Article
Clinical Neurology
Xiaowei Jiang, Xinrui Wang, Linna Jia, Ting Sun, Jiahui Kang, Yifang Zhou, Shengnan Wei, Feng Wu, Lingtao Kong, Fei Wang, Yanqing Tang
Summary: The study combined MRI and follow-up to investigate the pathologic changes in MDD and BD patients, revealing distinct alterations in gray matter volume and functional connectivity in the brain, providing a scientific basis for differential diagnosis.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychiatry
Xiao-Li Sun, Li-Na Ma, Zhen-Zhu Chen, Yan-Bing Xiong, Jiao Jia, Yu Wang, Yan Ren
Summary: This study found significant differences in the metabolic phenotypes between bipolar disorder (BD), major depressive disorder (MDD), and healthy controls. Glycerolipid metabolism was significantly involved in both BD and MDD, while pyruvate metabolism was significantly involved in MDD. Pyruvate, choline, and acetate may be potential biomarkers for distinguishing MDD from BD, and pantothenic acid may be a potential biomarker for distinguishing BD from MDD.
FRONTIERS IN PSYCHIATRY
(2023)
Review
Clinical Neurology
Xipeng Long, Lei Li, Xiuli Wang, Yuan Cao, Baolin Wu, Neil Roberts, Qiyong Gong, Graham J. Kemp, Zhiyun Jia
Summary: This study conducted a comprehensive meta-analysis of gray matter volume alterations in adolescents with major depressive disorder and bipolar disorder. The findings suggest that distinct patterns of GMV alterations in these two populations could aid in differentiation and provide potential diagnostic biomarkers.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Clinical Neurology
Giulia Cattarinussi, Giuseppe Delvecchio, Fabio Sambataro, Paolo Brambilla
Summary: This study provides an overview of the association between polygenic risk score (PRS) for major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia (SCZ) and MRI abnormalities. The study found that PRS for BD and SCZ showed either positive or negative correlations with cortical thickness, mostly involving fronto-temporal areas. PRS for MDD was associated with cortical alterations in prefrontal regions in healthy subjects. Overall, the evidence on the effect of PRS for these psychiatric disorders on the brain is heterogeneous and inconclusive.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychology, Clinical
Guanmao Chen, Pan Chen, JiaYing Gong, Yanbin Jia, Shuming Zhong, Feng Chen, Jurong Wang, Zhenye Luo, Zhangzhang Qi, Li Huang, Ying Wang
Summary: This study investigated the shared and specific patterns of dynamic functional connectivity (dFC) variability of the striato-cortical circuitry in bipolar disorder (BD) and major depressive disorder (MDD). The results showed that both BD and MDD patients had common dFC alterations in the dorsal striatal-sensorimotor and ventral striatal-cognitive circuitries, while MDD patients had specific dFC alterations in the ventral striatal-affective circuitry.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Clinical Neurology
Ziqing Zhu, Sibin Wang, Tatia M. C. Lee, Ruibin Zhang
Summary: This study investigated the relationship between the neural abnormalities of the Habenula and major depressive disorder (MDD). It found differences in functional connectivity between MDD individuals and healthy controls. Additionally, a positive correlation was observed between dynamic functional connectivity and depressive severity.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Xiaotong Wen, Bukui Han, Huanhuan Li, Fengyu Dou, Guodong Wei, Gangqiang Hou, Xia Wu
Summary: Previous studies have suggested a connection between altered amygdala function and symptoms of major depressive disorder (MDD). This study aimed to examine how the interactions between the amygdala and other brain regions/networks are altered in MDD patients, using functional magnetic resonance imaging (fMRI) data.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Feng Chen, Jiaying Gong, Guanmao Chen, Pan Chen, Shuming Zhong, Guixian Tang, Jurong Wang, Zhenye Luo, Ting Su, Siying Fu, Shunkai Lai, Li Huang, Ying Wang
