Review
Health Care Sciences & Services
Suet-Kei Wu, Wei-Jen Chen, Jane Pei-Chen Chang, Ta-Wei Guu, Ming-Che Hsin, Chih-Kun Huang, David Mischoulon, Lucile Capuron, Kuan-Pin Su
Summary: The co-occurrence of depression and obesity has become a global public health concern. Metabolic dysfunction, characterized by inflammation, insulin resistance, leptin resistance, and hypertension, is a critical risk factor for depression. Omega-3 polyunsaturated fatty acids (n-3 PUFAs) show promise as a dietary intervention to reduce inflammation in patients with depression and comorbid obesity and/or metabolic dysregulation.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Clinical Neurology
Jing Gao, Huiyu Fan, Xiaohong Wang, Yangyinglin Cheng, Jingjing Hao, Siqi Han, Suping Wu
Summary: The study revealed that elderly patients with geriatric depression and cognitive impairment (CI) had higher serum levels of TC, LDL-C, and inflammatory markers IL-6, TNF-alpha, and hs-CRP, but lower levels of omega-3 PUFAs EPA, DHA, and AA. Linear regression analysis showed significant associations between EPA, DHA, TNF-alpha, hs-CRP levels and the occurrence and severity of CI among these patients.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Biochemistry & Molecular Biology
Mayra Montecillo-Aguado, Belen Tirado-Rodriguez, Gabriela Antonio-Andres, Mario Morales-Martinez, Zhen Tong, Jun Yang, Bruce D. Hammock, Rogelio Hernandez-Pando, Sara Huerta-Yepez
Summary: Lung cancer is the leading cause of cancer death worldwide, and the intake of omega-6 polyunsaturated fatty acids (PUFAs) in the diet is associated with increased cancer risk and progression. This study found that a diet rich in omega-6 PUFAs enhances the malignancy of tumor cells, promoting cell proliferation, angiogenesis, and inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Nutrition & Dietetics
Miguel A. Ortega, Oscar Fraile-Martinez, Cielo Garcia-Montero, Miguel Angel Alvarez-Mon, Guillermo Lahera, Jorge Monserrat, Maria Llavero-Valero, Luis Gutierrez-Rojas, Rosa Molina, Roberto Rodriguez-Jimenez, Javier Quintero, Melchor Alvarez De Mon
Summary: Major Depressive Disorder (MDD) is a growing disabling condition affected by around 280 million people worldwide, and diet plays a crucial role in influencing MDD. Dietary interventions are considered one of the most promising tools to explore in the field of MDD.
Article
Agriculture, Dairy & Animal Science
Anna Wyrostek, Katarzyna Czyz, Ewa Sokola-Wysoczanska, Bozena Patkowska-Sokola, Wieslaw Bielas
Summary: This study examined the effect of supplementation with ethyl esters of linseed oil on the fatty acid profile in blood serum, erythrocyte membranes, and hair sebum of healthy beagle dogs. The results showed that the supplementation decreased the content of saturated fatty acids and increased the level of beneficial unsaturated fatty acids, especially those from the omega-3 family.
Article
Oncology
Jiachi Ma, Chensong Zhang, Wanqing Liang, Lei Li, Jun Du, Chengwu Pan, Bangling Chen, Yuzhong Chen, Yuanpeng Wang
Summary: This study found that ω-6 PUFAs can enhance the metastatic potential of gastric cancer cells via the COX-2/PGE2 pathway, while ω-3 PUFAs inhibit the metastatic potential of gastric cancer cells through the COX-1/PGE3 signaling axis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Francesca Borasio, Valentina De Cosmi, Veronica D'Oria, Silvia Scaglioni, Marie-Louise Eva Syren, Stefano Turolo, Carlo Agostoni, Marilena Coniglio, Massimo Molteni, Alessandro Antonietti, Maria Luisa Lorusso
Summary: The study investigates the associations between PUFA blood levels, nutritional status, and reading ability. Significant correlations were found between PUFA levels and reading scores, with fatty acids mediating the association between reading speed and nutritional status. Additionally, reading speed performances moderated the associations between blood PUFA levels and dietary intake. The findings suggest that reading skills are influenced by a complex interplay of factors, including fatty acids and nutritional status.
