Article
Psychiatry
Nur Dikmeer, Lutfullah Besiroglu, Maria A. Di Biase, Andrew Zalesky, Meltem I. Kasal, Aslihan Bilge, Ercan Durmaz, Serap Polat, Fazil Gelal, Nabi Zorlu
Summary: In comparison to healthy controls, OCD patients showed reduced FA and increased RD in certain key areas of the brain. OCD group also exhibited weaker connectivity in the right hemisphere compared to controls. Siblings of OCD patients had intermediate levels of white matter microstructure and connectivity, suggesting a familial predisposition for OCD.
ACTA PSYCHIATRICA SCANDINAVICA
(2021)
Article
Psychiatry
Maria Pico-Perez, Renato Barbosa, Beatriz Couto, Ines Castro, Ricardo Magalhaes, Nuno Sousa, Sonia Ferreira, Pedro Morgado
Summary: Patients with OCD show increased brain activity and altered connectivity during negative emotions, suggesting deficits in emotion regulation. They are less successful at lowering the emotional impact of negative images. Frontoparietal connectivity in OCD patients may serve as a compensatory mechanism during emotion regulation.
PSYCHIATRY RESEARCH
(2022)
Article
Clinical Neurology
M. Alemany-Navarro, M. Tubio-Fungueirino, S. Diz-de Almeida, R. Cruz, A. Lombroso, E. Real, V. Soria, S. Bertolin, M. Fernandez-Prieto, P. Alonso, J. M. Menchon, A. Carracedo, C. Segalas
Summary: This study analyzed the association of SNPs with neurocognitive variables in a sample of 133 OCD probands. The results suggest that studying neurocognitive variables in GWAS may provide more insight into the genetic basis of OCD and facilitate the development of individualized treatment approaches.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychiatry
Stephan Heinzel, Katharina Bey, Rosa Gruetzmann, Julia Klawohn, Christian Kaufmann, Leonhard Lennertz, Michael Wagner, Norbert Kathmann, Anja Riesel
Summary: The study found impairments in spatial working memory (SWM) performance in individuals with OCD, but it is unclear whether this deficit is a core cognitive endophenotype of OCD. Performance in SWM was best in healthy controls, intermediate in unaffected relatives of OCD individuals, and worst in those with OCD, with no significant difference between healthy controls and relatives.
Article
Clinical Neurology
Jiali He, Shuya Yan, Zijin Song, Qianyi Lu, Shuming Zhong, Shunkai Lai, Ying Wang, Guanmao Chen, Hui Zhao, Pan Chen, Yiliang Zhang, Yanbin Jia
Summary: Both OCD and MDD patients exhibited cognitive impairment in working memory and altered neurometabolism in the prefrontal cortex (PFC). MDD patients showed more severe and broader working memory impairment compared to OCD patients. The dysfunction of PFC may underlie the neural basis of working memory impairment in MDD.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Neurosciences
Qianqian Li, Jun Yan, Jinmin Liao, Xiao Zhang, Lijun Liu, Xiaoyu Fu, Hao Yang Tan, Dai Zhang, Hao Yan
Summary: This study found that stress exacerbated the symptoms of OCD patients and impaired their working memory. Healthy controls showed less brain area activation during the task, while patients did not exhibit this. This indicates that the neural response of patients to stress differs from that of healthy controls.
NEUROSCIENCE BULLETIN
(2021)
Article
Psychiatry
Mariela Rance, Zhiying Zhao, Brian Zaboski, Stephen A. Kichuk, Emma Romaker, William N. Koller, Christopher Walsh, Cheyenne Harris-Starling, Suzanne Wasylink, Thomas Adams Jr, Patricia Gruner, Christopher Pittenger, Michelle Hampson
Summary: This study aimed to use fMRI neurofeedback as a treatment for OCD. The results showed that neurofeedback targeting the aPFC can reduce symptoms in OCD, but did not significantly affect control over the aPFC. Future studies should optimize the training protocol and clarify the mechanism of action.
PSYCHIATRY RESEARCH
(2023)
Editorial Material
Clinical Neurology
Trevor. W. Robbins
Summary: This scientific commentary discusses the research conducted by Kim et al. on the unbalanced fronto-pallidal neurocircuit underlying set shifting in patients with obsessive-compulsive disorder, published in the journal Brain.
