Article
Allergy
Wisdom Alemya Akurugu, Carel Jacobus Van Heerden, Nicola Mulder, Ekkehard Werner Zollner
Summary: This study found that some SNPs of the CRHR1 and NR3C1 genes are associated with HPAS in asthmatic children, with the C allele of rs41423247 potentially having a protective effect on HPAS, and the CC genotype being associated with the highest PMTP ACTH response.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2021)
Review
Endocrinology & Metabolism
Jody A. Rusch, Brian T. Layden, Lara R. Dugas
Summary: Cognitive function in humans relies on the complex interplay between multiple body systems, including the HPA axis. The gut microbiota, which outnumbers human cells and has a greater genetic potential, plays a crucial role through the MGB axis, a bidirectional communication pathway. Stress can affect the MGB axis through the HPA axis and other pathways, and animal research has contributed to a paradigm shift in understanding the influence of microbiota on human health and disease. Preclinical and human trials are currently investigating the applicability of these findings in humans.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Martin Werdermann, Ilona Berger, Laura D. Scriba, Alice Santambrogio, Pia Schlinkert, Heike Brendel, Henning Morawietz, Andreas Schedl, Mirko Peitzsch, Aileen J. F. King, Cynthia L. Andoniadou, Stefan R. Bornstein, Charlotte Steenblock
Summary: This study investigated the impact of metabolic diseases on progenitor cells in the hypothalamic-pituitary-adrenal axis, showing that insulin enhances proliferation and differentiation of these cells, while chronic metabolic stress leads to hyperactivation of the axis. This suggests a potential link between early life stress and the development of metabolic syndrome in adulthood.
MOLECULAR METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Bei Zhou, Qilong Xu, Junjie Guo, Qinliang Chen, Qingqing Lv, Kan Xiao, Huiling Zhu, Jiangchao Zhao, Yulan Liu
Summary: This study investigates the role of necroptosis in the activation of the hypothalamic-pituitary-adrenal (HPA) axis in a stress model induced by Escherichia coli lipopolysaccharide (LPS). The findings indicate that necroptosis is present and contributes to HPA axis activation induced by LPS. Necroptosis may serve as a potential intervention target for alleviating HPA axis activation and stress responses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pediatrics
Cynthia R. Rovnaghi, Joseph Rigdon, Jean-Michel Roue, Monica O. Ruiz, Victor G. Carrion, Kanwaljeet J. S. Anand
Summary: This study aimed to identify children at risk for altered HPA-axis function due to early life stress by examining longitudinal trajectories of hair cortisol concentrations. The results revealed different classes of children with distinct HCC profiles, suggesting varying impacts of ELS on HPA-axis function.
FRONTIERS IN PEDIATRICS
(2021)
Review
Biochemistry & Molecular Biology
Mojca Jensterle, Rok Herman, Andrej Janez, Wael Al Mahmeed, Khalid Al-Rasadi, Kamila Al-Alawi, Maciej Banach, Yajnavalka Banerjee, Antonio Ceriello, Mustafa Cesur, Francesco Cosentino, Massimo Galia, Su-Yen Goh, Sanjay Kalra, Peter Kempler, Nader Lessan, Paulo Lotufo, Nikolaos Papanas, Ali A. Rizvi, Raul D. Santos, Anca P. Stoian, Peter P. Toth, Vijay Viswanathan, Manfredi Rizzo
Summary: The article reviews the rationale for glucocorticoid use in COVID-19 and emphasizes the need to be cautious about glucocorticoid-induced adrenal insufficiency. The authors also discuss other mechanisms that may affect HPA axis function and the increased risk and severity of COVID-19 in patients with pre-existing HPA axis disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Endocrinology & Metabolism
You Lee Son, Takayoshi Ubuka, Kazuyoshi Tsutsui
Summary: Under stressful conditions, the GnIH neuropeptide may play a key role in regulating reproductive function. Different types and durations of stress can modulate the GnIH system, impacting the activity of the HPG axis. GnIH appears to be a potential novel mediator responsible for stress-induced reproductive dysfunction.
