期刊
BIOLOGICAL RESEARCH FOR NURSING
卷 14, 期 1, 页码 5-15出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/1099800410393273
关键词
attention; breast cancer; cognition; serotonin; tryptophan depletion
类别
资金
- Department of Defense Breast Cancer Research [BC043199]
- Indiana University General Clinical Research Center NIH [M01 RR00750]
- Indiana University, General Clinical Research Center [M01 RR00750]
- Indiana CTSI, Indiana Clinical Research Center [UL RR025761]
- Oncology Nursing Foundation
- National Institute of Nursing Research (NINR), National Institutes of Health (NIH) [T32 NR007066]
- Robert Wood Johnson Foundation [64194]
- National Institutes of Health [R01 AG026096, R01 AG09956, U01 NR04508, P30 AG10133]
- American Cancer Society [RSGPB04-089-01-PBP]
- IU Cancer Center
Although cognitive dysfunction is a prevalent and disruptive problem for many breast cancer survivors (BCSs), little research has examined its etiology. One potential mechanism that remains to be explored is serotonin. Serotonin has been implicated in normal and dysfunctional cognitive processes, and serotonin levels are significantly affected by estrogen withdrawal, a common side effect of breast cancer treatment. However, no study has evaluated serotonin's role on cognitive dysfunction in BCSs. The purpose of this study was to examine the role of serotonin in cognitive dysfunction in survivors by lowering central serotonin concentrations via acute tryptophan depletion (ATD). Based on previous research in noncancer populations, we hypothesized that alterations in central serotonin levels would induce cognitive dysfunction in these women controlling for confounding characteristics such as fluctuating mood and glucose levels. Secondarily, we explored whether genetic variations in serotonin genes would partly explain ATD. Participants included 20 female BCSs, posttreatment for nonmetastatic breast cancer, who received ATD or control in a double-blind, crossover design. Cognitive performance was measured at the 5-hr tryptophan/serotonin nadir on each test day using standardized neuropsychological tests. Specific impairment was noted in episodic memory (delayed recall) and motor speed during ATD versus control. ATD did not alter new learning (immediate recall), working memory, verbal fluency, or information processing speed. Findings suggest that serotonin may play a critical role in memory consolidation and motor functioning in BCSs.
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