Article
Neurosciences
Frhan I. Alanazi, Suneil K. Kalia, Mojgan Hodaie, Adriana Lopez L. Rios, Andres M. Lozano, Luka Milosevic, William D. Hutchison
Summary: The neurophysiology of selective attention in visual and auditory systems was studied in animal models and recorded neuronal activity in human patients with parkinsonian and non-parkinsonian tremors. The results showed that the firing rate of neurons decreased during the auditory oddball task, specifically related to auditory attention. The study also found that dopamine modulates thalamic beta oscillations for selective attention in Parkinson's disease patients.
NPJ PARKINSONS DISEASE
(2023)
Article
Neurosciences
Martynas Dervinis, Vincenzo Crunelli
Summary: The researchers constructed a large-scale corticothalamic model to reproduce the generation of EEG sleep rhythms and revealed the intrinsic ability of neocortical networks and single thalamic neurons in generating these waves. The model simulated the transition from desynchronized EEG to spindles, slow oscillations, and delta waves by progressively increasing neuronal membrane hyperpolarization. The results showed that slow waves often started in a small assembly of thalamocortical neurons, but could also originate in cortical layer 5, and the input of thalamocortical neurons increased the frequency of EEG slow waves.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Behavioral Sciences
M. Wolff, S. Morceau, R. Folkard, J. Martin-Cortecero, A. Groh
Summary: Adapting to dynamic environments requires tracking multiple signals and integrating communication between sensory and cognitive brain circuits, with thalamic nuclei acting as a crucial bridge in this process. Thalamus plays a key role in linking perception, cognition, and potentially affective processes.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Review
Neurosciences
Dheeraj S. Roy, Ying Zhang, Michael M. Halassa, Guoping Feng
Summary: Recent studies using advanced expression profiling have revealed gene expression gradients within and across thalamic nuclei, redefining functional units of the thalamus. Thalamic subnetworks, defined by the intersection of genetics, connectivity, and computation, provide a more appropriate level of functional description.
NATURE NEUROSCIENCE
(2022)
Article
Behavioral Sciences
Jennifer J. Hamilton, John C. Dalrymple-Alford
Summary: The nucleus reuniens (RE) in the midline thalamus is an important link between the hippocampus and prefrontal cortex, and it plays a role in memory consolidation beyond spatial memory and contextual fear memory.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2023)
Article
Neurosciences
Perez -Ramirez Maria-Belen, Parada Isabel, Prince David
Summary: Status epilepticus (SE) is a life-threatening emergency that can lead to the development or worsening of epilepsy. The study found that neocortical focal status epilepticus (FSE) can induce structural and functional changes in the thalamus, which may contribute to hyperexcitability in thalamocortical circuit. These changes include cell loss in the ventrobasal nucleus (VB) and increased excitatory synapses in intra-thalamic and cortico-thalamic networks.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Neurosciences
Priyodarshan Goswamee, Elizabeth Leggett, A. Rory McQuiston
Summary: The study demonstrates that optogenetic stimulation of reuniens afferents can mediate both excitation and inhibition of CA1 principal cells, and recruit distinct subpopulations of local GABAergic interneurons in CA1 to modulate neuronal activity.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Neurosciences
Erwan Leprince, Robin F. Dard, Salome Mortet, Caroline Filippi, Marie Giorgi-Kurz, Romain Bourboulou, Pierre-Pascal Lenck-Santini, Michel A. Picardo, Marco Bocchio, Agnes Baude, Rosa Cossart
Summary: The adult CA1 region of the hippocampus produces coordinated neuronal dynamics with minimal reliance on its extrinsic inputs. Neonatal CA1, on the other hand, is tightly linked to externally generated sensorimotor activity, but the circuit mechanisms underlying early synchronous activity in CA1 remain unclear. In this study, researchers use a combination of in vivo and ex vivo circuit mapping, calcium imaging, and electrophysiological recordings in mouse pups to investigate the dynamics in the ventro-intermediate CA1. They find that these dynamics are influenced by both the entorhinal (EC) and thalamic (VMT) inputs, but movement-related population bursts are exclusively driven by the EC. The differential effects reflect the different intrahippocampal targets of these inputs, suggesting distinct contributions to the development of the hippocampal microcircuit and related cognitive maps.