FRONTIERS IN NEUROENDOCRINOLOGY
(2022)
Article
Cell Biology
Manxiu Ma, Alyssa A. Brunal, Kareem C. Clark, Carleigh Studtmann, Katelyn Stebbins, Shin-ichi Higashijima, Y. Albert Pan
Summary: The expression of corticotropin-releasing hormone (CRH) in the hypothalamus plays a critical role in regulating the hypothalamic-pituitary-adrenal (HPA) axis, which is involved in the stress response. Through studying zebrafish, researchers identified dscaml1 as an important factor in CRH neuron development and HPA axis function. Mutations in dscaml1 led to increased CRH expression and cell number in hypothalamic CRH neurons, as well as altered stress hormone levels and response to stressors. These findings suggest a role for dscaml1 in stress axis development and its potential contribution to neuropsychiatric disorders.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Feiye Wu, Jing Zhu, Yang Wan, Subinuer Kurexi, Jia Zhou, Ke Wang, Tongyu Chen
Summary: This study aimed to investigate the effects of electroacupuncture (EA) on the hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis and its potential mechanisms. The results showed that EA treatment effectively inhibited the hyperactivity of the HPA axis and promoted postoperative recovery by activating the oxytocin/oxytocin receptor (OXT/OXTR) signaling pathway.
NEUROCHEMICAL RESEARCH
(2023)
Article
Psychology, Multidisciplinary
Isabel Crespo-Sanmiguel, Mariola Zapater-Fajari, Matias M. Pulopulos, Vanesa Hidalgo, Alicia Salvador
Summary: The study found that early life stress (ELS) is associated with perceived stress, but not with HPA axis functioning. Loneliness mediates the relationship between ELS and perceived stress, but not between ELS and HPA axis functioning.
FRONTIERS IN PSYCHOLOGY
(2021)
Review
Endocrinology & Metabolism
Selina Schaer, Ines Muerner-Lavanchy, Stefanie J. Schmidt, Julian Koenig, Michael Kaess
Summary: This series of meta-analyses aimed to quantify the effect of child maltreatment on various measures of HPA axis activity. The results showed evidence for blunted cortisol stress reactivity in individuals exposed to child maltreatment. However, no overall differences were found in other measures of HPA axis activity. The study also discussed moderators, methodological shortcomings, and potential directions for future research.
FRONTIERS IN NEUROENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Christina Tatsi, Megan Neely, Chelsi Flippo, Maria-Eleni Bompou, Meg Keil, Constantine A. Stratakis
Summary: The recovery of adrenal function in pediatric patients with CD after TSS may not be influenced by most clinical and biochemical factors, except for an increase in urinary free cortisol which may prolong the recovery time. Patients who recover adrenal function earlier are at a higher risk for CD recurrence, highlighting the importance of close follow-up and counseling for these patients.
