Article
Psychology, Multidisciplinary
Jiyoung Park, Joshua Woolley, Wendy Berry Mendes
Summary: This study examined the role of oxytocin in modulating reactions to social acceptance or rejection during interracial interactions. The results showed that black participants who received intranasal oxytocin displayed more positive cardiovascular responses, cooperative behavior, and perceived their partner to have more favorable attitudes after receiving positive social feedback from a white stranger.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Behavioral Sciences
James Brooks, Fumihiro Kano, Yuri Kawaguchi, Shinya Yamamoto
Summary: Previous research has found that oxytocin is associated with intergroup behavior in humans and wild chimpanzees. However, it is unclear how oxytocin affects the responses of bonobos and chimpanzees to ingroup and outgroup individuals. This study found that oxytocin increases the attention of bonobos and chimpanzees towards outgroup individuals of the sex primarily involved in intergroup encounters in each species.
HORMONES AND BEHAVIOR
(2022)
Article
Neurosciences
Tanya L. Procyshyn, Michael Lombardo, Meng-Chuan Lai, Nazia Jassim, Bonnie Auyeung, Sarah K. Crockford, Julia B. Deakin, Sentil Soubramanian, Akeem Sule, David Terburg, Simon Baron-Cohen, Richard A. Bethlehem
Summary: This study found that oxytocin affects the basolateral amygdala in autistic women, increasing activation in the left basolateral amygdala and enhancing functional connectivity with brain regions associated with socio-emotional information processing, reducing group differences observed in the placebo condition.
SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Caleigh D. Guoynes, Catherine A. Marler
Summary: The study reveals that the administration of OXT through the intranasal route rapidly and selectively enhances maternal USV production, and improves maternal care efficiency towards offspring. The frequency of USVs between mothers and offspring are correlated during reunions, but IN OXT does not influence this correlation.
Article
Behavioral Sciences
Jun Chen, Yu L. L. Luo, Yiping Xie, Ziyan Yang, Huajian Cai
Summary: The study found that oxytocin can increase human vigilance towards death-related stimuli and heighten anxiety and fear of death.
HORMONES AND BEHAVIOR
(2021)
Article
Neurosciences
Fei Xin, Feng Zhou, Xinqi Zhou, Xiaole Ma, Yayuan Geng, Weihua Zhao, Shuxia Yao, Debo Dong, Bharat B. Biswal, Keith M. Kendrick, Benjamin Becker
Summary: Attention and salience processing are closely related to the dynamics of large-scale networks. The study shows that oxytocin enhances functional integration within subsystems and increases functional segregation between networks. Autistic traits may modulate the effects of oxytocin on network interactions.
Review
Biochemistry & Molecular Biology
Kah Kheng Goh, Chun-Hsin Chen, Hsien-Yuan Lane
Summary: Schizophrenia is characterized by abnormal behavior, and dysregulation of oxytocin may play a role in its expression. Studies have shown potential clinical benefits of oxytocin in improving the psychopathology of patients with schizophrenia. Oxytocin has the potential to be a therapeutic agent for schizophrenia and may have implications for future treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Behavioral Sciences
Julia S. Krimberg, Francisco S. Lumertz, Rodrigo Orso, Thiago W. Viola, Rosa Maria M. de Almeida
Summary: Social isolation stress is associated with negative developmental outcomes and may be related to the oxytocinergic system. Decreased OXTR levels are associated with behavioral alterations such as increased aggression and anxiety-like behavior, hyperactivity, and diminished social behaviors and memory. Administration of synthetic oxytocin or its agonists can partially decrease these behavioral alterations.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Chemistry, Multidisciplinary
Jana Lieberz, Simone G. Shamay-Tsoory, Nira Saporta, Timo Esser, Ekaterina Kuskova, Birgit Stoffel-Wagner, Rene Hurlemann, Dirk Scheele
Summary: Loneliness is associated with decreased trust, larger social distances, and lower trustworthiness. Lonely individuals show reduced limbic and striatal activation, as well as weakened functional connectivity between the anterior insula and occipitoparietal regions during initial trust decisions.
Article
Psychology, Clinical
Kah Kheng Goh, Nobuhisa Kanahara, Yi-Hang Chiu, Mong-Liang Lu
Summary: Childhood trauma is associated with schizophrenia and social dysfunction, while oxytocin and the OXTR gene may play a role in regulating social behavior. This study found significant differences in childhood trauma exposure, social functioning, and oxytocin levels among patients with schizophrenia, with certain OXTR SNPs being associated with increased risk for the disorder. The results suggest that oxytocin and its receptor gene could be potential targets for interventions to improve social functioning in individuals with a history of childhood trauma and schizophrenia, although more research is needed to fully understand their effects and applications in this population.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Management
Ayala Arad, Amnon Maltz
Summary: Introducing a small interest rate on positive balances of checking accounts may decrease allocations to checking accounts and increase investments with higher returns. This violation of monotonicity is a potential outcome of a novel behavioral phenomenon.
