Article
Psychology, Clinical
E. Martin, C. T. Dourish, R. Hook, S. R. Chamberlain, S. Higgs
Summary: The study found that symptoms of ADHD and impulsivity are associated with disordered eating, and depression plays a mediating role in this relationship.
PSYCHOLOGICAL MEDICINE
(2022)
Review
Nutrition & Dietetics
Javier C. Vazquez, Ona Martin de la Torre, Judit Lopez Palome, Diego Redolar-Ripoll
Summary: Research has shown that caffeine treatment can increase attention and improve learning, memory, and olfactory discrimination without affecting blood pressure and body weight. However, the role of caffeine in modulating ADHD-like symptoms is contradictory, requiring further clarification.
Article
Psychiatry
Rebeca Mejias, Juan J. Rodriguez-Gotor, Minae Niwa, Irina N. Krasnova, Abby Adamczyk, Mei Han, Gareth M. Thomas, Zheng-Xiong Xi, Richard L. Huganir, Mikhail Pletnikov, Akira Sawa, Jean-Lud Cadet, Tao Wang
Summary: This study explores the role of zdhhc15 gene in novelty-seeking behaviors and impulsivity by using knockout mice as experimental models. The research reveals that the absence of zdhhc15 gene may lead to elevated locomotion and extracellular dopamine levels in response to novel environments, suggesting a novel regulatory mechanism of dopamine in the striatum.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Yuichi Hiraoka, Kaori Sugiyama, Daiki Nagaoka, Iku Tsutsui-Kimura, Kenji F. Tanaka, Kohichi Tanaka
Summary: Research suggests that glutamatergic dysfunction due to GLT1 deficiency is a potential mechanism underlying ADHD-like symptoms, distinct from the dopamine deficit hypothesis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Psychiatry
Mariah K. Evans, Jeremy L. Grove, Tapan A. Patel, Molly Gromatsky, Patrick S. Calhoun, Jean C. Beckham, Nathan A. Kimbrel
Summary: This study aimed to explore the association between attention-deficit/hyperactivity disorder (ADHD) symptoms and nonsuicidal self-injury (NSSI) in veterans. Contrary to hypotheses, adult ADHD symptoms were not associated with NSSI history or disorder. Instead, disorders characterized by negative affect may have greater utility for predicting NSSI.
PSYCHIATRY RESEARCH
(2022)
Article
Psychology, Developmental
Ayoze Gonzalez-Hernandez, Andres Cano-Yepes, Victoria Sainz de Aja-Curbelo, Ruyman Santana-Farre, Teresa Rodriguez-Sosa, Fernando Cabrera-Naranjo
Summary: This study aims to determine whether there is a higher prevalence of ADHD symptoms or impulsivity in patients with episodic migraine. The results showed that adults with migraine have a higher occurrence of ADHD symptoms. This should be taken into consideration when assessing these patients.
JOURNAL OF ATTENTION DISORDERS
(2023)
Article
Psychology, Multidisciplinary
Shaikh I. Ahmad, Jocelyn I. Meza, Maj-Britt Posserud, Erlend J. Brevik, Stephen P. Hinshaw, Astri J. Lundervold
Summary: The study found differential associations between childhood hyperactive/impulsive and inattention symptoms and adolescent peer problems across two diverse samples using a shared methodology. Higher levels of childhood hyperactive/impulsive symptoms independently predicted adolescent peer problems in the all-female clinical sample, while higher levels of inattention symptoms independently predicted preadolescent peer problems in the mixed-sex population sample. Associations between ADHD symptom dimensions and peer problems within the Norwegian sample were not moderated by child sex.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Clinical Neurology
Cibele E. Bandeira, Eugenio H. Grevet, Renata B. Cupertino, Maria E. de Araujo Tavares, Clara S. Gusmao, Djenifer B. Kappel, Eduardo S. Vitola, Felipe A. Picon, Luis A. Rohde, Bruna S. da Silva, Claiton H. D. Bau, Diego L. Rovaris
Summary: ADHD is associated with smaller brain volumes in subcortical regions and cortical surface area, with greater impact in children than adults. Dysregulation of the HPA axis is also linked to ADHD. Variations in the NR3C1 gene may partly explain the unclear relationship between brain structures and ADHD in adults.
