Article
Medical Laboratory Technology
Rihwa Choi, Sang Gon Lee, Eun Hee Lee
Summary: The low prevalence and incidence of celiac disease in Korea may be attributed to the underutilization of diagnostic assays, as indicated by the low number of serological biomarker tests conducted on Korean patients during the study period.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Article
Biochemistry & Molecular Biology
Adam Dios, Bharani Srinivasan, Judit Gyimesi, Katharina Werkstetter, Rudolf Valenta, Sibylle Koletzko, Ilma R. Korponay-Szabo
Summary: Celiac disease is an autoimmune disorder characterized by immune response and antibody production to gluten. TG2 plays a role in the pathomechanism of celiac disease. This study investigates early antibody responses to reveal the development of celiac disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Ingrid Swanson Pultz, Malcolm Hill, Joanne M. Vitanza, Clancey Wolf, Lasse Saaby, Tina Liu, Peter Winkle, Daniel A. Leffler
Summary: The novel enzyme TAK-062 shows promising results in degrading gluten, providing potential therapeutic benefits for patients with CeD. Clinical studies demonstrate that TAK-062 is well tolerated and rapidly and effectively degrades gluten in complex meals.
Article
Pharmacology & Pharmacy
Arathi Kulkarni, Shuchi Patel, Deepesh Khanna, Mayur S. Parmar
Summary: Celiac Disease (CeD) is an autoimmune disorder caused by the consumption of gluten, leading to inflammation in the small intestine. The current treatment recommendation is to avoid gluten-based products, as there is no FDA-approved medication for CeD. However, several clinical trials are underway to develop pharmacological approaches to treat CeD.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Adam Dios, Rita Elek, Ildiko Szabo, Szilvia Horvath, Judit Gyimesi, Robert Kiraly, Katharina Werkstetter, Sibylle Koletzko, Laszlo Fesus, Ilma R. Korponay-Szabo
Summary: Celiac disease is characterized by a T-cell dependent enteropathy with antibodies targeting TG2-deamidated gamma-gliadin peptides. However, serum reactivity towards p31-43 and p57-68 peptides has been identified, which is due to cross-reactive gamma-gliadin specific antibodies. Cross-reactive antibodies recognizing disease-relevant alpha-gliadins were also found in CeD patients.
Review
Biochemistry & Molecular Biology
Charlene B. Van Buiten, Ryan J. Elias
Summary: Celiac disease is an autoimmune disorder characterized by heightened immune response to gluten proteins, with treatment involving complete avoidance of gluten in the diet. Ongoing clinical trials are targeting the immune response and gluten proteins, while recent studies suggest that polyphenols may offer protection by disrupting enzymatic hydrolysis of gluten and exerting anti-inflammatory effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Maria Vittoria Barone, Salvatore Auricchio
Summary: Celiac disease is a chronic inflammatory disease caused by a combination of factors including nutrient-induced T cell response and environmental predisposition to inflammation. Viruses, bacteria, Western diet, and gliadin protein all play a role in the development of the disease, while the anti-inflammatory Mediterranean diet has a protective effect on children with CD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Yasmina Rodriguez-Sillke, Michael Schumann, Donata Lissner, Federica Branchi, Fabian Proft, Ulrich Steinhoff, Britta Siegmund, Rainer Glauben
Summary: By analyzing patients with celiac disease and inflammatory bowel disease, it was found that antigen-specific effector T-cells can respond to barrier disruption and antigen translocation in the peripheral blood. Using antigen-reactive T-cell enrichment technique, it was observed that the frequency and phenotype of nutritional antigen-specific T-cells correlated to the presence of intestinal inflammation in patients with Celiac disease and Crohn's disease. These findings suggest that active small intestinal inflammation is crucial for the development of a peripheral food antigen-specific T-cell response in Crohn's disease and celiac disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Jorma Isola, Markku Maeki, Martin Hils, Ralf Pasternack, Keijo Viiri, Valeriia Dotsenko, Toni Montonen, Timo Zimmermann, Ralf Mohrbacher, Roland Greinwald, Detlef Schuppan
Summary: In this study, the accumulation of ZED1227 after oral administration of the drug was studied. It was found that ZED1227 mainly accumulated in the villous enterocytes and had an inhibitory effect on TG2 activity. These findings are significant for the treatment of celiac disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Tian Yu, Yiting Xie, Juanli Yuan, Jinyan Gao, Zhiwen Xiao, Yong Wu, Hongbing Chen
Summary: This study investigated the alleviating effects of resveratrol on celiac disease. Resveratrol was found to reduce intestinal oxidative stress and inflammatory damage caused by wheat gluten in cell and mouse models of celiac disease. It played a role in regulating the development of autoimmunity, nutrient absorption, and the complex response system of oxidative stress, inflammatory response, and immune response in the intestine by activating specific signaling pathways and genes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Applied
Darina Pronin, Andreas Boerner, Katharina Anne Scherf
Summary: Analysis of the quantities of four CD-active peptides in 60 German hexaploid winter wheat cultivars from 1891 to 2010 showed that breeding has not significantly altered the immunoreactive potential of wheat. The levels of CD-active peptides were more influenced by harvest year than by cultivar, indicating similar immunoreactive potential in old and modern wheat cultivars.
