期刊
BIOLOGICAL RESEARCH
卷 44, 期 4, 页码 363-368出版社
SOC BIOLGIA CHILE
DOI: 10.4067/S0716-97602011000400008
关键词
Monoterpene; citronellal; anti-inflammatory; redox
类别
资金
- National Council of Technological and Scientific Development (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico/CNPq/Brazil) [470290/2008-0]
- Research Supporting Foundation of the State of Sergipe (Fundacao de Apoio a Pesquisa e a Inovacao Tecnologica do Estado de Sergipe/FAPITEC-SE) [019.203.00860/2009-6]
The anti-inflammatory and redox protective effects of the citronellal (CT) were evaluated using in vivo and in vitro tests. Intraperitoneal (i.p.) administration of CT (50, 100, and 200 mg/kg) inhibited (p < 0.05) the carrageenan-induced leukocyte migration to the peritoneal cavity. Additionally, the carrageenan- and arachidonic acid-induced rat hind paw edema was significantly inhibited (p < 0.05) by i.p. administration of 100 and 200 mg/kg of the compound. When the redox activity was evaluated, CT (200 mg/kg) significantly reduced hepatic lipoperoxidation (p < 0.001), as well as oxidation of plasmatic (p < 0.05) and hepatic (p < 0.01) proteins. The results of the present study support the hypothesis that CT possesses anti-inflammatory and redox protective activities. It is suggested that its effects are associated with the inhibition of the enzymes in the arachidonic acid pathway, which prevent cell migration by inhibiting leukotriene production, edema formation and the increase of reactive oxygen species in tissues. Therefore, CT is of potential benefit to manage inflammatory disorders and correlated damages caused by oxidant agents.
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