Article
Psychology, Clinical
Jason Smucny, Tyler A. A. Lesh, Tara A. A. Niendam, J. Daniel Ragland, Laura M. M. Tully, Cameron S. S. Carter
Summary: This study found that in individuals with recent onset schizophrenia, deficits in reward anticipation can be reversed after one year of coordinated specialty care treatment, and this improvement is associated with a reduction in positive symptoms of the illness.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Neurosciences
Kristin N. Meyer, Juliet Y. Davidow, Koene R. A. Van Dijk, Rosario M. Santillana, Jenna Snyder, Constanza M. Vidal Bustamante, Marissa Hollinshead, Bruce R. Rosen, Leah H. Somerville, Margaret A. Sheridan
Summary: The study aimed to characterize the impact of stimuli with a history of conditioned reward association on inhibitory control in healthy young adults. Results showed that a history of reward conditioning disrupted inhibitory control, with higher activity in frontal and striatal regions when inhibiting responses to previously rewarded stimuli compared to non-rewarded stimuli.
Article
Neurosciences
Nicole E. Keller, Augustin C. Hennings, Emily K. Leiker, Jarrod A. Lewis-Peacock, Joseph E. Dunsmoor
Summary: Neurobiological evidence suggests that incorporating reward associations with an extinction memory may be an effective strategy to attenuate threat responses. This study compared rewarded extinction to standard extinction in both short-term and long-term retrieval tests and found that rewarded extinction was more effective in reducing arousal and threat expectancy. The study also identified different patterns of brain activity and connectivity between reward-associated extinction and standard extinction.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Margaret Prenger, Madeline Gilchrist, Kathryne Van Hedger, Ken N. Seergobin, Adrian M. Owen, Penny A. Macdonald
Summary: Humor comprehension and appreciation are cognitive processes involving different brain regions. The dorsal striatum is important for humor comprehension, while the ventral striatum plays a critical role in humor appreciation.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Neurosciences
Hayley M. Dorfman, Momchil S. Tomov, Bernice Cheung, Dennis Clarke, Samuel J. Gershman, Brent L. Hughes
Summary: The study found that reward prediction errors modulated by causal beliefs are represented in the dorsal striatum, while unmodulated reward prediction errors are represented in the ventral striatum. Further analysis revealed that beliefs about causal structure are represented in the anterior insula and inferior frontal gyrus. Structural equation modeling showed effective connectivity from the anterior insula to the dorsal striatum, suggesting a neural architecture in which causal beliefs are integrated with prediction error signals to update action values.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Xiaoxue Gao, Hongbo Yu, Lu Peng, Xiaoliang Gong, Yang Xiang, Changjun Jiang, Xiaolin Zhou
Summary: In this study, researchers used a social interactive game and fMRI technology to investigate the emotional responses of transgressors after being forgiven or blamed by victims. The findings suggest that the victim's attitude and the severity of harm interactively modulate the transgressor's social emotions, with expectation violation serving as a mediator.
Article
Psychology, Biological
Franziska Magdalena Kausche, Gundula Zerbes, Lea Kampermann, Christian Buechel, Lars Schwabe
Summary: The study found that stress does not modulate fear generalization and its neural signature, but a temporal delay may increase the extent to which fear responses are generalized to stimuli resembling the threatening stimulus.
Article
Neurosciences
Patrick A. F. Laing, Trevor Steward, Christopher G. Davey, Kim L. Felmingham, Miguel Angel Fullana, Bram Vervliet, Matthew D. Greaves, Bradford Moffat, Rebecca K. Glarin, Ben J. Harrison
Summary: This study investigates the neural basis of safety learning using advanced fMRI technology, and finds that safety learning is mediated through a cortico-striatal circuitry separate from broader cortical regions involved in processing standard safety signals.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Cristian B. Calderon, Esther De Loof, Kate Ergo, Anna Snoeck, Carsten N. Boehler, Tom Verguts
Summary: Behavioral evidence suggests that reward prediction errors play a key role in episodic memory acquisition. In a novel task where RPEs were manipulated, fMRI results confirmed that signed RPEs are encoded in the ventral striatum and mediate their effects on episodic memory accuracy. Connectivity between processing areas and the hippocampus and ventral striatum increased with RPE value, supporting their central role in episodic memory formation.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Katherine W. Scangos, Ghassan S. Makhoul, Leo P. Sugrue, Edward F. Chang, Andrew D. Krystal
Summary: Deep brain stimulation shows promise in treating severe depression, but questions about anatomical targeting remain. A study implanting intracranial electrodes in a depressed patient found rapid, reproducible emotional responses that were context and state dependent, providing proof of concept for personalized, circuit-specific medicine in psychiatry.