Article
Gastroenterology & Hepatology
Francesco Valitutti, Maureen M. Leonard, Victoria Kenyon, Monica Montuori, Pasqua Piemontese, Ruggiero Francavilla, Basilio Malamisura, Lorenzo Norsa, Angela Calvi, Maria Elena Lionetti, Mariella Baldassarre, Chiara Maria Trovato, Michela Perrone, Tiziana Passaro, Naire Sansotta, Marco Crocco, Annalisa Morelli, Lidia Celeste Raguseo, Federica Malerba, Luca Elli, Fernanda Cristofori, Carlo Catassi, Alessio Fasano, CD-GEMM Team
Summary: The purpose of this study was to identify potential serum biomarkers predicting the onset of celiac disease (CD) in at-risk children. The results showed that 73.6% of the children had an increase in anti-deamidated gliadin peptides (DGPs) IgG levels before their first seroconversion of anti-tissue transglutaminase (anti-tTG) IgA antibodies, indicating that anti-DGPs IgG may serve as an early preclinical biomarker predicting CD onset in children.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Review
Nutrition & Dietetics
Veronica Segura, Angela Ruiz-Carnicer, Carolina Sousa, Maria de Lourdes Moreno
Summary: The only current treatment for celiac disease is a strict gluten-free diet, but there is a need for non-dietary alternatives to prevent damage from dietary transgressions. Recent therapies for CD focus on degrading gluten, regulating the immune response, and inducing immunological tolerance, with promising results seen in some phase III and II clinical trials.
Article
Immunology
Na Wang, Chenxu Cui, Chao Xu, Hongtao Ren, Fan Wang, Qiuying Yu, Gaiping Zhang
Summary: Peanut skin proanthocyanidins (PSPc) have a significant effect on CD intervention by inhibiting oxidative stress through regulation of the SIRT1/NRF2 pathway.
CLINICAL IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Yonatan Shneor Patt, Adi Lahat, Paula David, Chen Patt, Rowand Eyade, Kassem Sharif
Summary: Celiac disease is a complex immune-mediated disease with various pathological manifestations that extend beyond gastrointestinal symptoms. The existing main treatment, a gluten-free diet, presents challenges and alternative therapies are being developed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Psychiatry
F. Dickerson, A. Origoni, J. Schroeder, M. Adamos, E. Katsafanas, S. Khushalani, C. L. G. Savage, L. A. B. Schweinfurth, C. Stallings, K. Sweeney, R. Yolken
ACTA PSYCHIATRICA SCANDINAVICA
(2018)
Article
Immunology
Minna Torniainen-Holm, Jaana Suvisaari, Maija Lindgren, Tommi Harkanen, Faith Dickerson, Robert H. Yolken
BRAIN BEHAVIOR AND IMMUNITY
(2018)
Article
Pharmacology & Pharmacy
Deanna L. Kelly, Megan M. Powell, Heidi J. Wehring, MacKenzie A. Sayer, Ann Marie Kearns, Ann L. Hackman, Robert W. Buchanan, Rebecca B. Nichols, Heather A. Adams, Charles M. Richardson, Gopal Vyas, Robert P. McMahon, Amber K. Earl, Kelli M. Sullivan, Fang Liu, Sarah E. Luttrell, Faith B. Dickerson, Stephanie M. Feldman, Supriya Narang, Maju M. Koola, Peter F. Buckley, Jill A. RachBeisel, Joseph P. McEvoy
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
(2018)
Article
Clinical Neurology
Faith Dickerson, Andrea Origoni, Lucy A. B. Schweinfurth, Cassie Stallings, Christina L. G. Savage, Kevin Sweeney, Emily Katsafanas, Holly C. Wilcox, Sunil Khushalani, Robert Yolken
JOURNAL OF NERVOUS AND MENTAL DISEASE
(2018)
Review
Pharmacology & Pharmacy
Emily G. Severance, Faith B. Dickerson, Robert H. Yolken
PHARMACOLOGY & THERAPEUTICS
(2018)
Article
Health Policy & Services
Faith Dickerson, Jennifer Schroeder, Emily Katsafanas, Sunil Khushalani, Andrea E. Origoni, Christina Savage, Lucy Schweinfurth, Catherine R. Stallings, Kevin Sweeney, Robert H. Yolken
PSYCHIATRIC SERVICES
(2018)
Article
Psychiatry
