Editorial Material
Hematology
Andrew Wirth, N. George Mikhaeel
Summary: This study demonstrates that in patients with DLBCL, those who are EOT PET-negative may be spared from radiotherapy, while selected patients with EOT PET-positive sites can achieve outcomes comparable to PET-negative patients when receiving selective treatment.
Review
Oncology
Federica Matteucci, Giovanni Paganelli, Giovanni Martinelli, Claudio Cerchione
Summary: Recent advances in the diagnosis and treatment of multiple myeloma have emphasized the importance of imaging methods, particularly PET/CT, in providing accurate information for disease localization, prognosis, and therapy response evaluation. While 18F-FDG tracer is commonly used and has high sensitivity, limitations such as physiological uptake in the bone marrow and brain have prompted research on other PET tracers for improved accuracy in multiple myeloma management.
FRONTIERS IN ONCOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Irene Hernandez-Lozano, Severin Mairinger, Thomas Filip, Michael Sauberer, Thomas Wanek, Johann Stanek, Johannes A. Sake, Thomas Pekar, Carsten Ehrhardt, Oliver Langer
Summary: The study demonstrates that P-glycoprotein can affect the pulmonary disposition of inhaled drugs, with decreased P-gp activity potentially leading to lower lung exposure and decreased therapeutic efficacy. PET imaging with intratracheally aerosolized radiotracers shows promise for assessing the impact of membrane transporters on pulmonary drug delivery in both rodents and potentially in humans.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Haiyan Wang, Yaping Wu, Zhenxing Huang, Zhicheng Li, Na Zhang, Fangfang Fu, Nan Meng, Haining Wang, Yun Zhou, Yongfeng Yang, Xin Liu, Dong Liang, Hairong Zheng, Greta S. P. Mok, Meiyun Wang, Zhanli Hu
Summary: Our proposed deep learning method can synthesize highly correlated and consistent dynamic parametric images obtained from static lung PET. The image quality of the synthesized images was evaluated qualitatively and quantitatively, and statistical analysis of correlation and consistency was performed on the synthetic images.
EUROPEAN RADIOLOGY
(2023)
Article
Clinical Neurology
Pierre-Francois Meyer, Nicholas J. Ashton, Thomas K. Karikari, Cherie Strikwerda-Brown, Theresa Kobe, Julie Gonneaud, Alexa Pichet Binette, Hazal Ozlen, Yara Yakoub, Joel Simren, Josef Pannee, Juan Lantero-Rodriguez, Anne Labonte, Suzanne L. Baker, Michael Scholl, Eugeen Vanmechelen, John C. S. Breitner, Henrik Zetterberg, Kaj Blennow, Judes Poirier, Sylvia Villeneuve
Summary: This study evaluated novel plasma p-tau231 and p-tau181, as well as A beta(40) and A beta(42) assays as indicators of tau and A beta pathologies measured with positron emission tomography (PET) and their association with cognitive change in cognitively unimpaired older adults. The findings showed that plasma p-tau231 had stronger associations with PET biomarkers compared to p-tau181 in presymptomatic individuals. The combination of p-tau and A beta(42/40) biomarkers detected early AD pathology and cognitive decline.
ANNALS OF NEUROLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Qianrui Li, Wenxiu Hou, Mei Wu, Ling Li, Minggang Su, Bin Ma, Futao Cui, Yan Ren, Jiayue Xu, Kang Zou, Rong Tian, Xin Sun
Summary: This study systematically appraised the methodologies used for PET imaging guidelines and compared the consistency of these recommendations. The findings showed that current guidelines for PET imaging vary in methodological quality and provided considerably inconsistent recommendations. Efforts are needed to improve adherence to guideline development methodologies, to synthesize high-quality evidence, and to adopt standard terminologies.
