Review
Behavioral Sciences
Niki Hosseini-Kamkar, Cassandra Lowe, J. Bruce Morton
Summary: There is conflicting evidence on whether early-life adversity leads to increased or decreased cortisol reactivity. P-curve analysis revealed that trauma is associated with blunted cortisol reactivity, while adversity is linked to heightened cortisol reactivity. This suggests an inverted U-shaped relationship between severity of adversity and cortisol reactivity.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Behavioral Sciences
Jade Martins, Natan Yusupov, Elisabeth B. Binder, Tanja M. Braeckl, Darina Czamara
Summary: Childhood adversity has been consistently associated with mental disorders. The interaction between genetic variants and environmental factors plays a significant role in disease etiology. This review highlights the importance of implementing the gene by environment paradigm in psychiatric research and discusses the findings and limitations of gene by environment studies.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2022)
Article
Endocrinology & Metabolism
Yannuo Li, Ioannis P. Androulakis
Summary: The suprachiasmatic nucleus (SCN) synchronizes physiological rhythms and adapts to changes in photoperiod, affecting the phase distribution of neuron activities. Elevated glucocorticoid levels in short photoperiods are associated with peak disease incidence. Topological changes in the SCN network may influence seasonal variations in disease incidence.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Catherine Raymond, Marie-France Marin, Victoria Wolosianski, Audrey-Ann Journault, Charlotte Longpre, Sarah Leclaire, Rebecca Cernik, Robert-Paul Juster, Sonia J. Lupien
Summary: Early adversity can impact cortisol secretion patterns, with individuals first exposed between ages 3 and 7 showing differences in cortisol awakening response and reactivity compared to those exposed at other ages. The findings support the Life Cycle Model of Stress and emphasize the importance of considering the age of exposure to early adversity in assessing cortisol secretion patterns.
PSYCHONEUROENDOCRINOLOGY
(2021)
Article
Pediatrics
Cynthia R. Rovnaghi, Joseph Rigdon, Jean-Michel Roue, Monica O. Ruiz, Victor G. Carrion, Kanwaljeet J. S. Anand
Summary: This study aimed to identify children at risk for altered HPA-axis function due to early life stress by examining longitudinal trajectories of hair cortisol concentrations. The results revealed different classes of children with distinct HCC profiles, suggesting varying impacts of ELS on HPA-axis function.
FRONTIERS IN PEDIATRICS
(2021)
Article
Endocrinology & Metabolism
Haley M. Appelmann, Andrew W. Manigault, Ryan C. Shorey, Peggy M. Zoccola
Summary: Childhood adversity may alter adult HPA axis habituation to repeated stress, potentially leading to sex differences. Future research should further investigate how HPA axis habituation to repeated stress may impact the effects of childhood adversity on adult health.
PSYCHONEUROENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Ryan E. Adams, Jonathan Bruce Santo, William M. Bukowski
Summary: This study examines the indirect effects of HPA axis dysregulation on the link between adolescent peer victimization and depressive symptoms, finding that blunted cortisol reactivity is associated with depressive symptoms, particularly in cases of chronic peer victimization. These findings suggest that interventions targeting peer victimization may need to focus on those who experience chronic peer victimization over time.
PSYCHONEUROENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Cathy Degroote, Roland von Kanel, Livia Thomas, Claudia Zuccarella-Hackl, Nadine Messerli-Burgy, Hugo Saner, Roland Wiest, Petra H. Wirtz
Summary: Research shows that patients with coronary heart disease (CHD) and hypertension have decreased activity in the hypothalamus-pituitary-adrenal (HPA) axis, which may contribute to an increased risk of cardiovascular disease.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Clinical Neurology
Jelena Bakusic, Manosij Ghosh, Andrea Polli, Bram Bekaert, Wilmar Schaufeli, Stephan Claes, Lode Godderis
Summary: The study revealed that job stress was associated with increased levels of cortisol and cortisone in burnout participants. Changes in DNA methylation of the NR3C1 and SLC6A4 genes were observed in burnout individuals, and some of these methylation changes correlated with burnout symptoms. Increased methylation in a specific CpG in the SLC6A4 gene moderated the association between job stress and burnout, while DNA methylation in this CpG was also associated with increased cortisol levels. Furthermore, average methylation of NR3C1 was negatively associated with cortisone levels.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Horticulture
Hande Yilmaz-Duzyaman, Maria G. Medina-Alonso, Carlos Sanz, Ana G. Perez, Raul de la Rosa, Lorenzo Leon
Summary: This study assessed the influence of genotype and environment on the phenolic content and composition in extra virgin olive oil. The results showed that genotype had a stronger effect than environment, and there were significant variations among different cultivars. These findings suggest the feasibility of breeding new cultivars with distinctive phenolic content and composition.