Summary: Comparing the brain blood flow and functional connectivity of patients with bipolar disorder and major depressive disorder can help us understand their pathophysiological mechanisms and find more effective treatments. The research found that patients with bipolar disorder and major depressive disorder shared common features of increased blood flow in the posterior lobe of the cerebellum and middle temporal gyrus. Additionally, only patients with bipolar disorder showed decreased functional connectivity between the posterior lobe of the cerebellum and the inferior frontal gyrus.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Alessandro Miola, Leonardo Tondo, Marco Pinna, Martina Contu, Ross J. Baldessarini
Summary: The study compared patients diagnosed with DSM-5 type II bipolar disorder (BD2) and major depressive disorder (MDD). The results showed significant differences between BD2 and MDD patients in terms of symptoms, morbidity, and treatment, which can contribute to better differentiation and treatment planning for the two disorders.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
BingYang Bian, Bei Zhang, ChinTing Wong, Le Dou, XingChen Pan, HongChao Wang, ShiYu Guo, HuiMao Zhang, Lei Zhang
Summary: This review summarizes the anatomy and function of the human habenula (Hb) and discusses the use of noninvasive MRI approaches to study the Hb. It highlights the importance of overcoming contrast issues with adjacent structures and the need for multiparametric MRI for diagnosis and treatment follow-up.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Psychiatry
Joseigla Pinto de Oliveira, Karen Jansen, Taiane de Azevedo Cardoso, Thaise Campos Mondin, Luciano Dias de Mattos Souza, Ricardo Azevedo da Silva, Fernanda Pedrotti Moreira
Summary: The study aimed to assess the role of childhood trauma in differentiating MDD and BD, as well as to describe the conversion rate from MDD to BD and its predictors. Findings indicated that predictors of conversion to BD included lower education, substance abuse, younger age of onset, and family history, while childhood trauma was not a significant risk factor for conversion.
PSYCHIATRY RESEARCH
(2021)
Article
Clinical Neurology
Hyeyoung Kim, Kyu-Man Han, Kwan Woo Choi, Woo-Suk Tae, Wooyoung Kang, Youbin Kang, Aram Kim, Byung-Joo Ham
Summary: The study examined the volume differences in each amygdala subregion in adults with and without MDD, using automatic segmentation of the nine nuclei of the amygdala. Patients with MDD showed significantly lower volumes in the entire amygdala and subregions compared to healthy volunteers, with no significant associations with antidepressant use, illness duration, or depression severity.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychology, Clinical
Youbin Kang, Wooyoung Kang, Aram Kim, Woo-Suk Tae, Byung-Joo Ham, Kyu-Man Han
Summary: Early neurodevelopmental deviations, such as abnormal cortical folding patterns, are candidate biomarkers of major depressive disorder (MDD). This study investigated the association between MDD and the local gyrification index (LGI) in each cortical region, as well as the association between LGI and clinical characteristics of MDD. Patients with MDD showed decreased LGI values in multiple cortical regions compared to healthy controls, while within the MDD group, longer illness duration and recurrence were associated with increased gyrification in certain temporal and occipital regions.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Seo-Eun Cho, Chan-A Park, Kyoung-Sae Na, ChiHye Chung, Hyo-Jin Ma, Chang-Ki Kang, Seung-Gul Kang
Summary: This study investigated the volume and T1 value differences of the habenula (Hb) between patients with major depressive disorder (MDD) and healthy controls using high-resolution 7-T MR imaging data. The results showed that MDD patients had a smaller right Hb volume compared to healthy controls, with no significant volume difference in the left Hb between groups. Additionally, in the MDD group, the right Hb exhibited both smaller volume and lower T1 value compared to the left Hb.
