Article
Cell Biology
Paul G. G. Thomes, Gage Rensch, Carol A. A. Casey, Terrence M. M. Donohue
Summary: Ethanol exposure induces the accumulation of protein aggregates in ethanol-metabolizing VL-17A hepatoma cells, which can be cleared by autophagy activation.
Article
Biochemistry & Molecular Biology
Si-Yeon Kim, Jung-Ho Lee, Soon-Ae Kim
Summary: This study found that zinc deficiency induces autophagy in neurons and may have cytoprotective effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Yuping Luo, Yuanyuan Fu, Zhiying Huang, Min Li
Summary: Transition metal-based compounds have shown potential in drug development and modulation of autophagy, with copper, zinc, and manganese playing vital roles in disease progression. Enrichment of these metals can regulate autophagy, providing new therapeutic strategies for human diseases.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Bo Sun, Jing Ma, Liger Te, Xin Zuo, Junsheng Liu, Yuejia Li, Jiajie Bi, Shusong Wang
Summary: Zinc deficiency has detrimental effects on reproductive function in male mice, characterized by testicular structural disorders and decreased semen quality. However, these damages are reversible with the supplementation of a zinc-normal diet.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Camila Diehl, Ane Wichine Acosta Garcia, Uriel Perin Kinskovski, Nicolau Sbaraini, Rafael de Oliveira Schneider, Patricia Aline Grohs Ferrareze, Alexandra Lehmkuhl Gerber, Ana Tereza Ribeiro de Vasconcelos, Livia Kmetzsch, Marilene Henning Vainstein, Charley Christian Staats
Summary: The ZRG1 gene plays a crucial role in zinc metabolism in Cryptococcus, affecting bacterial growth and autophagy-like phenotypes, thus impacting its survival and virulence towards hosts.
Article
Biochemistry & Molecular Biology
Lucia Vazquez Alberdi, Gonzalo Rosso, Lucia Veloz, Carlos Romeo, Joaquina Farias, Maria Vittoria Di Tomaso, Miguel Calero, Alejandra Kun
Summary: Curcumin is proposed as a natural treatment for neurodegenerative diseases, showing neuroprotective effects on wild-type Schwann cells but impaired effects on Trembler-J Schwann cells due to the impact of ethanol used as a vehicle for curcumin administration.
Article
Chemistry, Applied
Kai Gao, Jerrik Mielby, Soren Kegnaes
Summary: The study demonstrates that Zn-containing MFI zeolites are highly active and selective catalysts for the catalytic dehydrogenation of ethanol. The best catalyst, comprising 5 wt % Zn on Silicalite-1 zeolite, achieves a selectivity of 94.5% towards acetaldehyde at 400 degrees C.
Article
Biochemistry & Molecular Biology
Fang Yuan, Yingying Xu, Kai You, Jiaye Zhang, Fan Yang, Yin-xiong Li
Summary: The study showed that calcitriol can alleviate ethanol-induced hepatocyte damage by enhancing autophagy, providing a convenient preventive and hepatoprotective means for people who occasionally engage in social drinking. Autophagy is significantly enhanced by calcitriol, and the effect is mediated through the AMPK/mTOR signaling pathway and dependent on the Vitamin D receptor (VDR).
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Environmental Sciences
Xingyao Pei, Dingkuo Liu, Jianjun Li, Liuan Li, Xiangbin Ding, Wenjuan Zhang, Zibin Li, Gang Xu, Cun Li, Daowen Li
Summary: This study investigates the hepatotoxic mechanism of ZnO NPs and reveals the crosstalk between autophagy and pyroptosis. The findings suggest that autophagy serves as a protective response against pyroptosis induced by ZnO NPs, and the regulation of autophagy and lysosome by TFEB can alleviate the pyroptosis. This study provides new insights for the risk assessment and therapeutic strategy of ZnO NPs-induced pyroptosis.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Yu Wang, Hongjing Zhao, Mengyao Mu, Menghao Guo, Mingwei Xing
Summary: Arsenic accumulation in the spleen due to environmental exposure can cause severe injuries, while zinc treatment may offer protection against arsenic-induced splenic toxicity in common carp.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Biochemistry & Molecular Biology
Emil Rudolf, Kamil Rudolf
Summary: The study showed that acutely increased intracellular zinc in melanoma cells specifically enhances their autophagic activity, leading to autophagic cell death. This discovery may contribute to controlling melanoma growth and survival by understanding the relationship between zinc and autophagy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Physical
Yan Li, Shuang Song, Lin-Bin Zhang, Xiao-Xue Lian, Lin-Xi Shan, Qing-Jun Zhou
Summary: A hollow porous ZnO@ZnS core-shell structure was successfully synthesized hydrothermally, showing high gas-sensing performance with high selectivity, quick response-recovery, and stability to ethanol. The gas-sensing enhancement can be attributed to the Schottky barrier at the interface and the special hollow porous structure of ZnO@ZnS.
JOURNAL OF ALLOYS AND COMPOUNDS
(2021)
Article
Biochemistry & Molecular Biology
Chang Guo, Linyan Zheng, Shuyu Chen, Xuxuan Liang, Xue Song, Yue Wang, Baoyu Hua, Longxin Qiu
Summary: Thymol has a therapeutic effect on ethanol-induced liver damage by reducing reactive oxygen species production and improving lipid accumulation. It also regulates gene expression and metabolic alterations induced by ethanol. Thymol restores autophagic flux and alleviates liver damage caused by ethanol. These findings suggest thymol as an attractive option for treating ethanol-induced liver damage.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Microbiology
Hsin-Yu Lu, Yu-Ling Huang, Pei-Ching Wu, Xian-Yong Wei, Jonar I. Yago, Kuang- Ren Chung
Summary: The tangerine pathotype of Alternaria alternata can resist high levels of reactive oxygen species (ROS), and a transcription regulator AaSRR1 plays a negative role in ROS resistance. AaSRR1 also regulates conidiogenesis, maintenance of cell wall and membrane integrities, and chitin biosynthesis. Additionally, this study reveals tradeoffs between stress responses and hyphal growth in A. alternata.