Article
Agriculture, Multidisciplinary
Juwu Gong, Depei Kong, Changwen Liu, Pengtao Li, Ping Liu, Xianghui Xiao, Ruixian Liu, Quanwei Lu, Haihong Shang, Yuzhen Shi, Junwen Li, Qun Ge, Aiying Liu, Xiaoying Deng, Senmiao Fan, Jingtao Pan, Quanjia Chen, Youlu Yuan, Wankui Gong
Summary: This study dissects the phenotype of kernel oil content (KOC) and the genotype-by-environment interaction factors using 250 recombinant inbred lines, parental cultivars, and CCRI70. The analysis reveals the significant contributions of genotype and environment to KOC accumulation and provides insight into the effects of genotype, environment, and genotype-environment interaction on KOC performance and stability. Additionally, the study identifies meteorological and geographical factors that explain a large portion of KOC variance.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Endocrinology & Metabolism
Pauline S. Effenberger, Tabea S. Send, Maria Gilles, Josef Frank, Stephan Bongard, Robert Kumsta, Stephanie H. Witt, Marcella Rietschel, Michael Deuschle, Fabian Streit, Isabell A. C. Wolf
Summary: There is no strong association between urbanicity and behavior problems or HPA axis regulation in preschool age, and urinary cortisol and salivary cortisol response after stress exposure are not identified as mediators of this relationship.
PSYCHONEUROENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Nicola Gartland, Judith G. M. Rosmalen, Daryl B. O'Connor
Summary: Childhood long-term difficulties were found to be associated with an increased likelihood of reporting suicidal thoughts or plans in adulthood. Early childhood and adolescent difficulties were equally important predictors of suicide thoughts and plans.
PSYCHONEUROENDOCRINOLOGY
(2022)
Article
Immunology
Susan K. Lutgendorf, Sharaf Zia, Yi Luo, Michael O'Donnell, Adrie van Bokhoven, Catherine S. Bradley, Robert Gallup, Jennifer Pierce, Bayley J. Taple, Bruce D. Naliboff, J. Quentin Clemens, Karl J. Kreder, Andrew Schrepf
Summary: Both early and recent life adversity are associated with chronic pain conditions and persistent alterations of neuroendocrine and inflammatory responses. Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS) is a chronic urologic disorder characterized by bladder and/or pelvic pain, and excessive urinary frequency and/ or urgency. This study investigated the potential role of early and recent life adversity as risk factors for inflammation in women with IC/BPS.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Review
Microbiology
Van A. Ortega, Emily M. Mercer, Gerald F. Giesbrecht, Marie-Claire Arrieta
Summary: This article discusses the biological and neuroendocrine networks regulating stress response, as well as the impact of gut microbiota on early-life development that may predispose individuals to various diseases later in life. Animal models have confirmed the influence of gut microbiota on HPA axis activity, stress reactivity, and brain development.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Psychology, Clinical
Laura Ghirardi, Ralf Kuja-Halkola, Erik Pettersson, Amir Sariaslan, Louise Arseneault, Seena Fazel, Brian M. D'Onofrio, Paul Lichtenstein, Henrik Larsson
Summary: This study investigated the association between neurodevelopmental disorders (NDs) and violent victimization in adolescence and young adulthood. The study found that females with NDs and males with attention-deficit/hyperactivity disorder (ADHD) were at a higher risk of violent victimization. Familial factors and externalizing problems may play important roles in this association.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Anesthesiology
Marco Battaglia, Gabrielle Garon-Carrier, Lance Rappaport, Mara Brendgen, Ginette Dionne, Frank Vitaro, Richard E. Tremblay, Michel Boivin
Summary: Adolescent pain is common and continues into adulthood, and defining its construct through empirical research can help early detection of persistent pain trajectories. This study found that back pain is consistently associated with frequent adolescent pain trajectory, and it has good sensitivity in predicting the trajectory.
Article
Psychology, Clinical
Sinziana Oncioiu, Michel Boivin, Marie-Claude Geoffroy, Louise Arseneault, Cedric Galera, Marie C. Navarro, Mara Brendgen, Frank Vitaro, Richard E. Tremblay, Sylvana M. Cote, Massimiliano Orri
Summary: Regardless of the timing and intensity, self-reported peer victimization is associated with mental health comorbidities in adolescence. The strongest association is observed for persistent peer victimization.
