Review
Neurosciences
Qian Wang, Fang-Yu Chen, Zhuo-Min Ling, Wen-Feng Su, Ya-Yu Zhao, Gang Chen, Zhong-Ya Wei
Summary: Peripheral neuropathy is a common neurological issue with limited treatment options. Schwann cell transplantation plays a crucial role in resolving peripheral neuropathy, and stem cells have the potential to differentiate into Schwann-like cells. These studies provide insights into cell therapy and uncover prospective therapeutic strategies for peripheral neuropathy.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Cell Biology
Clara Mutschler, Shaline V. Fazal, Nathalie Schumacher, Andrea Loreto, Michael P. Coleman, Peter Arthur-Farraj
Summary: Coculturing dissociated mouse Schwann cells (SCs) and dorsal root ganglion (DRG) neurons in microfluidic chambers can induce robust myelination and is a valuable technique for studying peripheral nervous system (PNS) myelination, injury, and regeneration. This model allows separate genetic manipulation of mouse SCs or neurons and can be used to complement in vivo mouse experiments. Live imaging of cocultures reveals that SCs are axo-protective and can clear axonal debris after traumatic axotomy.
JOURNAL OF CELL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
D. A. Santiago Gonzalez, V. T. Cheli, S. L. Rosenblum, G. Denaroso, P. M. Paez
Summary: Ceruloplasmin is an essential ferroxidase enzyme for cell iron efflux and plays a crucial role in promoting the maturation of OLs and SCs by regulating iron balance and preventing oxidative stress and neurodegeneration in the central and peripheral nervous systems.
Article
Neurosciences
John W. McLean, Julie A. Wilson, Tina Tian, Jennifer A. Watson, Mary VanHart, Andrew J. Bean, Steven S. Scherer, David K. Crossman, Eroboghene Ubogu, Scott M. Wilson
Summary: Endosomal sorting is crucial for neural development by regulating membrane receptor distribution and signaling pathways. Inactivation of the HGS protein in Schwann cells leads to peripheral neuropathy with deficits in motor and sensory functions, delayed myelination, and altered gene expression related to Schwann cell maturation. This study suggests that HGS is essential for endosomal sorting of ERBB2/3 receptors during Schwann cell development, implicating endosomal dysfunction in inherited peripheral neuropathies.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Iman F. Fergani, Luciana R. Frick
Summary: SUMOylation is a relatively novel posttranslational modification that has not been extensively studied in Schwann cells and the peripheral nervous system. It may play a role in peripheral myelination and neuropathies by affecting protein function, cellular localization, and interactions with other proteins.
Article
Neurosciences
Nicole M. Procacci, Robert Louis Hastings, Aamir A. Aziz, Nina M. Christiansen, Jie Zhao, Claire DeAngeli, Normand LeBlanc, Lucia Notterpek, Gregorio Valdez, Thomas W. Gould
Summary: This study identified Kir4.1 as a specifically expressed and active channel in non-myelinating Schwann cells (NMSC). The expression of Kir4.1 is downregulated selectively in myelinating Schwann cells (MSC). The findings suggest that Kir4.1 could serve as a potential modulator of immature Schwann cells and NMSC function.
Article
Neurosciences
Akihiro Ishii, Miki Furusho, Rashmi Bansal
Summary: Multiple intracellular signaling pathways, including Mek/ERK1/2-MAPK and PI3K/Akt/mTOR, are involved in regulating myelination in the peripheral nervous system. The roles of these pathways may differ during development and adulthood, highlighting the complexity of their interactions in Schwann cells.
Article
Biotechnology & Applied Microbiology
Peng Yu, Guanhua Zhang, Bo Hou, Enpeng Song, Jiaming Wen, Yueyang Ba, Donglin Zhu, Gangwei Wang, Feng Qin
Summary: Complete myelination and formation of myelinated fibers are essential for functional nerve regeneration after peripheral nerve injury. Suboptimal myelin regeneration is common and can hinder ideal nerve regeneration. Therefore, closely monitoring and supporting myelin regeneration in patients with PNI is important for optimal outcomes.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Clinical Neurology
Alan Pestronk, Robert E. Schmidt, Robert Bucelli, Julia Sim
Summary: This study examined the protein components of Schwann cells and myelin in normal and diseased human peripheral nerves, and found that the molecular composition of the central nervous system varies with age, axon size, and nerve pathology.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2023)
Article
Neurosciences
Bin Zhang, Wenfeng Su, Junxia Hu, Jinghui Xu, Parizat Askar, Shuangxi Bao, Songlin Zhou, Gang Chen, Yun Gu
Summary: Enhancing remyelination after injury is crucial for nerve function recovery. This study reveals the importance of Sin3A and other transcription factors and chromatin regulators in the process of myelination by Schwann cells (SCs). Sin3A affects SC migration, differentiation, and proliferation, as well as the remyelination of regenerating axons. These findings provide insights for developing new treatments to enhance remyelination and nerve regeneration.