CLINICAL ENDOCRINOLOGY
(2021)
Article
Geriatrics & Gerontology
Agnes Martin, Josiane Castells, Valentine Allibert, Andrea Emerit, Cindy Zolotoff, Victoire Cardot-Ruffino, Yann S. Gallot, Barbara Vernus, Veronique Chauvet, Laurent Bartholin, Laurent Schaeffer, Anne-Cecile Durieux, Christophe Hourde, Francois B. Favier, Laetitia Mazelin, Damien Freyssenet
Summary: This study found that the hypothalamic-pituitary-adrenal-glucocorticoid pathway plays an important role in the transcriptional regulation of skeletal muscle catabolism and hepatic metabolism during cancer cachexia.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Endocrinology & Metabolism
Wrivu N. Martin, Carol A. Wang, Stephen J. Lye, Stephen G. Matthews, Rebecca M. Reynolds, Carly E. McLaughlin, Roger Smith, Craig E. Pennell
Summary: The study found an inverse linear relationship between fetal growth and HPA-A function at age 18, with no consistent quadratic relationships identified. Removal of anticipatory responders from the models substantially attenuated the observed relationships. This suggests altered adrenal sensitivity may underlie the relationship.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Wrivu N. Martin, Carol A. Wang, Stephen J. Lye, Stephen G. Matthews, Rebecca M. Reynolds, Carly E. McLaughlin, Roger Smith, Craig E. Pennell
Summary: A study found an inverse linear relationship between fetal growth and HPA-A function at the age of 18, which may be related to altered adrenal sensitivity.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Psychology, Developmental
Alana J. McVey, Quinn Liu, Saashi A. Bedford, Anat Zaidman-Zait, Peter Szatmari, Isabel M. Smith, Tracy Vaillancourt, Lonnie Zwaigenbaum, Teresa Bennett, Eric Duku, Mayada Elsabbagh, Stelios Georgiades, Connor M. Kerns
Summary: Research on the quality of sibling relationships among autistic children is mixed. Some studies suggest poorer quality compared to children with other disabilities or who are neurotypical. Parents' perceptions of sibling relationship quality in relation to the clinical characteristics of autistic children are not well understood. This study examined the relationship between autism symptoms, behavioral difficulties, and communication abilities of autistic children, and parent-rated sibling relationship quality. The findings highlight the importance of considering clinical characteristics and multiple domains of relationship quality to better understand how parents view the relationships between autistic children and their siblings.
Article
Psychology, Developmental
Magdalena Janus, Julia Ryan, Molly Pottruff, Caroline Reid-Westoby, Marni Brownell, Teresa Bennett, Catherine S. Birken, Eric Duku, Mark A. Ferro, Barry Forer, Stelios Georgiades, Jan Willem Gorter, Martin Guhn, Jonathon Maguire, Heather Manson, Jacqueline Pei, Rob Santos, Robert J. Coplan
Summary: Despite being a prevalent mental health problem, there is little data on the pervasiveness and levels of anxiety symptoms in kindergarteners. This study collected data from Canada over a span of 11 years and found that highly anxious children were more likely to be male, have English/French as a second language, and have special needs designation. Furthermore, highly anxious children were more likely to score below the 10th percentile in physical, social, language/cognitive, and communication domains.
CHILD PSYCHIATRY & HUMAN DEVELOPMENT
(2023)
Article
Psychology, Developmental
Danielle A. Baribeau, Simone N. Vigod, Eleanor Pullenayegum, Connor M. Kerns, Tracy Vaillancourt, Eric Duku, Isabel M. Smith, Joanne Volden, Lonnie Zwaigenbaum, Teresa Bennett, Mayada Elsabbagh, Anat Zaidman-Zait, Annie E. Richard, Peter Szatmari
Summary: Autistic children experience high rates of anxiety, with insistence on sameness behavior being a core feature that correlates with anxiety severity. This study examined the longitudinal relations between anxiety and insistence on sameness (IS) in autistic children and found that IS may precede the development of anxiety symptoms in the future. The associations between anxiety and IS may decrease with age.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2023)
Article
Pediatrics
Jessica A. Omand, Xuedi Li, Charles D. G. Keown-Stoneman, Cornelia M. Borkhoff, Eric Duku, Gerald Lebovic, Jonathon L. Maguire, Muhammad M. Mamdani, Patricia C. Parkin, Caroline Reid-Westoby, Janis Randall Simpson, Mark S. Tremblay, Magdalena Janus, Catherine S. Birken
Summary: This study investigates the association between body weight in early childhood and school readiness in young children. Being classified as overweight or with obesity was found to be associated with poor school readiness in year 2 of kindergarten. Early interventions to promote healthy growth before school entry may help promote development and school readiness in young children.
Article
Psychology, Developmental
Diana Tajik-Parvinchi, Peter Rosenbaum, Mary Jo Cooley Hidecker, Eric Duku, Lonnie Zwaigenbaum, Caroline Roncadin, Stelios Georgiades, Stephen Gentles, Hanna Fang, Briano Di Rezze
Summary: This study examined the construct validity of the Autism Classification System of Functioning: Social Communication (ACSF) and found that it provides a valid classification system for social communication ability in children with autism aged 2-19 years.
