Article
Clinical Neurology
Thi Xuan Dai Cao, Christopher Filliter, Francois Montastruc, Oriana Hoi Yun Yu, Emma Fergusson, Soham Rej, Laurent Azoulay, Christel Renoux
Summary: This study found that there is no difference in the risk of T2DM between SSRIs with strong affinity and weak affinity in youths, providing reassurance for clinicians when choosing SSRIs.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Ma-Li Wong, Mauricio Arcos-Burgos, Sha Liu, Alice W. Licinio, Chenglong Yu, Eunice W. M. Chin, Wei-Dong Yao, Xin-Yun Lu, Stefan R. Bornstein, Julio Licinio
Summary: Rare functional variants were identified in antidepressant drug response, serving as potential genetic markers for predicting drug response. Limitations include small sample size and inability to use antidepressant blood level as a covariate. Further studies with larger cohorts are warranted.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Public, Environmental & Occupational Health
Avital Fischer, Hedy S. Rennert, Gad Rennert
Summary: The study found that the use of SSRIs before and after breast cancer diagnosis is associated with increased mortality in breast cancer patients. Research is needed to further understand the mechanisms behind this association.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Environmental Sciences
Daniela Correia, Ines Domingues, Melissa Faria, Miguel Oliveira
Summary: Fluoxetine, a selective serotonin reuptake inhibitor, is commonly detected in aquatic environments at concentrations ranging from ng/L to μg/L. It can have adverse effects on fish, including neurotoxicity, genetic and biochemical changes, and behavioral dysfunction. However, contradictory results have been found. A comprehensive review is needed to understand the effects of fluoxetine on fish at different biological levels, identify patterns, and discuss potential causes for contradictory results. This review also highlights the need for standardized testing with representative aquatic models to assess the actual environmental risk of fluoxetine to aquatic ecosystems.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Marco Picone, Gabriele Giuseppe Distefano, Roberta Zangrando, Andrea Gambaro, Annamaria Volpi Ghirardini
Summary: The presence of neonicotinoids and active pharmaceuticals ingredients (API) in the environment has raised increasing concerns for their potential adverse effects on wildlife. This study focused on non-invasive monitoring of these contaminants using hair samples from Red fox. Neonicotinoids were detected in many hair samples, while APIs were less frequently detected. The findings suggest that hair can be used as a good indicator for monitoring environmental exposure to neonicotinoids as well as certain antidepressants and NSAIDs.
ENVIRONMENTAL RESEARCH
(2023)
Article
Clinical Neurology
Jonathan S. Levin, Joie Acosta, Laura J. Faherty
Summary: This study found that the COVID-19 pandemic was associated with an increase in new SSRI prescription fills, particularly among women, young adults, and those under 18 years old.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Editorial Material
Medicine, Research & Experimental
Sidney H. Kennedy
Summary: Defining treatment response in depression as a 50% reduction in symptom severity acknowledges that some patients will still have residual symptoms. Assessing both symptom improvement and functional outcomes is important. Not all patients who experience symptom relief will achieve functional recovery. Combination therapy may be beneficial for patients with certain residual symptoms. Therefore, treatment selection should consider antidepressant efficacy, adverse effects, and patient acceptability.
ADVANCES IN THERAPY
(2022)
Review
Neurosciences
Tommaso B. Jannini, Giorgio D. Lorenzo, Emanuela Bianciardi, Cinzia Niolu, Massimiliano Toscano, Giacomo Ciocca, Emmanuele A. Jannini, Alberto Siracusano
Summary: Selective serotonin reuptake inhibitors (SSRIs) are widely prescribed psychiatric drugs for off-label use, but their use comes with potential side effects that should not be underestimated.