Article
Neurosciences
Lining Yin, Fang Han, Qingyun Wang
Summary: This study establishes a biophysical model to explain the mechanism of how high dopamine concentrations induce persistent neuronal activities and working memory defects, leading to obsession and compulsion. The theory highlights the importance of early intervention and behavioral therapies for obsessive-compulsive disorder, offering new approaches to dopaminergic pharmacotherapy and psychotherapy.
COGNITIVE NEURODYNAMICS
(2023)
Article
Neuroimaging
Lutfullah Besiroglu, Andrew Zalesky, Meltem Kasal, Nur Dikmeer, Ercan Durmaz, Serap Polat, Fazil Gelal, Nabi Zorlu
Summary: This study aimed to examine cortical thickness and surface area differences between patients with obsessive-compulsive disorder (OCD) and their unaffected siblings. The results showed that both OCD patients and unaffected siblings had significantly lower cortical thickness in the right anterior insula. Additionally, OCD patients had reduced surface areas in the superior frontal gyrus, paracentral gyrus, and precuneus of the right hemisphere. These findings suggest that lower cortical thickness in the right anterior insula may represent a potential structural endophenotype for OCD.
BRAIN IMAGING AND BEHAVIOR
(2022)
Article
Neurosciences
Xue Li, Hailong Li, Xi Jiang, Jing Li, Lingxiao Cao, Jing Liu, Haoyang Xing, Xiaoqi Huang, Qiyong Gong
Summary: This study comprehensively analyzed the modular architecture alterations in the brain connectome of patients with obsessive-compulsive disorder (OCD) and found that these alterations were associated with clinical symptoms. The findings provide further insights into the involvement of different modules in functional network dysfunction in OCD.
HUMAN BRAIN MAPPING
(2022)
Review
Clinical Neurology
Valerie La Buissonniere-Ariza, Kate Fitzgerald, Avner Meoded, Laurel L. Williams, Gary Liu, Wayne K. Goodman, Eric A. Storch
Summary: The systematic review of functional MRI studies in youths with negative valence disorders suggests that variations in neural functioning may impact response to CBT. However, the overall weak to moderate quality and limited number of studies, as well as the heterogeneity in study designs and results, considerably restrict the conclusions that can be drawn from this literature.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Neurosciences
Wanyi Cao, Haiyan Liao, Sainan Cai, Wanrong Peng, Zhaoxia Liu, Kaili Zheng, Jinyu Liu, Mingtian Zhong, Changlian Tan, Jinyao Yi
Summary: Abnormal connectivity between the right inferior parietal lobule and the right dorsolateral prefrontal cortex was found in MDD patients during 2-back task. Dynamic causal modeling analysis revealed increased forward modulation connectivity from the right IPL to the right dlPFC in MDD patients during 2-back task, compared to healthy controls.
HUMAN BRAIN MAPPING
(2021)
Review
Psychiatry
Louise Destree, Mary-Ellen E. Brierley, Lucy Albertella, Laura Jobson, Leonardo F. Fontenelle
Summary: This study conducted a systematic review on the relationships between childhood trauma and obsessive-compulsive symptoms (OCS) severity. The results showed a significant relationship between exposure to childhood trauma and OCS severity in both clinical and non-clinical populations. It was also found that a range of childhood trauma types, rather than a single type, was associated with OCD.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Irena Smaga, Malgorzata Frankowska, Malgorzata Filip
Summary: N-acetylcysteine (NAC) is a well-known mucolytic agent that has shown beneficial effects on different psychiatric disorders. It exerts its effects through regulating neurotransmitters, oxidative balance, and inflammatory mediators. While preclinical studies have shown positive results, further research is needed to establish the clinical efficacy of NAC for psychiatric disorders.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Neurosciences
Xiang-Zhen Kong, Clyde Francks
Summary: The problem of poor reproducibility of scientific findings has been a topic of concern in recent years. A recent multisite collaborative study investigated the reproducibility of brain anatomical left-right asymmetries in regional measures of surface area and cortical thickness. The study found an average reproducibility rate of 63.2%, with larger effects and larger datasets having higher reproducibility.
