Article
Chemistry, Multidisciplinary
Guojin Liang, Jiaxiong Zhu, Boxun Yan, Qing Li, Ao Chen, Ze Chen, Xiaoqi Wang, Bo Xiong, Jun Fan, Jin Xu, Chunyi Zhi
Summary: The article introduces a method to solve the irreversibility issue of zinc metal anodes through a solution-dipping approach that constructs a protective coating. The synergistic combination of electric conductive coatings, insulating coatings, and 3D structural frameworks enables highly reversible zinc metal anode chemistry with suppressed gas production and dendrite growth.
ENERGY & ENVIRONMENTAL SCIENCE
(2022)
Review
Cardiac & Cardiovascular Systems
Eisuke Amiya
Summary: Heart failure (HF) has various characteristics, such as etiology, clinical course, and clinical characteristics. The relationship between social factors and clinical course in non-ischemic cardiomyopathies is not well understood. Further research is needed to better understand this relationship.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Environmental Sciences
Li Luo, Jumi Xu, Ruo Jiang, Baodong Yao, Jianzhong Di
Summary: Limited evidence exists on the association between serum copper and zinc status and handgrip strength. This study aimed to evaluate this association using NHANES data from 2011-2014. The results showed an inverse association between serum copper level and handgrip strength, as well as the copper/zinc ratio. However, no significant association was found between serum zinc level and handgrip strength.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Andreea Maria Ursaru, Antoniu Octavian Petris, Irina Iuliana Costache, Nicolae Dan Tesloianu
Summary: This single-center study focused on the cardiovascular outcomes in ischemic and non-ischemic heart failure patients who received ICD therapy for the prevention of sudden cardiac death. The results showed similar rates of cardiovascular and all-cause mortality between ICMP and NICMP patients, as well as comparable rates of recurrent ventricular tachyarrhythmias and appropriate ICD therapies.
Article
Biochemistry & Molecular Biology
Yongzhi Sun, Jianfeng Chen, Hongmei Wang, Xinyu Song, Zhaohui Sun, Rui Zhang, Jiayi Zhong, Xinxin Gu, Mengxu Wang, Chenghai Peng, Maoqing Wang
Summary: This study found that marginal zinc deficiency after birth has an impact on the heart, although the specific effects are not yet clear. Through experiments on mice, it was found that marginal zinc deficiency can lead to reduced food intake, weight, serum zinc, and heart weight. Although the function and morphology of the heart did not change, the expression of cardiac proteins and pathways were altered, some of which are related to cardiovascular diseases.
Article
Cardiac & Cardiovascular Systems
Yimu Zhao, Amandine Godier-Furnemont, Lewis M. Brown, Barry Fine, Gordana Vunjak-Novakovic, Noortje A. M. Bax, Carlijn V. C. Bouten
Summary: Ischemic and non-ischemic cardiomyopathies have distinct etiologies and disease mechanisms, which can be characterized by changes in extracellular matrix (ECM) and influence cardiomyocyte function. This study explored the differential disease phenotypes and reverse remodeling potential in heart failure patients with ischemic and non-ischemic cardiomyopathy, and investigated the impact of diseased human ECM on cardiomyocytes.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Yifan Wang, Hao Jia, Jiangping Song
Summary: This article reviews the accurate classification of non-ischemic cardiomyopathy, including the methods, basis, subtype characteristics, and prognosis. It emphasizes the similarities and differences between different classifications. The article describes the accurate classification from the perspective of morphology, function, and genomics in various types of cardiomyopathy, and discusses their clinical characteristics and treatment needs.
CURRENT CARDIOLOGY REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Yang Sun, Lei Xiao, Ke Li, Hong Wang, Xiuli Song, Zongzhe Li, Chenze Li, Yanghui Chen, Shiyang Li, Jin Huang, Lun Tan, Dong Hu, Ting Yu, Rui Li, Hong Wang, Li Jin, Leming Shi, Ali J. Marian, Dao Wen Wang
Summary: The study suggests that pathogenic variants and likely pathogenic variants in genes known to cause primary dilated cardiomyopathy are enriched in patients with ischemic dilated cardiomyopathy, indicating that these variants play a role in the susceptibility to cardiac dilatation and dysfunction post myocardial ischemic injury.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Nutrition & Dietetics
Jia-Li Yin, Tao Tao, Zhao-Yan Wen, Ran Wang, Ming-Hui Sun, Chang Gao, Yu-Jiao Chang, Shi Yan, Xue Qin, Yu-Hong Zhao, Lan Wang, Song Gao
Summary: This study investigated the relationship between dietary copper, zinc, and copper-to-zinc ratio and the severity of ovarian cancer. The findings suggest that pre-diagnostic dietary copper and copper-to-zinc ratio are associated with reducing the severity of ovarian cancer at diagnosis.
