Article
Endocrinology & Metabolism
James L. Abelson, Brisa N. Sanchez, Stefanie E. Mayer, Hedieh Briggs, Israel Liberzon, Nirmala Rajaram
Summary: Salivary cortisol stress biomarkers are commonly used in epidemiological research to examine the relationship between stress and health problems. However, there has been limited effort to connect these measures with the biological mechanisms involved in stress-related health outcomes. This study found associations between cortisol diurnal decline and feedback sensitivity, as well as between morning cortisol levels and adrenal sensitivity. It also raised questions about the biological meaning of other curve components, such as morning cortisol levels and the cortisol awakening response.
PSYCHONEUROENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Yannuo Li, Ioannis P. Androulakis
Summary: The suprachiasmatic nucleus (SCN) synchronizes physiological rhythms and adapts to changes in photoperiod, affecting the phase distribution of neuron activities. Elevated glucocorticoid levels in short photoperiods are associated with peak disease incidence. Topological changes in the SCN network may influence seasonal variations in disease incidence.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biology
Isabella Robertson-Dixon, Melanie J. Murphy, Sheila G. Crewther, Nina Riddell
Summary: This systematic review evaluated the effects of daytime exposure to lights of different spectral wavelength characteristics and luminance intensity on cortisol levels in healthy individuals. The analysis indicated that exposure to bright lights of any color during the late night or early morning can significantly increase cortisol secretion, and exposure to bright lights with stronger short-wavelength (blue/green) components in the early morning typically induces greater increases in cortisol. Therefore, the circadian regulation of cortisol is sensitive to the wavelength composition of environmental lighting.
Article
Endocrinology & Metabolism
Cathy Degroote, Roland von Kanel, Livia Thomas, Claudia Zuccarella-Hackl, Nadine Messerli-Burgy, Hugo Saner, Roland Wiest, Petra H. Wirtz
Summary: Research shows that patients with coronary heart disease (CHD) and hypertension have decreased activity in the hypothalamus-pituitary-adrenal (HPA) axis, which may contribute to an increased risk of cardiovascular disease.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Clinical Neurology
Jelena Bakusic, Manosij Ghosh, Andrea Polli, Bram Bekaert, Wilmar Schaufeli, Stephan Claes, Lode Godderis
Summary: The study revealed that job stress was associated with increased levels of cortisol and cortisone in burnout participants. Changes in DNA methylation of the NR3C1 and SLC6A4 genes were observed in burnout individuals, and some of these methylation changes correlated with burnout symptoms. Increased methylation in a specific CpG in the SLC6A4 gene moderated the association between job stress and burnout, while DNA methylation in this CpG was also associated with increased cortisol levels. Furthermore, average methylation of NR3C1 was negatively associated with cortisone levels.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Endocrinology & Metabolism
Pauline S. Effenberger, Tabea S. Send, Maria Gilles, Josef Frank, Stephan Bongard, Robert Kumsta, Stephanie H. Witt, Marcella Rietschel, Michael Deuschle, Fabian Streit, Isabell A. C. Wolf
Summary: There is no strong association between urbanicity and behavior problems or HPA axis regulation in preschool age, and urinary cortisol and salivary cortisol response after stress exposure are not identified as mediators of this relationship.
PSYCHONEUROENDOCRINOLOGY
(2022)
Article
Neurosciences
Trina Basu, Jamie Maguire, Jay A. Salpekar
Summary: Stress is a common seizure trigger in persons with epilepsy, and prolonged exposure to stress hormones may exacerbate epilepsy and increase the risk of psychiatric comorbidities. Hyperactivity of the HPA axis negatively impacts the structure and function of the temporal lobe, leading to neuronal damage and a cycle of increased susceptibility for seizures and psychiatric comorbidities. Targeting the HPA axis in treatment may improve seizure control and alleviate stress-related psychiatric comorbidities.