HUMAN BRAIN MAPPING
(2022)
Article
Neurosciences
Danai Dima, Amirhossein Modabbernia, Efstathios Papachristou, Gaelle E. Doucet, Ingrid Agartz, Moji Aghajani, Theophilus N. Akudjedu, Anton Albajes-Eizagirre, Dag Alnaes, Kathryn Alpert, Micael Andersson, Nancy C. Andreasen, Ole A. Andreassen, Philip Asherson, Tobias Banaschewski, Nuria Bargallo, Sarah Baumeister, Ramona Baur-Streubel, Alessandro Bertolino, Aurora Bonvino, Dorret Boomsma, Stefan Borgwardt, Josiane Bourque, Daniel Brandeis, Alan Breier, Henry Brodaty, Rachel M. Brouwer, Jan K. Buitelaar, Geraldo F. Busatto, Randy L. Buckner, Vincent Calhoun, Erick J. Canales-Rodriguez, Dara M. Cannon, Xavier Caseras, Francisco X. Castellanos, Simon Cervenka, Tiffany M. Chaim-Avancini, Christopher R. K. Ching, Victoria Chubar, Vincent P. Clark, Patricia Conrod, Annette Conzelmann, Benedicto Crespo-Facorro, Fabrice Crivello, Eveline A. Crone, Anders M. Dale, Cristopher Davey, Eco J. C. de Geus, Lieuwe de Haan, Greig de Zubicaray, Anouk den Braber, Erin W. Dickie, Annabella Di Giorgio, Nhat Trung Doan, Erlend S. Dorum, Stefan Ehrlich, Susanne Erk, Thomas Espeseth, Helena Fatouros-Bergman, Simon E. Fisher, Jean-Paul Fouche, Barbara Franke, Thomas Frodl, Paola Fuentes-Claramonte, David C. Glahn, Ian H. Gotlib, Hans-Joergen Grabe, Oliver Grimm, Nynke A. Groenewold, Dominik Grotegerd, Oliver Gruber, Patricia Gruner, Rachel E. Gur, Ruben C. Gur, Ben J. Harrison, Catharine A. Hartman, Sean N. Hatton, Andreas Heinz, Dirk J. Heslenfeld, Derrek P. Hibar, Ian B. Hickie, Beng-Choon Ho, Pieter J. Hoekstra, Sarah Hohmann, Avram J. Holmes, Martine Hoogman, Norbert Hosten, Fleur M. Howells, Hilleke E. Hulshoff Pol, Chaim Huyser, Neda Jahanshad, Anthony James, Terry L. Jernigan, Jiyang Jiang, Erik G. Jonsson, John A. Joska, Rene Kahn, Andrew Kalnin, Ryota Kanai, Marieke Klein, Tatyana P. Klyushnik, Laura Koenders, Sanne Koops, Bernd Kraemer, Jonna Kuntsi, Jim Lagopoulos, Luisa Lazaro, Irina Lebedeva, Won Hee Lee, Klaus-Peter Lesch, Christine Lochner, Marise W. J. Machielsen, Sophie Maingault, Nicholas G. Martin, Ignacio Martinez-Zalacain, David Mataix-Cols, Bernard Mazoyer, Colm McDonald, Brenna C. McDonald, Andrew M. McIntosh, Katie L. McMahon, Genevieve McPhilemy, Jose M. Menchon, Sarah E. Medland, Andreas Meyer-Lindenberg, Jilly Naaijen, Pablo Najt, Tomohiro Nakao, Jan E. Nordvik, Lars Nyberg, Jaap Oosterlaan, Victor Ortiz-Garcia De la Foz, Yannis Paloyelis, Paul Pauli, Giulio Pergola, Edith Pomarol-Clotet, Maria J. Portella, Steven G. Potkin, Joaquim Radua, Andreas Reif, Daniel A. Rinker, Joshua L. Roffman, Pedro G. P. Rosa, Matthew D. Sacchet, Perminder S. Sachdev, Raymond Salvador, Pascual Sanchez-Juan, Salvador Sarro, Theodore D. Satterthwaite, Andrew J. Saykin, Mauricio H. Serpa, Lianne Schmaal, Knut Schnell, Gunter Schumann, Kang Sim, Jordan W. Smoller, Iris Sommer, Carles Soriano-Mas, Dan J. Stein, Lachlan T. Strike, Suzanne C. Swagerman, Christian K. Tamnes, Henk S. Temmingh, Sophia Thomopoulos, Alexander S. Tomyshev, Diana Tordesillas-Gutierrez, Julian N. Trollor, Jessica A. Turner, Anne Uhlmann, Odile A. van den Heuvel, Dennis van den Meer, Nic J. A. van der Wee, Neeltje E. M. van Haren, Dennis Van't Ent, Theo G. M. van Erp, Ilya M. Veer, Dick J. Veltman, Aristotle Voineskos, Henry Voelzke, Henrik Walter, Esther Walton, Lei Wang, Yang Wang, Thomas H. Wassink, Bernd Weber, Wei Wen, John D. West, Lars T. Westlye, Heather Whalley, Lara M. Wierenga, Steven C. R. Williams, Katharina Wittfeld, Daniel H. Wolf, Amanda Worker, Margaret J. Wright, Kun Yang, Yulyia Yoncheva, Marcus Zanetti, Georg C. Ziegler, Paul M. Thompson, Sophia Frangou
Summary: Age has a significant impact on brain volume, with different regions showing varying trajectories. Basal ganglia volume decreases with age, while lateral ventricles continue to enlarge. These findings provide important insights into the functional significance of age-related morphometric patterns in the brain.