NEUROSCIENCE BULLETIN
(2022)
Article
Oncology
Erik A. Williams, Ajay Ravindranathan, Rohit Gupta, Nicholas O. Stevers, Abigail K. Suwala, Chibo Hong, Somang Kim, Jimmy Bo Yuan, Jasper Wu, Jairo Barreto, Calixto-Hope G. Lucas, Emily Chan, Melike Pekmezci, Philip E. LeBoit, Thaddeus Mully, Arie Perry, Andrew Bollen, Jessica Van Ziffle, W. Patrick Devine, Alyssa T. Reddy, Nalin Gupta, Kristen M. Basnet, Robert J. B. Macaulay, Patrick Malafronte, Han Lee, William H. Yong, Kevin Jon Williams, Tareq A. Juratli, Douglas A. Mata, Richard S. P. Huang, Matthew C. Hiemenz, Dean C. Pavlick, Garrett M. Frampton, Tyler Janovitz, Jeffrey S. Ross, Susan M. Chang, Mitchel S. Berger, Line Jacques, Jun S. Song, Joseph F. Costello, David A. Solomon
Summary: In this study, comprehensive genomic profiling and DNA methylation profiling were performed on 96 human schwannomas. The researchers identified novel recurrent in-frame insertion/deletion mutations in the SOX10 gene in a subset of sporadic schwannomas. Functional studies showed that these mutations impaired the differentiation of immature Schwann cells, suggesting they may drive a unique subtype of schwannomas.
Article
Cell Biology
Haijiao Huang, Bo Jing, Feiyan Zhu, Wanxiang Jiang, Ping Tang, Liyang Shi, Huiting Chen, Guoru Ren, Shiyao Xia, Luoling Wang, Yiyuan Cui, Zhiwen Yang, Alexander J. Platero, Andrew P. Hutchins, Mina Chen, Paul F. Worley, Bo Xiao
Summary: The mechanism of how neuronal signaling affects brain myelination is still not well understood. Our study reveals that dysregulated neuronal RHEB-mTORC1-DLK1 axis impairs brain myelination. Neuronal Rheb cKO inhibits oligodendrocyte differentiation and myelination, with activated neuronal expression of Dlk1 gene. Neuronal Dlk1 cKO improves myelination deficit in neuronal Rheb cKO mice, indicating that activated neuronal Dlk1 expression contributes to impaired myelination caused by Rheb cKO. The effect of Rheb cKO on Dlk1 expression is mediated by mTORC1; neuronal mTor cKO, Raptor cKO, and pharmacological inhibition of mTORC1 also lead to elevated neuronal Dlk1 expression. We demonstrate that both a secreted form of DLK1 and a membrane-bound DLK1 inhibit the differentiation of cultured oligodendrocyte precursor cells into myelin protein-expressing oligodendrocytes. Furthermore, neuronal expression of Dlk1 in transgenic mice reduces the formation of mature oligodendrocytes and myelination. This study identifies Dlk1 as an inhibitor of oligodendrocyte myelination and provides a mechanism linking altered neuronal signaling with oligodendrocyte dysfunction.
Review
Neurosciences
Qing Min, David B. Parkinson, Xin-Peng Dun
Summary: Schwann cells in the peripheral nervous system have the ability to promote repair of various tissues, including nerve gaps, skin wounds, digit tips, and tooth regeneration. They are highly motile, secrete signaling molecules, attract macrophages, support neuronal survival, promote axonal regrowth, and interact with other cell types in the regeneration process. The migration of Schwann cells is essential for successful tissue repair, especially in cases of peripheral nerve transection injuries where the cells form cords to guide axon regeneration. Understanding the molecular mechanisms of Schwann cell migration may lead to new therapeutic strategies for peripheral nerve repair.