Vishwajit L. Nimgaonkar, Faith Dickerson, Jennie G. Pouget, Kodavali Chowdari, Colm O'Dushlaine, Joel Wood, Lambertus Klei, Bernie Devlin, Robert Yolken
PSYCHIATRY RESEARCH
(2018)
Meeting Abstract
Psychiatry
Faith Dickerson, Robert Yolken
SCHIZOPHRENIA BULLETIN
(2018)
Meeting Abstract
Psychiatry
Alan Breier, Faith Dickerson, Robert Buchanan, Stephen Marder, Keith Neuchterlein, Deepak D'Souza, Michael Francis, Alexander Radnovich, Robert Yolken, Sheldon Preskorn, Matthew Macaluso, Ziyi Yang, Nicole Mehdyoun, Rishi Kakar, Walter Dunn, Debra Hoffmeyer, Gerald Maguire
SCHIZOPHRENIA BULLETIN
(2018)
Meeting Abstract
Psychiatry
Faith Dickerson
SCHIZOPHRENIA BULLETIN
(2018)
Meeting Abstract
Psychiatry
Vishwajit Nimgaonkar, Smita Deshpande, Triptish Bhatia, Konasale Prasad, Faith Dickerson, Raquel Gur, Ruben Gur, Kehui Chen, Joel Wood, Robert H. Yolken
SCHIZOPHRENIA BULLETIN
(2018)
Article
Psychiatry
Jianchun Xiao, Emese Prandovszky, Geetha Kannan, Mikhail V. Pletnikov, Faith Dickerson, Emily G. Severance, Robert H. Yolken
SCHIZOPHRENIA BULLETIN
(2018)
Article
Psychiatry
Triptish Bhatia, Joel Wood, Satish Iyengar, Sreelatha S. Narayanan, Ram Pratap Beniwal, Konasale M. Prasad, Kehui Chen, Robert H. Yolken, Faith Dickerson, Ruben C. Gur, Raquel E. Gur, Smita N. Deshpande, Vishwajit L. Nimgaonkar
SCHIZOPHRENIA RESEARCH
(2018)
Meeting Abstract
Clinical Neurology
M. Frye, B. Coombes, S. McElroy, L. Jones-Brando, M. Veldic, C. Colby, W. Bobo, B. Singh, F. Dickerson, J. Biernacka, R. Yolken
Meeting Abstract
Clinical Neurology
F. Dickerson
Review
Neurosciences
Maya Jammoul, Dareen Jammoul, Kevin K. Wang, Firas Kobeissy, Ralph G. Depalma
Summary: This article reviews the possible mechanisms by which traumatic brain injury (TBI) may stimulate the development of opioid use disorder (OUD) and discusses the interaction between these two processes. CNS damage due to TBI appears to drive adverse effects of subsequent OUD, with pain being a risk factor for opioid use after TBI.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Danusa Mar Arcego, Jan-Paul Buschdorf, Nicholas O'Toole, Zihan Wang, Barbara Barth, Irina Pokhvisneva, Nirmala Arul Rayan, Sachin Patel, Euclides Jose de Mendonca Filho, Patrick Lee, Jennifer Tan, Ming Xuan Koh, Chu Ming Sim, Carine Parent, Randriely Merscher Sobreira de Lima, Andrew Clappison, Kieran J. O'Donnell, Carla Dalmaz, Janine Arloth, Nadine Provencal, Elisabeth B. Binder, Josie Diorio, Patricia Pelufo Silveira, Michael J. Meaney
Summary: This study investigates the impact of environmental influences on mental health by integrating transcriptomic data from animal models with human data. The results suggest that hippocampal glucocorticoid-related transcriptional activity mediates the effects of early adversity on neural mechanisms implicated in psychiatric disorders.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Milenna T. van Dijk, Ardesheer Talati, Pratik Kashyap, Karan Desai, Nora C. Kelsall, Marc J. Gameroff, Natalie Aw, Eyal Abraham, Breda Cullen, Jiook Cha, Christoph Anacker, Myrna M. Weissman, Jonathan Posner
Summary: This study found that maternal stress is associated with future depressive symptoms and alterations in microstructure of the dentate gyrus (DG) in offspring. These results were consistent across two independent cohorts.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Josephine C. McGowan, Liliana R. Ladner, Claire X. Shubeck, Juliana Tapia, Christina T. LaGamma, Amanda Anqueira-Gonzalez, Ariana DeFrancesco, Briana K. Chen, Holly C. Hunsberger, Ezra J. Sydnor, Ryan W. Logan, Tzong-Shiue Yu, Steven G. Kernie, Christine A. Denny
Summary: Traumatic brain injury (TBI) leads to fear generalization by altering fear memory traces, and this symptom can be improved with (R,S)-ketamine.
BIOLOGICAL PSYCHIATRY
(2024)