Article
Plant Sciences
Xu Zeng, Jiaxue Li, Tongyao Chen, Yuanyuan Li, Shunxing Guo
Summary: In this study, the metabolic profiles and chemical composition of different Gastrodia elata varieties were determined. The results showed that different varieties have diverse bioactive ingredients and exhibit various biological activities and healthcare value.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Food Science & Technology
Baiyu Zhang, Mengmeng Liu, Gang Liu, Dan Li, Benhong Zhou
Summary: This study elucidated the mechanisms of oral absorption of GEP polysaccharides through animal and Caco-2 cell models, demonstrating absorption through the small intestine, distribution in the liver and kidneys, and transport via endocytosis processes. The research provides guidance for clinical medicine administration and deepens the biological understanding of oral polysaccharides.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Pharmacology & Pharmacy
Lijun Cheng, Hui Wang, Kejian Ma, Yang Deng, Maoru Li, Ji Ma
Summary: In this study, a novel processing technology-alcohol steamed GE (AGE) was proposed as an alternative to traditional processing. Compared with fresh GE, AGE showed changes in the relative content of certain compounds, but both fresh and steamed GE demonstrated promising hypnotic and anti-anxiety effects. Furthermore, the anti-anxiety mechanism of GE was found to be related to the tryptophan metabolic pathway.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biology
Yu-En Lin, Chin-Hsien Lin, En-Peng Ho, Yi-Ci Ke, Stavroula Petridi, Christopher J. H. Elliott, Lee-Yan Sheen, Cheng-Ting Chien
Summary: The water extracts of Gastrodia elata Blume (GE) show neuroprotective effects in G2019S-induced Parkinson's disease fruit flies and transgenic mice by improving motor abilities and protecting dopaminergic neurons. The mechanism involves the activation of the Nrf2 protein in glial cells, which inhibits degenerative signaling pathways in neurons, ultimately preventing neuronal loss and maintaining coordination.
Review
Plant Sciences
Meng-qi Gong, Fei-fan Lai, Jian-zhen Chen, Xiao-hong Li, Ya-jie Chen, Yu He
Summary: Gastrodia elata Blume has a long historical application in Asian countries and has been widely used in medicine and food. It contains various active components with neuroprotective, learning and memory improvement, cardioprotective, anti-depressant, anti-cancer effects, etc. However, research on its polysaccharide structure and non-medicinal parts is relatively limited.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Chemistry, Medicinal
Xiaoning Sun, Bo Jia, Jingran Sun, Jianguo Lin, Bingjiu Lu, Jinlong Duan, Cheng Li, Qingqing Wang, Xin Zhang, Meng Tan, Dongsheng Zhong, Xiaoxiao Zhang, Ziyi Sun, Yan Zhang, Kuiwu Yao
Summary: Gastrodia elata Blume (Tianma) is a valuable herbal Traditional Chinese Medicine commonly used to treat various disorders. Modern pharmacological studies have shown that it possesses diverse pharmacological effects and can be beneficial in cardiovascular diseases.
Article
Pharmacology & Pharmacy
Hong Huang, Yiwen Zhang, Caihong Yao, Qinghu He, Fang Chen, Han Yu, Guanghua Lu, Ning Jiang, Xinmin Liu
Summary: This study evaluated the effects of Fresh Gastrodia elata Blume (FG) on cognitive deficits induced by chronic restraint stress (CRS) and found that FG improved learning and memory abilities by regulating mitochondrial apoptosis-related proteins and proinflammatory cytokines.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Ning Ji, Peng Liu, Ni Zhang, Shengyan Yang, Mingsheng Zhang
Summary: This study investigated the composition, physicochemical properties, in vitro biological activity, and hypoglycemic activity of polysaccharides from four varieties of G. elata. The polysaccharides had the same monosaccharide composition but different content in each variety. They also exhibited differences in in vitro antioxidant and hypoglycemic activity, molecular weight, yield, and chemical composition. GaE-R showed the best polysaccharide activity.
