Article
Neurosciences
Marion Psomiades, Marine Mondino, Filipe Galvao, Nathalie Mandairon, Mikail Nourredine, Marie-Francoise Suaud-Chagny, Jerome Brunelin
Summary: This study found that the level of mature BDNF (mBDNF) is associated with the efficacy of electroconvulsive therapy (ECT) for patients with treatment-resistant depression. Patients with higher baseline mBDNF levels were more likely to achieve remission after ECT sessions.
Article
Neurosciences
Pingping Tan, Ting Xue, Yue Wang, Zhichao Hu, Jianbin Su, Rongrong Yang, Jianlin Ji, Minxiu Ye, Zhuo Chen, Chao Huang, Xu Lu
Summary: The abnormal increase of NR6A1 in the hippocampus impairs the CREB-BDNF signaling cascade, leading to the development of depression-like behaviors. Genetic knockdown of NR6A1 can prevent stress-induced depression-like behaviors.
Article
Immunology
Xu Lu, Huijun Liu, Zixuan Cai, Zhichao Hu, Minxiu Ye, Yue Gu, Yue Wang, Dan Wang, Qun Lu, Zhongxia Shen, Xinhua Shen, Chao Huang
Summary: Depressed mice have lower numbers of microglia in the dentate gyrus. Reversing this decline with a single low dose of lipopolysaccharide has antidepressant effects. The antidepressant effect is related to the synthesis and signaling pathway of brain-derived neurotrophic factor.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Biochemistry & Molecular Biology
Danielle M. Diniz, Francesca Calabrese, Paola Brivio, Marco A. Riva, Joanes Grandjean, Judith R. Homberg
Summary: BDNF plays a crucial role in neuroplasticity, vulnerability and resilience to stress-related disorders. Modulation of BDNF levels in the ventral hippocampus of SERT-/- rats led to positive behavioral outcomes, suggesting BDNF upregulation as a potential target for new therapeutic approaches in improving depressive symptoms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Rongjun Liu, Daofan Sun, Xiuzhong Xing, Qingge Chen, Bo Lu, Bo Meng, Hui Yuan, Lan Mo, Liufang Sheng, Jinwei Zheng, Qiusheng Wang, Junping Chen, Xiaowei Chen
Summary: The coexistence of pain and depression is frequently observed in patients with chronic pain and depression. Oxytocin, a neuropeptide, has been reported to relieve chronic pain and depressive symptoms. This study investigated the effect of intranasal oxytocin on neuropathic pain and comorbid depressive symptoms, and found that oxytocin attenuated depression-like behavior but did not alleviate mechanical hyperalgesia. The results suggest that intranasal oxytocin may have the potential to treat depressive symptoms in neuropathic pain patients.
Article
Clinical Neurology
Emi Nakamura-Maruyama, Risa Kai, Naoyuki Himi, Naohiko Okabe, Kazuhiko Narita, Tetsuji Miyazaki, Shozo Aoki, Osamu Miyamoto
Summary: This study found that the protein expressions of RyR1 and RyR3 significantly increased in the hippocampus of mouse models with depression-like symptoms, and ECS therapy could attenuate this increase and improve depression symptoms. However, pre-injection with RyRs blocker dantrolene reduced the antidepressant effects of ECS.
Review
Psychiatry
Shakila Meshkat, Yazen Alnefeesi, Muhammad Youshay Jawad, Joshua D. Di Vincenzo, Nelson B. Rodrigues, Felicia Ceban, Leanna M. W. Lui, Roger S. McIntyre, Joshua D. Rosenblat
Summary: This synthesis study found that TRD treatments can affect peripheral BDNF levels, but changes in peripheral BDNF levels are not significantly associated with antidepressant effects.
PSYCHIATRY RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Yuanyuan Zhang, Yong Luo, Xuenan Hou, Kang Lu, Yanhong He, Baoying Yang, Yi Qin
Summary: This study explored the effect of Xiaoyao Powder (XYP) on depression induced by chronic unpredictable mild stress (CUMS) and its underlying mechanisms. The results showed that XYP supplementation significantly reduced CUMS-induced hippocampal damage and elevated corticosterone levels. The protective effect of XYP on hippocampal neurons in CUMS-induced depression model rats was realized by up-regulating the Cx43/GR/BDNF axis.
Article
Biochemistry & Molecular Biology
Di Qu, Zichen Ye, Wenli Zhang, Bing Dai, Guo Chen, Li Wang, Xiaolong Shao, An Xiang, Zifan Lu, Juan Shi
Summary: Depression is a global disease that has a significant impact on human health. Neuroinflammation and disturbance of glutamate metabolism in brain regions, such as the hippocampus, are important factors in the development of depression. The study found that cyanidin chloride has antidepressant effects in an LPS-induced depression model by reducing hippocampal inflammation, improving function, and attenuating induced damage.