CURRENT NEUROPHARMACOLOGY
(2022)
Article
Psychiatry
Kuan Li, Guibao Zhou, Yan Xiao, Jiayu Gu, Qiuling Chen, Shouxia Xie, Junyan Wu
Summary: This meta-analysis study found that exposure to antidepressants, especially SSRIs, significantly increased the risk of suicide and suicide attempt in children and adolescents compared to those not using antidepressants. SSRIs were specifically associated with an increased risk of suicide and suicide attempt, while the risk between SSRIs and other antidepressants was similar.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Immunology
Cecilie V. Vollmond, Malte M. Tetens, Fie W. Paulsen, Jan Gerstoft, Gitte Kronborg, Isik S. Johansen, Carsten S. Larsen, Lothar Wiese, Michael Dalager-Pedersen, Steffen Leth, Preben B. Mortensen, Anne-Mette Lebech, Niels Obel, Lars H. Omland
Summary: In this nationwide, population-based, matched cohort study in Denmark, we found that people with HIV have an increased risk of depression, receipt of antidepressants, treatment with electroconvulsive therapy, and suicide compared to the general population. This risk decreases after 2 years but remains higher than the general population. Familial factors are unlikely to explain this risk.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Psychology, Clinical
Romain Colle, Khalil El Asmar, Celine Verstuyft, Pierre-Marie Lledo, Francoise Lazarini, Kenneth Chappell, Eric Deflesselle, Abd El Kader Ait Tayeb, Bruno Falissard, Emmanuelle Duron, Samuel Rotenberg, Jean-Francois Costemale-Lacoste, Denis J. David, Florence Gressier, Alain M. Gardier, Thomas Hummel, Laurent Becquemont, Emmanuelle Corruble
Summary: The study found significant differences in olfactory performance between depressed patients and healthy controls, but after venlafaxine treatment, some patients showed improvements in olfaction, which were mediated by the alleviation of depressive symptoms.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Clinical Neurology
Lars Vedel Kessing, Simon Christoffer Ziersen, Esben Budtz-Jorgensen, Thomas Gerds
Summary: The study confirmed a decreased response to antidepressants in patients with depression and comorbid epilepsy, especially among younger and unemployed patients. This emphasizes the importance of close monitoring and psychological support for these patients.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Megan Galbally, Stuart J. Watson, Philip Boyce, Rebecca Anglin, Elizabeth McKinnon, Andrew J. Lewis
Summary: The study found that women with untreated depression during pregnancy had higher intake of unhealthy takeaway food throughout the postpartum period, while higher depressive symptoms in the postpartum were also associated with higher takeaway intake. However, there was no difference in fruit and vegetable intake among the three groups, and intake was highest for all women late in pregnancy and declined in the postpartum period.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Lijun Zhang, Guo Li, Meiyan Liu
Summary: This meta-analysis aimed to explore the association between SSRIs and blood pressure in patients with CVD and depression. The results showed that SSRIs had no effect on SBP and DBP overall, but significantly lowered DBP in hypertensive patients. Further research is needed to understand the potential mechanisms.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Chemistry, Multidisciplinary
Michal Wicinski, Bartlomiej J. Kaluzny, Slawomir Liberski, Daria Marczak, Jakub J. Kaluzny
Summary: Acute angle closure (AAC) is a rare but serious ophthalmological condition, often associated with the use of selective serotonin reuptake inhibitors (SSRIs). AAC in individuals receiving SSRIs is mainly caused by pupillary block mechanism, but may also result from other mechanisms such as uveal effusion.
APPLIED SCIENCES-BASEL
(2021)
Review
Psychiatry
Kevin P. Hill, Mark S. Gold, Charles B. Nemeroff, William McDonald, Adrienne Grzenda, Alik S. Widge, Carolyn Rodriguez, Nina Kraguljac, John H. Krystal, Linda L. Carpenter
Summary: This review aims to outline the evidence for the therapeutic use of cannabinoids for specific medical conditions and the potential side effects associated with acute and chronic cannabis use. The results show that there are currently no approved psychiatric indications for cannabinoids, and the evidence supporting their use in the treatment of psychiatric disorders is limited. The strongest evidence for cannabinoid prescription is for the management of pain and spasticity.