FRONTIERS IN CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Yiwen Zhang, Hong Huang, Caihong Yao, Xinran Sun, Qinghu He, Muhammad Iqbal Choudharyc, Shanguang Chen, Xinmin Liu, Ning Jiang
Summary: The study found that fresh Gastrodia elata Blume has a positive effect on cognitive impairment caused by simulated weightlessness. It improves spatial memory and cognitive ability in mice, protects the nervous system by balancing oxidative stress and inflammation factors, regulates protein expression through the PI3K/AKT/mTOR pathway, and corrects abnormal changes in neurons.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Cell Biology
Hengtao Xie, Yingying Chen, Wei Wu, Xiaobo Feng, Kairong Du
Summary: The study found that GBP treatment enhanced paw withdrawal latency and threshold in rats, restored Vin-induced sciatic nerve damage, and attenuated the increase of proinflammatory cytokine levels. GBP also downregulated the mRNA levels of inflammatory cytokines in the nerves and enhanced SIRT1 activity. This suggests that GBP has a potential protective effect against chemotherapy-induced neuropathic pain through inhibition of neuroinflammation.
MEDIATORS OF INFLAMMATION
(2021)
Article
Chemistry, Analytical
Pan-pan Yang, Zhong-da Zeng, Ying Hou, Ai-ming Chen, Juan Xu, Long-qing Zhao, Xiang-yi Liu
Summary: The rapid and accurate authentication of variants of plants with high chemical complexity is of great academic and practical significance. The combination of near infrared spectroscopy (NIR) and chemometrics, specifically partial least squares discrimination analysis (PLS-DA), proved to be an effective method for classification and prediction. Various preprocessing techniques and feature selection methods were compared to optimize the PLS-DA models, achieving high prediction accuracy.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Review
Pharmacology & Pharmacy
Changcheng Lu, Shuhui Qu, Zhangfeng Zhong, Hua Luo, Si San Lei, Hai-Jing Zhong, Huanxing Su, Yitao Wang, Cheong-Meng Chong
Summary: Parkinson's disease is an age-related neurodegenerative disease caused by the death and degeneration of dopaminergic neurons in the midbrain. Current drugs mainly aim to increase dopamine levels but cannot prevent or slow down the loss of dopaminergic neurons. Gastrodia elata Blume, a traditional medicinal herb, has shown potential as an add-on therapy for Parkinson's disease by reducing dopaminergic neuron death and pathological changes in various models.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Food Science & Technology
Chuanmao Zheng, Jieqing Li, Honggao Liu, Yuanzhong Wang
Summary: This study presents a fast and non-invasive method for the authentication of geographical indication (GI) of food or medicinal plants. Using infrared spectroscopy analysis and data fusion, accurate certification models were established, demonstrating that specific bands can serve as fingerprint regions for verifying the origin.
Article
Plant Sciences
Rongchun Wang, Qingyu Ren, Daili Gao, Yam Nath Paudel, Xia Li, Lizhen Wang, Pengyu Zhang, Baokun Wang, Xueliang Shang, Meng Jin
Summary: This study aimed to investigate the anti-depressant effect of Gastrodia elata (Tian Ma) and its molecular mechanism. The results showed that Gastrodia elata had a therapeutic effect on depression by acting on RTN4R and apoptosis-related targets, enhancing cell viability and inhibiting apoptosis. Moreover, Gastrodia elata alleviated depression-like symptoms in zebrafish by regulating related gene expressions.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Microbiology
Danqi Wang, Jun-Xia Wang, Chunri Yan, Yize Liu, Hongye Liu, Dongxu Li, Jun Zhu, Zhao-Bo Luo, Sheng-Zhong Han, Zheng-Yun Jin, Shuang-Yan Chang, Liu-Hui Yang, Jin-Dan Kang, Lin-Hu Quan
Summary: The study revealed that Gastrodia elata Blume extract (GEBE) can ameliorate type 2 diabetes by increasing GLUT4 expression in white adipose tissue, remodeling gut microbiota, and modifying serum bile acid concentrations.
FRONTIERS IN MICROBIOLOGY
(2022)