ACS CHEMICAL NEUROSCIENCE
(2022)
Article
Psychiatry
Krzysztof Gbyl, Mette Marie Stottrup, Jayachandra Mitta Raghava, Song Xue Jie, Poul Videbech
Summary: Temporary increases in hippocampal subregions volume induced by ECT within patients are associated with memory impairment. Hippocampal alterations following ECT should be a focus in investigating the causes of cognitive side effects.
ACTA PSYCHIATRICA SCANDINAVICA
(2021)
Article
Neurosciences
Emily T. Cowan, Matthew Fain, Ian O'Shea, Lauren M. Ellman, Vishnu P. Murty
Summary: The study shows that novelty has an impact on brain circuits, particularly the interactions between the hippocampal-VTA circuit and cortical networks. Following exposure to novelty, functional coupling is enhanced between the right anterior hippocampus and VTA, with distinct patterns of post-novelty functional coupling enhancements observed in the anterior hippocampus and VTA, targeting task-relevant regions and large-scale networks respectively.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Behavioral Sciences
Yufang Si, Xing Xue, Si Liu, Caixia Feng, Huiping Zhang, Sisi Zhang, Yating Ren, Hengyu Ma, Yankai Dong, Hui Li, Longshan Xie, Zhongliang Zhu
Summary: Prenatal stress can lead to depression-like behavior in offspring, with the involvement of CRTC1 signaling. The aberration in CRTC1 expression and/or phosphorylation activity may play a vital role in the manifestation of depression-like behavior in prenatally stressed offspring rats.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Behavioral Sciences
Xiaoju Wang, Peng Xia, Jiulong Song, Ting Yang, Changjun Yu, Kai Cheng, Anliang Chen, Xueping Li
Summary: CES improves depression-like behavior of PSD rats through upregulation of GPX4-mediated BDNF expression in the hippocampus.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Geriatrics & Gerontology
Nina E. Baumgartner, Katelyn L. Black, Shannon M. McQuillen, Jill M. Daniel
Summary: Both previous and continuous midlife estradiol treatment can increase levels of nuclear ER alpha in the hippocampus, impacting gene expression and protein levels related to estrogen effects on memory, indicating a long-lasting regulatory role of hippocampal ER alpha in memory.
NEUROBIOLOGY OF AGING
(2021)
Article
Neurosciences
Ye Li, Cuiqin Fan, Rui Gao, Tian Lan, Wenjing Wang, Shu Yan Yu
Summary: The study reveals that altered levels of miR-211-5p in the hippocampal DG area have a significant impact on neurogenesis, apoptosis, and depression-like behaviors in rats. Specifically, up-regulation of miR-211-5p can alleviate depression-like behaviors, reduce neuronal apoptosis, and promote neuronal regeneration; while down-regulation of miR-211-5p can induce depression-like behaviors, increase neuronal apoptosis, and decrease neuronal regeneration.
Article
Biochemistry & Molecular Biology
M. J. A. G. Henckens, Y. Printz, U. Shamgar, J. Dine, M. Lebow, Y. Drori, C. Kuehne, A. Kolarz, M. Eder, J. M. Deussing, N. J. Justice, O. Yizhar, A. Chen
MOLECULAR PSYCHIATRY
(2017)
Review
Behavioral Sciences
M. Engel, A. Chen
GENES BRAIN AND BEHAVIOR
(2018)
Article
Biochemistry & Molecular Biology
N. Dedic, M. L. Poehlmann, J. S. Richter, D. Mehta, D. Czamara, M. W. Metzger, J. Dine, B. T. Bedenk, J. Hartmann, K. V. Wagner, A. Jurik, L. M. Almli, A. Lori, S. Moosmang, F. Hofmann, C. T. Wotjak, G. Rammes, M. Eder, A. Chen, K. J. Ressler, W. Wurst, M. V. Schmidt, E. B. Binder, J. M. Deussing
MOLECULAR PSYCHIATRY
(2018)
Article
Neurosciences
Assaf Ramot, Zhiying Jiang, Jin-Bin Tian, Tali Nahum, Yael Kuperman, Nicholas Justice, Alon Chen
NATURE NEUROSCIENCE
(2017)
Article
Neurosciences
Silja McIlwrick, Tobias Pohl, Alon Chen, Chadi Touma
FRONTIERS IN CELLULAR NEUROSCIENCE
(2017)
Article
Multidisciplinary Sciences
Georgia Balsevich, Alexander S. Haeusl, Carola W. Meyer, Stoyo Karamihalev, Xixi Feng, Max L. Poehlmann, Carine Dournes, Andres Uribe-Marino, Sara Santarelli, Christiana Labermaier, Kathrin Hafner, Tianqi Mao, Michaela Breitsamer, Marily Theodoropoulou, Christian Namendorf, Manfred Uhr, Marcelo Paez-Pereda, Gerhard Winter, Felix Hausch, Alon Chen, Matthias H. Tschoep, Theo Rein, Nils C. Gassen, Mathias V. Schmidt
NATURE COMMUNICATIONS
(2017)
Article
Psychiatry
W. J. Giardino, E. D. Rodriguez, M. L. Smith, M. M. Ford, D. Galili, S. H. Mitchell, A. Chen, A. E. Ryabinin
TRANSLATIONAL PSYCHIATRY
(2017)
Article
Multidisciplinary Sciences
Ada H. Zohar, Tamar Eilat, Maya Amitai, Michal Taler, Romi Bari, Alon Chen, Alan Apter, Avraham Weizman, Silvana Fennig
Article
Endocrinology & Metabolism
Mariana Schroeder, Yonat Drori, Yair J. Ben-Efraim, Alon Chen
