medication during chemotherapy.
JOURNAL OF INTEGRATIVE MEDICINE-JIM
(2022)
Article
Crystallography
Marwa S. Salem, Ahmed Shaker, Amal H. Al-Bagawia, Ghada Mohamed Aleid, Mohamed S. Othman, Mohammad T. Alshammari, Mostafa Fedawy
Summary: This study presents a filter-less narrowband photodetector based on the architecture of perovskite/organic heterojunction, which achieves satisfactory performance in the near-infrared wavelength range.
Article
Environmental Sciences
Rasha S. Albeltagy, Shauq M. Dawood, Farah Mumtaz, Ahmed E. Abdel Moneim, Ola H. El-Habit
Summary: The study found that N-acetylcysteine (NAC) can attenuate oxidative stress and cytotoxicity of hepatic tissue induced by cadmium chloride (CdCl2). NAC was found to reduce the levels of oxidative stress markers, regulate the apoptotic signaling pathway, and decrease liver tissue injury.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Food Science & Technology
Ahmed A. Nada, Eman A. Ali, Ahmed B. Shazly, Mohamed T. Fouad, Marwa Al-Moghazy, Faten H. H. Abdellatif
Summary: Antimicrobial membranes for food packaging were created by grafting hydroxyethyl cellulose (HEC) with a synthesized monomer, 1-butyl-3-vinylimidazolium bromide (BVIm)[Br], and methyl acrylate (MA). The elasticity of the film increased with the content of BVIm[Br], while the stress strength values varied among different samples. The membranes demonstrated the ability to inhibit the spoilage of Karish cheese without affecting the lactic acid and probiotic bacteria.
JOURNAL OF FOOD PROCESSING AND PRESERVATION
(2022)
Article
Chemistry, Analytical
Ahmed A. Nada, Iman H. Nour, Aly M. Metwally, Aya M. Asaad, Safa M. Shams Eldin, Reham S. Ibrahim
Summary: This study implemented an integrated method for standardization of propolis using chromatographic, spectroscopic, palynological and biological analyses. Different digitalization algorithms were utilized to evaluate the HPTLC images, and ImageJ (R) and Gel Analyzer (R) showed superior performance. Multivariable pattern recognition models were constructed to discriminate between different types of propolis, and HPTLC-ESI-MS was used for precise identification. Several health-relevant markers were discovered. An independent UV spectroscopic method and palynological analysis were also used for prediction and determination of plant sources. The identification of plant sources is crucial for the standardization of propolis.
MICROCHEMICAL JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Abdulsalam Alkhudhayri, Ahmed E. Abdel Moneim, Sara Rizk, Amira A. Bauomy, Mohamed A. Dkhil
Summary: Echinops spinosus is a medicinal plant with various pharmacological effects, including antioxidant, anti-inflammatory, and antibacterial properties. This study found that E. spinosus extract has neuroprotective and anticonvulsant characteristics, reducing seizure duration and preventing cell death. It also showed potential as a natural anticonvulsant.
NEUROCHEMICAL RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Mohamed S. S. Othman, Sofian T. T. Obeidat, Ghada M. M. Aleid, Amal H. H. Al-Bagawi, Mohamed A. A. Fareid, Reda Abdel Hameed, Kareem M. M. Mohamed, Mohamed S. S. Abdelfattah, Alaa Fehaid, Manal M. M. Hussein, Shimaa M. H. Aboelnaga, Ahmed E. E. Abdel Moneim
Summary: The study aimed to explore the potential anticonvulsant effect of green synthetized selenium nanoparticles (SeNPs) using Syzygium aromaticum extract (SAE) (SAE-SeNPs) on epileptic seizures and cortical damage induced by pentylenetetrazole (PTZ) injection in rats, as well as its mechanism. SAE-SeNPs demonstrated a significant increase in seizure latency time, reduction in seizure duration and death rate, counteracted PTZ-induced changes in oxidants and antioxidants, restored pro-inflammatory cytokine levels, and suppressed glial fibrillary acidic protein activity. Furthermore, SAE-SeNPs reduced PTZ-induced cortical cell apoptosis and modulated neurotransmitter levels. The study concludes that SAE-SeNPs exhibit anticonvulsant activity through antioxidant, anti-inflammatory, and anti-apoptotic effects, and modulation of neurotransmitters.
APPLIED SCIENCES-BASEL
(2023)
Article
Materials Science, Paper & Wood
Eman AboBakr Ali, Heba M. Abo-Salem, Amany A. Arafa, Ahmed A. Nada
Summary: New chitosan derivative nanofibers with antibacterial properties were successfully produced in this study. Two CS Schiff base derivatives (CS-APC and CS-2APC) were prepared by incorporating 4-amino antipyrine moiety in different ratios, and further modified to obtain CS-APCR and CS-2APCR. The chemical structure was confirmed using spectral analyses. Molecular docking evaluation showed that CS-APCR has good fitting in the active sites of three enzymes with docking score values of - 32.76, - 35.43, and - 30.12 kcal/mol, respectively. CS derivative nanofibers were obtained by blending CS-2APC and CS-2APCR with PVP, resulting in decreased fiber diameters compared to pure PVP. The CS derivatives and their nanofibers exhibited antibacterial activities against Staphylococcus aureus and Escherichia coli, with CS-2APCR nanofibers showing stronger activity against E. coli strains than CS-2APC nanofibers.
Article
Chemistry, Multidisciplinary
Mohamed S. Othman, Shimaa M. Aboelnaga, Ola A. Habotta, Ahmed E. Abdel Moneim, Manal M. Hussein
Summary: This study investigated the effect of selenium nanoparticles biosynthesized with carvacrol (SeNPs-CV) on breast cancer cell lines and explored the underlying pathways. The results showed that SeNPs-CV effectively reduced the proliferation and viability of breast cancer cells in a dose-dependent manner. It induced oxidative stress, inflammation, and apoptosis in the tumor cells, suggesting its potential as a novel approach for combination chemotherapy in breast cancer.
APPLIED SCIENCES-BASEL
(2023)
Article
Pharmacology & Pharmacy
Mohamed M. Othman, Sofian Obeidat, Amal Al-Bagawi, Mohamed Fareid, Ola El-Borady, Rami Kassab, Ahmed Abdel Moneim
Summary: The study demonstrated that AgNPs-BER significantly improved survival rate, decreased body weight and tumor size, induced oxidative stress, and triggered apoptosis in tumor cells. It could potentially be utilized as an antitumor agent due to its pro-oxidant, pro-apoptotic, and antiangiogenic effects.
PHARMACEUTICAL SCIENCES
(2022)