NEUROSCIENCE LETTERS
(2021)
Article
Endocrinology & Metabolism
Jessica L. Irwin, Amy L. Meyering, Gage Peterson, Laura M. Glynn, Curt A. Sandman, Laurel M. Hicks, Elysia Poggi Davis
Summary: The study investigated the relationship between maternal prenatal cortisol levels and infant cortisol reactivity during inoculation. The results showed that elevated prenatal cortisol levels in mothers are associated with a larger cortisol response in infants at 6 and 12 months when faced with a challenging event.
PSYCHONEUROENDOCRINOLOGY
(2021)
Review
Clinical Neurology
Raphael J. Dressle, Bernd Feige, Kai Spiegelhalder, Christine Schmucker, Fee Benz, Nina C. Mey, Dieter Riemann
Summary: This study aimed to evaluate the differences in cortisol levels, the hormonal end product of the HPA axis, between patients with insomnia and good sleeper controls. The results suggested that patients with insomnia showed moderately increased cortisol levels, with higher effect sizes found when analyzing studies that used blood samples. There was a positive but insignificant association between the extent of objective sleep loss in insomnia patients and group differences in cortisol levels.
SLEEP MEDICINE REVIEWS
(2022)
Article
Endocrinology & Metabolism
Bernhard C. L. Maier, Lea Zillich, Fabian Streit, Katharina Wildenberg, Marcella Rietschel, Hans-Peter Hammes, Stephanie H. Witt, Michael Deuschle
Summary: Adverse childhood experiences (ACEs) have negative effects on health outcomes, and alterations in the hypothalamic pituitary adrenal (HPA) axis might play a role. This study examined the relationship between ACEs and diurnal HPA axis functioning in older adults, and found that type and timing of ACEs influence HPA axis activity in old age.
PSYCHONEUROENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Ursula G. Saelzler, Paul Verhaeghen, Matthew S. Panizzon, Scott D. Moffat
Summary: This investigation reviewed decades of research on the hypersecretion of the glucocorticoid cortisol in individuals with Alzheimer's disease (AD), finding that AD is associated with basal cortisol elevations. However, there was no evidence of circadian dysrhythmia among individuals with AD, suggesting that basal hypersecretion of cortisol is a characteristic of AD while circadian dysrhythmia is not. Further research is needed to understand the role and timing of cortisol elevations in the progression of AD.
PSYCHONEUROENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Lycia D. de Voogd, Rosalie Anne Kampen, Reinoud Kaldewaij, Wei Zhang, Mahur Melina Hashemi, Saskia B. J. Koch, Floris Klumpers, Jeffrey C. Glennon, Karin Roelofs
Summary: This study provides the first longitudinal evidence of a dose-response relationship between trauma and human GR mRNA expression changes, indicating that increased traumatic events during police training lead to stronger GR mRNA expression. Additionally, increases in GR mRNA expression are associated with blunted HPA-axis stress-reactivity.
PSYCHONEUROENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Nina E. Ahlers, Sandra J. Weiss
Summary: The study found that increased prenatal exposure to PM2.5 was associated with more severe depressive symptoms in the third trimester. Greater PM2.5 exposure was also linked to higher cortisol AUCG and average cortisol levels among women, though no cortisol parameter appeared to mediate the relationship between PM2.5 exposure and depressive symptoms.
Article
Multidisciplinary Sciences
Ivan Salaric, Ivana Karmelic, Jasna Lovric, Ksenija Bazdaric, Marko Rozman, Igor Cvrljevic, Ivan Zajc, Davor Brajdic, Darko Macan
Summary: This study aimed to investigate salivary melatonin levels in oral squamous cell carcinoma (OSCC) patients and found significantly higher melatonin levels in the saliva of OSCC patients, along with significantly lower sleep quality. The results suggest salivary MLT as a potential biomarker for non-invasive detection of early stage OSCC.