Article
Behavioral Sciences
Filip Grill, Lars Nyberg, Anna Rieckmann
Summary: The study suggests that the fMRI response to rewards in the ventral striatum reflects a mixture of component processes of reward, with an inferior ventral striatal component and hippocampus being involved in reward-based processing during gambling. The more superior ventral striatal component is linked to networks associated with executive functioning and responds to both reward and cognitive control demands.
BRAIN AND BEHAVIOR
(2021)
Article
Neurosciences
Natasha Duell, Michael T. Perino, Ethan M. McCormick, Eva H. Telzer
Summary: The present study investigated the differences in risky decision-making between delinquent and non-delinquent youth. Behavioral results showed that delinquent youth took fewer risks and earned fewer rewards compared to non-delinquent youth. Neural analyses revealed that delinquent youth exhibited greater neural tracking of reward outcomes, suggesting a preference for immediate rewards. These findings provide important insights into differential decision-making processes between delinquent and non-delinquent youth.
SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE
(2023)
Article
Neurosciences
Michael H. Parrish, Janine M. Dutcher, Keely A. Muscatell, Tristen K. Inagaki, Mona Moieni, Michael R. Irwin, Naomi Eisenberger
Summary: This study used fMRI to investigate the relationship between self-enhancement and emotion regulation in social evaluation tasks. The results showed that stable state self-esteem and higher trait self-esteem were associated with increased functional connectivity between RVLPFC and VS during positive evaluation. Additionally, participants with stable-state self-esteem showed stronger RVLPFC activation during all types of feedback processing and left VS activation during negative feedback processing.
SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE
(2022)
Article
Neurosciences
Sameer A. Sheth, Kelly R. Bijanki, Brian Metzger, Anusha Allawala, Victoria Pirtle, Joshua A. Adkinson, John Myers, Raissa K. Mathura, Denise Oswalt, Evangelia Tsolaki, Jiayang Xiao, Angela Noecker, Adriana M. Strutt, Jeffrey F. Cohn, Cameron C. McIntyre, Sanjay J. Mathew, David Borton, Wayne Goodman, Nader Pouratian
Summary: The success of deep brain stimulation (DBS) in treating Parkinson's disease has led to its application in other disorders, including treatment-resistant depression. However, the inconsistent results of DBS for treatment-resistant depression can be attributed to a lack of understanding of the brain networks regulating mood, especially on an individual level. This study reports the results of the first subject treated with DBS for treatment-resistant depression using an approach that incorporates intracranial recordings to personalize understanding of network behavior and its response to stimulation. The findings demonstrate the feasibility of this personalized platform, which has the potential to improve surgical neuromodulation for various neurological and psychiatric disorders.
BIOLOGICAL PSYCHIATRY
(2022)
Article
Neurosciences
Gina Joue, Karima Chakroun, Janine Bayer, Jan Glaescher, Lei Zhang, Johannes Fuss, Nora Hennies, Tobias Sommer
Summary: The study found that women showed enhanced brain activity related to reward prediction error compared to men, and this effect was further amplified when estrogen levels were elevated in both sexes. However, both female sex and estrogen slowed adaptation to reward prediction errors, resulting in a smaller learning rate.
Article
Neurosciences
Sarah D. Lichenstein, Corey Roos, Robert Kohler, Brian Kiluk, Kathleen M. Carroll, Patrick D. Worhunsky, Katie Witkiewitz, Sarah W. Yip
Summary: This study reveals the existence of multiple neurodevelopmental subgroups at the population level, supported by empirical analysis of functional magnetic resonance imaging data. These subgroups differ in terms of gender, household income, cognitive performance, screen time, impulsivity, and rates of neurodevelopmental disorders when compared to a moderate subgroup.
