Article
Biochemistry & Molecular Biology
Mi-Hyun Kim, Mi-Kyeong Choi
Summary: Supplementation of silicon can have varying effects on bone metabolism depending on the calcium intake level in growing female rats. In low-calcium diets, silicon supplementation can reduce bone turnover markers, while in high-calcium diets, it can lead to decreased bone mineral density. Further research is needed to fully understand the impact of silicon supplementation on bone health in growing females.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Article
Food Science & Technology
Natalia Wawrzyniak, Anna Gramza-Michalowska, Pawel Kurzawa, Pawel Kolodziejski, Joanna Suliburska
Summary: This study aimed to investigate the effect of CaCO3-enriched pumpkin on calcium status in ovariectomized rats. The results showed that CaCO3-enriched pumpkin increased calcium content in femurs and improved bone recovery in ovariectomized rats. Additionally, enriched pumpkin contributed to calcium accumulation in the kidneys, especially when combined with alendronate.
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
(2023)
Article
Multidisciplinary Sciences
Ziaul H. Rana, Megan W. Bourassa, Filomena Gomes, Anuradha Khadilkar, Rubina Mandlik, Victor Owino, John M. Pettifor, Daniel E. Roth, Julie Shlisky, Prashanth Thankachan, Connie M. Weaver
Summary: Population calcium status depends on various factors, and there is currently no single indicator to accurately assess it.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Zaneta Ciosek, Karolina Kot, Danuta Kosik-Bogacka, Natalia Lanocha-Arendarczyk, Iwona Rotter
Summary: Bones are metabolically active organs that play a crucial role in skeletal growth and remodeling, fracture healing, and maintaining mineral balance. This study examines the impact of macroelements, microelements, and heavy metals on bone tissue, discussing their concentrations and influences on bone metabolism and properties.
Article
Urology & Nephrology
Willem Boer, Tom Fivez, Margot Vander Laenen, Liesbeth Bruckers, Hans Jurgen Groen, Miet Schetz, Heleen Oudemans-van Straaten
Summary: In this study, it was found that a higher dose of citrate led to a more negative calcium balance in continuous venovenous hemofiltration (CVVH) due to increased effluent calcium loss. Physician-ordered calcium supplementation resulted in a positive calcium balance in both low and high citrate groups. Intact parathormone (iPTH) and oxidized PTH (oxPTH) levels decreased, indicating reduced oxidative stress, while non-oxidized PTH (noxPTH) remained unchanged. Additionally, 25-hydroxy-Vitamin D (25D) decreased while 1,25-dihydroxy-Vitamin D (1,25D) increased. Magnesium balance was negative in both groups, with a greater negative balance seen in the high citrate group.
Article
Biotechnology & Applied Microbiology
Yan Chen, Tie Zhang, Qi Zhang, QingJian Lei, ShiJie Gao, KangWen Xiao, FeiFei Yan, Lin Cai
Summary: A composite bone cement, cubic crystalline magnesium-doped calcium sulfate/bioglass (MgCS/BG), was prepared and found to have increased compressive strength and good bioactivity. It promotes the adhesion and differentiation of mesenchymal stem cells, and enhances bone defect repair and new bone formation.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Jiawei Liu, Honglei Kang, Wenying Wei, Rong Tu, Takashi Goto, Feng Li, Honglian Dai
Summary: Bioactive calcium and magnesium phosphate bone adhesive (MPBA) is a promising material for the treatment of bone fractures and implant fixation. It has the advantages of easy preparation, strong adhesion, and biological activity, and can effectively restore bone strength and promote bone regeneration.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2023)
Article
Engineering, Biomedical
Julia Gao, Yingchao Su, Yi-Xian Qin
Summary: This study compared the in vitro and in vivo degradation and biocompatibility behaviors of magnesium alloys with calcium phosphate coatings, showing that the CaP coating significantly improved biodegradation behavior and biocompatibility of the Mg alloy. In vitro tests were found to be a quick screening tool for biodegradation rate, with the in vivo degradation rate being slower than in vitro immersion degradation rate.