JOURNAL OF NEURAL TRANSMISSION
(2021)
Review
Psychiatry
Andrea Mckenzie, Shakila Meshkat, Leanna M. W. Lui, Roger Ho, Joshua D. Di Vincenzo, Felicia Ceban, Bing Cao, Roger S. McIntyre
Summary: Psychostimulants have shown to improve certain aspects of cognition in individuals with ADHD, particularly in attention and memory. However, the efficacy of psychostimulants in other cognitive domains remains inconclusive.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Psychiatry
Barbara D. Fontana, Florian Reichmann, Ceinwen A. Tilley, Perrine Lavlou, Alena Shkumatava, Nancy Alnassar, Courtney Hillman, Karl aegir Karlsson, William H. J. Norton, Matthew O. Parker
Summary: Externalizing disorders (ED) are a public health concern and have a high heritability. The ADGRL3 gene is strongly associated with EDs and affects various ED-related behaviors. This study found that adgrl3.1(-/-) zebrafish exhibited impulsive, risk-taking, attention deficits, and hyperactive behaviors, which could be rescued by atomoxetine. Transcriptomic analysis revealed potential functional pathways and targets for the treatment of ED.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yingqian Chen, Shu Su, Yan Dai, Mengsha Zou, Liping Lin, Long Qian, Qin Zhou, Hongyu Zhang, Meina Liu, Jing Zhao, Zhiyun Yang
Summary: This study used quantitative susceptibility mapping (QSM) technique to compare the iron deposition in the whole brain between attention-deficit/hyperactivity disorder (ADHD) patients and typically developing (TD) children. The results showed iron deficiency in several brain regions of children with ADHD, including bilateral striatums, anterior cingulum, olfactory gyrus, and right lingual gyri. Further correlation analysis revealed a positive correlation between the severity of symptoms and the left anterior cingulum.
EUROPEAN RADIOLOGY
(2022)
Article
Psychology, Multidisciplinary
Morgan M. Grotewiel, Megan E. Crenshaw, Amelia Dorsey, Elizabeth Street
Summary: Hyperfocus and flow are intense concentration experiences associated with reduced perception of irrelevant stimuli and improved task performance. Hyperfocus has been historically seen as a symptom of ADHD, autism, or schizophrenia, while flow is regarded as an enjoyable experience in positive psychology. Recent studies suggest that hyperfocus and flow may be the same phenomenon viewed from different perspectives.
CURRENT PSYCHOLOGY
(2023)
Review
Clinical Neurology
F. M. Villa, A. Crippa, E. Rosi, M. Nobile, P. Brambilla, G. Delvecchio
Summary: ADHD is a common neurodevelopmental disorder characterized by overactivity, inattention, and impulsivity. Recent studies have found that 20% of children with ADHD also develop eating disorders, such as anorexia nervosa, bulimia nervosa, and binge eating disorder. However, the association between ADHD and eating disorders during childhood and adolescence is not yet well understood.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Multidisciplinary Sciences
Ruben van den Bosch, Britt Lambregts, Jessica Maatta, Lieke Hofmans, Danae Papadopetraki, Andrew Westbrook, Robbert-Jan Verkes, Jan Booij, Roshan Cools
Summary: Psychostimulants like methylphenidate have varying effects on cognitive enhancement, which depend on baseline striatal dopamine levels and corticostriatal gating of reward/punishment-related representations in sensory cortex. Methylphenidate can improve attention and reward learning, but the mechanisms behind these effects are still unclear.
NATURE COMMUNICATIONS
(2022)
Article
Psychology, Developmental
Emily A. Rosenthal, Hannah C. Broos, Kiara R. Timpano, Sheri L. Johnson
Summary: Attention-Deficit/Hyperactivity Disorder (ADHD) is associated with emotion dysregulation, and this study found that the symptoms of inattention and hyperactivity/impulsivity are related to different facets of emotion-related impulsivity (ERI).
JOURNAL OF ATTENTION DISORDERS
(2023)
Article
Biochemistry & Molecular Biology
Mohammad B. Haskali, Peter D. Roselt, Terence J. O'Brien, Craig A. Hutton, Idrish Ali, Lucy Vivash, Bianca Jupp
Summary: This study investigates the use of late-stage copper-mediated radiofluorination of aryl stannanes to improve the production of clinically suitable [F-18]FMZ 1. Mass spectrometry was used to identify the chemical by-products that were produced under the reaction conditions. The fully automated synthesis of [F-18]FMZ 1 using the iPhase FlexLab radiochemistry module yielded a high radiochemical purity and molar activity.
Article
Biochemistry & Molecular Biology
Valtteri Kaasinen, Emma A. Honkanen, Kari Lindholm, Elina Jaakkola, Joonas Majuri, Riitta Parkkola, Tommi Noponen, Tero Vahlberg, Valerie Voon, Luke Clark, Juho Joutsa, Marko Seppanen
Summary: Gambling disorder is a major public health issue, and it shares similarities with substance use disorders in terms of the role of brain monoamines in addiction susceptibility and outcome. The study used [I-123]FP-CIT SPECT imaging to assess the roles of striatal dopamine transporter binding and extrastriatal serotonin transporter binding in gambling disorder, and found that patients with gambling disorder had higher impulsivity scores and higher binding in the ventromedial prefrontal cortex, likely reflecting serotonin transporter activity.