Article
Biochemistry & Molecular Biology
Yanjun Liu, Bing Chen, Yirong Cai, Yuan Han, Ying Xia, Nanqi Li, Bingqian Fan, Tianjie Yuan, Junli Jiang, P. O. Gao, Weifeng Yu, Yingfu Jiao, Wenxian Li
Summary: The neural activity of the anterior TRN is suppressed during propofol anesthesia but robustly activated during recovery. Activation of anterior TRN neurons shortens emergency time without changing induction time, while inhibition leads to delayed recovery. Anterior TRN is crucial for behavioral arousal during propofol anesthesia, independent of induction time.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2021)
Article
Neurosciences
Vladimir Visocky, Brian J. Morris, John Dunlop, Nick Brandon, Shuzo Sakata, Judith A. Pratt
Summary: Using optogenetics and electrophysiology in C57BL/6 mice, we found that the caudal and rostral subpopulations of the thalamic reticular nucleus (TRN) have distinct effects on cortical alpha and delta oscillations and sleep stability. Silencing the rostral TRN prolongs sleep episodes, while silencing the caudal TRN fragments sleep. These findings demonstrate the different roles exerted by the rostral and caudal TRN in sleep regulation and oscillatory activity.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Article
Cell Biology
Elisabetta Iavarone, Jane Simko, Ying Shi, Marine Bertschy, Maria Garcia-Amado, Polina Litvak, Anna-Kristin Kaufmann, Christian O'Reilly, Oren Amsalem, Marwan Abdellah, Grigori Chevtchenko, Benoit Coste, Jean-Denis Courcol, Andras Ecker, Cyrille Favreau, Adrien Christian Fleury, Werner Van Geit, Michael Gevaert, Nadir Roman Guerrero, Joni Herttuainen, Genrich Ivaska, Samuel Kerrien, James G. King, Pramod Kumbhar, Patrycja Lurie, Ioannis Magkanaris, Vignayanandam Ravindernath Muddapu, Jayakrishnan Nair, Fernando L. Pereira, Rodrigo Perin, Fabien Petitjean, Rajnish Ranjan, Michael Reimann, Liviu Soltuzu, Mohameth Francois Sy, M. Anil Tuncel, Alexander Ulbrich, Matthias Wolf, Francisco Clasca, Henry Markram, Sean L. Hill
Summary: A detailed computational model of mouse somatosensory thalamus and thalamic reticular nucleus has been developed to simulate the biological connectivity of over 14,000 neurons and reproduce experimental findings in different brain states. The model suggests that inhibitory rebound enhances thalamic responses to specific frequencies during wakefulness and thalamic interactions are responsible for the characteristic changes in spindle oscillations. Changes in thalamic excitability control spindle frequency and incidence. The openly available model provides a new tool for studying the function and dysfunction of the thalamoreticular circuitry in various brain states.
Article
Multidisciplinary Sciences
Heather C. Ratigan, Seetha Krishnan, Shai Smith, Mark E. J. Sheffield
Summary: The NR-CA1 pathway actively suppresses fear by disrupting contextual fear memory retrieval in CA1 during fearful freezing behavior, which also reduces fear generalization and accelerates extinction.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Diellor Basha, Sylvain Chauvette, Maxim Sheroziya, Igor Timofeev
Summary: Using recordings from cats, we found that the rhythms of gamma oscillations in the mPFC are controlled by the exhalation phase of the respiratory cycle. The respiratory timing is propagated by synaptic activity in the Reu region, leading to gamma bursts in the prefrontal cortex. These findings highlight the importance of breathing in the synchronization of neuronal activities in the prefrontal circuit.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Vinod Jangir Kumar, Klaus Scheffler, Wolfgang Grodd
Summary: The intralaminar nuclei of the thalamus play a crucial role in various cognitive and sensory processes, and they have extensive structural connections with other brain regions. This study uses probabilistic tracking of diffusion data to demonstrate the direct structural connectivity of the intralaminar nuclei with the thalamus, midbrain, and cortex.
SCIENTIFIC REPORTS
(2023)
Article
Pharmacology & Pharmacy
Caroline S. Copeland, Stuart A. Neale, Eric S. Nisenbaum, Thomas E. Salt
Summary: The activation of mGlu(3) receptors in the thalamus potentiates responses to somatosensory stimulation by reducing inhibition from TRN. This mechanism may play a crucial role in governing attentional processes and could be a specific therapeutic target for cognitive function enhancement in diseases like schizophrenia.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Review
Neurosciences
Maya Jammoul, Dareen Jammoul, Kevin K. Wang, Firas Kobeissy, Ralph G. Depalma
Summary: This article reviews the possible mechanisms by which traumatic brain injury (TBI) may stimulate the development of opioid use disorder (OUD) and discusses the interaction between these two processes. CNS damage due to TBI appears to drive adverse effects of subsequent OUD, with pain being a risk factor for opioid use after TBI.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Danusa Mar Arcego, Jan-Paul Buschdorf, Nicholas O'Toole, Zihan Wang, Barbara Barth, Irina Pokhvisneva, Nirmala Arul Rayan, Sachin Patel, Euclides Jose de Mendonca Filho, Patrick Lee, Jennifer Tan, Ming Xuan Koh, Chu Ming Sim, Carine Parent, Randriely Merscher Sobreira de Lima, Andrew Clappison, Kieran J. O'Donnell, Carla Dalmaz, Janine Arloth, Nadine Provencal, Elisabeth B. Binder, Josie Diorio, Patricia Pelufo Silveira, Michael J. Meaney
Summary: This study investigates the impact of environmental influences on mental health by integrating transcriptomic data from animal models with human data. The results suggest that hippocampal glucocorticoid-related transcriptional activity mediates the effects of early adversity on neural mechanisms implicated in psychiatric disorders.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Milenna T. van Dijk, Ardesheer Talati, Pratik Kashyap, Karan Desai, Nora C. Kelsall, Marc J. Gameroff, Natalie Aw, Eyal Abraham, Breda Cullen, Jiook Cha, Christoph Anacker, Myrna M. Weissman, Jonathan Posner
Summary: This study found that maternal stress is associated with future depressive symptoms and alterations in microstructure of the dentate gyrus (DG) in offspring. These results were consistent across two independent cohorts.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Josephine C. McGowan, Liliana R. Ladner, Claire X. Shubeck, Juliana Tapia, Christina T. LaGamma, Amanda Anqueira-Gonzalez, Ariana DeFrancesco, Briana K. Chen, Holly C. Hunsberger, Ezra J. Sydnor, Ryan W. Logan, Tzong-Shiue Yu, Steven G. Kernie, Christine A. Denny
Summary: Traumatic brain injury (TBI) leads to fear generalization by altering fear memory traces, and this symptom can be improved with (R,S)-ketamine.
BIOLOGICAL PSYCHIATRY
(2024)