Article
Neurosciences
M. Angela Cenci, Katrine Skovgard, Per Odin
Summary: Dopamine replacement therapy is the most effective treatment for Parkinson's disease, but it is limited by its side effects. Recent evidence suggests that altered dopamine transmission affects non-dopaminergic neurotransmitter systems in the brain. Researchers are exploring drugs that target non-dopaminergic receptors to improve the side effects of dopamine replacement therapy. This review discusses the different non-dopaminergic targets that have been studied, with a particular focus on modulators of glutamatergic and serotonergic transmission.
Review
Cell Biology
Kevin Domanegg, Wolfgang H. Sommer, Marcus W. Meinhardt
Summary: Alcohol abuse is a leading risk factor for public health burden. Approved pharmacotherapies have limited effectiveness in treating alcohol use disorders, making new therapeutic approaches urgently needed. Clinical trials using psychedelics in conjunction with psychotherapy have shown promising results in reducing heavy drinking in AUD patients, but the specific mechanisms by which psychedelics counteract the neuronal circuit alterations of addiction are still not well understood.
Article
Multidisciplinary Sciences
Jonathan L. Crooke-Rosado, Sara C. Diaz-Mendez, Yamil E. Claudio-Roman, Nilsa M. Rivera, Maria A. Sosa
Summary: By utilizing bioinformatics and de novo transcriptome assembly, potential targets for specific antibodies specific to nervous system markers in freshwater prawns of the Macrobrachium spp. were identified. Antibodies were successfully developed for prawn AMPA ionotropic glutamate receptor 1, metabotropic glutamate receptor 1 and 4, and ionotropic NMDA glutamate receptor subunit 2B, aiming to expand knowledge of structural and functional mechanisms underlying prawn behavioral responses to environmental impacts.
Article
Multidisciplinary Sciences
Marcus W. Meinhardt, Simone Pfarr, Gregory Fouquet, Cathrin Rohleder, Manuela L. Meinhardt, Janet Barroso-Flores, Rebecca Hoffmann, Jerome Jeanblanc, Elisabeth Paul, Konstantin Wagner, Anita C. Hansson, Georg Koehr, Nils Meier, Oliver von Bohlen und Halbach, Richard L. Bell, Heike Endepols, Bernd Neumaier, Kai Schoenig, Dusan Bartsch, Mickael Naassila, Rainer Spanagel, Wolfgang H. Sommer
Summary: The study identified a common molecular pathological mechanism for both executive dysfunction and alcohol craving in alcohol-dependent patients, and proposed a personalized mGluR2 mechanism-based intervention strategy for medication development.
Article
Biochemistry & Molecular Biology
Carlos Alberto Castillo, Inmaculada Ballesteros-Yanez, David Agustin Leon-Navarro, Jose Luis Albasanz, Mairena Martin
Summary: The amyloid beta peptide plays a central role in Alzheimer's disease pathology. Exposure to A beta(25-35) in rat cortical neurons increased mGluR density and affinity, along with up-regulation of adenosine A(1)R and A(2A)R. The study highlights the possible involvement of metabotropic glutamate and adenosine receptors in the early events of AD physiopathology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Behavioral Sciences
Stephen W. White, Gwendolyn D. Squires, Sequioa J. Smith, Gwendolyn M. Wright, Kenneth J. Sufka, John M. Rimoldi, Rama S. Gadepalli
Summary: Research on modulation of glutamate receptors in aves under stress models shows potential clinical value in treating panic disorder and treatment-resistant depression.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2023)
Review
Pharmacology & Pharmacy
Ananth Prasad Burada, Rajesh Vinnakota, Pratibha Bharti, Priyanka Dutta, Neelima Dubey, Janesh Kumar
Summary: GluD receptors are a subfamily of ionotropic glutamate receptors that play a crucial role in synapse formation, maturation, and maintenance of central nervous system functions. Despite the lack of knowledge about their endogenous ligands, significant discoveries have been made regarding their role in mediating trans-synaptic interactions and their unique non-swapped architecture. Additionally, the prospect of GluD ionotropic activity being regulated by direct interaction with metabotropic glutamate receptors is exciting.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Reuben Levy-Myers, Daniel Daudelin, Chan Hyun Na, Shanthini Sockanathan
Summary: This study demonstrates that the protein GDE3 regulates actin remodeling to release a unique subtype of extracellular vesicles (EVs) with distinct functions. GDE3 is expressed in astrocytes but not neurons and is responsible for releasing EVs containing annexin A1 and GDE3 via the protein WAVE3. Mice lacking GDE3 show decreased miniature excitatory postsynaptic current amplitudes in hippocampal neurons.
Article
Pharmacology & Pharmacy
Vanessa Pereira, Juri Aparicio Arias, Amadeu Llebaria, Cyril Goudet
Summary: Neuropathic pain is a challenging condition to manage. In this study, the role of the amygdala in regulating neuropathic pain was investigated. The activation of mGlu4 receptors in the amygdala was found to alleviate sensory and depressive-like symptoms in a mouse model of neuropathy.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Neurosciences
Ferdinando Nicoletti, Luisa Di Menna, Luisa Iacovelli, Rosamaria Orlando, Anna Rita Zuena, P. Jeffrey Conn, Shalini Dogra, Max E. Joffe
Summary: Cellular responses to metabotropic glutamate (mGlu) receptor activation are influenced by mechanisms of receptor-receptor interaction, including receptor dimerization and complex formation with other GPCRs. The interactions between different mGlu receptor subtypes and other receptors have been studied in various brain regions and have been implicated in the pathophysiology of several neurological and psychiatric disorders. Understanding these interactions could lead to the development of new therapeutic targets for these conditions.