HUMAN BRAIN MAPPING
(2022)
Article
Neurosciences
Sophia Frangou, Amirhossein Modabbernia, Steven C. R. Williams, Efstathios Papachristou, Gaelle E. Doucet, Ingrid Agartz, Moji Aghajani, Theophilus N. Akudjedu, Anton Albajes-Eizagirre, Dag Alnaes, Kathryn Alpert, Micael Andersson, Nancy C. Andreasen, Ole A. Andreassen, Philip Asherson, Tobias Banaschewski, Nuria Bargallo, Sarah Baumeister, Ramona Baur-Streubel, Alessandro Bertolino, Aurora Bonvino, Dorret Boomsma, Stefan Borgwardt, Josiane Bourque, Daniel Brandeis, Alan Breier, Henry Brodaty, Rachel M. Brouwer, Jan K. Buitelaar, Geraldo F. Busatto, Randy L. Buckner, Vincent Calhoun, Erick J. Canales-Rodriguez, Dara M. Cannon, Xavier Caseras, Francisco X. Castellanos, Simon Cervenka, Tiffany M. Chaim-Avancini, Christopher R. K. Ching, Victoria Chubar, Vincent P. Clark, Patricia Conrod, Annette Conzelmann, Benedicto Crespo-Facorro, Fabrice Crivello, Eveline A. Crone, Anders M. Dale, Christopher Davey, Eco J. C. de Geus, Lieuwe de Haan, Greig de Zubicaray, Anouk den Braber, Erin W. Dickie, Annabella Di Giorgio, Nhat Trung Doan, Erlend S. Dorum, Stefan Ehrlich, Susanne Erk, Thomas Espeseth, Helena Fatouros-Bergman, Simon E. Fisher, Jean-Paul Fouche, Barbara Franke, Thomas Frodl, Paola Fuentes-Claramonte, David C. Glahn, Ian H. Gotlib, Hans-Joergen Grabe, Oliver Grimm, Nynke A. Groenewold, Dominik Grotegerd, Oliver Gruber, Patricia Gruner, Rachel E. Gur, Ruben C. Gur, Ben J. Harrison, Catharine A. Hartman, Sean N. Hatton, Andreas Heinz, Dirk J. Heslenfeld, Derrek P. Hibar, Ian B. Hickie, Beng-Choon Ho, Pieter J. Hoekstra, Sarah Hohmann, Avram J. Holmes, Martine Hoogman, Norbert Hosten, Fleur M. Howells, Hilleke E. Hulshoff Pol, Chaim Huyser, Neda Jahanshad, Anthony James, Terry L. Jernigan, Jiyang Jiang, Erik G. Jonsson, John A. Joska, Rene Kahn, Andrew Kalnin, Ryota Kanai, Marieke Klein, Tatyana P. Klyushnik, Laura Koenders, Sanne Koops, Bernd Kraemer, Jonna Kuntsi, Jim Lagopoulos, Luisa Lazaro, Irina Lebedeva, Won Hee Lee, Klaus-Peter Lesch, Christine Lochner, Marise W. J. Machielsen, Sophie Maingault, Nicholas G. Martin, Ignacio Martinez-Zalacain, David Mataix-Cols, Bernard Mazoyer, Colm McDonald, Brenna C. McDonald, Andrew M. McIntosh, Katie L. McMahon, Genevieve McPhilemy, Jose M. Menchon, Sarah E. Medland, Andreas Meyer-Lindenberg, Jilly Naaijen, Pablo Najt, Tomohiro Nakao, Jan E. Nordvik, Lars Nyberg, Jaap Oosterlaan, Victor Ortiz-Garcia de la Foz, Yannis Paloyelis, Paul Pauli, Giulio Pergola, Edith Pomarol-Clotet, Maria J. Portella, Steven G. Potkin, Joaquim Radua, Andreas Reif, Daniel A. Rinker, Joshua L. Roffman, Pedro G. P. Rosa, Matthew D. Sacchet, Perminder S. Sachdev, Raymond Salvador, Pascual Sanchez-Juan, Salvador Sarro, Theodore D. Satterthwaite, Andrew J. Saykin, Mauricio H. Serpa, Lianne Schmaal, Knut Schnell, Gunter Schumann, Kang Sim, Jordan W. Smoller, Iris Sommer, Carles Soriano-Mas, Dan J. Stein, Lachlan T. Strike, Suzanne C. Swagerman, Christian K. Tamnes, Henk S. Temmingh, Sophia Thomopoulos, Alexander S. Tomyshev, Diana Tordesillas-Gutierrez, Julian N. Trollor, Jessica A. Turner, Anne Uhlmann, Odile A. van den Heuvel, Dennis van den Meer, Nic J. A. van der Wee, Neeltje E. M. van Haren, Dennis van't Ent, Theo G. M. van Erp, Ilya M. Veer, Dick J. Veltman, Aristotle Voineskos, Henry Voelzke, Henrik Walter, Esther Walton, Lei Wang, Yang Wang, Thomas H. Wassink, Bernd Weber, Wei Wen, John D. West, Lars T. Westlye, Heather Whalley, Lara M. Wierenga, Katharina Wittfeld, Daniel H. Wolf, Amanda Worker, Margaret J. Wright, Kun Yang, Yulyia Yoncheva, Marcus Zanetti, Georg C. Ziegler, Paul M. Thompson, Danai Dima