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2022)
Article
Neurosciences
Krishna T. Patel, Michael C. Stevens, Amanda Dunlap, Alana Gallagher, Stephanie S. O'Malley, Kelly DeMartini, Marc N. Potenza, John H. Krystal, Godfrey D. Pearlson
Summary: The study used a Fyn/Src inhibitor to investigate the differences in ventral striatal activation during task performance between individuals with and without familial alcohol use disorder. The results suggest that elevated signaling in striatal protein kinase A-dependent pathways may contribute to familial AUD risk by amplifying the neural response to reward prospect. These findings also indicate a potential therapeutic role for Src/Fyn kinase inhibitors in AUD risk.
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Gustavo A. Angarita, Patrick D. Worhunsky, Mika Naganawa, Takuya Toyonaga, Nabeel B. Nabulsi, Chiang-Shan R. Li, Irina Esterlis, Patrick D. Skosnik, Rajiv Radhakrishnan, Brian Pittman, Ralitza Gueorguieva, Marc N. Potenza, Sjoerd J. Finnema, Yiyun Huang, Richard E. Carson, Robert T. Malison
Summary: The study found lower synaptic density in the PFC of individuals with CUD. Synaptic density was positively correlated with recent cocaine use frequency and negatively correlated with cocaine abstinence.
Article
Biochemical Research Methods
Hamed Ekhtiari, Mehran Zare-Bidoky, Arshiya Sangchooli, Amy C. Janes, Marc J. Kaufman, Jason A. Oliver, James J. Prisciandaro, Torsten Wustenberg, Raymond F. Anton, Patrick Bach, Alex Baldacchino, Anne Beck, James M. Bjork, Judson Brewer, Anna Rose Childress, Eric D. Claus, Kelly E. Courtney, Mohsen Ebrahimi, Francesca M. Filbey, Dara G. Ghahremani, Peyman Ghobadi Azbari, Rita Z. Goldstein, Anna E. Goudriaan, Erica N. Grodin, J. Paul Hamilton, Colleen A. Hanlon, Peyman Hassani-Abharian, Andreas Heinz, Jane E. Joseph, Falk Kiefer, Arash Khojasteh Zonoozi, Hedy Kober, Rayus Kuplicki, Qiang Li, Edythe D. London, Joseph McClernon, Hamid R. Noori, Max M. Owens, Martin Paulus, Irene Perini, Marc Potenza, Stephane Potvin, Lara Ray, Joseph P. Schacht, Dongju Seo, Rajita Sinha, Michael N. Smolka, Rainer Spanagel, Vaughn R. Steele, Elliot A. Stein, Sabine Steins-Loeber, Susan F. Tapert, Antonio Verdejo-Garcia, Sabine Vollstaedt-Klein, Reagan R. Wetherill, Stephen J. Wilson, Katie Witkiewitz, Kai Yuan, Xiaochu Zhang, Anna Zilverstand
Summary: This study established parameters and reporting standards for cue reactivity research in functional magnetic resonance imaging, and conducted a review on relevant published studies, revealing gaps in the reporting of important items.
Article
Neurosciences
Philip R. Corlett, Jessica A. Mollick, Hedy Kober
Summary: This study used a multi-level kernel-based density meta-analysis to explore prediction error signals in the midbrain and insula during reward, punishment, action, cognition, and perception tasks. The findings demonstrated the existence of domain-specific error signals and provided valuable insight into cognitive functions and dysfunctions in humans and other animals.
NEUROPSYCHOPHARMACOLOGY
(2022)
Review
Neurosciences
Sarah D. Lichenstein, Nick Manco, Lora M. Cope, Leslie Egbo, Kathleen A. Garrison, Jillian Hardee, Ansel T. Hillmer, Kristen Reeder, Elisa F. Stern, Patrick Worhunsky, Sarah W. Yip
Summary: This systematic review aims to synthesize existing literature on the effects of cannabis on the developing adolescent brain, identify research gaps, and provide recommendations for future studies. Preliminary evidence suggests functional and structural alterations in specific brain regions among adolescent cannabis users, but larger and more rigorous studies are needed to reconcile conflicting results and assess the reversibility of these effects with abstinence.
