Article
Neurosciences
Yu-zhu Gao, Xin-miao Wu, Zhi-qiang Zhou, Pan-miao Liu, Jian-jun Yang, Mu-huo Ji
Summary: Accumulating evidence suggests that many sepsis survivors experience long-term cognitive impairments after hospital discharge, causing reduced quality of life and burden for their families. This study utilized a mouse model and various techniques to investigate the role of NRG1/ErbB4 signaling, PV interneurons, and hippocampal neural oscillations in memory decline after repeated LPS injections. The results demonstrated that dysfunction of NRG1/ErbB4 signaling in the hippocampus may contribute to the long-term memory decline observed in the systemic inflammation mouse model. Targeting NRG1/ErbB4 signaling in the hippocampus could be a promising approach for preventing and treating this memory decline.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Psychiatry
Amanda Kiemes, Maria Elisa Serrano Navacerrada, Eugene Kim, Karen Randall, Camilla Simmons, Loreto Rojo Gonzalez, Marija-Magdalena Petrinovic, David J. Lythgoe, Diana Rotaru, Davide Di Censo, Lydiane Hirschler, Emmanuel L. Barbier, Anthony C. Vernon, James M. Stone, Cathy Davies, Diana Cash, Gemma Modinos
Summary: This study found that specific disruption of cortical inhibitory interneurons in mice can reproduce some of the neuroimaging findings in patients with psychosis, linking inhibitory interneuron deficits to non-invasive measures of brain function and neurochemistry that can be used across species.
SCHIZOPHRENIA BULLETIN
(2023)
Article
Neurosciences
Kara A. Lau, Xin Yang, Mengia S. Rioult-Pedotti, Stephen Tang, Mark Appleman, Jianan Zhang, Yuyang Tian, Caitlin Marino, Mudi Yao, Qin Jiang, Ayumi C. Tsuda, Yu-Wen Alvin Huang, Cong Cao, John Marshall
Summary: Angelman Syndrome (AS) is a severe cognitive disorder caused by loss of neuronal expression of the E3 ubiquitin ligase UBE3A. Researchers have found that a peptidomimetic compound called CN2097, which binds to the TrkB-associated scaffolding protein PSD-95, can restore synaptic plasticity and learning deficits in AS mice. CN2097 normalizes autophagy and restores synaptic protein levels, leading to improvements in cognitive and motor function.
PROGRESS IN NEUROBIOLOGY
(2023)
Article
Multidisciplinary Sciences
Adriana Harbuzariu, Annette Nti, Keri Oxendine Harp, Juan C. Cespedes, Adel Driss, Jonathan K. Stiles
Summary: Human cerebral malaria is a severe complication of Plasmodium falciparum infection that leads to capillary occlusions, blood-brain barrier rupture, cellular injury, and brain swelling. The parasite-derived HRP2 plays a role in inducing brain injury and inflammation, while the neuroprotective factor NRG1 shows potential as a therapy against HRP2 effects.
Article
Biology
Ana Caulino-Rocha, Nadia Carolina Rodrigues, Joaquim Alexandre Ribeiro, Diana Cunha-Reis
Summary: Regulation of synaptic plasticity through control of disinhibition is crucial in preventing excessive plasticity, and VIP acts as a key modulator of this process through its effects on VPAC(1) receptors.
Article
Biochemistry & Molecular Biology
Yi-Hua Chen, Neng-Yuan Hu, Ding-Yu Wu, Lin-Lin Bi, Zheng-Yi Luo, Lang Huang, Jian-Lin Wu, Meng-Ling Wang, Jing-Ting Li, Yun-Long Song, Sheng-Rong Zhang, Wei Jie, Xiao-Wen Li, Shi-Zhong Zhang, Jian-Ming Yang, Tian-Ming Gao
Summary: Neuroplasticity in the medial prefrontal cortex is essential for fear extinction, particularly in the sustained plasticity of the parvalbumin neuronal network. The involvement of neuregulin 1-ErbB4 signaling in fear extinction and the dependence of fear extinction regulation by basal medial amygdala-projecting IL neurons on PV network configuration are also identified in this study. These findings reveal local molecular circuit mechanisms underlying mPFC-mediated control of fear extinction and suggest alternative therapeutic approaches for fear disorders.