Article
Neurosciences
Katharina Zuhlsdorff, Jeffrey W. Dalley, Trevor W. Robbins, Sharon Morein-Zamir
Summary: Behavioral and cognitive flexibility enable individuals to adapt to a changing environment. This study introduces a novel "change your mind task" to assess volitional switching under uncertainty, without the need for rule-based learning. The findings suggest that individuals are more likely to change their response when the feedback is negative or when their initial response is incorrect.
Article
Neurosciences
Nana Feng, Lena Palaniyappan, Trevor W. Robbins, Luolong Cao, Shuanfeng Fang, Xingwei Luo, Xiang Wang, Qiang Luo
Summary: Impaired working memory (WM) is a core dysfunction in schizophrenia, characterized by deficits in both attention and WM processing. Patients show linear modulation of brain activation in frontoparietal and dorsal attention networks, while controls exhibit an inverted U-shaped response pattern in the left anterior cingulate cortex. These modulation effects are associated with gene expressions related to the dopamine neurotransmitter system.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Psychology, Clinical
Jonathan W. Kanen, Qiang Luo, Mojtaba Rostami Kandroodi, Rudolf N. Cardinal, Trevor W. Robbins, David J. Nutt, Robin L. Carhart-Harris, Hanneke E. M. den Ouden
Summary: The study aimed to investigate how LSD affects probabilistic reversal learning in healthy individuals. The results showed that LSD increased the reward and punishment learning rates, decreased stimulus stickiness, and induced a state of heightened plasticity.
PSYCHOLOGICAL MEDICINE
(2023)
Review
Neurosciences
Olivia Stupart, Trevor W. Robbins, Jeffrey W. Dalley
Summary: The meta-analysis showed that unconditioned tasks are generally poor at consistently demonstrating differences between control and separated groups in rats, indicating the need for more objective tasks in translational research on stress-related disorders.
PSYCHOPHARMACOLOGY
(2023)
Article
Clinical Neurology
Roxanne W. Hook, Masanori Isobe, George Savulich, Jon E. Grant, Konstantinos Ioannidis, David Christmas, Barbara J. Sahakian, Trevor W. Robbins, Samuel R. Chamberlain
Summary: This study found that single-dose istradefylline can impact human cognition, particularly in the social information preference task with emotional loading. This indicates the under-studied role of the adenosine neurochemical system in human cognition, which requires further exploration.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Psychiatry
Michal M. Graczyk, Barbara J. Sahakian, Trevor W. Robbins, Karen D. Ersche
Summary: Not everyone who uses drugs loses control over their intake, which is a hallmark of addiction. Although familial risk studies suggest significant addiction heritability, the genetic basis of vulnerability to drug addiction remains largely unknown. In this study, the researchers examined the relationship between self-control, cocaine use, and a specific gene variant (rs36024) associated with the noradrenaline transporter gene. They found that individuals carrying the C-allele of this gene exhibited impaired self-control, particularly in the context of chronic cocaine use. Patients with cocaine use disorder who had the CC genotype showed longer stop-signal reaction time and fewer successful stops compared to healthy controls and patients with the TT genotype. These findings suggest that rs36024 may be a potential genetic vulnerability marker for cocaine addiction.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Neurosciences
Yi-Jie Zhao, Yingying Zhang, Qianfeng Wang, Luis Manssuer, Hailun Cui, Qiong Ding, Bomin Sun, Wenjuan Liu, Valerie Voon
Summary: This study reveals impairments in uncertainty processing in obsessive-compulsive disorder, especially in more certain trials. It also indicates that neural differentiation of high and low uncertainty is compromised and uncertainty processing may be a trait cognitive endophenotype. This has important implications for the treatment and management of individuals with OCD.
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2023)
Article
Clinical Neurology
Linbin Wang, Jun Li, Yixin Pan, Peng Huang, Dianyou Li, Valerie Voon
Summary: This study evaluated the subacute effect of bilateral ventral subthalamic nucleus stimulation at 10Hz on emotional processing in Parkinson's disease patients. The results showed that 10Hz stimulation increased arousal ratings in patients with higher depression scores and induced a positive shift in valence ratings to negative emotional stimuli in patients with lower apathy scores. In contrast, 130Hz stimulation led to reduced arousal ratings in all patients and more positive valence ratings in patients with higher apathy scores.