Summary: The study used data from the ENIGMA Consortium to explore the relationship between age and cortical thickness, finding that most regions peak in cortical thickness during childhood, with a negative association between age and cortical thickness where the slope is steeper before the age of 30 and more gradual afterwards.
HUMAN BRAIN MAPPING
(2022)
Article
Psychology, Developmental
Cees J. Weeland, Chris Vriend, Ysbrand van der Werf, Chaim Huyser, Manon Hillegers, Henning Tiemeier, Tonya White, Odile A. van den Heuvel
Summary: This study investigated the relationship between obsessive-compulsive symptoms and volume of thalamic subregions in a population-based sample of children. The results showed that children with probable OCD had larger thalamic subregion volumes compared to those without symptoms. However, these associations did not survive multiple testing correction.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2022)
Article
Clinical Neurology
Niels T. de Joode, Anders L. Thorsen, Eline L. Vester, Chris Vriend, Petra J. W. Pouwels, Kristen Hagen, Olga T. Ousdal, Bjarne Hansen, Gerd Kvale, Odile A. van den Heuvel
Summary: The study found no abnormalities in neurometabolites in the dACC of OCD patients before treatment or over time, and the changes induced by ERP treatment seem to depend more on comorbid mood disorders and disease stage rather than OCD itself.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Letter
Clinical Neurology
Samson G. Khachatryan, Lyudmila Korostovtseva, Oana Deleanu, Barbara Gnidovec-Strazisar, Peter Young, Morten Engstrom, Ysbrand D. van Der Werf
JOURNAL OF SLEEP RESEARCH
(2022)
Article
Psychiatry
Cees J. Weeland, Selina Kasprzak, Niels T. de Joode, Yoshinari Abe, Pino Alonso, Stephanie H. Ameis, Alan Anticevic, Paul D. Arnold, Srinivas Balachander, Nerisa Banaj, Nuria Bargallo, Marcelo C. Batistuzzo, Francesco Benedetti, Jan C. Beucke, Irene Bollettini, Vilde Brecke, Silvia Brem, Carolina Cappi, Yuqi Cheng, Kang Ik K. Cho, Daniel L. C. Costa, Sara Dallaspezia, Damiaan Denys, Goi Khia Eng, Sonia Ferreira, Jamie D. Feusner, Martine Fontaine, Jean-Paul Fouche, Rachael G. Grazioplene, Patricia Gruner, Mengxin He, Yoshiyuki Hirano, Marcelo Q. Hoexter, Chaim Huyser, Hao Hu, Fern Jaspers-Fayer, Norbert Kathmann, Christian Kaufmann, Minah Kim, Kathrin Koch, Yoo Bin Kwak, Jun Soo Kwon, Luisa Lazaro, Chiang-Shan R. Li, Christine Lochner, Rachel Marsh, Ignacio Martinez-Zalacain, David Mataix-Cols, Jose M. Menchon, Luciano Minnuzi, Pedro Silva Moreira, Pedro Morgado, Akiko Nakagawa, Takashi Nakamae, Janardhanan C. Narayanaswamy, Erika L. Nurmi, Ana E. Ortiz, Jose C. Pariente, John Piacentini, Maria Pico-Perez, Fabrizio Piras, Federica Piras, Christopher Pittenger, Y. C. Janardhan Reddy, Daniela Rodriguez-Manrique, Yuki Sakai, Eiji Shimizu, Venkataram Shivakumar, Helen Blair Simpson, Noam Soreni, Carles Soriano-Mas, Nuno Sousa, Gianfranco Spalletta, Emily R. Stern, Michael C. Stevens, S. Evelyn Stewart, Philip R. Szeszko, Jumpei Takahashi, Tais Tanamatis, Jinsong Tang, Anders Lillevik Thorsen, David Tolin, Ysbrand D. van der Werf, Hein van Marle, Guido A. van Wingen, Daniela Vecchio, G. Venkatasubramanian, Susanne Walitza, Jicai Wang, Zhen Wang, Anri Watanabe, Lidewij H. Wolters, Xiufeng Xu, Je-Yeon Yun, Qing Zhao, Tonya White, Paul M. Thompson, Dan J. Stein, Odile A. van den Heuvel, Chris Vriend
