期刊
BIOLOGICAL PSYCHIATRY
卷 68, 期 9, 页码 818-824出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.biopsych.2010.06.025
关键词
Arousal; brain-derived neurotrophic factor (BDNF) Val66Met polymorphism; brain imaging; Brain Research And Integrative Neuroscience Network (BRAINnet); depression; early life stress; emotion regulation; serotonin 3A receptor HTR3A polymorphism
资金
- Australian Research Council (ARC) [LP0455104]
- Pfizer foundation
- National Health and Medical Research Council (NHMRC) [157209]
- National Institute of Mental Health [MH-42088, MH-52899, MH-39415]
- Brain Research And Integrative Neuroscience Network (BRAINnet)
- Brain Resource, Ltd. (BR)
- ARC
- Mt. Cook Pharma, Inc.
- NovaDel Pharma, Inc.
- AstraZeneca
- CeNeRx BioPharma
- PharmaNeuroBoost
- Apollo Life Sciences, Ltd.
- Brain Resource Company
- Australian Research Council [LP0455104] Funding Source: Australian Research Council
Background: Depression will be the second largest burden of disease by 2020. Developing new tools for identifying risk and ultimately prevention of depression relies on elucidating the integrative relationships between susceptibility markers from gene-stress interactions and how they impact emotional brain and arousal systems. They have largely been studied in isolation. Methods: We examined how genetic (brain-derived neurotrophic factor [BDNF] valine 66 to methionine [Val66Met] and serotonin receptor gene 3A [HTR3A]) and early life stress susceptibility factors interact in predicting electroencephalogram (EEG) asymmetry, emotion-elicited heart rate, and self-reported negativity bias, each correlates of risk for depression. Caucasian volunteers (n = 363) were derived from the Brain Resource International Database, via the Brain Research And Integrative Neuroscience Network. Results: Individuals with both BDNF methionine and HTR3A CC risk genotypes and early life stressors demonstrated a profile of elevated emotion-elicited heart rate and right frontal hyper-activation with right parietotemporal hypoactivation in EEG asymmetry. Elevations in heart rate were a moderator of negativity bias. Conclusions: The findings provide new evidence that these gene-stress susceptibility factors contribute to a brain-arousal profile indicative of risk for depression. They are a step toward identifying biological markers for detecting risk before overt symptoms. It would be valuable for future studies to examine comorbidity and specificity issues; for instance, whether these gene-stress factors contribute in different ways to the partially distinct EEG asymmetry profiles found with anxiety.
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