Article
Psychology, Clinical
Sofia Cussotto, Ines Delgado, Giovanni Oriolo, Jonas Kemper, Diane Begarie, Sandra Dexpert, Julie Sauvant, Marion Leboyer, Bruno Aouizerate, Rocio Martin-Santos, Martin Schaefer, Lucile Capuron
Summary: The study found that baseline levels of polyunsaturated fatty acids (PUFAs) can predict the response of depressed patients to standard antidepressants. This suggests that PUFA intake and metabolism may be a novel modifiable tool for managing treatment-resistant depression.
DEPRESSION AND ANXIETY
(2022)
Article
Immunology
Pan-Yen Lin, Chin Cheng, Senthil Kumaran Satyanarayanan, Lu-Ting Chiu, Yu-Chuan Chien, Chih-Pin Chuu, Tsuo-Hung Lan, Kuan-Pin Su
Summary: The study found that n-3 PUFAs supplements did not significantly reduce cognitive, functional, and depressive symptoms outcomes in Alzheimer's disease patients, but showed improvements in spoken language ability and constructional praxis scores. Attention to clinical heterogeneity in dementia is crucial, and CCL4 may be a better indicator for EPA treatment response compared to other inflammatory cytokines.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Nutrition & Dietetics
Elise Grytten, Johnny Laupsa-Borge, Pavol Bohov, Bodil Bjorndal, Elin Strand, Jon Skorve, Jan Erik Nordrehaug, Rolf K. Berge, Espen Rostrup, Gunnar Mellgren, Simon N. Dankel, Ottar K. Nygard
Summary: The high-dose supplementation of n-3 (EPA + DHA) or n-6 (LA) PUFAs led to reductions in TAG- or cholesterol-related markers, respectively, indicating potential benefits for cardiometabolic risk reduction, even among individuals with normal TAG or LDL-C levels.
CLINICAL NUTRITION
(2021)
Article
Nutrition & Dietetics
Yi Zhang, Hongbin Guo, Jieyu Liang, Wenfeng Xiao, Yusheng Li
Summary: This study examines the relationship between dietary levels of omega-3 and omega-6 polyunsaturated fatty acids (PUFAs) and sarcopenia. The results suggest that a higher dietary omega-3 PUFAs level is associated with a lower risk of sarcopenia, while the relationship between dietary omega-6 PUFAs level and sarcopenia is not significant.
FRONTIERS IN NUTRITION
(2022)
Article
Food Science & Technology
Dimitra Karageorgou, Ulrika Rova, Paul Christakopoulos, Petros Katapodis, Leonidas Matsakas, Alok Patel
Summary: This review summarizes the role of omega-3 and omega-6 fatty acids, determined by chain length, saturation degree, and position of double bonds, in human health. It highlights oleaginous microalgae as a reliable, economical, and sustainable source of these fatty acids. Humans cannot synthesize these fatty acids and need to absorb them through the diet. The demand for microbial omega-3 fatty acids is increasing due to the growing prevalence of cardiovascular diseases and changing dietary preferences. The importance of a healthy immune system, especially following the COVID-19 pandemic, has further strengthened the market for omega-3 fatty acids.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Camila Tureck, Bernardo Paz Barboza, Liliana Paula Bricarello, Anabelle Retondario, Mariane de Almeida Alves, Amanda de Moura Souza, Ricardo Fernandes, Francisco de Assis Guedes de Vasconcelos
Summary: This study conducted a systematic review of the scientific evidence on the oral intake of omega-3 and omega-6 fatty acids and metabolic syndrome in adolescents. The results suggest that oral intake of omega-3 fatty acids may have a decreasing effect on blood pressure, glycemia, and triglycerides, and an increasing effect on HDL cholesterol. However, there is controversy in the scientific evidence due to the heterogeneity between studies and the divergence of results for the same metabolic syndrome component.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Article
Endocrinology & Metabolism
Oksana Maksymchuk, Angela Shysh, Dmytro Stroy
Summary: Long-term treatment with omega-3 PUFAs does not increase the risk of CYP2E1-dependent oxidative stress and development of liver pathology but prevents some diabetic ultrastructural damage to hepatocytes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Joseph Schwager, Albine Bompard, Daniel Raederstorff, Hubert Hug, Igor Bendik
Summary: The study evaluated the effects of nutrients such as omega-3 polyunsaturated fatty acids and resveratrol on the differentiation and function of M1 and M2 macrophages. The results showed that these substances significantly promoted the differentiation and function of macrophages and enhanced their impact on the immune response.