Article
Clinical Neurology
Qin Tang, Qian Cui, Yuyan Chen, Jiaxin Deng, Wei Sheng, Yang Yang, Fengmei Lu, Yuhong Zeng, Kexing Jiang, Huafu Chen
Summary: Using the DRePS method, common and specific alterations in local functional connectivity patterns were found in patients with BDD and MDD. Patients with both disorders showed decreased DRePS values in multiple brain regions, with MDD patients exhibiting specific decreases in the left caudate. Voxel signals in these regions also contributed to the classification of the two diagnoses.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Neurosciences
Sophia Frangou, Amirhossein Modabbernia, Steven C. R. Williams, Efstathios Papachristou, Gaelle E. Doucet, Ingrid Agartz, Moji Aghajani, Theophilus N. Akudjedu, Anton Albajes-Eizagirre, Dag Alnaes, Kathryn Alpert, Micael Andersson, Nancy C. Andreasen, Ole A. Andreassen, Philip Asherson, Tobias Banaschewski, Nuria Bargallo, Sarah Baumeister, Ramona Baur-Streubel, Alessandro Bertolino, Aurora Bonvino, Dorret Boomsma, Stefan Borgwardt, Josiane Bourque, Daniel Brandeis, Alan Breier, Henry Brodaty, Rachel M. Brouwer, Jan K. Buitelaar, Geraldo F. Busatto, Randy L. Buckner, Vincent Calhoun, Erick J. Canales-Rodriguez, Dara M. Cannon, Xavier Caseras, Francisco X. Castellanos, Simon Cervenka, Tiffany M. Chaim-Avancini, Christopher R. K. Ching, Victoria Chubar, Vincent P. Clark, Patricia Conrod, Annette Conzelmann, Benedicto Crespo-Facorro, Fabrice Crivello, Eveline A. Crone, Anders M. Dale, Christopher Davey, Eco J. C. de Geus, Lieuwe de Haan, Greig de Zubicaray, Anouk den Braber, Erin W. Dickie, Annabella Di Giorgio, Nhat Trung Doan, Erlend S. Dorum, Stefan Ehrlich, Susanne Erk, Thomas Espeseth, Helena Fatouros-Bergman, Simon E. Fisher, Jean-Paul Fouche, Barbara Franke, Thomas Frodl, Paola Fuentes-Claramonte, David C. Glahn, Ian H. Gotlib, Hans-Joergen Grabe, Oliver Grimm, Nynke A. Groenewold, Dominik Grotegerd, Oliver Gruber, Patricia Gruner, Rachel E. Gur, Ruben C. Gur, Ben J. Harrison, Catharine A. Hartman, Sean N. Hatton, Andreas Heinz, Dirk J. Heslenfeld, Derrek P. Hibar, Ian B. Hickie, Beng-Choon Ho, Pieter J. Hoekstra, Sarah Hohmann, Avram J. Holmes, Martine Hoogman, Norbert Hosten, Fleur M. Howells, Hilleke E. Hulshoff Pol, Chaim Huyser, Neda Jahanshad, Anthony James, Terry L. Jernigan, Jiyang Jiang, Erik G. Jonsson, John A. Joska, Rene Kahn, Andrew Kalnin, Ryota Kanai, Marieke Klein, Tatyana P. Klyushnik, Laura Koenders, Sanne Koops, Bernd Kraemer, Jonna Kuntsi, Jim Lagopoulos, Luisa Lazaro, Irina Lebedeva, Won Hee Lee, Klaus-Peter Lesch, Christine Lochner, Marise W. J. Machielsen, Sophie Maingault, Nicholas G. Martin, Ignacio Martinez-Zalacain, David Mataix-Cols, Bernard Mazoyer, Colm McDonald, Brenna C. McDonald, Andrew M. McIntosh, Katie L. McMahon, Genevieve McPhilemy, Jose M. Menchon, Sarah E. Medland, Andreas Meyer-Lindenberg, Jilly Naaijen, Pablo Najt, Tomohiro Nakao, Jan E. Nordvik, Lars Nyberg, Jaap Oosterlaan, Victor Ortiz-Garcia de la Foz, Yannis Paloyelis, Paul Pauli, Giulio Pergola, Edith Pomarol-Clotet, Maria J. Portella, Steven G. Potkin, Joaquim Radua, Andreas Reif, Daniel A. Rinker, Joshua L. Roffman, Pedro G. P. Rosa, Matthew D. Sacchet, Perminder S. Sachdev, Raymond Salvador, Pascual Sanchez-Juan, Salvador Sarro, Theodore D. Satterthwaite, Andrew J. Saykin, Mauricio H. Serpa, Lianne Schmaal, Knut Schnell, Gunter Schumann, Kang Sim, Jordan W. Smoller, Iris Sommer, Carles Soriano-Mas, Dan J. Stein, Lachlan T. Strike, Suzanne C. Swagerman, Christian K. Tamnes, Henk S. Temmingh, Sophia Thomopoulos, Alexander S. Tomyshev, Diana Tordesillas-Gutierrez, Julian N. Trollor, Jessica A. Turner, Anne Uhlmann, Odile A. van den Heuvel, Dennis van den Meer, Nic J. A. van der Wee, Neeltje E. M. van Haren, Dennis van't Ent, Theo G. M. van Erp, Ilya M. Veer, Dick J. Veltman, Aristotle Voineskos, Henry Voelzke, Henrik Walter, Esther Walton, Lei Wang, Yang Wang, Thomas H. Wassink, Bernd Weber, Wei Wen, John D. West, Lars T. Westlye, Heather Whalley, Lara M. Wierenga, Katharina Wittfeld, Daniel H. Wolf, Amanda Worker, Margaret J. Wright, Kun Yang, Yulyia Yoncheva, Marcus Zanetti, Georg C. Ziegler, Paul M. Thompson, Danai Dima
Summary: The study used data from the ENIGMA Consortium to explore the relationship between age and cortical thickness, finding that most regions peak in cortical thickness during childhood, with a negative association between age and cortical thickness where the slope is steeper before the age of 30 and more gradual afterwards.