MOLECULAR PSYCHIATRY
(2022)
Article
Multidisciplinary Sciences
Si-Yao Lu, Chong-Lei Fu, Liang Liang, Bo Yang, Wei Shen, Qiu-Wen Wang, Yun Chen, Yan-Fen Chen, Yao-Nan Liu, Lin Zhu, Jieqing Zhao, Wei Shi, Shuangli Mi, Jun Yao
Summary: miR-218-2 plays a crucial role in the cognitive functions of mice by regulating C3 to affect presynaptic functions, and synaptic and learning deficits can be rescued by restoring C3 activity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Neurosciences
Madeleine Kyrke-Smith, Lenora J. Volk, Samuel F. Cooke, Mark F. Bear, Richard L. Huganir, Jason D. Shepherd
Summary: Research shows that mice lacking the Arc gene do not exhibit deficits in hippocampal long-term potentiation (LTP), indicating that Arc is not necessary for LTP in the hippocampus.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Medicine, General & Internal
David E. Godler, Ling Ling, Dinusha Gamage, Emma K. Baker, Minh Bui, Michael J. Field, Carolyn Rogers, Merlin G. Butler, Alessandra Murgia, Emanuela Leonardi, Roberta Polli, Charles E. Schwartz, Cindy D. Skinner, Angelica M. Alliende, Lorena Santa Maria, James Pitt, Ronda Greaves, David Francis, Ralph Oertel, Min Wang, Cas Simons, David J. Amor
Summary: The findings of this study suggest that screening for all chromosome 15 imprinting disorders using SNRPN methylation analysis is feasible, with 5 individuals identified out of 16,579 infants screened.
Article
Biochemistry & Molecular Biology
Darwin Contreras, Ricardo Pina, Claudia Carvallo, Felipe Godoy, Gonzalo Ugarte, Marc Zeise, Carlos Rozas, Bernardo Morales
Summary: This study demonstrates that methylphenidate can restore behavioral impairments and neuroplasticity in an ADHD mouse model induced by prenatal nicotine exposure. The restoration is achieved through changes in AMPAR subunit composition and distribution, as well as the maturation of dendritic spines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Karl Peter Giese
Summary: Autophosphorylation of calcium/calmodulin-dependent kinase II (CaMKII) plays a critical role in synaptic potentiation by allowing kinase signaling to outlast NMDA receptor-dependent calcium influx. However, the role of CaMKII is conditional, depending on the developmental stage and location of the synapse.
Article
Neurosciences
Margarita Anisimova, Bas van Bommel, Rui Wang, Marina Mikhaylova, Joern Simon Wiegert, Thomas G. Oertner, Christine E. Gee
Summary: The study uses optogenetic stimulation to induce STDP and observes timing-dependent depression and potentiation. This study does not require electrodes and results suggest that synaptic depression after anticausal activation is a transient phenomenon.
Article
Neurosciences
Prudhvi Raj Rayi, Hanoch Kaphzan
Summary: Angelman syndrome is a neurogenetic disorder characterized by developmental delay, speech impairment, and other symptoms. Studies have shown that hippocampal deficits in AS mice may be related to altered calcium dynamics and increased alpha 1-Na/K-ATPase expression levels. However, the causal link between hippocampal deficits and major behavioral phenotypes in AS is still unclear.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Neurosciences
Andie Dodge, Nicole K. Morrill, Edwin J. Weeber, Kevin R. Nash
Summary: Experimental studies on the AS rat model have shown that injection of exogenous UBE3A protein can restore deficits in hippocampal long-term potentiation and rescue associative learning and memory deficits in fear conditioning tasks.
MOLECULAR AND CELLULAR NEUROSCIENCE
(2022)
Article
Neurosciences
Efrain A. Cepeda-Prado, Babak Khodaie, Gloria D. Quiceno, Swantje Beythien, Elke Edelmann, Volkmar Lessmann
Summary: In this study, low repeat STDP experiments were conducted at Schaffer collateral-CA1 synapses, and it was found that only 3-6 repeats were sufficient to trigger t-LTP. 6x 1:1 t-LTP relied on postsynaptic Ca2+ influx and increased presynaptic glutamate release, while 1:4 t-LTP depended on postsynaptic metabotropic GluRs and ryanodine receptor signaling, as well as postsynaptic insertion of AMPA receptors. Both t-LTP variants were strictly dependent on activation of postsynaptic Ca2+-permeable AMPARs, but were differentially regulated by dopamine receptor signaling. These findings indicate that synaptic changes can occur with just a few mild STDP stimulations within a short period of time.