Article
Psychology, Clinical
Shotaro Kinoshita, Kelley Cortright, Allison Crawford, Yuya Mizuno, Kazunari Yoshida, Donald Hilty, Daniel Guinart, John Torous, Christoph U. Correll, David J. Castle, Deyvis Rocha, Yuan Yang, Yu-tao Xiang, Pernille Kolbaek, David Dines, Mohammad ElShami, Prakhar Jain, Roy Kallivayalil, Marco Solmi, Angela Favaro, Nicola Veronese, Soraya Seedat, Sangho Shin, Gonzalo Salazar de Pablo, Chun-Hung Chang, Kuan-Pin Su, Hakan Karas, John M. Kane, Peter Yellowlees, Taishiro Kishimoto
Summary: This study investigated the telepsychiatry regulations in different countries/regions before and during the COVID-19 pandemic. The results showed that most regions relaxed their regulations on telepsychiatry during the pandemic, allowing for greater use and implementation of telepsychiatric care. These findings provide valuable information for future policy and regulatory decisions.
PSYCHOLOGICAL MEDICINE
(2022)
Review
Substance Abuse
Ping-Tao Tseng, Jia-Shyun Jeng, Bing-Syuan Zeng, Brendon Stubbs, Andre F. Carvalho, Andre R. Brunoni, Kuan-Pin Su, Yu-Kang Tu, Yi-Cheng Wu, Tien-Yu Chen, Pao-Yen Lin, Chih-Sung Liang, Chih-Wei Hsu, Yen-Wen Chen, Cheng-Ta Li
Summary: Non-invasive brain stimulation interventions targeting the prefrontal cortex appear to be effective in reducing the number of cigarettes smoked, with good acceptability.
Article
Immunology
Yue Xu, Miaomiao Shao, Xinyu Fang, Wei Tang, Chao Zhou, Xiuxiu Hu, Xiangrong Zhang, Kuan-Pin Su
Summary: The study found alternations in gut microbiota in schizophrenia patients with antipsychotic-induced constipation, indicating potential effects of antipsychotic agents on gastrointestinal motility through microbiome-related metabolites. Specific bacteria like Synergistetes might act as anti-inflammatory factors in the healthy gut and be related to colonic transit motility, which contradicts previous findings in gastroenterology literature. The causal effects remain unknown, but the study provides new insights into understanding antipsychotic-induced constipation mechanisms.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Clinical Neurology
Marco Solmi, Andres Estrade, Trevor Thompson, Agorastos Agorastos, Joaquim Radua, Samuele Cortese, Elena Dragioti, Friedrich Leisch, Davy Vancampfort, Lau Caspar Thygesen, Harald Aschauer, Monika Schloegelhofer, Elena Akimova, Andres Schneeberger, Christian G. Huber, Gregor Hasler, Philippe Conus, Kim Q. Do Cuenod, Roland von Kanel, Gonzalo Arrondo, Paolo Fusar-Poli, Philip Gorwood, Pierre-Michel Llorca, Marie-Odile Krebs, Elisabetta Scanferla, Taishiro Kishimoto, Golam Rabbani, Karolina Skonieczna-Zydecka, Paolo Brambilla, Angela Favaro, Akihiro Takamiya, Leonardo