期刊
BIOLOGICAL PSYCHOLOGY
卷 83, 期 3, 页码 214-221出版社
ELSEVIER
DOI: 10.1016/j.biopsycho.2009.12.010
关键词
Acoustic startle response; TPH2; Functional gene variation; Sex; Age; Fear
资金
- Deutsche Forschungsgemeinschaft [K1 536/20-1, 20-2, SFB 581, KFO 125, SFB TTR 58]
Serotonin, a key regulator of emotional behavior, is synthesized by tryptophan hydroxylase (TPH). Allelic variation of TPH2 gene expression influences serotonin synthesis in the brain and therefore may modulate emotional processing. Here, we investigated the influence of the -703 G/T polymorphism in the regulatory promoter region of the TPH2 gene on the startle response in three different age samples: children (N = 110), young adults (N = 209), and older adults (N = 95). Startle magnitudes to intense noise bursts were recorded during baseline and while participants viewed unpleasant, pleasant or neutral pictures. There was a significant TPH2 x sex interaction effect in young adults with male T allele carriers showing stronger overall startle responses compared to male G/G homozygotes while in young women this effect appeared to be reversed. The difference between TPH2 genotype groups also reached significance in the female subsample when including menstrual cycle phase. In contrast, there was no effect of TPH2 or a TPH2 x sex interaction effect in children or in older adults. (C) 2010 Elsevier B.V. All rights reserved.
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