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2023)
Article
Pediatrics
Kimberly M. Nurse, Magdalena Janus, Catherine S. Birken, Charles D. G. Keown-Stoneman, Jessica A. Omand, Jonathon L. Maguire, Caroline Reid-Westoby, Eric Duku, Muhammad Mamdani, Mark S. Tremblay, Patricia C. Parkin, Cornelia M. Borkhoff
Summary: The American Academy of Pediatrics recommends developmental surveillance and screening at an early age. This study examines the predictive validity of the Infant Toddler Checklist (ITC) at the 18-month health supervision visit, using school readiness at kindergarten age as the criterion measure.
ACADEMIC PEDIATRICS
(2023)
Article
Psychology, Developmental
Myriam L. H. Beauchamp, Stefano Rezzonico, Terry Bennett, Eric Duku, Stelios Georgiades, Connor Kerns, Pat Mirenda, Annie Richard, Isabel M. Smith, Peter Szatmari, Tracy Vaillancourt, Charlotte Waddell, Anat Zaidman-Zait, Lonnie Zwaigenbaum, Mayada Elsabbagh
Summary: This study examined the narrative abilities of bilingual and monolingual children on the autism spectrum and investigated the differences in social and pragmatic language abilities between bilinguals and monolinguals. The results showed that bilinguals performed similarly to monolinguals on measures of narrative, social, and pragmatic language skills, but balanced bilinguals excelled in a nonliteral language task.
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2023)
Article
Psychiatry
Mahdis Kamali, Jordan Edwards, Laura N. N. Anderson, Eric Duku, Katholiki Georgiades
Summary: This study examines differences in mental health-related service contacts among immigrant, refugee, racial and ethnic minoritized children and youth. The results show that after adjusting for mental health symptoms and perceptions of need, these populations were less likely to have mental health-related service contacts compared to non-immigrant peers and those who identified as White. The differences generally remained the same or widened after adjusting for social and economic characteristics. The findings highlight the importance of addressing barriers to recognition and treatment of mental health issues for children and youth from minoritized backgrounds.
CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE
(2023)
Article
Psychology, Developmental
Michael H. Boyle, Laura Duncan, Li Wang, Katholiki Georgiades
Summary: The classifications of child/youth psychiatric disorder from parent-reported checklists and interviews are psychometrically equivalent.
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
(2023)
Article
Psychology, Developmental
Virginia Carter Leno, Nicola Wright, Andrew Pickles, Rachael Bedford, Anat Zaidman-Zait, Connor Kerns, Lonnie Zwaigenbaum, Eric Duku, Teresa Bennett, Stelios Georgiades, Isabel M. M. Smith, Annie Richards, Tracy Vaillancourt, Peter Szatmari, Mayada Elsabbagh
Summary: This study examined the predictive role of irritability in early childhood on depression symptoms in autistic adolescents, and the potential mediating effects of peer relationships and educational engagement. The results showed a positive association between early childhood irritability and adolescent depression symptoms, with peer relationships partially mediating this association. No mediation effects were found for educational engagement. These findings highlight the importance of early screening and intervention for co-occurring irritability and peer problems in young autistic children.
DEVELOPMENT AND PSYCHOPATHOLOGY
(2023)
Article
Education, Special
Kate Tsiplova, Wendy J. Ungar, Peter Szatmari, Katherine Cost, Eleanor Pullenayegum, Eric Duku, Joanne Volden, Isabel M. Smith, Charlotte Waddell, Lonnie Zwaigenbaum, Teresa A. Bennett, Mayada Elsabbagh, Stelios Georgiades, Anat Zaidman-Zait
Summary: This study aims to examine the association between behavioural services received by children with autism spectrum disorder (ASD) between the ages of 2 and 5 years and outcomes during their primary school years. The results show that children who received behavioural services during at least one time period from T1 to T3 did not have significantly different outcomes at T8 compared to children who did not receive any behavioural services.