Zoccante, Marco Colizzi, Julie Bourgin, Karol Kaminski, Maryam Moghadasin, Soraya Seedat, Evan Matthews, John Wells, Emilia Vassilopoulou, Ary Gadelha, Kuan-Pin Su, Jun Soo Kwon, Minah Kim, Tae Young Lee, Oleg Papsuev, Denisa Mankova, Andrea Boscutti, Cristiano Gerunda, Diego Saccon, Elena Righi, Francesco Monaco, Giovanni Croatto, Guido Cereda, Jacopo Demurtas, Natascia Brondino, Nicola Veronese, Paolo Enrico, Pierluigi Politi, Valentina Ciappolino, Andrea Pfennig, Andreas Bechdolf, Andreas Meyer-Lindenberg, Kai G. Kahl, Katharina Domschke, Michael Bauer, Nikolaos Koutsouleris, Sibylle Winter, Stefan Borgwardt, Istvan Bitter, Judit Balazs, Pal Czobor, Zsolt Unoka, Dimitris Mavridis, Konstantinos Tsamakis, Vasilios P. Bozikas, Chavit Tunvirachaisakul, Michael Maes, Teerayuth Rungnirundorn, Thitiporn Supasitthumrong, Ariful Haque, Andre R. Brunoni, Carlos Gustavo Costardi, Felipe Barreto Schuch, Guilherme Polanczyk, Jhoanne Merlyn Luiz, Lais Fonseca, Luana Aparicio, Samira S. Valvassori, Merete Nordentoft, Per Vendsborg, Sofie Have Hoffmann, Jihed Sehli, Norman Sartorius, Sabina Heuss, Daniel Guinart, Jane Hamilton, John Kane, Jose Rubio, Michael Sand, Ai Koyanagi, Aleix Solanes, Alvaro Andreu-Bernabeu, Antonia San Jose Caceres, Celso Arango, Covadonga M. Diaz-Caneja, Diego Hidalgo-Mazzei, Eduard Vieta, Javier Gonzalez-Penas, Lydia Fortea, Mara Parellada, Miquel A. Fullana, Norma Verdolini, Eva Farkova, Karolina Janku, Mark Millan, Mihaela Honciuc, Anna Moniuszko-Malinowska, Igor Loniewski, Jerzy Samochowiec, Lukasz Kiszkiel, Maria Marlicz, Pawel Sowa, Wojciech Marlicz, Georgina Spies, Brendon Stubbs, Joseph Firth, Sarah Sullivan, Asli Enez Darcin, Hatice Aksu, Nesrin Dilbaz, Onur Noyan, Momoko Kitazawa, Shunya Kurokawa, Yuki Tazawa, Alejandro Anselmi, Cecilia Cracco, Ana Ines Machado, Natalia Estrade, Diego De Leo, Jackie Curtis, Michael Berk, Philip Ward, Scott Teasdale, Simon Rosenbaum, Wolfgang Marx, Adrian Vasile Horodnic, Liviu Oprea, Ovidiu Alexinschi, Petru Ifteni, Serban Turliuc, Tudor Ciuhodaru, Alexandra Bolos, Valentin Matei, Dorien H. Nieman, Iris Sommer, Jim van Os, Therese van Amelsvoort, Ching-Fang Sun, Ta-wei Guu, Can Jiao, Jieting Zhang, Jialin Fan, Liye Zou, Xin Yu, Xinli Chi, Philippe de Timary, Ruud van Winke, Bernardo Ng, Edilberto Pena, Ramon Arellano, Raquel Roman, Thelma Sanchez, Larisa Movina, Pedro Morgado, Sofia Brissos, Oleg Aizberg, Anna Mosina, Damir Krinitski, James Mugisha, Dena Sadeghi-Bahmani, Masoud Sadeghi, Samira Hadi, Serge Brand, Antonia Errazuriz, Nicolas Crossley, Dragana Ignjatovic Ristic, Carlos Lopez-Jaramillo, Dimitris Efthymiou, Praveenlal Kuttichira, Roy Abraham Kallivayalil, Afzal Javed, Muhammad Iqbal Afridi, Bawo James, Omonefe Joy Seb-Akahomen, Jess Fiedorowicz, Andre F. Carvalho, Jeff Daskalakis, Lakshmi N. Yatham, Lin Yang, Tarek Okasha, Aicha Dahdouh, Bjorn Gerdle, Jari Tiihonen, Jae Il Shin, Jinhee Lee, Ahmed Mhalla, Lotfi Gaha, Takoua Brahim, Kuanysh Altynbekov, Nikolay Negay, Saltanat Nurmagambetova, Yasser Abu Jamei, Mark Weiser, Christoph U. Correll