FRONTIERS IN NUTRITION
(2022)
Article
Materials Science, Multidisciplinary
Kyungsob Choi, Hyunsik Park
Summary: This study proposed gaseous reduction by hydrogen as a method to decrease carbon dioxide emissions during the recovery of zinc and copper from brass waste. The reduction behavior and kinetics of brass waste were investigated under different hydrogen partial pressures and temperatures, and it was found that the reduction rate increased with higher hydrogen partial pressure and temperature.
Article
Medical Laboratory Technology
Duncan Andrew, Robertson Gail, Bramwell Morag, Raja Kishor
Summary: This study aimed to establish appropriate reference intervals for copper and zinc concentrations in serum that can be used by other laboratories. The effects of various variables on serum concentrations of copper and zinc were also assessed. After controlling for these variables, age and gender-related reference intervals were calculated.
CLINICA CHIMICA ACTA
(2023)
Article
Clinical Neurology
Firat Karaaslan, Fidel Demir, Resit Yilmaz, Esref Akil
Summary: This study aimed to investigate the relationship between total antioxidant status, total oxidant status, and copper and zinc situations and the short-term prognosis and stroke severity in patients with acute ischemic stroke who were successfully recanalized by mechanical thrombectomy. The study found that high admission copper levels were associated with poor prognosis, but this association was limited. In addition, copper and zinc levels were lower in patients. There was no relationship between total antioxidant/oxidant status and short-term prognosis or stroke severity.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2023)
Article
Biochemistry & Molecular Biology
Ylva Bengtsson, Kamil Demircan, Johan Vallon-Christersson, Martin Malmberg, Lao H. Saal, Lisa Ryden, Ake Borg, Lutz Schomburg, Malte Sandsveden, Jonas Manjer
Summary: This study aimed to investigate the relationship between serum copper, zinc, and copper/zinc ratio levels and survival after breast cancer diagnosis. The results showed that a higher copper/zinc ratio was associated with lower overall survival rates. However, there was no significant association between serum copper or zinc levels alone and survival after breast cancer diagnosis.
Article
Emergency Medicine
Kavya Magham, Josiah Han, Wesley Eilbert, E. Bradshaw Bunney
Summary: This article reports a rare case of severe anemia in a patient with copper deficiency caused by the use of zinc supplement.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2023)
Article
Materials Science, Multidisciplinary
Geyong Guo, Qing Xu, Chongzun Zhu, Jinlong Yu, Qiaojie Wang, Jin Tang, Zhiguang Huan, Hao Shen, Jiang Chang, Xianlong Zhang
Summary: A sequential immunomodulatory strategy using Cu-Zn bi-layer nanofibrous membranes was proposed to address implant-related infections and implant osseointegration disorders, based on the immunological characteristics of these complications. The biomaterial exhibited controlled release of Cu2+ and Zn2+, regulating macrophage phenotype shift and demonstrating anti-infection and osteogenic abilities in vitro and in vivo.
APPLIED MATERIALS TODAY
(2021)
Article
Cardiac & Cardiovascular Systems
Maryam Nabati, Mahmood Moosazadeh, Ehsan Soroosh, Hanieh Shiraj, Mahnaneh Gholami, Ali Ghaemian
BMC CARDIOVASCULAR DISORDERS
(2020)
Review
Oncology
Muhammad T. Islam, Eunus S. Ali, Ishaq N. Khan, Subrata Shaw, Shaikh Jamal Uddin, Razina Rouf, Shrabanti Dev, Seyed S. S. Saravi, Niranjan Das, Swati Tripathi, Santosh U. Yele, Asish K. Das, Jamil A. Shilpi, Siddhartha K. Mishra, Mohammad S. Mubarak
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2020)
Article
Cardiac & Cardiovascular Systems
Seyed Soheil Saeedi Saravi, Juerg H. Beer
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2020)
Editorial Material
Cardiac & Cardiovascular Systems
Seyed Soheil Saeedi Saravi, Massimo Barbagallo, Martin F. Reiner, Hans R. Schmid, Jonas Rutishauser, Juerg H. Beer
EUROPEAN HEART JOURNAL
(2020)
Article
Cardiac & Cardiovascular Systems
Simon Meier, Marcel Frick, Michael Liu, Seyed Soheil Saeedi Saravi, Giulia Montrasio, Helga Preiss, Lisa Pasterk, Nicole Bonetti, Michael Egloff, Hans-Rudolf Schmid, Isabella Sudano, Giovanni G. Camici, Francois Mach, Thomas F. Luescher, Georg Ehret, Juerg H. Beer
Summary: Patients treated with PCSK9 inhibitors show a significantly lower cortisol response to ACTH, with lower stimulated cortisol levels in the early months of treatment, indicating a reduced adrenal stress response.