Article
Biochemistry & Molecular Biology
Atsuhiko Okura, Koichi Inoue, Eisuke Sakuma, Hiroshi Takase, Takatoshi Ueki, Mitsuhito Mase
Summary: Schwann cells are crucial for peripheral myelination and the activation of the SGK1 signaling pathway plays a significant role in determining cell fate during nerve injury and repair.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Neurosciences
Tak-Ho Chu, Kabita Baral, Elodie Labit, Nicole Rosin, Sarthak Sinha, Daniel Umansky, Saud Alzahrani, Rohit Arora, Leslie Cao, Derrick Rancourt, Jeff Biernaskie, Rajiv Midha
Summary: Skin-derived Schwann cells (Sk-SCs) and nerve-derived Schwann cells (N-SCs) share similar gene expression profiles with subtle differences, particularly in HLA genes. In vitro experiments showed comparable functions between the two cell types, while in vivo experiments indicated that Sk-SCs may have a stronger effect on dorsal root ganglion (DRG) neurite outgrowth complexity.
Article
Neurosciences
Cristian Gonzalez-Cabrera, Florencia Garrido-Charad, Alejandro Roth, Gonzalo J. Marin
JOURNAL OF COMPARATIVE NEUROLOGY
(2015)
Article
Multidisciplinary Sciences
Paulina Falcon-Urrutia, Carlos M. Carrasco, Pablo Lois, Veronica Palma, Alejandro D. Roth
Article
Biochemistry & Molecular Biology
Dalinda Liazoghli, Alejandro D. Roth, Peter Thostrup, David R. Colman
ACS CHEMICAL NEUROSCIENCE
(2012)
Article
Biology
Yorka Munoz, Karen Fuenzalida, Miguel Bronfman, Arnaldo Gatica, Marcelo Sepulveda, Juan Bacigalupo, Alejandro D. Roth, Ricardo Delgado
BIOLOGICAL RESEARCH
(2013)
Article
Neurosciences
Neev Golan, Konstantin Adamsky, Elena Kartvelishvily, Damln Brockschnieder, Wiebke Moebius, Ivo Spiegel, Alejandro D. Roth, Christine E. Thomson, Gideon Rechavi, Elior Peles
Article
Neurosciences
Ajit S. Dhaunchak, Jeffrey K. Huang, Omar De Faria Junior, Alejandro D. Roth, Liliana Pedraza, Jack P. Antel, Amit Bar-Or, David R. Colman
Article
Immunology
Thierry Vincent, Philippe Saikali, Romain Cayrol, Alejandro D. Roth, Amit Bar-Or, Alexandre Prat, Jack P. Antel
JOURNAL OF IMMUNOLOGY
(2008)
Article
Nanoscience & Nanotechnology
M. S. Leal, X. Briones, V. Villalobos, Y. Queneau, A. Leiva, H. E. Rios, J. Pavez, C. P. Silva, C. Carrasco, Andronico Neira-Carrillo, A. D. Roth, L. Tamayo, M. D. Urzua
ACS APPLIED MATERIALS & INTERFACES
(2019)
Article
Education & Educational Research
Federico Navarro, Julieta Orlando, Caren Vega-Retter, Alejandro D. Roth
Summary: This study examines the impact of teaching students self-assessment of scientific posters in a higher education science class, showing that intervention-treated teams produced posters with significantly better reliability and retrievability of sources, as well as more student-made figures, projections, and conclusions. The results support the use of self-assessment and poster construction as effective pedagogical strategies in science teacher education.
INTERNATIONAL JOURNAL OF SCIENCE AND MATHEMATICS EDUCATION
(2022)
Article
Multidisciplinary Sciences
Omar de Faria, Ajit S. Dhaunchak, Yasmine Kamen, Alejandro D. Roth, Tanja Kuhlmann, David R. Colman, Timothy E. Kennedy
SCIENTIFIC REPORTS
(2019)
Meeting Abstract
Biochemistry & Molecular Biology
A. Dhaunchak, J. K. Huang, A. D. Roth, O. de Faria, L. Pedraza, J. P. Antel, A. Bar-Or, D. R. Colman
JOURNAL OF NEUROCHEMISTRY
(2010)
Article
Multidisciplinary Sciences
JK Huang, GR Phillips, AD Roth, L Pedraza, WS Shan, W Belkaid, S Mi, A Fex-Svenningsen, L Florens, JR Yates, DR Colman
Article
Neurosciences
Alejandro D. Roth, Anna Ivanova, David R. Colman
NEURON GLIA BIOLOGY
(2006)
Article
Biology
AD Roth, G Ramirez, R Alarcon, R von Bernhardi
BIOLOGICAL RESEARCH
(2005)