Review
Neurosciences
Shalini Dogra, P. Jeffrey Conn
Summary: Compounds targeting mGlu receptors show promise as potential novel antidepressant strategies, with mGlu5 negative allosteric modulators and mGlu2/3 receptor antagonists demonstrating antidepressant effects in preclinical models. Despite inconclusive clinical trials, these compounds offer an exciting alternative for the development of safer and more efficacious antidepressants.
Article
Neurosciences
Carla L. Busceti, Roxana P. Ginerete, Luisa Di Menna, Giovanna D'Errico, Francesca Cisani, Paola Di Pietro, Tiziana Imbriglio, Valeria Bruno, Giuseppe Battaglia, Francesco Fornai, James A. Monn, Anna Pittaluga, Ferdinando Nicoletti
Summary: Genetic knockout of mGlu2 and mGlu3 receptors affects mice's preference and motor responses to methamphetamine, indicating different roles of these two receptors in methamphetamine addiction. mGlu3(-/-) mice show increased sensitization and elevated levels of phospho-ERK1/2 and free radicals in relevant brain areas, while mGlu2(-/-) mice exhibit reduced motor response to the first methamphetamine injection.
Review
Neurosciences
Ananth Prasad Burada, Rajesh Vinnakota, Bertrand Lambolez, Ludovic Tricoire, Janesh Kumar
Summary: Enigmatic orphan glutamate delta receptors (GluD) are a type of ionotropic glutamate receptors (iGluRs) that do not bind glutamate or evoke currents when binding glycine and D-serine. They are believed to function as structural proteins that facilitate synapse formation, maturation, and maintenance in the hippocampus and cerebellum. Recent research suggests that GluD receptors have interactions with metabotropic glutamate receptors (mGlus) and are gated by their activation, with new tools and structures helping to define their role in synaptic physiology.
Article
Reproductive Biology
Alexandra Spirkova, Veronika Kovarikova, Zuzana Sefcikova, Jozef Pisko, Martina Ksinanova, Juraj Koppel, Dusan Fabian, Stefan Cikos
Summary: The study reveals that glutamic acid can affect preimplantation embryo development through cell membrane receptors. High extracellular concentrations of glutamic acid can inhibit blastocyst development, which is of practical significance.
BIOLOGY OF REPRODUCTION
(2022)
Review
Immunology
Jie Huang, Xuekun Fu, Xinxin Chen, Zheng Li, Yuhong Huang, Chao Liang
Summary: Rheumatoid arthritis (RA) is a systemic poly-articular chronic autoimmune joint disease that affects a significant portion of the global population. While progress has been made with disease-modifying antirheumatic drugs, there is still a need for new therapeutic targets and approaches for some patients with limited response to existing treatments.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Neurosciences
Maya Jammoul, Dareen Jammoul, Kevin K. Wang, Firas Kobeissy, Ralph G. Depalma
Summary: This article reviews the possible mechanisms by which traumatic brain injury (TBI) may stimulate the development of opioid use disorder (OUD) and discusses the interaction between these two processes. CNS damage due to TBI appears to drive adverse effects of subsequent OUD, with pain being a risk factor for opioid use after TBI.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Danusa Mar Arcego, Jan-Paul Buschdorf, Nicholas O'Toole, Zihan Wang, Barbara Barth, Irina Pokhvisneva, Nirmala Arul Rayan, Sachin Patel, Euclides Jose de Mendonca Filho, Patrick Lee, Jennifer Tan, Ming Xuan Koh, Chu Ming Sim, Carine Parent, Randriely Merscher Sobreira de Lima, Andrew Clappison, Kieran J. O'Donnell, Carla Dalmaz, Janine Arloth, Nadine Provencal, Elisabeth B. Binder, Josie Diorio, Patricia Pelufo Silveira, Michael J. Meaney
Summary: This study investigates the impact of environmental influences on mental health by integrating transcriptomic data from animal models with human data. The results suggest that hippocampal glucocorticoid-related transcriptional activity mediates the effects of early adversity on neural mechanisms implicated in psychiatric disorders.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Milenna T. van Dijk, Ardesheer Talati, Pratik Kashyap, Karan Desai, Nora C. Kelsall, Marc J. Gameroff, Natalie Aw, Eyal Abraham, Breda Cullen, Jiook Cha, Christoph Anacker, Myrna M. Weissman, Jonathan Posner
Summary: This study found that maternal stress is associated with future depressive symptoms and alterations in microstructure of the dentate gyrus (DG) in offspring. These results were consistent across two independent cohorts.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Josephine C. McGowan, Liliana R. Ladner, Claire X. Shubeck, Juliana Tapia, Christina T. LaGamma, Amanda Anqueira-Gonzalez, Ariana DeFrancesco, Briana K. Chen, Holly C. Hunsberger, Ezra J. Sydnor, Ryan W. Logan, Tzong-Shiue Yu, Steven G. Kernie, Christine A. Denny
Summary: Traumatic brain injury (TBI) leads to fear generalization by altering fear memory traces, and this symptom can be improved with (R,S)-ketamine.
BIOLOGICAL PSYCHIATRY
(2024)