Review
Biochemistry & Molecular Biology
Xinjian Zhang, Daisuke Tsuboi, Yasuhiro Funahashi, Yukie Yamahashi, Kozo Kaibuchi, Taku Nagai
Summary: Dopamine regulates emotional behaviors, including rewarding and aversive behaviors, through the mesolimbic dopaminergic pathway. Protein phosphorylation plays a critical role in intracellular signaling pathways and physiological functions, and dopamine regulates neuronal excitability and synaptic plasticity through phosphorylation of intracellular substrates. Understanding the mechanisms by which dopamine controls emotional behaviors is crucial.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Wen Ting Cai, Wha Young Kim, Myung Ji Kwak, Haeun Rim, Seung Eun Lee, Lars Bjorn Riecken, Helen Morrison, Jeong-Hoon Kim
Summary: Repeated injections of psychomotor stimulants can induce behavioral sensitization and lead to addictive behaviors. This study found that a specific mutant can inhibit the development of sensitization, providing important clues for understanding the role of dendritic spines in psychomotor stimulant addiction.
JOURNAL OF NEUROCHEMISTRY
(2022)
Article
Cell Biology
Karolina Farrell, Armin Lak, Aman B. Saleem
Summary: Midbrain dopamine neurons encode reward prediction error signals to improve goal-directed navigation.
Article
Neurosciences
Tong-Yu Liang, Hua Zhou, Yan-Gang Sun
Summary: Ventral tegmental area (VTA) dopaminergic neurons participate in itch processing through their projection to the nucleus accumbens (NAc). The roles of dopamine receptor subtypes in different subregions of the NAc during itch processing were investigated. It was found that dopamine D1 receptors (D1R) blockade in the lateral shell (LaSh) impaired pruritogen-induced scratching behavior, while D2R activation in both LaSh and medial shell (MeSh) attenuated scratching behavior. Dopamine release in LaSh was elevated during scratching behavior, suggesting a motivational component of itch processing. This study highlights the importance of D1R in the LaSh of the NAc in itch signal processing.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Biology
Jessica N. Goedhoop, Bastijn J. G. van den Boom, Rhiannon Robke, Felice Veen, Lizz Fellinger, Wouter van Elzelingen, Tara Arbab, Ingo Willuhn
Summary: This study systematically investigates the role of dopamine in processing aversive stimuli and finds that NAC dopamine primarily tracks the prediction and duration of aversive events, rather than aversive prediction errors.
Article
Neurosciences
Valeska Cid-Jofre, Macarena Garate-Perez, Philip J. Clark, Viviana Valero-Jara, Rodrigo A. Espana, Ramon Sotomayor-Zarate, Gonzalo Cruz, Georgina M. Renard
Summary: Chronic Mod treatment during preadolescence impairs dopaminergic neurotransmission in NAc and decreases the capacity of rats to perceive rewarding effects of social play. It is important to consider potential effects on social behavior when evaluating Mod to treat ADHD in children and adolescents. Social interactions play a crucial role in neurodevelopment during this particular stage.
Article
Multidisciplinary Sciences
Daniel J. Christoffel, Jessica J. Walsh, Paul Hoerbelt, Boris D. Heifets, Pierre Llorach, Ricardo C. Lopez, Charu Ramakrishnan, Karl Deisseroth, Robert C. Malenka
Summary: The study reveals that dopamine and serotonin modulate excitatory synaptic transmission in the nucleus accumbens in input-specific ways, influencing motivated behaviors differently. Endogenous release of DA and 5-HT, as well as optogenetic inhibition, alter the behavioral effects of drugs in distinct manners.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Behavioral Sciences
Marisela Hernandez-Gonzalez, Francisco Javier Barrera-Cobos, Enrique Hernandez-Arteaga, Ignacio Gonzalez-Burgos, Mario Flores-Soto, Miguel Angel Guevara, Pedro Manuel Cortes
Summary: Sexual experience improves copulatory performance in male rats by promoting changes in the density of dendritic spines in the medial prefrontal cortex (mPFC) and nucleus accumbens (NAcc). Specifically, sexually experienced rats exhibited higher total dendritic density and increased numerical density of certain types of dendritic spines in the mPFC and NAcc. Furthermore, there was a shift in the proportional density of different types of dendritic spines towards a higher proportion of mushroom spines. These findings suggest that sexual experience can lead to consolidation of synaptic information in the brain regions involved in sexual behavior.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Neurosciences
Jessica Goedhoop, Tara Arbab, Ingo Willuhn
Summary: By comparing two different experimental paradigms, this study reveals that dopamine signals contain both reward-related and action-related information. The action component of dopamine release is characterized by sustained signals, which reflect the motivation for appetitive action.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Neurosciences