PSYCHOLOGICAL MEDICINE
(2023)
Review
Psychiatry
Katherine R. K. Saunders, Sabine Landau, Louise M. Howard, Helen L. Fisher, Louise Arseneault, Geraldine F. H. McLeod, Sian Oram
Summary: The study found that depression is associated with increased risk of past-year intimate partner violence (IPV), with differences by gender. Among women, depression was associated with a 7.4% increase in past-year physical IPV perpetration, while among men the increase was 4.8%. Alcohol misuse did not mediate this association, but past-year IPV victimisation mediated the effect of depression on IPV perpetration among women.
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
(2023)
Article
Psychology, Developmental
Rene Carbonneau, Frank Vitaro, Mara Brendgen, Michel Boivin, Richard E. Tremblay
Summary: This study investigated prenatal and early postnatal risk factors associated with the development of disruptive behaviors. The findings showed that pure forms of disruptive behaviors have specific etiologies, while co-occurrent disruptive behaviors share common risk factors. Risk factors such as male sex, a higher number of siblings, maternal symptoms of depression and conduct problems, young motherhood, lack of positive parenting, family dysfunction, and lower socioeconomic status were found to affect the development of disruptive behaviors.
DEVELOPMENTAL PSYCHOLOGY
(2022)
Article
Psychology, Clinical
Marie-Claude Geoffroy, Louise Arseneault, Alain Girard, Isabelle Ouellet-Morin, Chris Power
Summary: This study found that individuals who are frequently bullied have a slightly increased risk of dying by suicide. The results suggest that suicide prevention should start in childhood, with bullying considered as a potential risk factor.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychology, Developmental
Mara Brendgen, Yao Zheng, Frank Vitaro, Ginette Dionne, Michel Boivin
Summary: This study examined the role of genetic and environmental factors in explaining different trajectories of adolescents' depressive symptoms, as well as the correlation between genetic factors and peer victimization. The results showed that genetic factors explained about half of the probability of following a low or increasing trajectory, while nonshared environmental factors explained the remaining variance. Moreover, frequent peer victimization increased the influence of nonshared environmental factors.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2023)
Article
Education & Educational Research
Rene Carbonneau, Richard E. Tremblay, Frank Vitaro, Mara Brendgen, Michel Boivin, Pascale Domond, Sylvana Cote
Summary: This study explores the patterns of relative academic achievement of children in the classroom from grade 1 to grade 6 and their associations with child, parental, and socio-familial characteristics. The findings indicate that low parental education and family income, male sex, and poor parental behaviors and attitudes towards the child are associated with a lower trajectory of relative academic achievement.
EARLY CHILDHOOD RESEARCH QUARTERLY
(2023)
Article
Psychology, Developmental
Genevieve Morneau-Vaillancourt, Olakunle Oginni, Elham Assary, Georgina Krebs, Ellen J. J. Thompson, Elisavet Palaiologou, Celestine Lockhart, Louise Arseneault, Thalia C. C. Eley
Summary: This study found reciprocal influences between emotional symptoms and interpersonal difficulties during adolescence, with social isolation and peer victimisation being important risk factors for the long-term persistence of emotional symptoms. Early peer victimisation predicted later emotional symptoms via social isolation, highlighting the need for early intervention.
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Dominique Petit, Evelyne Touchette, Marie-Helene Pennestri, Jean Paquet, Sylvana Cote, Richard E. Tremblay, Michel Boivin, Jacques Y. Montplaisir
Summary: Sleep duration during early childhood is associated with long-term academic achievement. Children who slept less than 8 hours per night at 2.5 years had higher odds of having below average grades in various subjects compared to those who slept sufficiently. Sufficient sleep in early childhood is important for academic success.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Psychiatry
Joanne B. Newbury, Louise Arseneault, Terrie E. Moffitt, Candice L. Odgers, Laura D. Howe, Ioannis Bakolis, Aaron Reuben, Andrea Danese, Karen Sugden, Benjamin Williams, Line J. H. Rasmussen, Antonella Trotta, Antony P. Ambler, Helen L. Fisher
Summary: Children exposed to socioenvironmental adversities are more likely to develop subclinical psychotic experiences during adolescence. This association is partly explained by cognitive ability and inflammation.
SCHIZOPHRENIA BULLETIN
(2023)
Article
Psychology, Biological
Jasmin Wertz, Terrie E. Moffitt, Louise Arseneault, J. C. Barnes, Michel Boivin, David L. Corcoran, Andrea Danese, Robert J. Hancox, HonaLee Harrington, Renate M. Houts, Stephanie Langevin, Hexuan Liu, Richie Poulton, Karen Sugden, Peter T. Tanksley, Benjamin S. Williams, Avshalom Caspi
Summary: A study of 36,516 parents from six international cohorts reveals associations between parental genetics and parental investments in offspring, from behaviors during pregnancy to wealth inheritance in adulthood. The effects of parental genetics on behaviors tend to be small at any given time point, but accumulate over development. This suggests that parents pass on advantages to their children through genetic associations with investments across various stages of development.