SCIENTIFIC REPORTS
(2021)
Article
Geriatrics & Gerontology
Ryuzo Orihashi, Yoshiomi Imamura, Shigeto Yamada, Akira Monji, Yoshito Mizoguchi
Summary: This study investigated the association between serum cortisol levels and brain volume among older adults in rural Japan aged 65 years and above. The results showed a negative correlation between serum cortisol levels at baseline and brain volume in the left hippocampus region. Serum cortisol levels may serve as a peripheral biomarker of age-related volume changes involving the hippocampus in older adults.
Article
Cardiac & Cardiovascular Systems
Steven H. J. Hageman, Jannick A. N. Dorresteijn, Michiel L. Bots, Folkert W. Asselbergs, Jan Westerink, Miriam P. van der Meulen, Arend Mosterd, Frank L. J. Visseren, F. W. Asselbergs, H. M. Nathoe, G. J. de Borst, M. L. Bots, M. Geerlings, M. H. Emmelot, P. A. de Jong, T. Leiner, A. T. Lely, N. P. van der Kaaij, L. J. Kappelle, Y. M. Ruigrok, M. C. Verhaar, F. L. J. Visseren, J. Westerink
Summary: This study aimed to compare the cost-effectiveness of treatment strategies guided by predicted lifetime benefit versus risk factor levels in patients with symptomatic atherosclerotic disease. The results showed that treatment based on lifetime benefit led to more CVD-free life years and more events avoided compared to risk factor-based treatment, indicating it is a potentially effective and cost-effective strategy for reducing residual CVD risk in these patients.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Article
Clinical Neurology
Ina Rissanen, Mirjam Geerlings, Seppo Juvela, Jouko Miettunen, Markus Paananen, Sami Tetri
Summary: The study suggests that the general health condition of mothers during pregnancy may impact the risk of cerebrovascular disease in offspring. Factors such as hospitalization, having multiple ill health conditions, and not using vitamin or iron supplements were associated with an increased risk of cerebrovascular disease in the offspring.
INTERNATIONAL JOURNAL OF STROKE
(2022)
Article
Clinical Neurology
Ina Rissanen, Carlo Lucci, Rashid Ghaznawi, Jeroen Hendrikse, L. Jaap Kappelle, Mirjam Geerlings
Summary: Symptomatic cerebrovascular disease is associated with smaller brain volume, larger WMH volume, and increased risk for new infarcts during follow-up. Silent vascular lesions are linked to smaller brain volume, steeper brain atrophy slope, larger WMH volume, and increased risk for lacunes. Individuals with imaging-negative ischemia have an increased risk for cortical infarcts.
Article
Behavioral Sciences
Lonneke A. van Tuijl, Adri C. Voogd, Alexander de Graeff, Adriaan W. Hoogendoorn, Adelita V. Ranchor, Kuan-Yu Pan, Maartje Basten, Femke Lamers, Mirjam I. Geerlings, Jessica G. Abell, Philip Awadalla, Marije F. Bakker, Aartjan T. F. Beekman, Ottar Bjerkeset, Andy Boyd, Yunsong Cui, Henrike Galenkamp, Bert Garssen, Sean Hellingman, Martijn Huisman, Anke Huss, Melanie R. Keats, Almar A. L. Kok, Annemarie I. Luik, Nolwenn Noisel, N. Charlotte Onland-Moret, Yves Payette, Brenda W. J. H. Penninx, Lutzen Portengen, Ina Rissanen, Annelieke M. Roest, Judith G. M. Rosmalen, Rikje Ruiter, Robert A. Schoevers, David M. Soave, Mandy Spaan, Andrew Steptoe, Karien Stronks, Erik R. Sund, Ellen Sweeney, Alison Teyhan, Ilonca Vaartjes, Kimberly D. van der Willik, Flora E. van Leeuwen, Rutger van Petersen, W. M. Monique Verschuren, Frank Visseren, Roel Vermeulen, Joost Dekker
Summary: The study aims to explore the relationship between psychosocial factors and cancer risk, including the association between psychosocial factors and various types of cancer (breast, lung, prostate, colorectal, etc.), the interaction between psychosocial factors and various cancer risk factors, and the mediating role of health behaviors in the relationship between psychosocial factors and cancer incidence.