MANAGEMENT SCIENCE
(2022)
Article
Biology
Aubrey M. Kelly, Jose AntonioGonzalez Abreu, Richmond R. Thompson
Summary: The study found that testosterone can facilitate or inhibit prosocial behaviors depending on social context, and have rapid and prolonged effects on prosocial responses. This hormone also affects oxytocin signaling mechanisms which mediate its context-dependent behavioral influences.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2022)
Article
Behavioral Sciences
Xiao-E Cai, Jiao Le, Xiao-Jing Shou, Gao-Wa Wu-Yun, Xiao-Xi Wang, Song-Ping Han, Ji-Sheng Han, Keith M. Kendrick, Rong Zhang
Summary: Children with autism exhibit reduced attention to social paired with nonsocial stimuli compared to typically developing children. Using eye-tracking we show this difference is due to typically developing rather than autistic boys being more influenced by how interesting competing nonsocial objects are. On the other hand, reduced time looking at the eyes in autistic relative to typically developing boys is unaffected by nonsocial object salience. Time spent viewing social stimuli is associated with cognitive development and blood levels of oxytocin.
Article
Neurosciences
Shiyi Li, Shuangmei Ma, Danyang Wang, Hejing Zhang, Yunzhu Li, Jiaxin Wang, Jingyi Li, Boyu Zhang, Joerg Gross, Carsten K. W. De Dreu, Wen-Xu Wang, Yina Ma
Summary: This study investigates how individual cooperation spreads through human social networks and identifies oxytocin and costly punishment as biobehavioral mechanisms that facilitate the propagation of cooperation. The experiments show that giving oxytocin to central individuals increases their trust and enforcement of cooperation norms, thereby explaining the spreading of cooperation throughout the social network. Simulation results confirm that central cooperators' willingness to punish noncooperation allows the permeation of the network and enables the evolution of network cooperation.
JOURNAL OF NEUROSCIENCE
(2022)
Review
Clinical Neurology
Michel Sabe, Nan Zhao, Alessio Crippa, Gregory P. Strauss, Stefan Kaiser
Summary: A systematic review and meta-analysis on the effects of intranasal oxytocin for treating negative symptoms in schizophrenia showed inconsistent results, with no consistent beneficial effect found. Higher doses of oxytocin may have a beneficial effect on negative symptoms, but further studies are needed to confirm this. There was no beneficial effect of oxytocin on positive symptoms in the main meta-analysis, although a potential advantage of higher doses was suggested in the dose-response meta-analysis.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2021)
Review
Neurosciences
Maya Jammoul, Dareen Jammoul, Kevin K. Wang, Firas Kobeissy, Ralph G. Depalma
Summary: This article reviews the possible mechanisms by which traumatic brain injury (TBI) may stimulate the development of opioid use disorder (OUD) and discusses the interaction between these two processes. CNS damage due to TBI appears to drive adverse effects of subsequent OUD, with pain being a risk factor for opioid use after TBI.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Danusa Mar Arcego, Jan-Paul Buschdorf, Nicholas O'Toole, Zihan Wang, Barbara Barth, Irina Pokhvisneva, Nirmala Arul Rayan, Sachin Patel, Euclides Jose de Mendonca Filho, Patrick Lee, Jennifer Tan, Ming Xuan Koh, Chu Ming Sim, Carine Parent, Randriely Merscher Sobreira de Lima, Andrew Clappison, Kieran J. O'Donnell, Carla Dalmaz, Janine Arloth, Nadine Provencal, Elisabeth B. Binder, Josie Diorio, Patricia Pelufo Silveira, Michael J. Meaney
Summary: This study investigates the impact of environmental influences on mental health by integrating transcriptomic data from animal models with human data. The results suggest that hippocampal glucocorticoid-related transcriptional activity mediates the effects of early adversity on neural mechanisms implicated in psychiatric disorders.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Milenna T. van Dijk, Ardesheer Talati, Pratik Kashyap, Karan Desai, Nora C. Kelsall, Marc J. Gameroff, Natalie Aw, Eyal Abraham, Breda Cullen, Jiook Cha, Christoph Anacker, Myrna M. Weissman, Jonathan Posner
Summary: This study found that maternal stress is associated with future depressive symptoms and alterations in microstructure of the dentate gyrus (DG) in offspring. These results were consistent across two independent cohorts.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Josephine C. McGowan, Liliana R. Ladner, Claire X. Shubeck, Juliana Tapia, Christina T. LaGamma, Amanda Anqueira-Gonzalez, Ariana DeFrancesco, Briana K. Chen, Holly C. Hunsberger, Ezra J. Sydnor, Ryan W. Logan, Tzong-Shiue Yu, Steven G. Kernie, Christine A. Denny
Summary: Traumatic brain injury (TBI) leads to fear generalization by altering fear memory traces, and this symptom can be improved with (R,S)-ketamine.
BIOLOGICAL PSYCHIATRY
(2024)