BIOACTIVE MATERIALS
(2021)
Article
Materials Science, Ceramics
Manqi Yan, Yanan Zhao, Yue Dai, Xiaokang Yao, Honglian Dai
Summary: In this study, modified calcium magnesium phosphate bone cement (MCPC) composites were constructed by introducing gelatin solutions. The modified MCPC composites exhibited improved microenvironment, enhanced osteogenic differentiation and biomineralization. When incorporated with 1% and 5% of gelatin, the MCPC composites showed higher mechanical properties and osteogenic ability of BMSCs.
CERAMICS INTERNATIONAL
(2022)
Article
Biophysics
Fupo He, Jin Rao, Jielin Zhou, Wenhao Fu, Yao Wang, Yihang Zhang, Fei Zuo, Haishan Shi
Summary: Magnesium calcium phosphate composite bioceramic scaffolds were fabricated using 3D printing technology with Mg3(PO4)2 and β-Ca3(PO4)2 as starting materials. The porosity and compressive strength of the scaffolds could be adjusted by altering the sintering temperature and the formula of starting materials. The Ca3Mg3(PO4)4-based bioceramic scaffolds, prepared from 60 wt% Mg3(PO4)2 and 40 wt% β-Ca3(PO4)2, showed the highest compressive strength and stimulated cellular growth and osteoblastic differentiation.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Medicine, General & Internal
Hui-Yuan Shih, Jun-Hua Lu, Ai-Hua Xiong, Juliana Man-Wai Tse, Ben Siu-Tak Wong
Summary: This study investigated the effects of the natural plant extract, SDTL-E, in ovariectomized-induced osteoporosis rats. The results showed that 20 days of SDTL-E topical treatment improved bone strength and trabecular bone structure. These findings suggest that topical application of plant extract is a potential new approach for treating osteoporosis.
FRONTIERS IN MEDICINE
(2022)
Article
Engineering, Biomedical
Yanan Zhao, Honglei Kang, Xiaopei Wu, Pengzhen Zhuang, Rong Tu, Takashi Goto, Feng Li, Honglian Dai
Summary: A drug carrier system composed of gelatin-coated hollow mesoporous silica nanoparticles loaded with pro-osteogenic parathyroid (PTH) and anti-osteoclastogenic alendronate (ALN) is constructed and compounded into calcium magnesium phosphate cement (MCPC). It enhances osteoporotic bone regeneration in ovariectomized rats by promoting osteogenic differentiation, inhibiting osteoclastogenesis, and accelerating vascularization. The MCPC/HMSNs@ALN-PTH/GM demonstrates a synergistic effect on osteogenesis, osteoclastogenesis, and angiogenesis, holding potential for other biomaterials design and clinical management.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Engineering, Multidisciplinary
Wenjuan Liu, Zhiguang Huan, Chengtie Wu, Zhihua Zhou, Jiang Chang
Summary: This study developed a composite bone cement with high compressive strength and desirable bioactivity by incorporating calcium silicate bioceramic into magnesium phosphate bone cement. The composite bone cement showed significantly higher compressive strength compared to traditional bone cements and demonstrated apatite mineralization ability and moderate degradation behavior.
COMPOSITES PART B-ENGINEERING
(2022)
Article
Biochemistry & Molecular Biology
Joanna Suliburska, Natalia Wawrzyniak, Anna Gramza-Michalowska, Pawel Kurzawa
Summary: In women, menopause increases the risk of osteoporosis due to disorders related to calcium and iron content. This study investigated the impact of calcium deficiency on iron content in ovariectomized rats. The results showed that calcium deficiency improved the iron content in tissues of ovariectomized rats, and increased hemoglobin levels and osteoblast numbers in bones.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Integrative & Complementary Medicine
Dibachehr Rahmani, Bahareh Faal, Hakimeh Zali, Saeed Hesami Tackallou, Zahra Niknam
Summary: The simultaneous supplementation of L. reuteri and CaF2 NPs has favorable effects in reducing post-menopausal bone loss.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2023)
Article
Otorhinolaryngology
Gene Huh, Yun Jung, Hyun Jun Woo, Jung Hyun Park, Ja-Won Koo, Jae-Jin Song
CLINICAL AND EXPERIMENTAL OTORHINOLARYNGOLOGY
(2020)
Review
Radiology, Nuclear Medicine & Medical Imaging
Se Jin Cho, Yun Jung Bae, Jong-Min Kim, Donghyun Kim, Sung Hyun Baik, Leonard Sunwoo, Byung Se Choi, Jae Hyoung Kim
Summary: Neuromelanin-sensitive magnetic resonance imaging showed good diagnostic performance in discriminating patients with Parkinson's disease from healthy controls. Factors such as disease duration, imaging parameters, and segmentation methods were found to influence the diagnostic performance. Further investigations comparing these factors and optimizing parameters are necessary to improve diagnostic accuracy.