BRAIN AND BEHAVIOR
(2021)
Article
Neurosciences
Lotte Gerritsen, Emma L. Twait, Palmi Jonsson, Vilmundur Gudnason, Lenore J. Launer, Mirjam Geerlings
Summary: The study found that current depression is significantly associated with an increased risk of developing dementia, including Alzheimer's disease and non-Alzheimer's dementia. However, neither the glucocorticoid cascade nor vascular hypotheses fully explained the relationship between depression and dementia, suggesting multiple biological mechanisms may be involved.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Clinical Neurology
Milou J. Angevaare, Jet M. J. Vonk, Laiss Bertola, Laura Zahodne, Caitlin Wei-Ming Watson, Amelia Boehme, Nicole Schupf, Richard Mayeux, Mirjam Geerlings, Jennifer J. Manly
Summary: This study investigates the sociodemographic and medical predictors of incident mild cognitive impairment (MCI) and its subsequent course. The findings suggest that the predictors of incident MCI differ from those of subsequent MCI course, providing insights into the cognitive and functional outcomes for individuals with MCI.
Article
Cardiac & Cardiovascular Systems
Carlo Lucci, Tim C. van den Beukel, Jonas W. Bartstra, Jaco Zwanenburg, Anja van der Kolk, Richard Takx, Jeroen Hendrikse, Mirjam I. Geerlings, Daniel Bos, Wilko Spiering, Pim A. de Jong
Summary: The distribution and burden of intracranial atherosclerosis were similar between PXE patients and healthy controls, suggesting that PXE and its underlying mutations do not involve increased atherogenesis in the intracranial arteries. Vascular calcification or other mechanisms may explain the increased risk of stroke in PXE.
Article
Behavioral Sciences
Jet M. J. Vonk, Rashid Ghaznawi, Maarten H. T. Zwartbol, Yaakov Stern, Mirjam I. Geerlings
Summary: This study investigated the associations of cognitive and brain reserve with memory decline in mid-life and late-life. The results showed that higher cognitive and brain reserve can protect against memory decline, particularly in late-life.
Article
Neurosciences
A. de Bekker, M. Geerlings, I. E. Uitewaal-Poslawsky, J. M. de Man-van Ginkel
Summary: This study investigates the long-term development of depressive symptoms in stroke patients and identifies the association with physical function.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2022)
Article
Geriatrics & Gerontology
Lotte Gerritsen, Sigurdur Sigurdsson, Palmi Jonsson, Vilmundur Gudnason, Lenore J. Launer, Mirjam Geerlings
Summary: Late-life depression (LLD) may increase the risk of dementia, with severe LLD, mild LLD, and apathy being the main symptoms associated with higher risk. The increase in white matter lesions over time may partially mediate the relationship between mild LLD and dementia.
NEUROBIOLOGY OF AGING
(2022)
Article
Clinical Neurology
R. Ghaznawi, M. H. T. Zwartbol, J. de Bresser, H. J. Kuijf, K. L. Vincken, I. Rissanen, M. I. Geerlings, J. Hendrikse
Summary: This study found that microinfarcts in the deep gray matter on 7T MR imaging were associated with worse cognitive functioning, risk factors, and MR imaging markers of small-vessel and large-vessel disease. The findings suggest that microinfarcts in the deep gray matter may represent a novel imaging marker of vascular brain injury.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2022)
Editorial Material
Clinical Neurology
Rashid Ghaznawi, Ina Rissanen, Jeroen de Bresser, Hugo J. Kuijf, Nicolaas P. A. Zuithoff, Jeroen Hendrikse, Mirjam Geerlings
Summary: This study examined the association between carotid artery stenosis (CAS) and progression of hemispheric brain atrophy. The results showed that severe CAS on the right side was associated with a greater decrease in volume of both the left and right hemispheres, while increasing degrees of CAS on the left side were not associated with greater volume loss.