Summary: The COH-FIT project is an international study aiming to investigate the effects of the COVID-19 pandemic on physical and mental health. Through multiple waves of data collection, the project seeks to identify high-risk groups and provide evidence for interventions and policy-making.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Letter
Medicine, General & Internal
Chih-Sung Liang, Ping-Tao Tseng, Kuan-Pin Su
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Article
Psychiatry
Jerome Sarris, Arun Ravindran, Lakshmi N. Yatham, Wolfgang Marx, Julia J. Rucklidge, Roger S. McIntyre, Shahin Akhondzadeh, Francesco Benedetti, Constanza Caneo, Holger Cramer, Lachlan Cribb, Michael de Manincor, Olivia Dean, Andrea Camaz Deslandes, Marlene P. Freeman, Bangalore Gangadhar, Brian H. Harvey, Siegfried Kasper, James Lake, Adrian Lopresti, Lin Lu, Najwa-Joelle Metri, David Mischoulon, Chee H. Ng, Daisuke Nishi, Roja Rahimi, Soraya Seedat, Justin Sinclair, Kuan-Pin Su, Zhang-Jin Zhang, Michael Berk
Summary: The study aimed to provide definitive evidence-informed clinical guidelines for the use of nutrient-based 'nutraceuticals' and plant-based 'phytoceuticals' in treating major psychiatric disorders. These guidelines were developed by an international task force involving leading experts from 15 countries to assist clinicians in making informed decisions.
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
(2022)
Article
Medicine, General & Internal
Wei-Te Lei, Ling-Sai Chang, Bing-Yan Zeng, Yu-Kang Tu, Ritei Uehara, Yutaka J. Matsuoka, Kuan-Pin Su, Pi-Chang Lee, Joao L. Cavalcante, Brendon Stubbs, Pao-Yen Lin, Yi-Cheng Wu, Chih-Wei Hsu, Tien-Yu Chen, Yen-Wen Chen, Pin-Yang Yeh, Cheuk-Kwan Sun, Ping-Tao Tseng, Yu-Hsuan Kao
Summary: This network meta-analysis compared different interventions for Kawasaki disease (KD) and found that medium-dosage IVIG + aspirin + infliximab exhibited the shortest fever duration and the smallest incidence of coronary artery lesion (CAL) in the initial-stage KD. In the refractory-stage KD, high-dosage IVIG + pulse steroid therapy had the best rate of decline of fever, while high-dosage IVIG + ciclosporin exhibited the smallest incidence of CAL. Infliximab significantly improved resolution in refractory-stage KD. Further evidence from randomized trials is needed to support these findings.
