4.7 Article

Mood-Linked Responses in Medial Prefrontal Cortex Predict Relapse in Patients with Recurrent Unipolar Depression

期刊

BIOLOGICAL PSYCHIATRY
卷 70, 期 4, 页码 366-372

出版社

ELSEVIER SCIENCE INC
DOI: 10.1016/j.biopsych.2011.03.009

关键词

Depression; emotion; imaging; prediction; reactivity; relapse

资金

  1. National Institute of Mental Health [MH066992]
  2. Canadian Institutes of Health Research [MT81164]
  3. Ontario Mental Health Foundation

向作者/读者索取更多资源

Background: Altered cognitive processing following mood challenge is associated with elevated relapse risk in remitted unipolar depressed patients, but little is known about the neural basis of this reactivity and its link to depressive relapse and prophylaxis. Methods: Remitted unipolar depressed participants (n = 16) and healthy control subjects (n = 16) underwent functional magnetic resonance imaging (fMRI) while viewing sad and neutral film clips. Correlations were determined between emotional reactivity (neural responses to sad vs. neutral films) in remitted patients and subsequent relapse status over an 18 month follow-up period. A receiver operating characteristic analysis was used to determine signal cutoffs for predicting relapse. Emotional reactivity in relapse prognostic areas was compared between groups. Results: Within the remitted group, relapse was predicted by medial prefrontal cortical (mPFC; Brodmann's area 32) activity and contraindicated by visual cortical activity (Brodmann's area 17). mPFC reactivity predicted rumination, whereas visual cortical reactivity predicted distress tolerance (acceptance). Compared with control participants, remitted depressed patients demonstrated a more pronounced tradeoff between mPFC and visual cortex reactivity. The difference score between mPFC and visual reactivity yielded excellent prediction of depressive relapse. Conclusions: Medial prefrontal cortical reactivity to mood provocation in remitted unipolar depressed patients serves as a marker of relapse risk rather than successful emotion regulation. Enduring remission is characterized by normalization of the mPFC to that of healthy control subjects. Furthermore, visual cortex reactivity predicts resilience against depressive relapse, indicating a prophylactic role for sensory rather than ruminative cognitive reactivity in the processing of negative emotion.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

Article Neurosciences

Attentional Modulation of Primary Interoceptive and Exteroceptive Cortices

Norman A. S. Farb, Zindel V. Segal, Adam K. Anderson

CEREBRAL CORTEX (2013)

Article Behavioral Sciences

Abnormal network connectivity in frontotemporal dementia: Evidence for prefrontal isolation

Norman A. S. Farb, Cheryl L. Grady, Stephen Strother, David F. Tang-Wai, Mario Masellis, Sandra Black, Morris Freedman, Bruce G. Pollock, Karen L. Campbell, Lynn Hasher, Tiffany W. Chow

CORTEX (2013)

Review Neurosciences

Emotions: form follows function

Norman A. S. Farb, Hanah A. Chapman, Adam K. Anderson

CURRENT OPINION IN NEUROBIOLOGY (2013)

Article Neurosciences

Mindfulness meditation training alters cortical representations of interoceptive attention

Norman A. S. Farb, Zindel V. Segal, Adam K. Anderson

SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE (2013)

Article Psychology, Applied

Modeling the mindfulness-to-meaning theory's mindful reappraisal hypothesis: Replication with longitudinal data from a randomized controlled study

Adam W. Hanley, Michael de Vibe, Ida Solhaug, Norman Farb, Phillipe R. Goldin, James J. Gross, Eric L. Garland

Summary: The study found that mindfulness training can increase well-being by enhancing the trajectory of positive reappraisal. Additionally, mindfulness training can also facilitate components like decentering and broadened awareness, ultimately promoting well-being.

STRESS AND HEALTH (2021)

Article Neurosciences

Brief daily self-care reflection for undergraduate well-being: a randomized control trial of an online intervention

Alexandra Fiodorova, Norman Farb

Summary: Limited research has shown that even brief daily reflection on self-care can have powerful effects in promoting resilience against the accumulation of negative affect and stress, especially among college students.

