Article
Neurosciences
Agustin Zapata, Carl R. Lupica
Summary: Animal and human studies suggest that cannabis can increase cocaine seeking and is associated with impulse control deficits, possibly through involvement of the CB1 receptors. The CB1 receptors in the Lateral Habenula (LHb) play a role in impulsivity deficits, highlighting a potential therapeutic target for substance use disorders.
Article
Neurosciences
Brooke N. Bender, Mary M. Torregrossa
Summary: Intermittent access (IntA) models have been developed to mimic human cocaine use and have been shown to enhance pharmacological and behavioral effects of cocaine. This study examined sex differences and cue extinction in the IntA model. Results showed that IntA increased motivation for cocaine in females and facilitated punished cocaine self-administration in males. Additionally, after 10 days of IntA training, drug-seeking was dependent on DLS dopamine in males. These findings suggest that IntA is valuable for studying sex differences and early stages of drug use.
Article
Pharmacology & Pharmacy
Shiqiu Meng, Wei Yan, Xiaoxing Liu, Yimiao Gong, Shanshan Tian, Ping Wu, Yan Sun, Jie Shi, Lin Lu, Kai Yuan, Yanxue Xue
Summary: This study demonstrates that social interaction with a relapsed partner increases drug seeking behavior in rats, while interaction with an unrelapsed partner or relapsed stranger has no effect on cocaine seeking. Additionally, the impact of social interaction on drug seeking behavior can last for at least 1 day.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Psychiatry
Diana Mejia Cruz, Laurent Avila Chauvet, Luis Villalobos-Gallegos, Christian Gabriel Toledo-Lozano
Summary: Sexual addiction is associated with serious health problems. This study conducted a cross-cultural adaptation of the Sex Addiction Screening Test (SAST-R) on the Mexican population. The Mexican Spanish version of the SAST-R was found to have good psychometric properties and can be used in future research.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Neurosciences
Sasha L. Fulton, Swarup Mitra, Ashley E. Lepack, Jennifer A. Martin, Andrew F. Stewart, Jacob Converse, Mason Hochstetler, David M. Dietz, Ian Maze
Summary: This study demonstrates the importance of the histone post-translational modification H3Q5dop in cocaine and heroin addiction, showing its role in persistent transcriptional events and plasticity in reward relevant brain regions.
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Substance Abuse
Violaine Mongeau-Perusse, Suzanne Brissette, Julie Bruneau, Patricia Conrod, Simon Dubreucq, Guillaume Gazil, Emmanuel Stip, Didier Jutras-Aswad
Summary: This study tested the efficacy of CBD for reducing craving and preventing relapse in people with CUD. However, the findings showed that CBD treatment did not reduce cocaine craving or relapse among participants being treated for CUD.
Review
Pharmacology & Pharmacy
Saeideh Karimi-haghighi, Maedeh Mahmoudi, Fatemeh Sayehmiri, Roghayeh Mozafari, Abbas Haghparast
Summary: The mechanism behind relapse in addiction treatment with psychostimulant drugs is not fully understood, and there is conflicting evidence regarding the role of the endocannabinoid system in regulating relapse in preclinical studies. This systematic review evaluated the effect of endocannabinoid modulators on the reinstatement of commonly abused psychostimulants. Thirty-nine articles using different animal models were selected, and the results suggest that cannabinoid receptor antagonists and agonists may have potential in inhibiting the reinstatement of cocaine and methamphetamine addiction, but the effectiveness depends on time, dose, and route of administration.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Review
Clinical Neurology
Linda Rinehart, Sade Spencer
Summary: The relationships between impulse control deficits and substance use disorders have been studied extensively, with evidence showing that chronic drug abuse can remodel the brain and impact cognitive behaviors. Individual differences in impulse control may also play a role in susceptibility to substance use disorders. The debate remains as to whether impulsivity precedes drug use or is a result of problematic drug usage. Existing research has established a strong link between impulsivity and cocaine and alcohol use disorders, but much less is known about the relationship with cannabis use disorder.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Clinical Neurology
Tsen Vei Lim, Rudolf N. Cardinal, Edward T. Bullmore, Trevor W. Robbins, Karen D. Ersche
Summary: The study revealed that SUD patients have significantly reduced learning rates from punishment compared to healthy controls, while reward learning rates were not measurably impaired. Furthermore, the dopaminergic receptor agents modulated RL parameters differently in SUD patients and healthy participants.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Di Zhao, Mingming Zhang, Weiwen Tian, Xinyu Cao, Lu Yin, Yi Liu, Tian-Le Xu, Wenbo Luo, Ti-Fei Yuan
Summary: Previous studies have shown that abstinence can lead to an increase in cue-induced drug craving, including for nicotine, alcohol, cocaine, and methamphetamine. However, research on methamphetamine craving incubation has not fully explored the neuropsychological and electrophysiological dynamics associated with this process. This study utilized EEG signals to track cue-induced craving in individuals with methamphetamine use disorder, finding that craving peaked at 1-3 months of abstinence along with changes in sleep quality and specific brain wave frequencies, suggesting potential neurophysiological signatures for identifying those at risk for relapse and guiding future therapeutic interventions.