HUMAN BRAIN MAPPING
(2022)
Article
Neurosciences
Christoph Abe, Christopher R. K. Ching, Benny Liberg, Alexander V. Lebedev, Ingrid Agartz, Theophilus N. Akudjedu, Martin Alda, Dag Alnaes, Silvia Alonso-Lana, Francesco Benedetti, Michael Berk, Erlend Boen, Caterina del Mar Bonnin, Fabian Breuer, Katharina Brosch, Rachel M. Brouwer, Erick J. Canales-Rodriguez, Dara M. Cannon, Yann Chye, Andreas Dahl, Orwa Dandash, Udo Dannlowski, Katharina Dohm, Torbjorn Elvsashagen, Lukas Fisch, Janice M. Fullerton, Jose M. Goikolea, Dominik Grotegerd, Beathe Haatveit, Tim Hahn, Tomas Hajek, Walter Heindel, Martin Ingvar, Kang Sim, Tilo T. J. Kircher, Rhoshel K. Lenroot, Ulrik F. Malt, Colm McDonald, Sean R. McWhinney, Ingrid Melle, Tina Meller, Elisa M. T. Melloni, Philip B. Mitchell, Leila Nabulsi, Igor Nenadic, Nils Opel, Bronwyn J. Overs, Francesco Panicalli, Julia-Katharina Pfarr, Sara Poletti, Edith Pomarol-Clotet, Joaquim Radua, Jonathan Repple, Kai G. Ringwald, Gloria Roberts, Elena Rodriguez-Cano, Raymond Salvador, Kelvin Sarink, Salvador Sarro, Simon Schmitt, Frederike Stein, Chao Suo, Sophia I. Thomopoulos, Giulia Tronchin, Eduard Vieta, Lars T. Westlye, Adam G. White, Lakshmi N. Yatham, Nathalia Zak, Paul M. Thompson, Ole A. Andreassen, Mikael Landen
Summary: This study revealed that patients with BD showed faster ventricular enlargements and slower thinning of specific brain regions. More manic episodes were associated with faster cortical thinning, primarily in the prefrontal cortex.
BIOLOGICAL PSYCHIATRY
(2022)
Article
Neurosciences
Diana J. N. Armbruster-Genc, Vincent Valton, Louise Neil, Vivien Vuong, Zoe C. L. Freeman, Katy C. Packer, Marianne J. Kiffin, Jonathan P. Roiser, Essi Viding, Eamon McCrory
Summary: This longitudinal study found that abnormal effort-based decision making and neural activation in children with a history of maltreatment were associated with future internalizing symptoms.
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Environmental Studies
Eirini Flouri, Dongying Ji, Jonathan P. Roiser
Summary: According to Life History Theory, children living in urban areas with lower greenness in their residential areas are more likely to engage in fast decision-making strategies, showing higher sensitivity to rewards or lower sensitivity to punishments.
LANDSCAPE RESEARCH
(2022)
Article
Neuroimaging
Namik Kirlic, Rayus Kuplicki, James Touthang, Zsofia P. Cohen, Jennifer L. Stewart, Martin P. Paulus, Robin L. Aupperle
Summary: This study aimed to investigate the neural substrates and behavioral responses during fear learning in a large sample with depressive and/or anxious dysfunction. The results revealed that fear learning recruits a distributed network of brain regions and there are distinct subjective and neural response patterns. However, there were no robust relationships to demographic or cognitive-affective variables.