EUROPEAN RADIOLOGY
(2021)
Review
Clinical Neurology
Se Jin Cho, Jae Hyoung Kim, Sung Hyun Baik, Leonard Sunwoo, Yun Jung Bae, Byung Se Choi
Summary: Preoperative MRI detection of post-laminar optic nerve invasion (PLONI) in patients with retinoblastoma (RB) can guide surgical planning and treatment selection. The systematic review and meta-analysis showed that MRI has acceptable diagnostic performance, with factors such as magnetic field strength and imaging protocols influencing the results. Further development and optimization of MR protocols for RB patients may help improve diagnostic accuracy.
Article
Radiology, Nuclear Medicine & Medical Imaging
Yun Jung Bae, Yoo Sung Song, Byung Se Choi, Jong-Min Kim, Yoonho Nam, Jae Hyoung Kim
Summary: SMWI showed higher inter-observer agreement for nigral hyperintensity and a higher concordance rate with I-123-FP-CIT SPECT results compared to SWI. SMWI provided significantly higher diagnostic performance for PD than SWI.
EUROPEAN JOURNAL OF RADIOLOGY
(2021)
Article
Clinical Neurology
Sung-Woo Cho, Sang Y. Han, Yoonjae Song, Jeong-Whun Kim, Hyun J. Kim, Dong-Young Kim, Chae-Seo Rhee, Yun J. Bae, Ji-hoon Kim, Hong-Gyun Wu, Jae S. Bang, Tae-Bin Won
Summary: The study reviewed the clinical characteristics and treatment outcomes of patients with Skull base osteoradionecrosis (SB-ORN), and found that aggressive treatment was associated with higher survival rates and lower carotid artery blow out rates.
JOURNAL OF NEUROLOGICAL SURGERY PART B-SKULL BASE
(2022)
Article
Medicine, General & Internal
Jung Hyun Park, Byung Se Choi, Jung Ho Han, Chae-Yong Kim, Jungheum Cho, Yun Jung Bae, Leonard Sunwoo, Jae Hyoung Kim
Summary: Texture analysis on pre-treatment MRI of lung cancer patients with brain metastases may play a role in predicting the response to SRS. The primary tumor histology of small cell lung cancer (SCLC) and the texture feature RLN are associated with local PFS.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Clinical Neurology
Y. J. Bae, Y. S. Song, J-M Kim, B. S. Choi, Y. Nam, J-H Choi, W. W. Lee, J. H. Kim
Summary: This study aimed to investigate the correlation between nigrostriatal dopaminergic function and nigrosome-1 status, and found a concordance rate of 65.9% between I-123-FP-CIT SPECT and SMWI. The specific binding ratios of dopamine transporter were significantly lower in the absence of nigral hyperintensity.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2021)
Article
Medicine, General & Internal
Yejin Jeon, Kyeorye Lee, Leonard Sunwoo, Dongjun Choi, Dong Yul Oh, Kyong Joon Lee, Youngjune Kim, Jeong-Whun Kim, Se Jin Cho, Sung Hyun Baik, Roh-eul Yoo, Yun Jung Bae, Byung Se Choi, Cheolkyu Jung, Jae Hyoung Kim
Summary: A deep learning algorithm was developed for diagnosing sinusitis on both Waters' and Caldwell views, showing comparable diagnostic performance to radiologists. The algorithm can detect and classify frontal, ethmoid, and maxillary sinusitis without manual cropping, enhancing the value of radiography in assessing multiple sinusitis.