MICROBIOLOGICAL RESEARCH
(2022)
Article
Neurosciences
Jia-quan Lin, He Tian, Xiao-guang Zhao, Sen Lin, Dao-yong Li, Yuan-ye Liu, Chang Xu, Xi-fan Mei
Summary: The study demonstrates that zinc provides neuroprotection after SCI by regulating the NLRP3 inflammasome through autophagy and ubiquitination.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Review
Biochemistry & Molecular Biology
Mark Preciados, Changwon Yoo, Deodutta Roy
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2016)
Article
Biochemistry & Molecular Biology
Juan P. Liuzzi, Vijaya Narayanan, Huong Doan, Changwon Yoo
Article
Oncology
Jairo Ramos, Jayanta Das, Quentin Felty, Changwon Yoo, Robert Poppiti, Donna Murrell, Paula J. Foster, Deodutta Roy
BREAST CANCER RESEARCH AND TREATMENT
(2018)
Article
Pediatrics
JoAnne M. Youngblut, Dorothy Brooten, Teresa Del-Moral, G. Patricia Cantwell, Balagangadhar Totapally, Changwon Yoo
JOURNAL OF PEDIATRICS
(2019)
Article
Oncology
Jairo Ramos, Changwon Yoo, Quentin Felty, Zhenghua Gong, Juan P. Liuzzi, Robert Poppiti, Indu Shekhar Thakur, Ruchika Goel, Ashok Kumar Vaid, Ricardo Jorge Komotar, Nasreen Z. Ehtesham, Seyed E. Hasnain, Deodutta Roy
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2020)
Article
Neurosciences
Kaumudi Bhawe, Quentin Felty, Changwon Yoo, Nasreen Z. Ehtesham, Seyed E. Hasnain, Varindera Paul Singh, Ishani Mohapatra, Deodutta Roy
MOLECULAR NEUROBIOLOGY
(2020)
Article
Oncology
Sung Bae Park, Ki-Tae Hwang, Chun Kee Chung, Deodutta Roy, Changwon Yoo
CLINICAL & EXPERIMENTAL METASTASIS
(2020)
Article
Multidisciplinary Sciences
Musfiqur Sazal, Vitalii Stebliankin, Kalai Mathee, Changwon Yoo, Giri Narasimhan
Summary: Causal inference in biomedical research is crucial for understanding causal relationships in biological processes. A novel pipeline for microbiome analysis has been proposed to identify disease-relevant causal factors. The results have been validated using synthetic and real data sets, confirming the effectiveness of the approach.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Diaaidden Alwadi, Quentin Felty, Deodutta Roy, Changwon Yoo, Alok Deoraj
Summary: This study utilized a risk assessment approach to investigate the association between exposure to environmental phenol and paraben chemicals in urine samples and prostate cancer in US men. Integrated bioinformatics analysis was also employed to examine the molecular pathways influenced by these exposures.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Kaumudi Bhawe, Jayanta K. Das, Changwon Yoo, Quentin Felty, Zhenghua Gong, Alok Deoraj, Juan P. Liuzzi, Nasreen Z. Ehtesham, Seyed E. Hasnain, Varindera Paul Singh, Ishani Mohapatra, Ricardo Jorge Komotar, Deodutta Roy
Summary: This study reveals that NRF1-driven genes and miRNAs are involved in the aggressiveness and recurrence of glioblastoma. These genes and miRNAs are associated with cancer cell stemness and mesenchymal features.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Article
Medicine, General & Internal
Sung Bae Park, Changwon Yoo
Summary: This study highlights the potential of machine learning methods in uncovering interactions between genes and their environment. However, current methods are inadequate in accurately identifying upstream regulators, whereas causal Bayesian network (CBN) can help identify these factors through the inferred causal network from medical big data.
JOURNAL OF THE KOREAN MEDICAL ASSOCIATION
(2022)
Article
Environmental Sciences
Hamza Assaggaf, Changwon Yoo, Roberto G. Lucchini, Steven M. Black, Munerah Hamed, Faisal Minshawi, Quentin Felty
Summary: This study found that individuals with risk factors for pulmonary arterial hypertension (PAH) had higher levels of PCBs, with increased accumulation of PCB congeners with age. However, caution is needed in interpreting these findings due to the use of self-reported data and a small sample size.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Endocrinology & Metabolism
Elena M. Kaftanovskaya, Mariluz Soula, Courtney Myhr, Brian A. Ho, Stefanie N. Moore, Changwon Yoo, Briana Cervantes, Javier How, Juan Marugan, Irina U. Agoulnik, Alexander I. Agoulnik
JOURNAL OF THE ENDOCRINE SOCIETY
(2017)
Article
Urology & Nephrology
Min Soo Choo, Changwon Yoo, Sung Yong Cho, Seong Jin Jeong, Chang Wook Jeong, Ja Hyeon Ku, Seung-June Oh
INTERNATIONAL NEUROUROLOGY JOURNAL
(2017)
Article
Psychology, Social
JoAnne M. Youngblut, Dorothy Brooten, Joy Glaze, Teresita Promise, Changwon Yoo
JOURNAL OF LOSS & TRAUMA
(2017)