Article
Behavioral Sciences
Sarah L. Ferri, Ashley A. Pallathra, Hyong Kim, Holly C. Dow, Praachi Raje, Mary McMullen, Warren B. Bilker, Steven J. Siegel, Ted Abel, Edward S. Brodkin
GENES BRAIN AND BEHAVIOR
(2020)
Article
Neurosciences
Philipp Mews, Erin S. Calipari, Jeremy Day, Mary Kay Lobo, Timothy Bredy, Ted Abel
Summary: The central goal of neuroscience research is to understand how experiences modify brain circuits for future adaptive behavior, involving complex interactions between circuit activity and gene regulation. Disruptions in this interplay are linked to debilitating psychiatric conditions, emphasizing the importance of studying how neural circuits and the epigenome cooperate to produce behavioral adaptation.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
David M. Steffen, Sarah L. Ferri, Charles G. Marcucci, Kelsey L. Blocklinger, Michael J. Molumby, Ted Abel, Joshua A. Weiner
Summary: Cell adhesion molecules play a key role in neural circuit formation, with gamma-protocadherins negatively regulating neuroligins to limit synapse density. Loss of gamma-Pcdhs results in increased inhibitory synapse density and abnormal behavior phenotypes.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Clinical Neurology
Mathieu E. Wimmer, Rosa Cui, Jennifer M. Blackwell, Ted Abel
Summary: The study demonstrates that CREB is required in forebrain neurons but not noradrenergic locus coeruleus cells to drive and sustain wakefulness.
Article
Neurosciences
Sina Radke, Kathrin Jankowiak, Sanne Tops, Ted Abel, Ute Habel, Birgit Derntl
Summary: The study found that social rejection leads to a lower willingness to cooperate with others, and increased brain activity when receiving negative feedback. Intranasal oxytocin did not seem to alter responses to social rejection.
SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE
(2021)
Article
Behavioral Sciences
Sarah L. Ferri, Holly C. Dow, Hannah Schoch, Ji Youn Lee, Edward S. Brodkin, Ted Abel
Summary: Pcdh10(+/-) mice exhibit male-specific social deficits and dark phase hypoactivity. Fear conditioning deficits were observed in males at both ages and in both assays, while females only showed impairment in the cued condition as adults. These findings suggest that Pcdh10(+/-) mice may serve as a useful model for studying male specific brain and behavioral phenotypes related to social and emotional behaviors.
NEUROBIOLOGY OF LEARNING AND MEMORY
(2021)
Correction
Neurosciences
Alan Jung Park, Mahesh Shivarama Shetty, Jay M. Baraban, Ted Abel
Article
Clinical Neurology
Youri G. Bolsius, Peter Meerlo, Martien J. Kas, Ted Abel, Robbert Havekes
Summary: Sleep deprivation can reduce the density of different types of dendritic spines in the hippocampus, with specific effects on certain branches. Specifically, sleep deprivation results in a decrease in the number of mushroom and branched spines on branch 5, while there are no significant changes on branches 1 and 2.
JOURNAL OF SLEEP RESEARCH
(2022)
Article
Neurosciences
Marie E. Gaine, Ethan Bahl, Snehajyoti Chatterjee, Jacob J. Michaelson, Ted Abel, Lisa C. Lyons
Summary: Widespread sleep deprivation poses a significant public health issue globally, impacting both adolescents and adults. Acute sleep deprivation affects hippocampal gene expression, leading to changes in various biological processes. Recovery sleep following acute sleep deprivation partially normalizes gene expression levels in the hippocampus, demonstrating the complex and differential regulation of genes by sleep deprivation.
Review
Behavioral Sciences
Jill L. Silverman, Audrey Thurm, Sarah B. Ethridge, Makayla M. Soller, Stela P. Petkova, Ted Abel, Melissa D. Bauman, Edward S. Brodkin, Hala Harony-Nicolas, Markus Woehr, Alycia Halladay
Summary: Neurodevelopmental disorders (NDDs) are prevalent and lifelong disorders without evidence-based interventions. Optimal utilization of preclinical animal models is crucial. A workshop in the field of behavioral neuroscience reviewed current studies and proposed solutions, including re-evaluating animal model links to NDDs.
GENES BRAIN AND BEHAVIOR
(2022)
Article
Neurosciences
Emily Nicole Walsh, Mahesh Shivarama Shetty, Kamran Diba, Ted Abel
Summary: Sleep is important for memory storage and sleep loss can impair memory, especially hippocampus-dependent memory. Previous studies have shown that deficits in synaptic plasticity and reduced levels of cAMP in the hippocampus are associated with sleep deprivation. In this study, the researchers found that increasing cAMP levels during sleep deprivation prevented deficits in long-term potentiation (LTP) in the hippocampus. Targeting cAMP-dependent signaling pathways may be beneficial in preventing the negative effects of sleep loss.