EUROPEAN RADIOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Giordana Salvi de Souza, Dimitri B. A. Mantovani, Pascalle Mossel, Bartholomeus C. M. Haarman, Ana Maria Marques da Silva, Hendrikus H. Boersma, Cristiane R. G. Furini, Adriaan A. Lammertsma, Charalampos Tsoumpas, Gert Luurtsema
Summary: The oral route is widely used and preferred for drug administration. Accurate quantification of drug absorption, distribution, metabolism, excretion, and characterization is crucial for drug development. In vivo methods such as gamma-scintigraphy, MRI, and PET have been used to analyze gastrointestinal absorption. This review focuses on PET studies using oral tracers, revealing variations in acquisition protocols, quantification methods, and pharmacokinetic parameters. Human studies showed 10-30 minutes for tracer to reach the intestine and about 100 minutes to reach peak concentration in the brain. Rodent studies estimated different pharmacokinetic parameters, indicating PET's potential for non-invasive measurement of drug absorption and distribution. Long Axial Field of View (LAFOV) PET scanners can reduce administered dose, making oral administration feasible for clinical studies.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Multidisciplinary Sciences
Ou Yamaguchi, Kyoichi Kaira, Ichiro Naruse, Yukihiro Umeda, Takeshi Honda, Satoshi Watanabe, Kosuke Ichikawa, Kazunari Tateishi, Norimitsu Kasahara, Tetsuya Higuchi, Kosuke Hashimoto, Shun Shinomiya, Yu Miura, Ayako Shiono, Atsuto Mouri, Hisao Imai, Kunihiko Iizuka, Tamotsu Ishizuka, Koichi Minato, Satoshi Suda, Hiroshi Kagamu, Keita Mori, Ichiei Kuji, Nobuhiko Seki
Summary: This study aimed to investigate the clinical relevance of F-18-FDG PET/CT compared to CT in predicting the response to PD-1 blockade in the early phase. The results showed that metabolic assessment by MTV or TLG was superior to morphological changes on CT for predicting the therapeutic response and survival.
SCIENTIFIC REPORTS
(2022)
Review
Crystallography
Xin Yu, Xi Zhang, Heng Zhang, Hao Peng, Qiushi Ren, Jianfeng Xu, Qiyu Peng, Siwei Xie
Summary: Positron emission tomography (PET) is widely used for the diagnosis of tumors, cardiovascular diseases, and neurological diseases. This article introduces the principle and requirements of scintillation crystals in PET and analyzes the performance of different crystals. LYSO is currently the best-performing crystal, while LaBr3 has better timing characteristics and light output. GAGG detectors have a high depth of interaction resolution and great potential for applications.
Article
Biochemical Research Methods
Palak Wadhwa, Kris Thielemans, Nikos Efthimiou, Kristen Wangerin, Nicholas Keat, Elise Emond, Timothy Deller, Ottavia Bertolli, Daniel Deidda, Gaspar Delso, Michel Tohme, Floris Jansen, Roger N. Gunn, William Hallett, Charalampos Tsoumpas
Summary: This research demonstrates successful computational and physical modelling of the PET-MR system for image acquisition, generating images comparable to those from the manufacturer; the new software developments will be integrated into STIR, providing researchers worldwide with opportunities to establish and expand their image reconstruction methods; by modelling all effects within the system matrix, PET images showing the metabolic uptake of administered radiopharmaceuticals were reconstructed accurately.
Article
Medicine, General & Internal
Cecile Tissot, Joseph Therriault, Peter Kunach, Andrea L. Benedet, Tharick A. Pascoal, Nicholas J. Ashton, Thomas K. Karikari, Stijn Servaes, Firoza Z. Lussier, Mira Chamoun, Dana L. Tudorascu, Jenna Stevenson, Nesrine Rahmouni, Nina Margherita Poltronetti, Vanessa Pallen, Gleb Bezgin, Min Su Kang, Sulantha S. Mathotaarachchi, Yi-Ting Wang, Jaime Fernandez Arias, Pamela Cristina Lukasewicz Ferreira, Joao Pedro Ferrari-Souza, Eugeen Vanmechelen, Kaj Blennow, Henrik Zetterberg, Serge Gauthier, Pedro Rosa-Neto
Summary: This study investigated the agreement between [F-18]MK6240 tau-PET, plasma pTau181, and pTau231 in Alzheimer's disease. The findings suggest that these biomarkers reflect different stages of tau progression and can be useful in diagnosing and evaluating the disease stage.
Article
Radiology, Nuclear Medicine & Medical Imaging
Wan-Ming Chen, Mingchih Chen, Jeng-Guan Hsu, Tian-Shyug Lee, Ben-Chang Shia, Szu-Yuan Wu
Summary: The use of preoperative PET/CT is associated with a lower risk of death in patients with resectable stage IIIA-IIIB non-small cell lung cancer, but it does not improve survival rates in patients with stage I-II cancer.