ANXIETY STRESS AND COPING (2022)

Article Neurosciences

Web-based training for post-secondary student well-being during the pandemic: a randomized trial

Yiyi Wang, Norman A. S. Farb

Summary: This study investigates the cultivation of mindfulness and stress-reappraisal skills through three different web-based interventions and examines their effects on mental health. The results indicate that decentering improved across all conditions. Mindfulness with choice significantly reduced negative affect and rumination compared to stress mindset, while stress mindset significantly enhanced stress mindset skills compared to both mindfulness groups. Furthermore, stress mindset also increased positive affect.

ANXIETY STRESS AND COPING (2023)

Article Neurosciences

A machine learning approach towards the differentiation between interoceptive and exteroceptive attention

Zoey X. Zuo, Cynthia J. Price, Norman A. S. Farb

Summary: Interoception plays a central role in emotion, motivation, and wellbeing. However, its measurement is currently limited to self-report, lacking objective methods. Through machine learning, we successfully classified interoceptive sensibility and demonstrated its reliability. The classifiers also showed potential in predicting mental states, with implications for developing objective markers for interoceptive sensibility in mental health research.

EUROPEAN JOURNAL OF NEUROSCIENCE (2023)

Article Neurosciences

Interoceptive Awareness of the Breath Preserves Attention and Language Networks amidst Widespread Cortical Deactivation: A Within-Participant Neuroimaging Study

Norman A. S. Farb, Zoey Zuo, Cynthia J. Price

Summary: Interoception, the representation of the body's internal state, is important for emotion, motivation, and wellbeing. The neural mechanisms of interoceptive attention are not well understood. A novel neuroimaging paradigm called the Interoceptive/Exteroceptive Attention Task (IEAT) was used to study interoceptive attention. The study found that active interoception deactivated certain brain regions and greater self-reported interoceptive sensibility predicted less deactivation in specific regions. The results suggest that interoceptive attention involves reduced cortical activity but greater connectivity between the anterior cingulate cortex (ACC) and other brain regions.

ENEURO (2023)

Article Psychology, Clinical

Walking the Talk: a Randomized Trial Exploring the Role of Mindfulness Booster Sessions on Skill Acquisition Following Workshop Attendance

Jana Radosavljevic, Norman A. S. Farb

Summary: This study investigated the impact of online mindfulness booster sessions on the acquisition of mindfulness skills and the promotion of well-being in undergraduate students. The results showed that the booster sessions significantly increased the participants' ability to decenter from self and were positively associated with positive emotion regulation. This study demonstrates the importance of continuing mindfulness practice in cultivating the ability to decenter from self.

MINDFULNESS (2023)

Article Psychology, Clinical

Mindfulness-Based Stress Reduction Interventions for Mood in Older Adults: How Do Qualitative Experiences Inform Clinical Response?

Norman A. S. Farb, Janet Murchison, Robert Madan, Hailey Goldberg, Cindy Grief, David Conn, Nasreen Khatri

Summary: The study explored how a mindfulness training intervention adapted for older adults addressed unique mental health challenges, finding that focusing on present moment awareness was associated with decreased depressive symptoms.

MINDFULNESS (2021)

Article Health Care Sciences & Services

A Smartphone App-Based Mindfulness Intervention for Cancer Survivors: Protocol for a Randomized Controlled Trial

Utkarsh B. Subnis, Norman A. S. Farb, Katherine-Ann Laura Piedalue, Michael Speca, Sasha Lupichuk, Patricia A. Tang, Peter Faris, Mark Thoburn, Bechara J. Saab, Linda E. Carlson

JMIR RESEARCH PROTOCOLS (2020)

Article Neurosciences

Emotion Regulation in Social Anxiety Disorder: Reappraisal and Acceptance of Negative Self-beliefs