Article
Medicine, General & Internal
Malgorzata Galecka, Janusz Szemraj, Kuan-Pin Su, Angelos Halaris, Michael Maes, Aleksandra Skiba, Piotr Galecki, Katarzyna Blizniewska-Kowalska
Summary: This study found that there is increased expression of JAK3 and decreased expression of STAT1 in depressed patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Health Care Sciences & Services
Yung-Chieh Yen, Nan-Ying Chiu, Tzung-Jeng Hwang, Tung-Ping Su, Yen-Kuang Yang, Cheng-Sheng Chen, Cheng-Ta Li, Kuan-Pin Su, Te-Jen Lai, Chia-Ming Chang
Summary: Cognitive dysfunction is a common problem among patients with Major Depressive Disorder (MDD). This study aimed to identify the factors associated with cognitive impairment in MDD and develop a reliable questionnaire, the Taiwan Cognition Questionnaire (TCQ), to assess subjective cognitive dysfunction. The findings showed that TCQ scores were positively correlated with a history of acute psychiatric care and severity of depression, while being negatively correlated with objective cognitive measures.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Neurosciences
Liu Shu-Tsen, Lin Sheng-Che, Chang Jane Pei-Chen, Yang Kai-Jie, Chu Che-Sheng, Yang Chia-Chun, Liang Chih-Sung, Sun Ching-Fang, Wang Shao-Cheng, Senthil Kumaran Satyanarayanan, Su Kuan-Pin
Summary: There is growing evidence that COVID-19 is associated with increased risks of psychiatric sequelae, including depression, anxiety, cognitive impairments, sleep disturbance, and fatigue. This review provides timely updates on clinical research findings and identifies potential key targets for developing effective treatment strategies for long COVID. Additionally, the Formosa Long COVID Multicenter Study (FOCuS) applies the inflammation theory to the pathogenesis and treatment of post-COVID depression and anxiety.
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
(2023)
Review
Medicine, General & Internal
Chia-Chun Yang, Sheng-Ta Tsai, Berne Ting, Ying-Chih Cheng, Chin-Kun Wang, Jane Pei-Chen Chang, Kuan-Pin Su
Summary: This study aimed to investigate the impact of vitamin D supplementation on psychological outcomes and quality of life in fibromyalgia patients. The findings suggest that vitamin D supplementation has significant positive effects on physical function, role limitations due to emotional health, social function, and general health in patients with fibromyalgia. However, no significant improvement was observed in pain scores, Fibromyalgia Impact Questionnaire scores, and Beck's Depression Inventory scores.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Halliru Zailani, Senthil Kumaran Satyanarayanan, Wei-Chih Liao, Hsien-Feng Liao, Shih-Yi Huang, Piotr Galecki, Kuan-Pin Su, Jane Pei-Chen Chang
Summary: Chronic obstructive pulmonary disease (COPD) is a leading cause of death globally, particularly in individuals over 40 years old. Mood disorders are frequently comorbid with COPD, but often overlooked or undiagnosed, leading to poor treatment outcomes and increased mortality. The exact link between COPD and mood disorders is still uncertain, but it is believed that inflammation in the lungs, blood, and brain may contribute to the development of mood disorders in COPD. Antidepressants are commonly used to manage mood disorders in COPD, but their efficacy is limited due to tolerability issues. Omega-3 polyunsaturated fatty acids (n-3 PUFAs), which regulate inflammatory responses, may offer promising alternatives for managing mood disorders in COPD.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Health Care Sciences & Services
Suet-Kei Wu, Wei-Jen Chen, Jane Pei-Chen Chang, Ta-Wei Guu, Ming-Che Hsin, Chih-Kun Huang, David Mischoulon, Lucile Capuron, Kuan-Pin Su
Summary: The co-occurrence of depression and obesity has become a global public health concern. Metabolic dysfunction, characterized by inflammation, insulin resistance, leptin resistance, and hypertension, is a critical risk factor for depression. Omega-3 polyunsaturated fatty acids (n-3 PUFAs) show promise as a dietary intervention to reduce inflammation in patients with depression and comorbid obesity and/or metabolic dysregulation.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Clinical Neurology
Szu-Wei Cheng, Chung-Wen Chang, Wan-Jung Chang, Hao-Wei Wang, Chih-Sung Liang, Taishiro Kishimoto, Jane Pei-Chen Chang, John S. Kuo, Kuan-Pin Su
Summary: ChatGPT, a powerful language model, has immense potential in the field of psychiatry. Despite its limited practical applications in psychiatry, it can support psychiatrists in routine tasks and has the possibility of developing a fully-automated psychotherapy system.