CEREBROVASCULAR DISEASES
(2023)
Article
Neurosciences
Emma L. Twait, Kim Blom, Huiberdina L. Koek, Maarten H. T. Zwartbol, Rashid Ghaznawi, Jeroen Hendrikse, Lotte Gerritsen, Mirjam I. Geerlings
Summary: This study used high-field 7T MRI to explore the association between psychosocial factors and hippocampal (subfield) volumes. The results showed that depression and anxiety were not associated with specific hippocampal (subfield) volumes, while childhood maltreatment and recent stressful life events may have an impact on hippocampal volume. Additionally, low social support was associated with smaller CA3 volume.
HUMAN BRAIN MAPPING
(2023)
Article
Clinical Neurology
J. M. Spijkerman, J. J. M. Zwanenburg, W. H. Bouvy, M. I. Geerlings, G. J. Biessels, J. Hendrikse, P. R. Luijten, H. J. Kuijf
Summary: A method for automatic detection and quantification of perivascular spaces (PVS) was developed, showing good correlation between automatic and manual PVS counts. Additionally, differences in length and tortuosity of PVS in different brain regions were observed.
CEREBRAL CIRCULATION - COGNITION AND BEHAVIOR
(2022)
Meeting Abstract
Psychology, Clinical
Lonneke van Tuijl, Adelita Ranchor, Adri Voogd, Alexander de Graeff, Adriaan Hoogendoorn, Roel Vermeulen, Mirjam Geerlings, Femke Lamers, Joost Dekker
INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE
(2021)
Review
Neurosciences
Maya Jammoul, Dareen Jammoul, Kevin K. Wang, Firas Kobeissy, Ralph G. Depalma
Summary: This article reviews the possible mechanisms by which traumatic brain injury (TBI) may stimulate the development of opioid use disorder (OUD) and discusses the interaction between these two processes. CNS damage due to TBI appears to drive adverse effects of subsequent OUD, with pain being a risk factor for opioid use after TBI.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Danusa Mar Arcego, Jan-Paul Buschdorf, Nicholas O'Toole, Zihan Wang, Barbara Barth, Irina Pokhvisneva, Nirmala Arul Rayan, Sachin Patel, Euclides Jose de Mendonca Filho, Patrick Lee, Jennifer Tan, Ming Xuan Koh, Chu Ming Sim, Carine Parent, Randriely Merscher Sobreira de Lima, Andrew Clappison, Kieran J. O'Donnell, Carla Dalmaz, Janine Arloth, Nadine Provencal, Elisabeth B. Binder, Josie Diorio, Patricia Pelufo Silveira, Michael J. Meaney
Summary: This study investigates the impact of environmental influences on mental health by integrating transcriptomic data from animal models with human data. The results suggest that hippocampal glucocorticoid-related transcriptional activity mediates the effects of early adversity on neural mechanisms implicated in psychiatric disorders.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Milenna T. van Dijk, Ardesheer Talati, Pratik Kashyap, Karan Desai, Nora C. Kelsall, Marc J. Gameroff, Natalie Aw, Eyal Abraham, Breda Cullen, Jiook Cha, Christoph Anacker, Myrna M. Weissman, Jonathan Posner
Summary: This study found that maternal stress is associated with future depressive symptoms and alterations in microstructure of the dentate gyrus (DG) in offspring. These results were consistent across two independent cohorts.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Josephine C. McGowan, Liliana R. Ladner, Claire X. Shubeck, Juliana Tapia, Christina T. LaGamma, Amanda Anqueira-Gonzalez, Ariana DeFrancesco, Briana K. Chen, Holly C. Hunsberger, Ezra J. Sydnor, Ryan W. Logan, Tzong-Shiue Yu, Steven G. Kernie, Christine A. Denny
Summary: Traumatic brain injury (TBI) leads to fear generalization by altering fear memory traces, and this symptom can be improved with (R,S)-ketamine.
BIOLOGICAL PSYCHIATRY
(2024)