AMERICAN JOURNAL OF PSYCHIATRY
(2022)
Editorial Material
Psychiatry
Charles B. Nemero
AMERICAN JOURNAL OF PSYCHIATRY
(2022)
Article
Clinical Neurology
S. J. Sharp, M. A. Bond, K. S. Chiang, S. J. Collier, J. Farrington, T. Lanza di Scalea, C. B. Nemeroff, D. J. Newport, D. A. Spelber, S. M. Strakowski, J. R. C. Almeida
Summary: The study validated a significant positive correlation between the depression subscale of ASRS and PHQ-9 and QIDS-16, establishing meaningful clinical thresholds for depression assessment.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Biochemistry & Molecular Biology
Luca Sforzini, Courtney Worrell, Melisa Kose, Ian M. Anderson, Bruno Aouizerate, Volker Arolt, Michael Bauer, Bernhard T. Baune, Pierre Blier, Anthony J. Cleare, Philip J. Cowen, Timothy G. Dinan, Andrea Fagiolini, I. Nicol Ferrier, Ulrich Hegerl, Andrew D. Krystal, Marion Leboyer, R. Hamish McAllister-Williams, Roger S. McIntyre, Andreas Meyer-Lindenberg, Andrew H. Miller, Charles B. Nemeroff, Claus Normann, David Nutt, Stefano Pallanti, Luca Pani, Brenda W. J. H. Penninx, Alan F. Schatzberg, Richard C. Shelton, Lakshmi N. Yatham, Allan H. Young, Roland Zahn, Georgios Aislaitner, Florence Butlen-Ducuing, Christine Fletcher, Marion Haberkamp, Thomas Laughren, Fanni-Laura Mantyla, Koen Schruers, Andrew Thomson, Gara Arteaga-Henriquez, Francesco Benedetti, Lucinda Cash-Gibson, Woo Ri Chae, Heidi De Smedt, Stefan M. Gold, Witte J. G. Hoogendijk, Valeria Jordan Mondragon, Eduard Maron, Jadwiga Martynowicz, Elisa Melloni, Christian Otte, Gabriela Perez-Fuentes, Sara Poletti, Mark E. Schmidt, Edwin van de Ketterij, Katherine Woo, Yanina Flossbach, J. Antoni Ramos-Quiroga, Adam J. Savitz, Carmine M. Pariante
Summary: The document discusses the criteria for treatment-resistant depression (TRD) and partially responsive depression (PRD) as subtypes of major depressive disorder (MDD) which are not clearly defined, using a Delphi-method-based consensus approach. It reviews literature and gathers international experts to evaluate controversies and provide recommendations on designing clinical trials and guiding research. It aims to support the design of a protocol for platform trials of new medications for TRD/PRD as part of the EUropean Patient-cEntric clinicAl tRial pLatforms, Innovative Medicines Initiative (EU-PEARL, IMI) MDD project.
MOLECULAR PSYCHIATRY
(2022)
Review
Psychiatry
Mara Parellada, Alvaro Andreu-Bernabeu, Monica Burdeus, Antonia San Jose Caceres, Elena Urbiola, Linda L. Carpenter, Nina V. Kraguljac, William M. McDonald, Charles B. Nemeroff, Carolyn I. Rodriguez, Alik S. Widge, Matthew W. State, Stephan J. Sanders
Summary: The aim of this study was to evaluate response biomarkers correlated with autism spectrum disorder (ASD) symptoms. A systematic review was conducted and 280 articles were included, reporting on 940 biomarkers. However, the studies showed high heterogeneity and there is currently no sufficient evidence for response biomarkers in ASD clinical trials.
AMERICAN JOURNAL OF PSYCHIATRY
(2023)
Article
Psychiatry
Boadie W. Dunlop, Jungho Cha, Ki Sueng Choi, Justin K. Rajendra, Charles B. Nemeroff, W. Edward Craighead, Helen S. Mayberg
Summary: This study aimed to determine the shared and unique changes in brain resting-state functional connectivity (rsFC) between patients with major depressive disorder who achieved remission with cognitive-behavioral therapy (CBT) or with antidepressant medication. The results showed that remission from major depression via treatment with CBT or medication is associated with changes in rsFC that are mostly specific to the treatment modality, providing biological support for the clinical practice of switching between or combining these treatment approaches.