Matthew L. Dixon, Craig A. Moodie, Philippe R. Goldin, Norman Farb, Richard G. Heimberg, James J. Gross

BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING (2020)

Article Psychiatry

Effects of a Mindfulness Meditation App on Subjective Well-Being: Active Randomized Controlled Trial and Experience Sampling Study

Kathleen Marie Walsh, Bechara J. Saab, Norman A. S. Farb

JMIR MENTAL HEALTH (2019)

Article Psychology, Clinical

A Two-Factor Model of Relapse/Recurrence Vulnerability in Unipolar Depression

Norman A. S. Farb, Julie A. Irving, Adam K. Anderson, Zindel V. Segal

JOURNAL OF ABNORMAL PSYCHOLOGY (2015)

Review Neurosciences

Traumatic Brain Injury and Opioids: Twin Plagues of the Twenty-First Century

Maya Jammoul, Dareen Jammoul, Kevin K. Wang, Firas Kobeissy, Ralph G. Depalma

Summary: This article reviews the possible mechanisms by which traumatic brain injury (TBI) may stimulate the development of opioid use disorder (OUD) and discusses the interaction between these two processes. CNS damage due to TBI appears to drive adverse effects of subsequent OUD, with pain being a risk factor for opioid use after TBI.

BIOLOGICAL PSYCHIATRY (2024)

Article Neurosciences

A Glucocorticoid-Sensitive Hippocampal Gene Network Moderates the Impact of Early-Life Adversity on Mental Health Outcomes

Danusa Mar Arcego, Jan-Paul Buschdorf, Nicholas O'Toole, Zihan Wang, Barbara Barth, Irina Pokhvisneva, Nirmala Arul Rayan, Sachin Patel, Euclides Jose de Mendonca Filho, Patrick Lee, Jennifer Tan, Ming Xuan Koh, Chu Ming Sim, Carine Parent, Randriely Merscher Sobreira de Lima, Andrew Clappison, Kieran J. O'Donnell, Carla Dalmaz, Janine Arloth, Nadine Provencal, Elisabeth B. Binder, Josie Diorio, Patricia Pelufo Silveira, Michael J. Meaney

Summary: This study investigates the impact of environmental influences on mental health by integrating transcriptomic data from animal models with human data. The results suggest that hippocampal glucocorticoid-related transcriptional activity mediates the effects of early adversity on neural mechanisms implicated in psychiatric disorders.

BIOLOGICAL PSYCHIATRY (2024)

Article Neurosciences

Dentate Gyrus Microstructure Is Associated With Resilience After Exposure to Maternal Stress Across Two Human Cohorts

Milenna T. van Dijk, Ardesheer Talati, Pratik Kashyap, Karan Desai, Nora C. Kelsall, Marc J. Gameroff, Natalie Aw, Eyal Abraham, Breda Cullen, Jiook Cha, Christoph Anacker, Myrna M. Weissman, Jonathan Posner

Summary: This study found that maternal stress is associated with future depressive symptoms and alterations in microstructure of the dentate gyrus (DG) in offspring. These results were consistent across two independent cohorts.

BIOLOGICAL PSYCHIATRY (2024)

Article Neurosciences

Traumatic Brain Injury-Induced Fear Generalization in Mice Involves Hippocampal Memory Trace Dysfunction and Is Alleviated by (R,S)-Ketamine

Josephine C. McGowan, Liliana R. Ladner, Claire X. Shubeck, Juliana Tapia, Christina T. LaGamma, Amanda Anqueira-Gonzalez, Ariana DeFrancesco, Briana K. Chen, Holly C. Hunsberger, Ezra J. Sydnor, Ryan W. Logan, Tzong-Shiue Yu, Steven G. Kernie, Christine A. Denny

Summary: Traumatic brain injury (TBI) leads to fear generalization by altering fear memory traces, and this symptom can be improved with (R,S)-ketamine.

BIOLOGICAL PSYCHIATRY (2024)