MOLECULAR PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Thomas Lissek, Andry Andrianarivelo, Estefani Saint-Jour, Marie-Charlotte Allichon, Hanke Gwendolyn Bauersachs, Merie Nassar, Charlotte Piette, Priit Pruunsild, Yan-Wei Tan, Benoit Forget, Nicolas Heck, Jocelyne Caboche, Laurent Venance, Peter Vanhoutte, Hilmar Bading
Summary: Npas4 is a crucial regulator of medium spiny neuron function, affecting spine density and electrophysiological parameters, as well as cocaine-induced locomotion magnitude. Its induction is calcium-dependent and independent of common kinase pathways, controlling a regulon that includes synaptic molecules.
Article
Multidisciplinary Sciences
Loreen Tisdall, Kelly H. MacNiven, Claudia B. Padula, Josiah K. Leong, Brian Knutson
Summary: Diffusion tractography can predict relapse in patients with stimulant use disorder, and lowered diffusion metrics in the tract from the anterior insula to the NAcc are associated with subsequent relapse.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Jasper A. Heinsbroek, Giuseppe Giannotti, Mitchel R. Mandel, Megan Josey, Gary Aston-Jones, Morgan H. James, Jamie Peters
Summary: The study found that heroin choice and relapse involve different neural pathways in the brain, but share a common addiction-limiting circuit in the IL-NAshell pathway. This suggests that different mechanisms may be at play during drug choice and relapse, highlighting the complexity of addiction behaviors.
NATURE COMMUNICATIONS
(2021)
Review
Biochemistry & Molecular Biology
Carla Occhipinti, Raffaele La Russa, Naomi Iacoponi, Julia Lazzari, Andrea Costantino, Nicola Di Fazio, Fabio Del Duca, Aniello Maiese, Vittorio Fineschi
Summary: This article provides an overview of the role of miRNAs in substance addiction, evaluating their regulatory role in neuroadaptation and synaptic plasticity. It also explores the potential diagnostic role of miRNAs in various stages of drug and substance addiction, and discusses future prospects for miRNAs as potential novel therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Stevenson Desmercieres, Virginie Lardeux, Jean-Emmanuel Longueville, Myriam Hanna, Leigh Panlilio, Nathalie Thiriet, Marcello Solinas
Summary: The newly developed PSS procedure provides a quantifiable breakpoint to measure animals' propensity to continue working for a reward despite progressively increasing electric shock intensity. The break point is sensitive to hunger and changes in the qualitative incentive value of the reward, and it shows differences compared to the traditional PR procedure.
Review
Neurosciences
Naomi P. Friedman, Trevor W. Robbins
Summary: Concepts of cognitive control and executive function are defined in relation to goal-directed behavior versus habits, controlled versus automatic processing, and the functions of the prefrontal cortex and related regions and networks. There is unity and diversity in cognitive control constructs, including general cognitive control and components specific to mental set shifting and working memory updating. The relationships of cognitive control with psychopathology, impulsivity, genetic studies, and psychiatric classification are also explored.