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Psychiatry
Cees J. Weeland, Selina Kasprzak, Niels T. de Joode, Yoshinari Abe, Pino Alonso, Stephanie H. Ameis, Alan Anticevic, Paul D. Arnold, Srinivas Balachander, Nerisa Banaj, Nuria Bargallo, Marcelo C. Batistuzzo, Francesco Benedetti, Jan C. Beucke, Irene Bollettini, Vilde Brecke, Silvia Brem, Carolina Cappi, Yuqi Cheng, Kang Ik K. Cho, Daniel L. C. Costa, Sara Dallaspezia, Damiaan Denys, Goi Khia Eng, Sonia Ferreira, Jamie D. Feusner, Martine Fontaine, Jean-Paul Fouche, Rachael G. Grazioplene, Patricia Gruner, Mengxin He, Yoshiyuki Hirano, Marcelo Q. Hoexter, Chaim Huyser, Hao Hu, Fern Jaspers-Fayer, Norbert Kathmann, Christian Kaufmann, Minah Kim, Kathrin Koch, Yoo Bin Kwak, Jun Soo Kwon, Luisa Lazaro, Chiang-Shan R. Li, Christine Lochner, Rachel Marsh, Ignacio Martinez-Zalacain, David Mataix-Cols, Jose M. Menchon, Luciano Minnuzi, Pedro Silva Moreira, Pedro Morgado, Akiko Nakagawa, Takashi Nakamae, Janardhanan C. Narayanaswamy, Erika L. Nurmi, Ana E. Ortiz, Jose C. Pariente, John Piacentini, Maria Pico-Perez, Fabrizio Piras, Federica Piras, Christopher Pittenger, Y. C. Janardhan Reddy, Daniela Rodriguez-Manrique, Yuki Sakai, Eiji Shimizu, Venkataram Shivakumar, Helen Blair Simpson, Noam Soreni, Carles Soriano-Mas, Nuno Sousa, Gianfranco Spalletta, Emily R. Stern, Michael C. Stevens, S. Evelyn Stewart, Philip R. Szeszko, Jumpei Takahashi, Tais Tanamatis, Jinsong Tang, Anders Lillevik Thorsen, David Tolin, Ysbrand D. van der Werf, Hein van Marle, Guido A. van Wingen, Daniela Vecchio, G. Venkatasubramanian, Susanne Walitza, Jicai Wang, Zhen Wang, Anri Watanabe, Lidewij H. Wolters, Xiufeng Xu, Je-Yeon Yun, Qing Zhao, Tonya White, Paul M. Thompson, Dan J. Stein, Odile A. van den Heuvel, Chris Vriend
Summary: Larger thalamic volume has been found in children with obsessive-compulsive disorder (OCD) and particular subregions may drive these differences. In adults, smaller volumes were observed across all subregions and the whole thalamic volume, mostly driven by medicated patients and associated with symptom severity.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Psychology, Clinical
Richard B. Lopez, Kevin N. Ochsner, Hedy Kober
Summary: The study confirms the importance of craving regulation in smoking cessation and demonstrates that easily administered training procedures can effectively reduce smoking behaviors by targeting craving.
JOURNAL OF SUBSTANCE ABUSE TREATMENT
(2022)
Article
Substance Abuse
Kelly Smart, Patrick D. Worhunsky, Dustin Scheinost, Gustavo A. Angarita, Irina Esterlis, Richard E. Carson, John H. Krystal, Stephanie S. O'Malley, Kelly P. Cosgrove, Ansel T. Hillmer
Summary: This study examined the relationship between resting brain connectivity and mGlu5 receptor availability in individuals with AUD at two time points early in abstinence. Preliminary findings suggest alterations in global and network connectivity during the first month of abstinence may reflect the loss of efficient network function, potentially linked with glutamatergic relationship with network coherence.
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Review
Psychiatry
Nilofar Vafaie, Hedy Kober
Summary: The study indicates that drug cue and craving indicators play significant roles in drug use and relapse outcomes, supporting the incorporation of craving assessment across treatment stages, especially in the early stages of care.
Article
Neurosciences
Marinka M. G. Koenis, Janet Ng, Beth Anderson, Michael C. Stevens, Darren S. Tishler, Pavlos K. Papasavas, Andrea Stone, Tara McLaughlin, Allison Verhaak, Mirjana J. Domakonda, Godfrey D. Pearlson
Summary: This study found that LAGB surgery, which constricts the stomach, can indirectly alter brain activation in response to food cues, potentially leading to changes in food craving and preference that support sustained weight loss after surgery.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Neurosciences
Rajiv Radhakrishnan, Patrick D. Worhunsky, Ming-Qiang Zheng, Soheila Najafzadeh, Jean-Dominique Gallezot, Beata Planeta, Shannan Henry, Nabeel Nabulsi, Mohini Ranganathan, Patrick D. Skosnik, Brian Pittman, Deepak Cyril D'Souza, Richard E. Carson, Yiyun Huang, Marc N. Potenza, David Matuskey
Summary: The study examined the relationship between brain cannabinoid 1 receptors (CB1Rs) and age, gender, and body mass index (BMI) in healthy individuals. It found that CB1R availability declined with age and differed between genders and brain regions. The findings were different from previous studies and highlight the need for cross-validation studies using different PET ligands in the same cohort.