AMERICAN JOURNAL OF PSYCHIATRY
(2023)
Biographical-Item
Neurosciences
Charles B. B. Nemeroff
NEUROPSYCHOPHARMACOLOGY
(2023)
Review
Psychology, Clinical
Kevin M. Crombie, Tom G. Adams, Joseph E. Dunsmoor, Benjamin N. Greenwood, Jasper A. Smits, Charles B. Nemeroff, Josh M. Cisler
Summary: Posttraumatic stress disorder (PTSD) is often accompanied by heightened emotional responses, avoidance of trauma-related triggers, and physical health concerns. Traditional therapies focus on reducing anxiety symptoms, but do not address the physical health issues associated with PTSD. Recent evidence suggests that timed aerobic exercise can enhance fear extinction learning, making it a promising adjunctive strategy to improve physical health and enhance the effects of exposure therapies. This review provides an overview of relevant studies, discusses mechanisms behind enhanced fear extinction, and suggests areas for future research to further explore the importance of incorporating exercise into PTSD treatment.
JOURNAL OF ANXIETY DISORDERS
(2023)
Review
Psychiatry
Alik S. Widge, Ayana Jordan, Nina V. Kraguljac, Christi R. P. Sullivan, Saydra Wilson, Tami D. Benton, Jonathan E. Alpert, Linda L. Carpenter, John H. Krystal, Charles B. Nemeroff, Kafui Dzirasa
Summary: Investigators from minoritized backgrounds are underrepresented in psychiatric research, leading to disparities in mental health care. This underrepresentation is a result of the interlocking effects of structural biases, such as limited access to advanced training and opportunities, stereotype threats and microaggressions, isolation, limited funding, and unique financial pressures. Structural racism, which perpetuates race-based disparities, exists despite efforts to increase diversity. Potential approaches to address these biases include undergraduate research experiences, financial support for training programs, targeted mentoring, better use of diversity funding, scientific reentry support, diversity efforts in leadership, and examination of hiring and promotion practices. Implementing these approaches alongside outcome measurement has the potential to reverse decades of structural bias in psychiatry and psychiatric research.
AMERICAN JOURNAL OF PSYCHIATRY
(2023)
Article
Psychiatry
Jeffrey D. Shahidullah, James Custer, Oscar Widales-Benitez, Nazan Aksan, Carly Hatchell, Jeffrey Newport, Karen Dineen Wagner, Eric A. Storch, Cynthia Claassen, Amy Garrett, Irma T. Ugalde, Wade Weber, Charles B. Nemeroff, Paul J. Rathouz
Summary: This study aims to describe the rater training protocol for administering semi-structured psychiatric interviews in large, multi-site studies and evaluate its effectiveness. The training involved synchronous and asynchronous learning modules, and certification included critique of mock scale administration. The protocol resulted in strong interrater reliability across all measures.
PSYCHIATRY RESEARCH
(2023)
Article
Psychiatry
Shaunna L. Clark, Cody G. Dodd, Leslie Taylor, Sunita Stewart, Nancy Yang, Jeffrey D. Shahidullah, Andrew G. Guzick, Robyn Richmond, Nazan Aksan, Paul J. Rathouz, Justin F. Rousseau, D. Jeffrey Newport, Karen Dineen Wagner, Charles B. Nemeroff
Summary: This study investigated the substance use patterns and co-occurring psychiatric disorders in trauma-exposed youth. Four primary patterns of substance use were identified, with different characteristics. The findings highlight the importance of universal assessments of trauma, substance misuse, and mental health symptoms in youth.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Neurosciences
Boadie W. Dunlop, Jungho Cha, Ki Sueng Choi, Charles B. Nemeroff, W. Edward Craighead, Helen S. Mayberg
Summary: Using neuroimaging data, researchers identified increased connectivity between the subcallosal cingulate cortex and the anterior insula, as well as decreased connectivity between the subcallosal cingulate cortex and the bilateral primary visual cortex and the insula and the bilateral caudate, as predictive factors for recurrence in major depressive disorder (MDD).