NEUROPSYCHOPHARMACOLOGY
(2022)
Editorial Material
Neurosciences
Suzanne N. Haber, Trevor Robbins
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Neurosciences
Peter Zhukovsky, Sharon Morein-Zamir, Hisham Ziauddeen, Emilio Fernandez-Egea, Chun Meng, Ralf Regenthal, Barbara J. Sahakian, Edward T. Bullmore, Trevor W. Robbins, Jeffrey W. Dalley, Karen D. Ersche
Summary: This study found that atomoxetine can improve response inhibition in both control participants and individuals with CUD, and the improvement is dependent on baseline response inhibition performance and associated with increased activation in the inferior frontal gyrus.
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2022)
Article
Plant Sciences
Jung-Hung Chen, I-Hsin Lin, Thomas Y. Hsueh, Jeffrey W. Dalley, Tung-Hu Tsai
Summary: This study aimed to investigate the metabolism, distribution, and transplacental transfer mechanism of codeine and its metabolites in pregnant rats, as well as to assess the risk of medication for pregnant women.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Neurosciences
Katharina Zuhlsdorff, Jeffrey W. Dalley, Trevor W. Robbins, Sharon Morein-Zamir
Summary: Behavioral and cognitive flexibility enable individuals to adapt to a changing environment. This study introduces a novel "change your mind task" to assess volitional switching under uncertainty, without the need for rule-based learning. The findings suggest that individuals are more likely to change their response when the feedback is negative or when their initial response is incorrect.
Article
Neurosciences
Nana Feng, Lena Palaniyappan, Trevor W. Robbins, Luolong Cao, Shuanfeng Fang, Xingwei Luo, Xiang Wang, Qiang Luo
Summary: Impaired working memory (WM) is a core dysfunction in schizophrenia, characterized by deficits in both attention and WM processing. Patients show linear modulation of brain activation in frontoparietal and dorsal attention networks, while controls exhibit an inverted U-shaped response pattern in the left anterior cingulate cortex. These modulation effects are associated with gene expressions related to the dopamine neurotransmitter system.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Psychology, Clinical
Jonathan W. Kanen, Qiang Luo, Mojtaba Rostami Kandroodi, Rudolf N. Cardinal, Trevor W. Robbins, David J. Nutt, Robin L. Carhart-Harris, Hanneke E. M. den Ouden
Summary: The study aimed to investigate how LSD affects probabilistic reversal learning in healthy individuals. The results showed that LSD increased the reward and punishment learning rates, decreased stimulus stickiness, and induced a state of heightened plasticity.
PSYCHOLOGICAL MEDICINE
(2023)
Review
Neurosciences
Olivia Stupart, Trevor W. Robbins, Jeffrey W. Dalley
Summary: The meta-analysis showed that unconditioned tasks are generally poor at consistently demonstrating differences between control and separated groups in rats, indicating the need for more objective tasks in translational research on stress-related disorders.
PSYCHOPHARMACOLOGY
(2023)
Article
Clinical Neurology
Roxanne W. Hook, Masanori Isobe, George Savulich, Jon E. Grant, Konstantinos Ioannidis, David Christmas, Barbara J. Sahakian, Trevor W. Robbins, Samuel R. Chamberlain
Summary: This study found that single-dose istradefylline can impact human cognition, particularly in the social information preference task with emotional loading. This indicates the under-studied role of the adenosine neurochemical system in human cognition, which requires further exploration.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Psychiatry
Michal M. Graczyk, Barbara J. Sahakian, Trevor W. Robbins, Karen D. Ersche
Summary: Not everyone who uses drugs loses control over their intake, which is a hallmark of addiction. Although familial risk studies suggest significant addiction heritability, the genetic basis of vulnerability to drug addiction remains largely unknown. In this study, the researchers examined the relationship between self-control, cocaine use, and a specific gene variant (rs36024) associated with the noradrenaline transporter gene. They found that individuals carrying the C-allele of this gene exhibited impaired self-control, particularly in the context of chronic cocaine use. Patients with cocaine use disorder who had the CC genotype showed longer stop-signal reaction time and fewer successful stops compared to healthy controls and patients with the TT genotype. These findings suggest that rs36024 may be a potential genetic vulnerability marker for cocaine addiction.