Summary: Larger thalamic volume has been found in children with obsessive-compulsive disorder (OCD) and particular subregions may drive these differences. In adults, smaller volumes were observed across all subregions and the whole thalamic volume, mostly driven by medicated patients and associated with symptom severity.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Neuroimaging
Tim D. van Balkom, Odile A. van den Heuvel, Henk W. Berendse, Ysbrand D. van der Werf, Chris Vriend
Summary: This study investigated the effects of cognitive training on brain network connectivity and topology in Parkinson's disease. The results showed that eight weeks of computerized cognitive training did not have significant effects on the overall brain network, but there were localized connectivity changes in key regions involved in cognitive function.
NEUROIMAGE-CLINICAL
(2022)
Review
Clinical Neurology
Sophie M. D. D. Fitzsimmons, Ysbrand D. van der Werf, A. Dilene van Campen, Martijn Arns, Alexander T. Sack, Adriaan W. Hoogendoorn, Odile A. van den Heuvel
Summary: This study evaluated the efficacy and safety of repetitive transcranial magnetic stimulation (rTMS) for obsessive-compulsive disorder (OCD) and ranked the relative efficacy of different stimulation protocols. The results showed that rTMS is effective for OCD compared to sham stimulation. Different stimulation protocols, such as low frequency right dorsolateral prefrontal cortex (dlPFC) stimulation, high frequency bilateral dlPFC stimulation, and low frequency pre-supplementary motor area (preSMA) stimulation, were all found to be efficacious. However, further studies are needed to explore the relative merits of these protocols.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Tim D. van Balkom, Henk W. Berendse, Ysbrand D. van der Werf, Jos W. R. Twisk, Carel F. W. Peeters, Adriaan W. Hoogendoorn, Rob H. Hagen, Tanja Berk, Odile A. van den Heuvel, Chris Vriend
Summary: This study found no beneficial effect of eight-week computerized cognitive training on the primary outcome (planning accuracy) and only minor improvements on secondary outcomes (processing speed) with limited clinical impact.
PARKINSONISM & RELATED DISORDERS
(2022)
Review
Obstetrics & Gynecology
N. N. Schonewille, N. Rijkers, A. Berenschot, J. G. Lijmer, O. A. van den Heuvel, B. F. P. Broekman
Summary: Psychiatric vulnerability is associated with an increased risk of unintended pregnancies. However, there is a lack of research on this topic, and the quality of existing studies is relatively low. The findings suggest that women with psychiatric vulnerability have a higher risk of unintended pregnancies.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Clinical Neurology
Nina C. M. Schmitz, Ysbrand D. van der Werf, Heidi M. Lammers-van der Holst
Summary: Sleep and circadian rhythms are closely linked to the immune system and vaccination success. Lack of sleep and poor sleep quality can increase vulnerability, while sleep duration and timing may affect antibody response after vaccination. It is recommended to have at least 7 hours of sleep every night to reduce infection risk and optimize vaccine efficacy.