Biographical-Item
Neurosciences
Barbara J. Sahakian, Eileen M. Joyce, Trevor W. Robbins
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Nace Mikus, Christoph Eisenegger, Christoph Mathys, Luke Clark, Ulrich Mueller, Trevor W. Robbins, Claus Lamm, Michael Naef
Summary: The study investigates the impact of the D2/D3 dopamine receptor antagonist sulpiride on learning about other people's prosocial attitudes. The results show that sulpiride increases the volatility of beliefs, leading to higher precision weights on prediction errors. This effect is more significant in participants with genetically conferred higher dopamine availability and remains even after controlling for working memory performance. The findings demonstrate the importance of D2 receptors in regulating belief updating in a social context.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Marjan Biria, Paula Banca, Mairead P. Healy, Engin Keser, Stephen J. Sawiak, Christopher T. Rodgers, Catarina Rua, Ana Maria Frota Lisboa Pereira de Souza, Aleya A. Marzuki, Akeem Sule, Karen D. Ersche, Trevor W. Robbins
Summary: Little is known about the neurochemical basis of compulsive behavior. This study uses proton magnetic resonance spectroscopy to examine glutamate and GABA levels in the anterior cingulate cortex and supplementary motor area of healthy volunteers and individuals with OCD. The results show that glutamate levels in the supplementary motor area are related to compulsive behavior, while glutamate and GABA levels in the anterior cingulate cortex are associated with habitual control. This study provides insights into the neural mechanisms underlying compulsive behavior.
NATURE COMMUNICATIONS
(2023)
Article
Neurosciences
Shitong Xiang, Tianye Jia, Chao Xie, Zhichao Zhu, Wei Cheng, Gunter Schumann, Trevor W. Robbins, Jianfeng Feng
Summary: How to retrieve latent neurobehavioural processes from complex neurobiological signals is a challenge that has not been fully addressed. This study presents a novel approach, DeCoP, that outperforms traditional decoding methods in terms of false inference and robustness. The research reveals distinct evaluation and readiness processes during reward/punishment anticipation, modulated by different dopamine systems. Only a few brain regions encode exact input information, while others encode abstract information.
Review
Neurosciences
Maya Jammoul, Dareen Jammoul, Kevin K. Wang, Firas Kobeissy, Ralph G. Depalma
Summary: This article reviews the possible mechanisms by which traumatic brain injury (TBI) may stimulate the development of opioid use disorder (OUD) and discusses the interaction between these two processes. CNS damage due to TBI appears to drive adverse effects of subsequent OUD, with pain being a risk factor for opioid use after TBI.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Danusa Mar Arcego, Jan-Paul Buschdorf, Nicholas O'Toole, Zihan Wang, Barbara Barth, Irina Pokhvisneva, Nirmala Arul Rayan, Sachin Patel, Euclides Jose de Mendonca Filho, Patrick Lee, Jennifer Tan, Ming Xuan Koh, Chu Ming Sim, Carine Parent, Randriely Merscher Sobreira de Lima, Andrew Clappison, Kieran J. O'Donnell, Carla Dalmaz, Janine Arloth, Nadine Provencal, Elisabeth B. Binder, Josie Diorio, Patricia Pelufo Silveira, Michael J. Meaney
Summary: This study investigates the impact of environmental influences on mental health by integrating transcriptomic data from animal models with human data. The results suggest that hippocampal glucocorticoid-related transcriptional activity mediates the effects of early adversity on neural mechanisms implicated in psychiatric disorders.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Milenna T. van Dijk, Ardesheer Talati, Pratik Kashyap, Karan Desai, Nora C. Kelsall, Marc J. Gameroff, Natalie Aw, Eyal Abraham, Breda Cullen, Jiook Cha, Christoph Anacker, Myrna M. Weissman, Jonathan Posner
Summary: This study found that maternal stress is associated with future depressive symptoms and alterations in microstructure of the dentate gyrus (DG) in offspring. These results were consistent across two independent cohorts.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Josephine C. McGowan, Liliana R. Ladner, Claire X. Shubeck, Juliana Tapia, Christina T. LaGamma, Amanda Anqueira-Gonzalez, Ariana DeFrancesco, Briana K. Chen, Holly C. Hunsberger, Ezra J. Sydnor, Ryan W. Logan, Tzong-Shiue Yu, Steven G. Kernie, Christine A. Denny
Summary: Traumatic brain injury (TBI) leads to fear generalization by altering fear memory traces, and this symptom can be improved with (R,S)-ketamine.
BIOLOGICAL PSYCHIATRY
(2024)