RESEARCH IN DEVELOPMENTAL DISABILITIES
(2023)
Article
Public, Environmental & Occupational Health
Amanda Sim, Eve Puffer, Afreen Ahmad, Lina Hammad, Katholiki Georgiades
Summary: This study examines the resettlement stressors, mental health, coping strategies, and resources of refugee parents. The findings indicate significant exposure to economic and social stressors, as well as high levels of parental psychological distress. The study highlights the importance of family as a protective resource for coping with adversity.
Review
Psychology, Developmental
Stephen J. Gentles, Elise C. Ng-Cordell, Michelle C. Hunsche, Alana J. McVey, E. Dimitra Bednar, Yun-Ju Chen, Eric Duku, Connor M. Kerns, Laura Banfield, Peter Szatmari, Stelios Georgiades
Summary: Researchers use longitudinal trajectory methods to study developmental pathways of individuals with autism. This scoping review identified and summarized 103 published trajectory studies in children diagnosed with autism. The review highlights the methodological characteristics and varying statistical approaches used in these studies, as well as the outcome domains and ages covered. Gaps in research from low- and middle-income countries are discussed, along with the need for more outcome-specific data across different ages.
Article
Psychiatry
Jordan Edwards, Paul Kurdyak, Charlotte Waddell, Scott B. Patten, Graham J. Reid, Leslie Anne Campbell, Katholiki Georgiade
CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE
(2023)
Review
Neurosciences
Maya Jammoul, Dareen Jammoul, Kevin K. Wang, Firas Kobeissy, Ralph G. Depalma
Summary: This article reviews the possible mechanisms by which traumatic brain injury (TBI) may stimulate the development of opioid use disorder (OUD) and discusses the interaction between these two processes. CNS damage due to TBI appears to drive adverse effects of subsequent OUD, with pain being a risk factor for opioid use after TBI.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Danusa Mar Arcego, Jan-Paul Buschdorf, Nicholas O'Toole, Zihan Wang, Barbara Barth, Irina Pokhvisneva, Nirmala Arul Rayan, Sachin Patel, Euclides Jose de Mendonca Filho, Patrick Lee, Jennifer Tan, Ming Xuan Koh, Chu Ming Sim, Carine Parent, Randriely Merscher Sobreira de Lima, Andrew Clappison, Kieran J. O'Donnell, Carla Dalmaz, Janine Arloth, Nadine Provencal, Elisabeth B. Binder, Josie Diorio, Patricia Pelufo Silveira, Michael J. Meaney
Summary: This study investigates the impact of environmental influences on mental health by integrating transcriptomic data from animal models with human data. The results suggest that hippocampal glucocorticoid-related transcriptional activity mediates the effects of early adversity on neural mechanisms implicated in psychiatric disorders.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Milenna T. van Dijk, Ardesheer Talati, Pratik Kashyap, Karan Desai, Nora C. Kelsall, Marc J. Gameroff, Natalie Aw, Eyal Abraham, Breda Cullen, Jiook Cha, Christoph Anacker, Myrna M. Weissman, Jonathan Posner
Summary: This study found that maternal stress is associated with future depressive symptoms and alterations in microstructure of the dentate gyrus (DG) in offspring. These results were consistent across two independent cohorts.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Josephine C. McGowan, Liliana R. Ladner, Claire X. Shubeck, Juliana Tapia, Christina T. LaGamma, Amanda Anqueira-Gonzalez, Ariana DeFrancesco, Briana K. Chen, Holly C. Hunsberger, Ezra J. Sydnor, Ryan W. Logan, Tzong-Shiue Yu, Steven G. Kernie, Christine A. Denny
Summary: Traumatic brain injury (TBI) leads to fear generalization by altering fear memory traces, and this symptom can be improved with (R,S)-ketamine.
BIOLOGICAL PSYCHIATRY
(2024)