NEUROIMAGE-CLINICAL
(2022)
Article
Multidisciplinary Sciences
Heekyeong Park, Katherine L. Forthman, Rayus Kuplicki, Teresa A. Victor, Hung-Wen Yeh, Wesley K. Thompson, Martin P. Paulus
Summary: This study investigated the association between genetic risk for neuroticism and neural reward-punishment processing using functional magnetic resonance imaging. The findings can serve as reference data for future studies examining the role of genetic propensity for personality traits in the context of psychiatric disorders.
Article
Psychiatry
Cynthia H. Y. Fu, Guray Erus, Yong Fan, Mathilde Antoniades, Danilo Arnone, Stephen R. Arnott, Taolin Chen, Ki Sueng Choi, Cherise Chin Fatt, Benicio N. Frey, Vibe G. Frokjaer, Melanie Ganz, Jose Garcia, Beata R. Godlewska, Stefanie Hassel, Keith Ho, Andrew M. McIntosh, Kun Qin, Susan Rotzinger, Matthew D. Sacchet, Jonathan Savitz, Haochang Shou, Ashish Singh, Aleks Stolicyn, Irina Strigo, Stephen C. Strother, Duygu Tosun, Teresa A. Victor, Dongtao Wei, Toby Wise, Rachel D. Woodham, Roland Zahn, Ian M. Anderson, J. F. William Deakin, Boadie W. Dunlop, Rebecca Elliott, Qiyong Gong, Ian H. Gotlib, Catherine J. Harmer, Sidney H. Kennedy, Gitte M. Knudsen, Helen S. Mayberg, Martin P. Paulus, Jiang Qiu, Madhukar H. Trivedi, Heather C. Whalley, Chao-Gan Yan, Allan H. Young, Christos Davatzikos
Summary: In this study, a consortium called "COORDINATE-MDD" was established to define patterns of brain alteration in major depressive disorder (MDD) using neuroanatomical and neurofunctional heterogeneity as dimensions. By harmonizing imaging data and using machine learning methods, the project aims to predict treatment response at the individual level. International datasets from various MDD populations are being shared, and novel predictors of treatment response are being identified and validated externally.
Article
Clinical Neurology
Jonathan Savitz, Bryna D. Goeckner, Bart N. Ford, T. Kent Teague, Haixia Zheng, Jaroslaw Harezlak, Rebekah Mannix, L. Tugan Muftuler, Benjamin L. Brett, Michael A. McCrea, Timothy B. Meier
Summary: This study suggests that cytomegalovirus infection may contribute to structural brain abnormalities in individuals with concussion. The researchers evaluated the effect of cytomegalovirus serostatus on brain structure in athletes with concussion, finding significant differences in white and grey matter structure between athletes with and without cytomegalovirus infection.
Article
Clinical Neurology
Antoine Lefrere, Guillaume Auzias, Pauline Favre, Irene Kaltenmark, Josselin Houenou, Camille Piguet, Mircea Polosan, Lisa T. Eyler, Mary L. Phillips, Amelia Versace, Michele Wessa, Colm McDonald, Dara M. Cannon, Paolo Brambilla, Marcella Bellani, Christine Deruelle, Raoul Belzeaux
Summary: This study explores the cortical folding in relation to neuro-developmental disorders, focusing on a neurodevelopmental subtype of bipolar disorders (BD-ND). It finds that BD-ND is associated with specific brain morphology revealed by the analysis of sulcal pits, suggesting potential insights into the neurodevelopment process and stratification of patients based on pathophysiological hypothesis.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Harry Costello, Yumeya Yamamori, Suzanne Reeves, Anette-Eleonore Schrag, Robert Howard, Jonathan P. Roiser
Summary: This study found that dopaminergic dysfunction in the midbrain is associated with motivational symptoms such as apathy and anhedonia in Parkinson's disease (PD), and this association becomes evident as the disease progresses. These findings can inform intervention strategies for improving the treatment of PD patients.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Psychology, Clinical
