Article
Immunology
Harriet N. Garlant, Kalaiarasan Ellappan, Matthew Hewitt, Prem Perumal, Simon Pekeleke, Nadina Wand, Jo Southern, Saka Vinod Kumar, Harish Belgode, Ibrahim Abubakar, Sanjeev Sinha, Seshadri Vasan, Noyal Mariya Joseph, Karen E. Kempsell
Summary: Tuberculosis (TB) is a major global health crisis and the leading cause of death among infectious diseases. The diagnosis of TB is challenging and hinders its control and eradication. This study evaluates the diagnostic performance of nine biomarkers as protein targets in TB diagnosis. Some of these biomarkers show great potential for developing diagnostic tests for TB.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Polymer Science
Zahra Balzade, Farhad Sharif, Seyed Reza Ghaffarian Anbaran
Summary: Polyolefins play a crucial role in the polymer industry due to their low-cost monomers and established production processes. Recent advancements in direct and tandem copolymerization strategies have provided opportunities for developing polyolefins bearing polar groups with unique architectures and properties. The future applications of polar olefin copolymers include biomedical materials, catalysts, energy storage devices, and conductive polymers, opening up new avenues for academic research and industrial product development.
Article
Biology
Benzhe Su, Xiaoxiao Wang, Yang Ouyang, Xiaohui Lin
Summary: In this study, a novel omics data analysis method called DA-SRN was proposed to identify potential biomarkers and predict sample categories. The method defines informative features and a sample reference network, optimizes the network structure using genetic algorithm, and labels samples based on graph neural network, reference network, and selected informative features. Experimental results showed that DA-SRN outperformed other methods in terms of AUROC, sensitivity, specificity, and AUPRC in most cases.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Yi Zhang, Qi An, Shuting Zhang, Zequn Ma, Xiantong Hu, Mengchun Feng, Yihe Zhang, Yantao Zhao
Summary: Developing a novel antibiotics-free antibacterial strategy is crucial in preventing bacterial resistance. In this study, a piezoelectrically active antibacterial device was developed, inspired by chemical conversion processes in living organisms. This device successfully converts ambient O-2 and H2O to reactive oxygen species (ROS) through piezocatalytic processes, exhibiting high sterilizing rates and promoting wound healing.
Article
Chemistry, Analytical
Estefania Nunez-Carmona, Marco Abbatangelo, Veronica Sberveglieri
Summary: This study analyzed the volatile compounds of three major types of tea using different technologies and methods, providing a competitive tool to enhance product quality. The results demonstrate the potential of an innovative remote controllable technology supported by machine learning to increase food safety along the entire production chain.
Review
Materials Science, Multidisciplinary
Ritesh Kumar, Ipsita Pattanayak, Pragyan Aparajita Dash, Smita Mohanty
Summary: Since the second half of the 20th century, bioceramics have been widely used in tissue engineering as a substitute for hard tissue. With their excellent properties such as mechanical strength, biocompatibility, chemical stability, corrosion resistance, and wear resistance, bioceramic scaffolds play a vital role in tissue regeneration. This review provides a comprehensive insight into the classification, properties, degradation pathway, product development, and applications of bioceramics in tissue engineering.
JOURNAL OF MATERIALS SCIENCE
(2023)
Article
Chemistry, Physical
Bilal Fareed, Farooq Sher, Saba Sehar, Tahir Rasheed, Fatima Zafar, Mariam Ameen, Eder C. Lima
Summary: This study aimed to mitigate FCC using zeolite-Y and its modified forms, such as HZ-Y, ALZ-Y, and ALHZ-Y. By investigating the catalytic activities of these materials at high temperatures, lighter fractions of heavy diesel were obtained. Zeolite-Y and its modified forms showed conversion yields of 90.45%, 15%, and 14.36% respectively, indicating their potential for producing light oil.
Article
Genetics & Heredity
Maolin Yao, Lanyi Fu, Xuedong Liu, Dong Zheng
Summary: CALM1 is found to be highly expressed in most cancers and regulated by DNA methylation. It is associated with immune infiltration and has diagnostic and prognostic potential. CALM1 expression is an independent risk factor for overall survival and a newly developed nomogram shows higher clinical value. Additionally, elevated CALM1 expression contributes to the activation of cancer-related pathways.
FRONTIERS IN GENETICS
(2022)
Review
Biochemistry & Molecular Biology
Niousha Djahanpour, Naiyara Ahsan, Ben Li, Hamzah Khan, Kim Connelly, Howard Leong-Poi, Mohammad Qadura
Summary: This literature review summarizes the role of interleukins (ILs) in peripheral artery disease (PAD). The results show that several pro-inflammatory ILs are positively correlated with PAD diagnosis and progression, while anti-inflammatory ILs are protective against PAD. IL-6 and IL-8 are considered the most strongly associated biomarkers for PAD.
Article
Chemistry, Medicinal
Marjan Majdinasab, Mihaela Badea, Jean Louis Marty
Summary: The lateral flow assay (LFA) is a widely used paper-based platform for rapid and on-site detection of various analytes. While antibodies are traditionally used in LFAs, they have limitations such as poor stability and high cost, making aptamers a promising alternative for biorecognition molecules in LFAs.
