期刊
BIOLOGICAL PSYCHOLOGY
卷 86, 期 1, 页码 50-56出版社
ELSEVIER
DOI: 10.1016/j.biopsycho.2010.10.006
关键词
Salivary alpha amylase; Salivary diagnostics; Biomarker; Stress; Biosensor; Point of care measurement
资金
- NIH/National Institute on Drug Abuse [1UO1-DAO23815]
- NATIONAL INSTITUTE ON DRUG ABUSE [U01DA023815] Funding Source: NIH RePORTER
Recent developments in biosensor technology allow point-of-use reporting of salivary alpha amylase (sAA) levels while approaching the precision and accuracy of conventional laboratory-based testing. We deployed a portable prototype sAA biosensor in 54 healthy, male dental students during a low stress baseline and during final exams. At baseline, participants completed the Brief Symptom Inventory (BSI). At baseline and the exam week, participants provided saliva samples at 10 AM, 1 PM, and 5 PM, and rated concurrent subjective distress. Although subjective distress was higher during exams compared to baseline, sAA levels did not differ between baseline and exams. Higher sAA levels were related to higher concurrent subjective distress, and higher depressive and social isolation symptoms on the BSI were related to lower sAA during exams. Results from this study, in combination with previous validation data, suggest that the sAA biosensor is a promising tool for point-of-use measures of exposure to stress. (c) 2010 Elsevier B.V. All rights reserved.
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