期刊
ACS APPLIED MATERIALS & INTERFACES
卷 7, 期 50, 页码 27910-27917出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.5b09982
关键词
SILAR; SERS; paper substrate; AgNPs; HPV; malachite green; on-site bioassay
资金
- National Research Foundation of Korea (NRF) - Ministry of Education [2014R1A1A2054452]
- NRF - Korean government (MSIP) [2015R1A5A1037656]
- National Research Foundation of Korea [2014R1A1A2054452] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
We introduce a novel, facile, rapid, low-cost, highly reproducible, and power-free synthesizable fabrication method of paper-based silver nanoparticle (AgNP) immersed surface-enhanced Raman scattering (SERS) platform, known as the successive ionic layer absorption and reaction (SILAR) method. The rough and porous properties of the paper led to direct synthesis of AgNPs on the surface as well as in the paper due to capillary effects, resulting in improved plasmon coupling with interparticles and interlayers. The proposed SERS platforms showed an enhancement factor of 1.1 x 10(9), high reproducibility (relative standard deviation of 4.2%), and 10(-12) M rhodamine B highly sensitive detection limit by optimizing the SILAR conditions including the concentration of the reactive solution (20/20 m.M/mM AgNO3/NaBH4) and the number of SILAR cycles (six). The applicability of the SERS platform was evaluated using two samples including human cervical fluid for clinical diagnosis of human papillomavirus (HPV) infection, associated with cervical cancer, and a malachite green (MG) solution for fungicide and parasiticide in aquaculture, associated with human carcinogenesis. The AgNP-immersed SERS-functionalized platform using the SILAR technique allowed for high chemical structure sensitivity without additional tagging or chemical modification, making it a good alternative for early clinical diagnosis of HPV infection and detection of MG-activated human carcinogenesis.
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