TRANSLATIONAL PSYCHIATRY
(2023)
Biographical-Item
Neurosciences
Barbara J. Sahakian, Eileen M. Joyce, Trevor W. Robbins
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Nace Mikus, Christoph Eisenegger, Christoph Mathys, Luke Clark, Ulrich Mueller, Trevor W. Robbins, Claus Lamm, Michael Naef
Summary: The study investigates the impact of the D2/D3 dopamine receptor antagonist sulpiride on learning about other people's prosocial attitudes. The results show that sulpiride increases the volatility of beliefs, leading to higher precision weights on prediction errors. This effect is more significant in participants with genetically conferred higher dopamine availability and remains even after controlling for working memory performance. The findings demonstrate the importance of D2 receptors in regulating belief updating in a social context.
NATURE COMMUNICATIONS
(2023)
Article
Neurosciences
Shitong Xiang, Tianye Jia, Chao Xie, Zhichao Zhu, Wei Cheng, Gunter Schumann, Trevor W. Robbins, Jianfeng Feng
Summary: How to retrieve latent neurobehavioural processes from complex neurobiological signals is a challenge that has not been fully addressed. This study presents a novel approach, DeCoP, that outperforms traditional decoding methods in terms of false inference and robustness. The research reveals distinct evaluation and readiness processes during reward/punishment anticipation, modulated by different dopamine systems. Only a few brain regions encode exact input information, while others encode abstract information.
Article
Psychology, Experimental
Amy Rachel Bland, Jonathan Paul Roiser, Mitul Ashok Mehta, Barbara Jacquelyn Sahakian, Trevor William Robbins, Rebecca Elliott
Summary: The study found that COVID-19 social isolation has an impact on emotional and social cognitive function, with reduced contact with friends, smaller household size, and changes in communication methods leading to a decrease in positive bias in emotion recognition and attention to emotional faces. Conversely, increased contact with friends and family during social isolation was associated with greater cooperative behavior.
COGNITION & EMOTION
(2022)
Review
Neurosciences
Maya Jammoul, Dareen Jammoul, Kevin K. Wang, Firas Kobeissy, Ralph G. Depalma
Summary: This article reviews the possible mechanisms by which traumatic brain injury (TBI) may stimulate the development of opioid use disorder (OUD) and discusses the interaction between these two processes. CNS damage due to TBI appears to drive adverse effects of subsequent OUD, with pain being a risk factor for opioid use after TBI.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Danusa Mar Arcego, Jan-Paul Buschdorf, Nicholas O'Toole, Zihan Wang, Barbara Barth, Irina Pokhvisneva, Nirmala Arul Rayan, Sachin Patel, Euclides Jose de Mendonca Filho, Patrick Lee, Jennifer Tan, Ming Xuan Koh, Chu Ming Sim, Carine Parent, Randriely Merscher Sobreira de Lima, Andrew Clappison, Kieran J. O'Donnell, Carla Dalmaz, Janine Arloth, Nadine Provencal, Elisabeth B. Binder, Josie Diorio, Patricia Pelufo Silveira, Michael J. Meaney
Summary: This study investigates the impact of environmental influences on mental health by integrating transcriptomic data from animal models with human data. The results suggest that hippocampal glucocorticoid-related transcriptional activity mediates the effects of early adversity on neural mechanisms implicated in psychiatric disorders.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Milenna T. van Dijk, Ardesheer Talati, Pratik Kashyap, Karan Desai, Nora C. Kelsall, Marc J. Gameroff, Natalie Aw, Eyal Abraham, Breda Cullen, Jiook Cha, Christoph Anacker, Myrna M. Weissman, Jonathan Posner
Summary: This study found that maternal stress is associated with future depressive symptoms and alterations in microstructure of the dentate gyrus (DG) in offspring. These results were consistent across two independent cohorts.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Josephine C. McGowan, Liliana R. Ladner, Claire X. Shubeck, Juliana Tapia, Christina T. LaGamma, Amanda Anqueira-Gonzalez, Ariana DeFrancesco, Briana K. Chen, Holly C. Hunsberger, Ezra J. Sydnor, Ryan W. Logan, Tzong-Shiue Yu, Steven G. Kernie, Christine A. Denny
Summary: Traumatic brain injury (TBI) leads to fear generalization by altering fear memory traces, and this symptom can be improved with (R,S)-ketamine.
BIOLOGICAL PSYCHIATRY
(2024)