MOLECULAR METABOLISM
(2018)
Review
Biochemistry & Molecular Biology
Nina Dedic, Alon Chen, Jan M. Deussing
CURRENT MOLECULAR PHARMACOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Vini Nagaraj, Thomas Theis, Anmol Singh Johal, Arihant Seth, Jada Gore, Neha Arsha, Mukti Patel, Helen Baixia Hao, Nikki Kurian, Melitta Schachner
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Psychiatry
Dekel Taliaz, Amit Spinrad, Ran Barzilay, Zohar Barnett-Itzhaki, Dana Averbuch, Omri Teltsh, Roy Schurr, Sne Darki-Morag, Bernard Lerer
Summary: This study utilized machine learning algorithms to analyze genetic, clinical, and demographic factors in patients with major depressive disorder, generating an accurate predictive algorithm for antidepressant response. The results showed improved accuracy in individualized antidepressant prescription, supporting the feasibility of using ML algorithms applied to large datasets to enhance treatment selection.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Medicine, General & Internal
Dekel Taliaz, Daniel Souery
Summary: Traditional mental health diagnosis methods rely heavily on subjective data reported by patients, while a more effective approach would be to focus on behavioral characteristics. Utilizing digital biomarkers and smart devices to collect quantified behavioral data can lead to personalized treatments and better diagnosis accuracy.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Suneel Kumar, Thomas Theis, Monica Tschang, Vini Nagaraj, Francois Berthiaume
Summary: Traumatic injuries to the nervous system, such as spinal cord injury and brain injury, can result in neurological dysfunction, causing patients to be bed-ridden and immobile for extended periods. Secondary complications like bladder/bowel dysfunction and pressure ulcers can lead to further debilitating conditions.
Editorial Material
Neurosciences
Dekel Taliaz, Alessandro Serretti
Summary: The validity of clinical trials in psychiatry has been under discussion in the past two decades. The commonly used method of randomized controlled trials (RCTs) faces challenges when applied in the psychiatric field due to strict participant criteria and inconsistency in endpoint parameters. This has led to problematic clinical practice in psychiatry.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2023)
Review
Neurosciences
Maya Jammoul, Dareen Jammoul, Kevin K. Wang, Firas Kobeissy, Ralph G. Depalma
Summary: This article reviews the possible mechanisms by which traumatic brain injury (TBI) may stimulate the development of opioid use disorder (OUD) and discusses the interaction between these two processes. CNS damage due to TBI appears to drive adverse effects of subsequent OUD, with pain being a risk factor for opioid use after TBI.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Danusa Mar Arcego, Jan-Paul Buschdorf, Nicholas O'Toole, Zihan Wang, Barbara Barth, Irina Pokhvisneva, Nirmala Arul Rayan, Sachin Patel, Euclides Jose de Mendonca Filho, Patrick Lee, Jennifer Tan, Ming Xuan Koh, Chu Ming Sim, Carine Parent, Randriely Merscher Sobreira de Lima, Andrew Clappison, Kieran J. O'Donnell, Carla Dalmaz, Janine Arloth, Nadine Provencal, Elisabeth B. Binder, Josie Diorio, Patricia Pelufo Silveira, Michael J. Meaney
Summary: This study investigates the impact of environmental influences on mental health by integrating transcriptomic data from animal models with human data. The results suggest that hippocampal glucocorticoid-related transcriptional activity mediates the effects of early adversity on neural mechanisms implicated in psychiatric disorders.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Milenna T. van Dijk, Ardesheer Talati, Pratik Kashyap, Karan Desai, Nora C. Kelsall, Marc J. Gameroff, Natalie Aw, Eyal Abraham, Breda Cullen, Jiook Cha, Christoph Anacker, Myrna M. Weissman, Jonathan Posner
Summary: This study found that maternal stress is associated with future depressive symptoms and alterations in microstructure of the dentate gyrus (DG) in offspring. These results were consistent across two independent cohorts.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Josephine C. McGowan, Liliana R. Ladner, Claire X. Shubeck, Juliana Tapia, Christina T. LaGamma, Amanda Anqueira-Gonzalez, Ariana DeFrancesco, Briana K. Chen, Holly C. Hunsberger, Ezra J. Sydnor, Ryan W. Logan, Tzong-Shiue Yu, Steven G. Kernie, Christine A. Denny
Summary: Traumatic brain injury (TBI) leads to fear generalization by altering fear memory traces, and this symptom can be improved with (R,S)-ketamine.
BIOLOGICAL PSYCHIATRY
(2024)