Sean R. McWhinney, Christoph Abe, Martin Alda, Francesco Benedetti, Erlend Boen, Caterina del Mar Bonnin, Tiana Borgers, Katharina Brosch, Erick J. Canales-Rodriguez, Dara M. Cannon, Udo Dannlowski, Ana M. Diaz-Zuluaga, Lorielle M. F. Dietze, Torbjorn Elvsashagen, Lisa T. Eyler, Janice M. Fullerton, Jose M. Goikolea, Janik Goltermann, Dominik Grotegerd, Bartholomeus C. M. Haarman, Tim Hahn, Fleur M. Howells, Martin Ingvar, Neda Jahanshad, Tilo T. J. Kircher, Axel Krug, Rayus T. Kuplicki, Mikael Landen, Hannah Lemke, Benny Liberg, Carlos Lopez-Jaramillo, Ulrik F. Malt, Fiona M. Martyn, Elena Mazza, Colm McDonald, Genevieve McPhilemy, Sandra Meier, Susanne Meinert, Tina Meller, Elisa M. T. Melloni, Philip B. Mitchell, Leila Nabulsi, Igor Nenadic, Nils Opel, Roel A. Ophoff, Bronwyn J. Overs, Julia-Katharina Pfarr, Julian A. Pineda-Zapata, Edith Pomarol-Clotet, Joaquim Radua, Jonathan Repple, Maike Richter, Kai G. Ringwald, Gloria Roberts, Alex Ross, Raymond Salvador, Jonathan Savitz, Simon Schmitt, Peter R. Schofield, Kang Sim, Dan J. Stein, Frederike Stein, Henk S. Temmingh, Katharina Thiel, Sophia I. Thomopoulos, Neeltje E. M. van Haren, Cristian Vargas, Eduard Vieta, Annabel Vreeker, Lena Waltemate, Lakshmi N. Yatham, Christopher R. K. Ching, Ole A. Andreassen, Paul M. Thompson, Tomas Hajek
Summary: This study found that body mass index (BMI) and bipolar disorder (BD) have an impact on brain structure, particularly in cortical thickness. Both BMI and BD negatively affect the same brain regions, and BMI has a greater effect on brain alterations in individuals with BD. It is important to assess the neuroanatomical changes in BD caused by BMI and the effects of psychiatric medications on the brain.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Immunology
Kaiping Burrows, Leandra K. Figueroa-Hall, Ahlam M. Alarbi, Jennifer L. Stewart, Rayus Kuplicki, Chibing Tan, Bethany N. Hannafon, Rajagopal Ramesh, Jonathan Savitz, Sahib Khalsa, T. Kent Teague, Victoria B. Risbrough, Martin P. Paulus
Summary: This study examines the effects of ibuprofen on extracellular vesicles (AEEVs) miRNA and finds that ibuprofen dose-dependently increases the expression of AEEV miR-23b-3p. Individuals with higher miR-23b-3p expression show increased striatal brain activation during reward anticipation, suggesting that ibuprofen alters the composition of AEEV miRNA and may have implications for mental health.
BRAIN, BEHAVIOR, & IMMUNITY - HEALTH
(2023)
Article
Biochemistry & Molecular Biology
Haixia Zheng, Maree J. J. Webster, Cynthia Shannon Weickert, Clare L. L. Beasley, Martin P. P. Paulus, Robert H. H. Yolken, Jonathan Savitz
Summary: CMV reactivation may contribute to the neuroinflammation underlying some psychiatric disorders by exacerbating inflammation and translating peripheral inflammation into neuroinflammation. The study found significant associations between CMV infection and mood disorders, suicide, neuroinflammation, and microglial density in the dorsolateral prefrontal cortex.
MOLECULAR PSYCHIATRY
(2023)
Editorial Material
Neurosciences
Haixia Zheng, Jonathan Savitz
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Kaiping Burrows, Breanna A. McNaughton, Leandra K. Figueroa-Hall, Philip A. Spechler, Rayus Kuplicki, Teresa A. Victor, Robin Aupperle, Sahib S. Khalsa, Jonathan B. Savitz, T. Kent Teague, Martin P. Paulus, Jennifer L. Stewart
Summary: This study examined the associations between inflammation, metabolic hormones, and reward-related brain processing in MDD patients with high and low CRP levels compared to healthy individuals. The results demonstrated that both MDD-High and MDD-Low patients had higher leptin concentrations than healthy controls, and higher leptin levels were associated with decreased brain activation during reward anticipation in MDD patients but increased activation in healthy controls.
SCIENTIFIC REPORTS
(2023)