Article
Clinical Neurology
Se Jin Cho, Yun Jung Bae, Jong-Min Kim, Hyun Jin Kim, Sung Hyun Baik, Leonard Sunwoo, Byung Se Choi, Cheolkyu Jung, Jae Hyoung Kim
Summary: Iron-sensitive nigral magnetic resonance imaging showed favorable diagnostic performance in distinguishing patients with Parkinson's disease from control participants. Factors influencing diagnostic performance included disease duration, analysis method, pixel size, flip angle, slice thickness, and specific targeting of the substantia nigra pars compacta. Further improvements in spatial resolution and contrast-to-noise ratio are needed for objective analytic methods targeting the nigrosome-1.
JOURNAL OF NEUROLOGY
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Yun Jung Bae, Jong-Min Kim, Chul-Ho Sohn, Ji-Hyun Choi, Byung Se Choi, Yoo Sung Song, Yoonho Nam, Se Jin Cho, Beomseok Jeon, Jae Hyoung Kim
Summary: Parkinson disease is characterized by loss of dopaminergic cells in the substantia nigra of the midbrain. Recent advances in MRI technology have enabled elucidation of underlying pathophysiological changes in the nigral structure, contributing to improved diagnosis and monitoring of the disease progression.
Article
Medicine, General & Internal
Boeun Lee, Yun Jung Bae, Byung Se Choi, Byung Yoon Choi, Se Jin Cho, Hyojin Kim, Jae Hyoung Kim
Summary: The study found that certain MRI features can differentiate between GPA with skull base involvement and other conditions like SBO and NPC, which have similar radiologic findings. This can enhance the diagnostic performance of MRI, aid in treatment planning, and ultimately improve patient outcomes.
Article
Radiology, Nuclear Medicine & Medical Imaging
Yun Jung Bae, Jong-Min Kim, Byung Se Choi, Nayoung Ryoo, Yoo Sung Song, Yoonho Nam, In-Young Yoon, Se Jin Cho, Jae Hyoung Kim
Summary: This study aimed to investigate the glymphatic function of the brain in patients with isolated rapid eye movement sleep behavior disorder (RBD) using diffusion-tensor imaging (DTI) analysis along the perivascular space (ALPS) and explore its relevance to phenoconversion. The results showed that RBD patients had more severe reduction in glymphatic activity, indicated by a lower ALPS index, and the risk of phenoconversion decreased with an increasing ALPS index.
Article
Clinical Neurology
Yun Jung Bae, Jong -Min Kim, Byung Se Choi, Ji-Hyun Choi, Nayoung Ryoo, Yoo Sung Song, Se Jin Cho, Jae Hyoung Kim
Summary: DTI-ALPS was used to study glymphatic dysfunction in patients with PD, and it was found that the severity of glymphatic dysfunction was correlated with motor and cognitive dysfunction, but not with striatal dopamine transporter uptake.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hyunsu Choi, Leonard Sunwoo, Se Jin Cho, Sung Hyun Baik, Yun Jung Bae, Byung Se Choi, Cheolkyu Jung, Jae Hyoung Kim
Summary: A survey was conducted among neuroradiologists in Korea to investigate expectations and adoption of artificial intelligence (AI) software. The majority of respondents showed a proactive attitude toward AI and were familiar with it. The survey suggests that AI should be incorporated into training and active participation in AI development should be encouraged.
KOREAN JOURNAL OF RADIOLOGY
(2023)
Review
Nutrition & Dietetics
So Young Bu, Mi Ja Choi, Da Seul Choi, You-Mi Jung, In-Sil Jang, Narae Yang, Kirang Kim, Clara Yongjoo Park
Summary: This study aimed to summarize research findings on calcium intake, evaluate its impact on health outcomes, and determine the adequacy of revising the 2020 KDRIs for calcium. While no new evidence was found for the general Korean adult population, there may be evidence to improve EAR criteria in children and adolescents.
NUTRITION RESEARCH AND PRACTICE
(2022)