NATURE HUMAN BEHAVIOUR
(2023)
Article
Psychology, Clinical
Rachel Dufour, Edith Breton, Alexandre J. S. Morin, Sylvana M. Cote, Lise Dubois, Frank Vitaro, Michel Boivin, Richard E. Tremblay, Linda Booij
Summary: This study, using a longitudinal design, found that early hyperactivity, overeating, cognitive inflexibility, and working memory may precede the onset of eating-disorder symptoms in adolescence. Screening children's behavior and cognition early on may help identify those most at risk for eating disorders and guide preventive interventions.
JOURNAL OF EATING DISORDERS
(2023)
Article
Psychology, Developmental
Timothy Matthews, Avshalom Caspi, Andrea Danese, Helen L. Fisher, Terrie E. Moffitt, Louise Arseneault
Summary: This study used a longitudinal and discordant twin design to explore the developmental associations between victimization and loneliness. The results showed that different forms of victimization were associated with loneliness in a dose-response manner. Childhood bullying victimization was uniquely associated with loneliness, and this association continued into young adulthood. The findings indicate that vulnerability to loneliness varies depending on the specific form of victimization and the developmental period in which it is experienced.
DEVELOPMENT AND PSYCHOPATHOLOGY
(2022)
Article
Psychology, Developmental
Timothy Matthews, Helen L. Fisher, Bridget T. Bryan, Andrea Danese, Terrie E. Moffitt, Pamela Qualter, Lily Verity, Louise Arseneault
Summary: This study utilized quantitative and qualitative methods to examine how lonely young individuals are perceived by others, finding associations between loneliness and perceived personality traits, as well as revealing the complexity of severely lonely young adults' circumstances.
INTERNATIONAL JOURNAL OF BEHAVIORAL DEVELOPMENT
(2022)
Review
Neurosciences
Maya Jammoul, Dareen Jammoul, Kevin K. Wang, Firas Kobeissy, Ralph G. Depalma
Summary: This article reviews the possible mechanisms by which traumatic brain injury (TBI) may stimulate the development of opioid use disorder (OUD) and discusses the interaction between these two processes. CNS damage due to TBI appears to drive adverse effects of subsequent OUD, with pain being a risk factor for opioid use after TBI.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Danusa Mar Arcego, Jan-Paul Buschdorf, Nicholas O'Toole, Zihan Wang, Barbara Barth, Irina Pokhvisneva, Nirmala Arul Rayan, Sachin Patel, Euclides Jose de Mendonca Filho, Patrick Lee, Jennifer Tan, Ming Xuan Koh, Chu Ming Sim, Carine Parent, Randriely Merscher Sobreira de Lima, Andrew Clappison, Kieran J. O'Donnell, Carla Dalmaz, Janine Arloth, Nadine Provencal, Elisabeth B. Binder, Josie Diorio, Patricia Pelufo Silveira, Michael J. Meaney
Summary: This study investigates the impact of environmental influences on mental health by integrating transcriptomic data from animal models with human data. The results suggest that hippocampal glucocorticoid-related transcriptional activity mediates the effects of early adversity on neural mechanisms implicated in psychiatric disorders.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Milenna T. van Dijk, Ardesheer Talati, Pratik Kashyap, Karan Desai, Nora C. Kelsall, Marc J. Gameroff, Natalie Aw, Eyal Abraham, Breda Cullen, Jiook Cha, Christoph Anacker, Myrna M. Weissman, Jonathan Posner
Summary: This study found that maternal stress is associated with future depressive symptoms and alterations in microstructure of the dentate gyrus (DG) in offspring. These results were consistent across two independent cohorts.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Josephine C. McGowan, Liliana R. Ladner, Claire X. Shubeck, Juliana Tapia, Christina T. LaGamma, Amanda Anqueira-Gonzalez, Ariana DeFrancesco, Briana K. Chen, Holly C. Hunsberger, Ezra J. Sydnor, Ryan W. Logan, Tzong-Shiue Yu, Steven G. Kernie, Christine A. Denny
Summary: Traumatic brain injury (TBI) leads to fear generalization by altering fear memory traces, and this symptom can be improved with (R,S)-ketamine.
BIOLOGICAL PSYCHIATRY
(2024)