Article
Cardiac & Cardiovascular Systems
Nicole R. Bonetti, Luca Liberale, Alexander Akhmedov, Lisa Pasterk, Sara Gobbato, Yustina M. Puspitasari, Ana Vukolic, Seyed Soheil Saeedi Saravi, Bernd Coester, Carla Horvath, Elena Osto, Fabrizio Montecucco, Thomas F. Luescher, Jurg H. Beer, Giovanni G. Camici
Summary: A long-term dietary intervention with ALA has been shown to reduce stroke size and neurological dysfunction, maintain BBB integrity, and decrease inflammation. These findings suggest that ALA supplementation could pave the way for novel stroke treatments.
Article
Medicine, General & Internal
Hossein Karami, Hadiseh Khalilzadeh Arjmandi, Ebrahim Salehifar, Hadi Darvishi-Khezri, Mojdeh Dabirian, Mehrnoush Kosaryan, Aily Aliasgharian, Rosetta Akbarzadeh, Raheleh Naeimayi Aali, Amirreza Nasirzadeh
Summary: This study found that amlodipine may improve myocardial MRI T2* and serum ferritin levels compared to placebo. However, larger clinical studies are needed to confirm these results.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
(2021)
Article
Multidisciplinary Sciences
Seyed Soheil Saeedi Saravi, Nicole R. Bonetti, Benoit Pugin, Florentin Constancias, Lisa Pasterk, Sara Gobbato, Alexander Akhmedov, Luca Liberale, Thomas F. Luescher, Giovanni G. Camici, Juerg H. Beer
Summary: This study demonstrates that lifelong intake of ALA can reduce platelet hyperresponsiveness and thrombus formation in aged mice, partly attributed to alteration of microbial composition, reduction of trimethylamine-N-oxide, and changes in inflammatory mediators.
Article
Cardiac & Cardiovascular Systems
Fotios Spyropoulos, Andrea Sorrentino, Jiska van der Reest, Peiran Yang, Markus Waldeck-Weiermair, Benjamin Steinhorn, Emrah Eroglu, Seyed Soheil Saeedi Saravi, Paul Yu, Marcia Haigis, Helen Christou, Thomas Michel
Summary: In this study, we developed a chemogenetic animal model of heart failure that mimics a central feature of human heart failure: increased cardiac redox stress. By using recombinant DAAO enzyme to generate H2O2 in cardiomyocytes, we induced cardiomyopathy. We observed significant changes in cardiac metabolome and transcriptome following chemogenetic heart failure, similar to those observed in human heart failure. Our findings help validate chemogenetic approaches for discovering novel therapeutic targets in heart failure.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Marco Luciani, Daniel Mueller, Chiara Vanetta, Thamonwan Diteepeng, Arnold von Eckardstein, Stefanie Aeschbacher, Nicolas Rodondi, Giorgio Moschovitis, Tobias Reichlin, Tim Sinnecker, Jens Wuerfel, Leo H. Bonati, Seyed Soheil Saeedi Saravi, Patricia Chocano-Bedoya, Michael Coslovsky, Giovanni G. Camici, Thomas F. Luescher, Michael Kuehne, Stefan Osswald, David Conen, Juerg Hans Beer
Summary: This study investigated the role of trimethylamine-N-oxide (TMAO) in predicting adverse events in patients with atrial fibrillation. The results showed that high levels of TMAO are associated with increased risk of cardiovascular mortality and cerebral infarction.
Review
Cell Biology
Meret Sarah Allemann, Pratintip Lee, Jurg H. Beer, Seyed Soheil Saeedi Saravi
Summary: Cardiovascular aging poses a significant challenge and requires innovative strategies to restore aging cardiovascular tissues. Targeting the redox machinery holds promise to optimize cardiovascular regenerative therapies by enhancing stem cell function and rejuvenating cardiovascular tissues.
Article
Oncology
Javad Boskabadi, Ehsan Yousefi-Mazhin, Ebrahim Salehifar
Summary: This article describes a case of acute kidney injury and dialysis treatment in a patient with LMS who underwent chemotherapy with ifosfamide. The metabolite of ifosfamide, chloroacetaldehyde, can cause acute kidney injury, which may not fully recover and lead to chronic kidney disease. Mesna is ineffective in preventing ifosfamide's nephrotoxicity, while N-acetylcysteine may be effective.
Meeting Abstract
Cardiac & Cardiovascular Systems
S. S. Saeedi Saravi, N. R. Bonetti, A. Vukolic, L. Liberale, T. F. Luscher, G. G. Camici, J. H. Beer
Meeting Abstract
Cardiac & Cardiovascular Systems
S. S. Saeedi Saravi, G. G. Camici, T. F. Luscher, J. H. Beer
EUROPEAN HEART JOURNAL
(2020)
Article
Cardiac & Cardiovascular Systems
Ali Ghaemian, Jamshid Yazdani, Ali Asghar Farsavian, Samad Golshani, Maryam Nabati, Mozhdeh Dabirian, Rozita Jalalian, Seyed Mohamad Abedi, Bahareh Mirjani
CARDIOVASCULAR REVASCULARIZATION MEDICINE
(2020)