Article
Genetics & Heredity
Itty Sethi, Gh. Rasool Bhat, Rakesh Kumar, Ekta Rai, Swarkar Sharma
Summary: Telomeres, highly repetitive regions at chromosome ends, are challenging to quantify due to their complex structure. A cost-effective qPCR method utilizing a dual labeled fluorescence probe has been developed to improve accuracy in telomere length measurement.
Article
Cell Biology
Sebastian R. Schreglmann, Tomas Goncalves, Melissa Grant-Peters, Demis A. Kia, Lilach Soreq, Mina Ryten, Nicholas W. Wood, Kailash P. Bhatia, Kazunori Tomita
Summary: Age is a risk factor for neurodegenerative diseases, and telomere shortening with age is a known phenomenon. However, the changes in telomere length in the brain and its association with neurodegenerative diseases are still unknown.
Article
Genetics & Heredity
Don M. Matshazi, Cecil J. Weale, Rajiv T. Erasmus, Andre P. Kengne, Saarah F. G. Davids, Shanel Raghubeer, Glenda M. Davison, Tandi E. Matsha
Summary: The study investigated the expression levels of five microRNAs in the blood of participants with hypertension, revealing dysregulated expression of miR-126-3p, 182-5p, and 30a-5p in hypertension. This suggests potential for these microRNAs as targets for hypertension diagnosis and therapy.
FRONTIERS IN GENETICS
(2021)
Article
Medicine, General & Internal
Sofia Pavanello, Manuela Campisi, Paolo Rigotti, Marianna Di Bello, Erica Nuzzolese, Flavia Neri, Lucrezia Furian
Summary: This study examines the biological age of kidneys and blood leukocytes and explores whether blood can be used as an indicator of kidney biological aging. The findings suggest that kidneys have a higher biological age and faster biological aging compared to blood leukocytes. The length of telomeres in kidneys is longer than in blood, and there is a correlation between kidney telomere attrition and Remuzzi-Karpinski score. Blood and kidney telomere length and age-methylation changes are also correlated. These markers can potentially be used as indicators of the biological age and quality of donor organs.
FRONTIERS IN MEDICINE
(2022)
Article
Cell Biology
Waylon J. Hastings, Laura Etzel, Christine M. Heim, Jennie G. Noll, Emma J. Rose, Hannah M. C. Schreier, Chad E. Shenk, Xin Tang, Idan Shalev
Summary: DNAmTL, an alternative method to estimate telomere length, is a sensitive measure of TL in pediatric populations, providing valuable insights into population differences in biological aging.
Article
Cell Biology
Emily E. Pearce, Steve Horvath, Shilpa Katta, Casey Dagnall, Geraldine Aubert, Belynda D. Hicks, Stephen R. Spellman, Hormuzd Katki, Sharon A. Savage, Rotana Alsaggaf, Shahinaz M. Gadalla
Summary: Telomere length (TL) is a marker of biological aging, with high-throughput reproducible measurements needed for large epidemiological studies. The study compared the DNA methylation-based estimator (DNAmTL) with qPCR and flow FISH methods in healthy adults, finding moderate correlations. DNAmTL correctly classified 70% of TL above or below the median, suggesting its potential in capturing aspects of telomere maintenance mechanisms.
Article
Peripheral Vascular Disease
Jacob K. Kresovich, Dale P. Sandler, Jack A. Taylor
Summary: This study found a positive association between hypertension and DNA methylation-based biological age metrics in older individuals. Women with higher biological age were more likely to have prevalent hypertension at baseline and to be diagnosed with incident hypertension during follow-up. These findings suggest that epigenetic markers may be helpful in early diagnosis and treatment of hypertension.
Article
Biochemistry & Molecular Biology
Anjali Shah, Merin George, Somprakash Dhangar, Aruna Rajendran, Sheila Mohan, Babu Rao Vundinti
Summary: Fanconi Anemia (FA) is a rare genetic disease characterized by bone marrow failure, physical abnormalities, and increased risk of malignancy. Telomere shortening has been observed in FA patients, with different complementation groups showing varying degrees of telomere shortening. FANCL group had the most severe telomere shortening. This study suggests that telomere length can serve as a biological marker for prognosis in FA patients.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Health Care Sciences & Services
Linlin Ding, Xinhong Zhu, Zhenfang Xiong, Fen Yang, Xiaona Zhang
Summary: This study investigated the association between age at diagnosis of hypertension and decline in cognitive performance. The study found that hypertension diagnosed in mid-life is associated with worse cognition compared to late life, and longer duration of hypertension is associated with worse memory. Blood pressure control is critical for the preservation of cognitive function.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2023)
Article
Genetics & Heredity
Waylon J. Hastings, Dan T. A. Eisenberg, Idan Shalev
Summary: This study compared different approaches for estimating amplification efficiency, revealing significantly lower efficiency for telomere reactions compared to single-copy gene reactions. It suggests future analyses consider external methods for efficiency calculations and re-analyze existing data for potential improvements.
FRONTIERS IN GENETICS
(2021)
Article
Biochemistry & Molecular Biology
Don M. Matshazi, Cecil J. Weale, Rajiv T. Erasmus, Andre P. Kengne, Saarah F. G. Davids, Shanel Raghubeer, Glenda M. Davison, Tandi E. Matsha
Summary: The study on novel microRNAs in an African population revealed that some microRNAs are dysregulated in high blood pressure status, suggesting their potential as biomarker targets for diagnosis or treatment of hypertension.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Clinical Neurology
Vid Mlakar, Viktoria Birkenaes, Torbjorn Elvsaashagen, Monica B. E. G. Ormerod, Daniel S. Quintana, Torill Ueland, Ingrid Melle, Trine Lagerberg, Srdjan Djurovic, Carmen Martin-Ruiz, Ole A. Andreassen, Monica Aas
Summary: Recent studies show that patients with bipolar disorder experience accelerated ageing, shorter telomere length, and poorer cognitive functioning. However, the neurobiology underlying cognitive function in bipolar disorder is not yet known. This study found a positive association between shorter telomere length and reduced learning performance in bipolar disorder patients.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Geriatrics & Gerontology
H. Gong, Q. Yu, M. Yuan, Y. Jiang, J. Wang, P. Huang, J. Zhou
Summary: This study found a positive relationship between dietary copper intake and telomere length in patients with hypertension, providing evidence for guiding dietary copper intake in these patients.
JOURNAL OF NUTRITION HEALTH & AGING
(2022)
Article
Biochemistry & Molecular Biology
Florentin Remot, Victor Ronget, Hannah Froy, Benjamin Rey, Jean-Michel Gaillard, Daniel H. Nussey, Jean-Francois Lemaitre
Summary: The study found that telomere length generally decreases with age in adult vertebrates, but this decline is weak and varies among different classes. Detectable telomere length declines with age were only found in studies using TRF with in-gel hybridisation and qFISH methods, while no such trend was observed in studies using other methods.
Review
Genetics & Heredity
Alexander Vaiserman, Dmytro Krasnienkov
Summary: Telomere length has long been considered one of the best biomarkers of aging, but recent research suggests that it can only provide a rough estimate of aging rate. Other indicators such as immune parameters and epigenetic age may be stronger predictors of health status and risk for chronic diseases.
FRONTIERS IN GENETICS
(2021)