Article
Radiology, Nuclear Medicine & Medical Imaging
Yong Du, Jennifer M. Coughlin, Alireza Amindarolzarbi, Shannon Eileen Sweeney, Courtney K. Harrington, Mary Katherine Brosnan, Adeline Zandi, Laura K. Shinehouse, Alejandra N. Reyes Sanchez, Rehab Abdallah, Daniel P. Holt, Hong Fan, Wojciech G. Lesniak, Ayon Nandi, Steven P. Rowe, Lilja B. Solnes, Robert F. Dannals, Andrew G. Horti, Martin A. Lodge, Martin G. Pomper
Summary: This study reported the test-retest repeatability of [F-18]FNDP brain PET binding and [F-18]FNDP whole-body dosimetry in healthy individuals. The results showed that [F-18]FNDP brain PET imaging and whole-body dosimetry had favorable repeatability in healthy individuals.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Medicine, General & Internal
Ken Kudura, Florentia Dimitriou, Daniela Mihic-Probst, Urs J. Muehlematter, Tim Kutzker, Lucas Basler, Robert Forster, Reinhard Dummer, Joanna Mangana, Lars Husmann, Irene A. Burger, Michael Christoph Kreissl
Summary: The use of FDG-PET/CT in metastatic melanoma patients has increased significantly due to improved survival rates. Indeterminate findings on FDG-PET/CT in these patients should be further investigated, as almost half of them are malignant with the majority being melanoma metastases. Other primary malignancies are also found in a significant proportion of cases, impacting clinical management in the majority of malignant findings.
Article
Chemistry, Multidisciplinary
Joaquin L. Herraiz, Adrian Bembibre, Alejandro Lopez-Montes
Summary: This work demonstrates that a trained deep neural network is able to accurately correct the blurring present in PET images caused by the positron range, achieving up to 95% image restoration without significant noise increase. The proposed method can provide accurate positron range correction in a few seconds for a typical PET acquisition.
APPLIED SCIENCES-BASEL
(2021)
Review
Neurosciences
Maya Jammoul, Dareen Jammoul, Kevin K. Wang, Firas Kobeissy, Ralph G. Depalma
Summary: This article reviews the possible mechanisms by which traumatic brain injury (TBI) may stimulate the development of opioid use disorder (OUD) and discusses the interaction between these two processes. CNS damage due to TBI appears to drive adverse effects of subsequent OUD, with pain being a risk factor for opioid use after TBI.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Danusa Mar Arcego, Jan-Paul Buschdorf, Nicholas O'Toole, Zihan Wang, Barbara Barth, Irina Pokhvisneva, Nirmala Arul Rayan, Sachin Patel, Euclides Jose de Mendonca Filho, Patrick Lee, Jennifer Tan, Ming Xuan Koh, Chu Ming Sim, Carine Parent, Randriely Merscher Sobreira de Lima, Andrew Clappison, Kieran J. O'Donnell, Carla Dalmaz, Janine Arloth, Nadine Provencal, Elisabeth B. Binder, Josie Diorio, Patricia Pelufo Silveira, Michael J. Meaney
Summary: This study investigates the impact of environmental influences on mental health by integrating transcriptomic data from animal models with human data. The results suggest that hippocampal glucocorticoid-related transcriptional activity mediates the effects of early adversity on neural mechanisms implicated in psychiatric disorders.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Milenna T. van Dijk, Ardesheer Talati, Pratik Kashyap, Karan Desai, Nora C. Kelsall, Marc J. Gameroff, Natalie Aw, Eyal Abraham, Breda Cullen, Jiook Cha, Christoph Anacker, Myrna M. Weissman, Jonathan Posner
Summary: This study found that maternal stress is associated with future depressive symptoms and alterations in microstructure of the dentate gyrus (DG) in offspring. These results were consistent across two independent cohorts.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Josephine C. McGowan, Liliana R. Ladner, Claire X. Shubeck, Juliana Tapia, Christina T. LaGamma, Amanda Anqueira-Gonzalez, Ariana DeFrancesco, Briana K. Chen, Holly C. Hunsberger, Ezra J. Sydnor, Ryan W. Logan, Tzong-Shiue Yu, Steven G. Kernie, Christine A. Denny
Summary: Traumatic brain injury (TBI) leads to fear generalization by altering fear memory traces, and this symptom can be improved with (R,S)-ketamine.
BIOLOGICAL PSYCHIATRY
(2024)