Article
Medicine, Research & Experimental
Yu Miao, Yosuke Konno, Baojin Wang, Lin Zhu, Tianyue Zhai, Kei Ihira, Noriko Kobayashi, Hidemichi Watari, Xin Jin, Junming Yue, Peixin Dong, Mingyan Fang
Summary: This study comprehensively investigated the expression and clinical significance of cancer-testis antigens (CTAs) in endometrial cancer (EC). The TTK gene was found to be overexpressed in EC and associated with lower survival rates. TTK could accurately distinguish early stage EC and may serve as a potential biomarker for early detection. Further research revealed the role of TTK in promoting chemoresistance and epithelial-mesenchymal transition (EMT) in EC cells.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Metallurgy & Metallurgical Engineering
Sebastian Riehm, Vera Friederici, Sandra Wieland, Yuanbin Deng, Simone Herzog, Anke Kaletsch, Christoph Broeckmann
Summary: The combination of Additive Manufacturing and Hot Isostatic Pressing technology has great potential for industrial applications, allowing for the production of functional composite components with precise shapes. By optimizing the geometry design, a manufacturing process is created which unites the advantages of both approaches and opens up new opportunities for the field of industrial manufacturing.
Article
Immunology
Neda H. Bidoki, Kristy A. Zera, Huda Nassar, Lauren L. Drag, Michael Mlynash, Elizabeth Osborn, Muhith Musabbir, Da Eun Kim, Maria Paula Mendez, Maarten G. Lansberg, Nima Aghaeepour, Marion S. Buckwalter
Summary: This study used proteomics and machine learning to investigate the relationship between plasma protein data and mood in chronic stroke patients. While no single protein or set of proteins could predict mood at an individual level, analysis of proteins associated with mood allowed the development of a model for chronic post-stroke depression. The study also revealed an overactive immune system in chronic post-stroke depression.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Oncology
Junjie Ao, Tetsuhiro Chiba, Hiroaki Kanzaki, Kengo Kanayama, Shuhei Shibata, Akane Kurosugi, Terunao Iwanaga, Motoyasu Kan, Takafumi Sakuma, Na Qiang, Yaojia Ma, Ryuta Kojima, Yuko Kusakabe, Masato Nakamura, Kazufumi Kobayashi, Soichiro Kiyono, Naoya Kanogawa, Tomoko Saito, Ryo Nakagawa, Takayuki Kondo, Sadahisa Ogasawara, Eiichiro Suzuki, Shingo Nakamoto, Ryosuke Muroyama, Akinobu Tawada, Jun Kato, Tatsuo Kanda, Hitoshi Maruyama, Naoya Kato
Summary: The study aimed to investigate the potential of Ang2 as a diagnostic and prognostic biomarker in HCC, finding its serum levels weakly correlated with AFP and DCP, with high specificity and comparability, and potential diagnostic value in patients with normal AFP and DCP levels. Additionally, high serum Ang2 levels were associated with poor prognosis and shorter recurrence-free survival in HCC patients.
Article
Geriatrics & Gerontology
Chongyi Zhao, Meiling Chen, Zhiyong Ding, Chunyan Liu, Xiaomei Wu
Summary: Alzheimer's disease (AD) is a common neurodegenerative disorder causing dementia in the elderly population. This study used a new method to directly quantify functional disconnections in AD patients and found decreased functional connections in certain brain regions compared to healthy controls. The changes in functional connections were closely associated with cognitive performance and could serve as effective biomarkers for distinguishing AD patients from healthy individuals.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Review
Neurosciences
Maya Jammoul, Dareen Jammoul, Kevin K. Wang, Firas Kobeissy, Ralph G. Depalma
Summary: This article reviews the possible mechanisms by which traumatic brain injury (TBI) may stimulate the development of opioid use disorder (OUD) and discusses the interaction between these two processes. CNS damage due to TBI appears to drive adverse effects of subsequent OUD, with pain being a risk factor for opioid use after TBI.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Danusa Mar Arcego, Jan-Paul Buschdorf, Nicholas O'Toole, Zihan Wang, Barbara Barth, Irina Pokhvisneva, Nirmala Arul Rayan, Sachin Patel, Euclides Jose de Mendonca Filho, Patrick Lee, Jennifer Tan, Ming Xuan Koh, Chu Ming Sim, Carine Parent, Randriely Merscher Sobreira de Lima, Andrew Clappison, Kieran J. O'Donnell, Carla Dalmaz, Janine Arloth, Nadine Provencal, Elisabeth B. Binder, Josie Diorio, Patricia Pelufo Silveira, Michael J. Meaney
Summary: This study investigates the impact of environmental influences on mental health by integrating transcriptomic data from animal models with human data. The results suggest that hippocampal glucocorticoid-related transcriptional activity mediates the effects of early adversity on neural mechanisms implicated in psychiatric disorders.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Milenna T. van Dijk, Ardesheer Talati, Pratik Kashyap, Karan Desai, Nora C. Kelsall, Marc J. Gameroff, Natalie Aw, Eyal Abraham, Breda Cullen, Jiook Cha, Christoph Anacker, Myrna M. Weissman, Jonathan Posner
Summary: This study found that maternal stress is associated with future depressive symptoms and alterations in microstructure of the dentate gyrus (DG) in offspring. These results were consistent across two independent cohorts.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Josephine C. McGowan, Liliana R. Ladner, Claire X. Shubeck, Juliana Tapia, Christina T. LaGamma, Amanda Anqueira-Gonzalez, Ariana DeFrancesco, Briana K. Chen, Holly C. Hunsberger, Ezra J. Sydnor, Ryan W. Logan, Tzong-Shiue Yu, Steven G. Kernie, Christine A. Denny
Summary: Traumatic brain injury (TBI) leads to fear generalization by altering fear memory traces, and this symptom can be improved with (R,S)-ketamine.
BIOLOGICAL PSYCHIATRY
(2024)