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2023)
Review
Nutrition & Dietetics
Halliru Zailani, Senthil Kumaran Satyanarayanan, Wei-Chih Liao, Yi-Ting Hsu, Shih-Yi Huang, Piotr Galecki, Kuan-Pin Su, Jane Pei-Chen Chang
Summary: Chronic obstructive pulmonary disease (COPD) is a common lung disease that is associated with pulmonary inflammation and cognitive impairment. The exact mechanisms of cognitive impairment in COPD patients are still unclear, but hypoxia, oxidative stress, systemic inflammation, and cerebral manifestations of these conditions are believed to play crucial roles. Current medications for cognitive impairment in COPD patients may have life-threatening adverse effects, indicating the need for alternative medications. This review discusses the potential role of omega-3 polyunsaturated fatty acids (omega-3 PUFAs) in improving cognitive deficits in COPD patients and highlights the importance of clinical studies to evaluate the efficacy of omega-3 PUFAs in managing cognitive impairment in COPD patients.
Review
Neurosciences
Maya Jammoul, Dareen Jammoul, Kevin K. Wang, Firas Kobeissy, Ralph G. Depalma
Summary: This article reviews the possible mechanisms by which traumatic brain injury (TBI) may stimulate the development of opioid use disorder (OUD) and discusses the interaction between these two processes. CNS damage due to TBI appears to drive adverse effects of subsequent OUD, with pain being a risk factor for opioid use after TBI.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Danusa Mar Arcego, Jan-Paul Buschdorf, Nicholas O'Toole, Zihan Wang, Barbara Barth, Irina Pokhvisneva, Nirmala Arul Rayan, Sachin Patel, Euclides Jose de Mendonca Filho, Patrick Lee, Jennifer Tan, Ming Xuan Koh, Chu Ming Sim, Carine Parent, Randriely Merscher Sobreira de Lima, Andrew Clappison, Kieran J. O'Donnell, Carla Dalmaz, Janine Arloth, Nadine Provencal, Elisabeth B. Binder, Josie Diorio, Patricia Pelufo Silveira, Michael J. Meaney
Summary: This study investigates the impact of environmental influences on mental health by integrating transcriptomic data from animal models with human data. The results suggest that hippocampal glucocorticoid-related transcriptional activity mediates the effects of early adversity on neural mechanisms implicated in psychiatric disorders.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Milenna T. van Dijk, Ardesheer Talati, Pratik Kashyap, Karan Desai, Nora C. Kelsall, Marc J. Gameroff, Natalie Aw, Eyal Abraham, Breda Cullen, Jiook Cha, Christoph Anacker, Myrna M. Weissman, Jonathan Posner
Summary: This study found that maternal stress is associated with future depressive symptoms and alterations in microstructure of the dentate gyrus (DG) in offspring. These results were consistent across two independent cohorts.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Josephine C. McGowan, Liliana R. Ladner, Claire X. Shubeck, Juliana Tapia, Christina T. LaGamma, Amanda Anqueira-Gonzalez, Ariana DeFrancesco, Briana K. Chen, Holly C. Hunsberger, Ezra J. Sydnor, Ryan W. Logan, Tzong-Shiue Yu, Steven G. Kernie, Christine A. Denny
Summary: Traumatic brain injury (TBI) leads to fear generalization by altering fear memory traces, and this symptom can be improved with (R,S)-ketamine.
BIOLOGICAL PSYCHIATRY
(2024)