Review
Biochemistry & Molecular Biology
Lisa C. Lyons, Yann Vanrobaeys, Ted Abel
Summary: Sleep deprivation has negative impacts on health, affecting memory, cognition, and increasing disease risks. It alters molecular signaling, gene expression, dendritic structure, and protein translation processes. Understanding the multiple levels of gene regulation impacted by sleep deprivation is crucial for developing effective therapeutics.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Hannah Warming, Katrin Deinhardt, Patrick Garland, John More, Diederik Bulters, Ian Galea, Mariana Vargas-Caballero
Summary: During subarachnoid haemorrhage, the release of extracellular haemoglobin (Hb) causes oxidative damage and cell death in surrounding tissues. This study shows that haptoglobin can protect surviving neurons by scavenging free Hb and preventing cellular damage and deficits in synaptic function. The findings support the potential use of haptoglobin as a therapy for subarachnoid haemorrhage.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Clinical Neurology
Arjun Sengupta, Jennifer C. Tudor, Danielle Cusmano, Joseph A. Baur, Ted Abel, Aalim M. Weljie
Summary: This study examines the common molecular underpinnings of sleep deprivation and aging by analyzing metabolic features in young and aged mice after acute sleep deprivation. The results show that sleep deprivation primarily impacts peripheral plasma and liver metabolism, while the hippocampus is more affected by aging. Additionally, aged animals exhibit similar metabolic features to sleep deprivation even at baseline.
Article
Neurosciences
Aleksandra P. Pitera, Iain J. Hartnell, Lucy Scullard, Kirsten L. Williamson, Delphine Boche, Vincent O'Connor, Katrin Deinhardt
Summary: The study found that different UPR markers did not change in the late stages of any human tauopathies investigated, but UPR signatures were often observed in non-demented controls. The results suggest an activation of UPR markers in the aged brain across all investigated cohorts, supporting the emerging evidence that misfolded cytosolic tau accumulation does not drive disease-associated UPR activation.
JOURNAL OF ALZHEIMERS DISEASE REPORTS
(2021)
Review
Neurosciences
Maya Jammoul, Dareen Jammoul, Kevin K. Wang, Firas Kobeissy, Ralph G. Depalma
Summary: This article reviews the possible mechanisms by which traumatic brain injury (TBI) may stimulate the development of opioid use disorder (OUD) and discusses the interaction between these two processes. CNS damage due to TBI appears to drive adverse effects of subsequent OUD, with pain being a risk factor for opioid use after TBI.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Danusa Mar Arcego, Jan-Paul Buschdorf, Nicholas O'Toole, Zihan Wang, Barbara Barth, Irina Pokhvisneva, Nirmala Arul Rayan, Sachin Patel, Euclides Jose de Mendonca Filho, Patrick Lee, Jennifer Tan, Ming Xuan Koh, Chu Ming Sim, Carine Parent, Randriely Merscher Sobreira de Lima, Andrew Clappison, Kieran J. O'Donnell, Carla Dalmaz, Janine Arloth, Nadine Provencal, Elisabeth B. Binder, Josie Diorio, Patricia Pelufo Silveira, Michael J. Meaney
Summary: This study investigates the impact of environmental influences on mental health by integrating transcriptomic data from animal models with human data. The results suggest that hippocampal glucocorticoid-related transcriptional activity mediates the effects of early adversity on neural mechanisms implicated in psychiatric disorders.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Milenna T. van Dijk, Ardesheer Talati, Pratik Kashyap, Karan Desai, Nora C. Kelsall, Marc J. Gameroff, Natalie Aw, Eyal Abraham, Breda Cullen, Jiook Cha, Christoph Anacker, Myrna M. Weissman, Jonathan Posner
Summary: This study found that maternal stress is associated with future depressive symptoms and alterations in microstructure of the dentate gyrus (DG) in offspring. These results were consistent across two independent cohorts.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Josephine C. McGowan, Liliana R. Ladner, Claire X. Shubeck, Juliana Tapia, Christina T. LaGamma, Amanda Anqueira-Gonzalez, Ariana DeFrancesco, Briana K. Chen, Holly C. Hunsberger, Ezra J. Sydnor, Ryan W. Logan, Tzong-Shiue Yu, Steven G. Kernie, Christine A. Denny
Summary: Traumatic brain injury (TBI) leads to fear generalization by altering fear memory traces, and this symptom can be improved with (R,S)-ketamine.
BIOLOGICAL PSYCHIATRY
(2024)