NEUROPSYCHOPHARMACOLOGY
(2023)
Editorial Material
Neurosciences
Mark A. A. Frye, Charles B. B. Nemeroff
Summary: Pharmacogenomic technology is a developing field with broad application potential. Although previous studies did not show significant benefit, they laid the foundation for further research that should address limitations and include diverse populations. Future research needs to include large scale pharmacogenomic trials with GWAS analytics and explore optimal EHR user interface design.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Psychiatry
Roger S. Mcintyre, Mohammad Alsuwaidan, Bernhard T. Baune, Michael Berk, Koen Demyttenaere, Joseph F. Goldberg, Philip Gorwood, Roger Ho, Siegfried Kasper, Sidney H. Kennedy, Josefina Ly-Uson, Rodrigo B. Mansur, R. Hamish McAllister-Williams, James W. Murrough, Charles B. Nemeroff, Andrew A. Nierenberg, Joshua D. Rosenblat, Gerard Sanacora, Alan F. Schatzberg, Richard Shelton, Stephen M. Stahl, Madhukar H. Trivedi, Eduard Vieta, Maj Vinberg, Nolan Williams, Allan H. Young, Mario Maj
Summary: Treatment-resistant depression is common and has serious public health implications. The lack of a consensus definition hampers accurate estimates of its prevalence and efforts to identify effective interventions, leading to heterogeneity in treatment decision-making and potentially compromising quality of care.
Article
Behavioral Sciences
Elizabeth T. C. Lippard, Charles B. Nemeroff
Summary: Childhood maltreatment increases the risk for mood disorders and has a negative impact on the development and course of these disorders. Longitudinal studies support the devastating effects of childhood maltreatment on mood disorders. Risky behaviors following maltreatment can further worsen the disease course. More research is needed on sex differences and the impact of maltreatment on vulnerable populations.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2022)
Review
Neurosciences
Maya Jammoul, Dareen Jammoul, Kevin K. Wang, Firas Kobeissy, Ralph G. Depalma
Summary: This article reviews the possible mechanisms by which traumatic brain injury (TBI) may stimulate the development of opioid use disorder (OUD) and discusses the interaction between these two processes. CNS damage due to TBI appears to drive adverse effects of subsequent OUD, with pain being a risk factor for opioid use after TBI.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Danusa Mar Arcego, Jan-Paul Buschdorf, Nicholas O'Toole, Zihan Wang, Barbara Barth, Irina Pokhvisneva, Nirmala Arul Rayan, Sachin Patel, Euclides Jose de Mendonca Filho, Patrick Lee, Jennifer Tan, Ming Xuan Koh, Chu Ming Sim, Carine Parent, Randriely Merscher Sobreira de Lima, Andrew Clappison, Kieran J. O'Donnell, Carla Dalmaz, Janine Arloth, Nadine Provencal, Elisabeth B. Binder, Josie Diorio, Patricia Pelufo Silveira, Michael J. Meaney
Summary: This study investigates the impact of environmental influences on mental health by integrating transcriptomic data from animal models with human data. The results suggest that hippocampal glucocorticoid-related transcriptional activity mediates the effects of early adversity on neural mechanisms implicated in psychiatric disorders.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Milenna T. van Dijk, Ardesheer Talati, Pratik Kashyap, Karan Desai, Nora C. Kelsall, Marc J. Gameroff, Natalie Aw, Eyal Abraham, Breda Cullen, Jiook Cha, Christoph Anacker, Myrna M. Weissman, Jonathan Posner
Summary: This study found that maternal stress is associated with future depressive symptoms and alterations in microstructure of the dentate gyrus (DG) in offspring. These results were consistent across two independent cohorts.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Josephine C. McGowan, Liliana R. Ladner, Claire X. Shubeck, Juliana Tapia, Christina T. LaGamma, Amanda Anqueira-Gonzalez, Ariana DeFrancesco, Briana K. Chen, Holly C. Hunsberger, Ezra J. Sydnor, Ryan W. Logan, Tzong-Shiue Yu, Steven G. Kernie, Christine A. Denny
Summary: Traumatic brain injury (TBI) leads to fear generalization by altering fear memory traces, and this symptom can be improved with (R,S)-ketamine.
BIOLOGICAL PSYCHIATRY
(2024)