Dan P. Covey, Edith Hernandez, Miguel A. Lujan, Joseph F. Cheer
Summary: The study found that dopamine release in the nucleus accumbens responds differently to cues signaling increasing cost of reward. Endocannabinoid signaling facilitates goal-seeking and nucleus accumbens dopamine release, while chronic MAGL treatment stably facilitates goal-seeking and dopamine encoding without the development of tolerance.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Gavin C. Jones, Christina A. Small, Dallin Z. Otteson, Caylor W. Hafen, Jacob T. Breinholt, Paul D. Flora, Matthew D. Burris, David W. Sant, Tysum R. Ruchti, Jordan T. Yorgason, Scott C. Steffensen, Kyle B. Bills
Summary: This study used a Wistar rat model to evaluate the effectiveness of whole-body vibration (WBV) as a preventative measure for the neuronal and behavioral effects of morphine withdrawal. The results showed that concurrent administration of WBV at 80 Hz with morphine significantly reduced adaptations in neuronal activity and dopamine release, as well as modulated the expression of δ-opioid receptors on cholinergic interneurons in the nucleus accumbens. WBV represents a promising adjunct to current intervention for opioid use disorder (OUD).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Zhixiong He, Lizi Zhang, Wenjuan Hou, Xin Zhang, Larry J. Young, Laifu Li, Limin Liu, Huan Ma, Yufeng Xun, Zijian Lv, Yitong Li, Rui Jia, Jingang Li, Fadao Tai
Summary: Paternal care is crucial for the development of offspring in monogamous species, and the activation of oxytocin neurons in the PVN to VTA or NAc plays a significant role in promoting paternal care. Understanding the neuronal circuitry underlying paternal care could have implications for treating abnormalities such as paternal postpartum depression or abuse.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Zheng-Dong Zhao, Xiao Han, Renchao Chen, Yiqiong Liu, Aritra Bhattacherjee, Wenqiang Chen, Yi Zhang
Summary: The striatum plays a critical role in regulating addiction-related behaviors. A subtype of D1 MSNs, Tac2+, demonstrates an unconventional and subtype/projection-specific negative regulatory function in drug addiction.
Article
Pharmacology & Pharmacy
Ana Paula S. Dornellas, Giovana C. Macedo, Minna H. McFarland, Alexander Gomez-A, Todd K. O'Buckley, Claudio Da Cunha, A. Leslie Morrow, Donita L. Robinson
Summary: Research has shown that allopregnanolone can reduce dopamine release in both male and female rats, with its effects modulated by sex and estrous cycle stages.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Xiaonan Li, Lehua Lu, Ying He, Hui Zhang, Yihui Zhang, Huaquan Sheng, Ming Chen, Jiexiong Ru, Yihan Gao
Summary: This study examined the effects of different nicotine salts on dopamine (DA) release in the nucleus accumbens (NAc) using a fluorescent probe and optical fiber photometric recording equipment. The results showed that different nicotine salts increased DA release in the NAc, but each salt had different efficiency in increasing DA release with concentration changes.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Endocrinology & Metabolism
M. N. Lehman, L. M. Coolen, R. A. Steiner, G. Neal-Perry, L. Wang, S. M. Moenter, A. M. Moore, R. L. Goodman, S. -H. Yeo, S. L. Padilla, A. S. Kauffman, J. Garcia, M. J. Kelly, J. Clarkson, S. Radovick, A. V. Babwah, S. Leon, M. Tena-Sempere, A. N. Comninos, S. Seminara, W. S. Dhillo, J. Levine, E. Terasawa, A. Negron, V. M. Navarro, A. E. Herbison
JOURNAL OF NEUROENDOCRINOLOGY
(2018)
Editorial Material
Endocrinology & Metabolism
M. Lehman, V. Navarro, D. Suchecki, R. Handa
JOURNAL OF NEUROENDOCRINOLOGY
(2018)
Article
Neurosciences
Lindsey B. Kuiper, Lauren N. Beloate, Braxton M. Dupuy, Lique M. Coolen
NEUROPSYCHOPHARMACOLOGY
(2019)
Article
Critical Care Medicine
J. Walker Wiggins, Natalie Kozyrev, Jonathan E. Sledd, George G. Wilson, Lique M. Coolen
JOURNAL OF NEUROTRAUMA
(2019)
Article
Endocrinology & Metabolism
Justin A. Lopez, Elizabeth C. Bowdridge, Richard B. McCosh, Michelle N. Bedenbaugh, Ashley N. Lindo, Makayla Metzger, Megan Haller, Michael N. Lehman, Stanley M. Hileman, Robert L. Goodman
JOURNAL OF NEUROENDOCRINOLOGY
(2020)
Editorial Material
Neurosciences
Hollis Cline, Lique Coolen, Saskia de Vries, Steven Hyman, Rosalind Segal, Oswald Steward
JOURNAL OF NEUROSCIENCE
(2020)
Article
Endocrinology & Metabolism
Danielle T. Porter, Robert L. Goodman, Stanley M. Hileman, Michael N. Lehman
Summary: The study found that there were higher numbers of vGlut2 inputs onto KNDy neurones in sheep during the follicular phase with high levels of estradiol. This suggests that the synaptic plasticity of glutamatergic inputs to KNDy neurones depends on increasing levels of estradiol during the ovine follicular phase. These synaptic changes likely contribute to the positive-feedback action of estrogen on GnRH/LH secretion and the generation of the preovulatory surge in sheep.