Article
Neurosciences
Hasti Hadizadeh, Jose M. Flores, Talia Mayerson, Patrick D. Worhunsky, Marc N. Potenza, Gustavo A. Angarita
Summary: This review discusses the influence of disruptions in glutamate neurotransmission on cocaine use disorder (CUD) and the potential treatment options. Ketamine is considered the most promising agent, although administration route and the risk of misuse are limitations. Other agents show potential based on preclinical data. Further research is needed to explore the use of these agents in targeting the glutamatergic system.
CURRENT BEHAVIORAL NEUROSCIENCE REPORTS
(2022)
Article
Neuroimaging
Caroline Larson, Karla Rivera-Figueroa, Hannah R. Thomas, Deborah Fein, Michael C. Stevens, Inge-Marie Eigsti
Summary: This study investigated the presence of structural language impairment in individuals with Autism Spectrum Disorder (ASD) and those who no longer meet criteria for ASD. The results showed no significant difference in the proportion of participants with structural language impairment between the ASD and LAD groups. Functional MRI results indicated greater left hemisphere lateralization in the group with structural language impairment. Structural language abilities were not significantly associated with social abilities or ADHD symptoms in the subgroups with structural language impairment.
NEUROIMAGE-CLINICAL
(2022)
Meeting Abstract
Neurosciences
Reuma Gadassi Polack, Yihan Xiong, Jessica Mollick, Hedy Kober
BIOLOGICAL PSYCHIATRY
(2022)
Review
Neurosciences
Maya Jammoul, Dareen Jammoul, Kevin K. Wang, Firas Kobeissy, Ralph G. Depalma
Summary: This article reviews the possible mechanisms by which traumatic brain injury (TBI) may stimulate the development of opioid use disorder (OUD) and discusses the interaction between these two processes. CNS damage due to TBI appears to drive adverse effects of subsequent OUD, with pain being a risk factor for opioid use after TBI.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Danusa Mar Arcego, Jan-Paul Buschdorf, Nicholas O'Toole, Zihan Wang, Barbara Barth, Irina Pokhvisneva, Nirmala Arul Rayan, Sachin Patel, Euclides Jose de Mendonca Filho, Patrick Lee, Jennifer Tan, Ming Xuan Koh, Chu Ming Sim, Carine Parent, Randriely Merscher Sobreira de Lima, Andrew Clappison, Kieran J. O'Donnell, Carla Dalmaz, Janine Arloth, Nadine Provencal, Elisabeth B. Binder, Josie Diorio, Patricia Pelufo Silveira, Michael J. Meaney
Summary: This study investigates the impact of environmental influences on mental health by integrating transcriptomic data from animal models with human data. The results suggest that hippocampal glucocorticoid-related transcriptional activity mediates the effects of early adversity on neural mechanisms implicated in psychiatric disorders.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Milenna T. van Dijk, Ardesheer Talati, Pratik Kashyap, Karan Desai, Nora C. Kelsall, Marc J. Gameroff, Natalie Aw, Eyal Abraham, Breda Cullen, Jiook Cha, Christoph Anacker, Myrna M. Weissman, Jonathan Posner
Summary: This study found that maternal stress is associated with future depressive symptoms and alterations in microstructure of the dentate gyrus (DG) in offspring. These results were consistent across two independent cohorts.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Josephine C. McGowan, Liliana R. Ladner, Claire X. Shubeck, Juliana Tapia, Christina T. LaGamma, Amanda Anqueira-Gonzalez, Ariana DeFrancesco, Briana K. Chen, Holly C. Hunsberger, Ezra J. Sydnor, Ryan W. Logan, Tzong-Shiue Yu, Steven G. Kernie, Christine A. Denny
Summary: Traumatic brain injury (TBI) leads to fear generalization by altering fear memory traces, and this symptom can be improved with (R,S)-ketamine.
BIOLOGICAL PSYCHIATRY
(2024)