JOURNAL OF NEUROENDOCRINOLOGY
(2021)
Review
Endocrinology & Metabolism
Robert L. Goodman, Allan E. Herbison, Michael N. Lehman, Victor M. Navarro
Summary: This article discusses the neural mechanisms underlying the episodic and surge secretion of GnRH, with a focus on the core components. Recent studies have revealed that the arcuate nucleus kisspeptin neurons, also known as KNDy cells, and their projections to GnRH dendrons serve as the GnRH pulse generator in mice and rats. Similar roles have been observed in sheep and goats, but the evidence is weaker in monkeys and humans. In spontaneous ovulators, the core endocrine signal for GnRH/luteinising hormone surge is an increase in estradiol secretion, with species variations in the neural trigger.
JOURNAL OF NEUROENDOCRINOLOGY
(2022)
Article
Health Policy & Services
Margaret E. Balfour, Arlene Hahn Stephenson, Ayesha Delany-Brumsey, Jason Winsky, Matthew L. Goldman
Summary: How a community responds to behavioral health emergencies is not just a public health issue, but also a social justice issue. Inadequate care in emergency departments, police shootings, and jail bookings are all problems faced by individuals experiencing behavioral health crises. Racism and implicit bias exacerbate these issues. Meaningful change requires comprehensive systemic approaches.
PSYCHIATRIC SERVICES
(2022)
Review
Endocrinology & Metabolism
Michael N. Lehman
JOURNAL OF NEUROENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Rebecca E. Campbell, Lique M. Coolen, Gloria E. Hoffman, Erik Hrabovszky
Summary: The anatomy and morphology of GnRH neurons present both joy and challenges in research. Understanding their anatomy is crucial for understanding reproductive function regulation, and comparative aspects exist in different species. Future research needs to address unanswered questions.
JOURNAL OF NEUROENDOCRINOLOGY
(2022)
Editorial Material
Endocrinology & Metabolism
Michael N. Lehman
JOURNAL OF NEUROENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Jason Roberge, Andrew McWilliams, Jing Zhao, William E. Anderson, Timothy Hetherington, Christine Zazzaro, Elisabeth Hardin, Amy Barrett, Manuel Castro, Margaret E. Balfour, James Rachal, Constance Krull, Wayne Sparks
Article
Endocrinology & Metabolism
Danielle T. Porter, Aleisha M. Moore, Jade A. Cobern, Vasantha Padmanabhan, Robert L. Goodman, Lique M. Coolen, Michael N. Lehman
Review
Neurosciences
Maya Jammoul, Dareen Jammoul, Kevin K. Wang, Firas Kobeissy, Ralph G. Depalma
Summary: This article reviews the possible mechanisms by which traumatic brain injury (TBI) may stimulate the development of opioid use disorder (OUD) and discusses the interaction between these two processes. CNS damage due to TBI appears to drive adverse effects of subsequent OUD, with pain being a risk factor for opioid use after TBI.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Danusa Mar Arcego, Jan-Paul Buschdorf, Nicholas O'Toole, Zihan Wang, Barbara Barth, Irina Pokhvisneva, Nirmala Arul Rayan, Sachin Patel, Euclides Jose de Mendonca Filho, Patrick Lee, Jennifer Tan, Ming Xuan Koh, Chu Ming Sim, Carine Parent, Randriely Merscher Sobreira de Lima, Andrew Clappison, Kieran J. O'Donnell, Carla Dalmaz, Janine Arloth, Nadine Provencal, Elisabeth B. Binder, Josie Diorio, Patricia Pelufo Silveira, Michael J. Meaney
Summary: This study investigates the impact of environmental influences on mental health by integrating transcriptomic data from animal models with human data. The results suggest that hippocampal glucocorticoid-related transcriptional activity mediates the effects of early adversity on neural mechanisms implicated in psychiatric disorders.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Milenna T. van Dijk, Ardesheer Talati, Pratik Kashyap, Karan Desai, Nora C. Kelsall, Marc J. Gameroff, Natalie Aw, Eyal Abraham, Breda Cullen, Jiook Cha, Christoph Anacker, Myrna M. Weissman, Jonathan Posner
Summary: This study found that maternal stress is associated with future depressive symptoms and alterations in microstructure of the dentate gyrus (DG) in offspring. These results were consistent across two independent cohorts.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Josephine C. McGowan, Liliana R. Ladner, Claire X. Shubeck, Juliana Tapia, Christina T. LaGamma, Amanda Anqueira-Gonzalez, Ariana DeFrancesco, Briana K. Chen, Holly C. Hunsberger, Ezra J. Sydnor, Ryan W. Logan, Tzong-Shiue Yu, Steven G. Kernie, Christine A. Denny
Summary: Traumatic brain injury (TBI) leads to fear generalization by altering fear memory traces, and this symptom can be improved with (R,S)-ketamine.
BIOLOGICAL PSYCHIATRY
(2024)